With two commercially available inhibitors, the cell cycle of the cancer cells in neuroblastomas can be disrupted at a key point causing tumour cell death. Neuroblastomas are malignant solid tumours that occur mainly in early childhood. Inhibiting the MYCN oncogene or its function could be a promising therapeutic opportunity.
University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…
Wearable devices can identify Covid-19 cases earlier than traditional diagnostic methods and can help track and improve management of the disease, Mount Sinai researchers report in one of the first studies on the topic. The findings were published in the Journal of Medical Internet Research. The Warrior Watch Study found that subtle changes in a participant’s heart rate variability (HRV)…
In a recent study, researchers at the Texas A&M University have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
A way of using machine learning to more accurately identify patients with a mix of psychotic and depressive symptoms has been developed by researchers at the University of Birmingham. Patients with depression or psychosis rarely experience symptoms of purely one or the other illness. Historically, this has meant that mental health clinicians give a diagnosis of a ‘primary’ illness, but with…
Providing the blind with visual impressions: That is the aim of the I See project, in which neuroscientists from the University of Bremen are involved. The approach: A miniature camera collects visual information and translates it into signal patterns that are transferred to brain implants.
Global greenhouse gas emissions over the last century have made southern China a hotspot for bat-borne coronaviruses, by driving growth of forest habitat favoured by bats. A new study published in the journal Science of the Total Environment provides the first evidence of a mechanism by which climate change could have played a direct role in the emergence of SARS-CoV-2, the virus that caused the…
Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…
USC researchers have developed a new method to counter emergent mutations of the coronavirus and hasten vaccine development to stop the pathogen responsible for killing thousands of people and ruining the economy.
A study reveals that scalp cooling physically protects hair follicles from chemotherapy drugs. It is the world’s first piece of biological evidence that explains how scalp cooling actually works and the mechanism behind its protection of the hair follicle. The data was part of an innovative hair follicle research project carried out by the dedicated Scalp Cooling Research Centre based at the…
Over 23 million people around the world suffer from heart failure. The disease is usually treated with a transplant, but because donated hearts are hard to come by, there is an ongoing need for alternative therapies. With new developments in cardiac assistance systems, we can delay the need for a transplant – or even eliminate it altogether,” says Professor Yves Perriard, head of EPFL’s…
Cancer ranks as a leading cause of death in every country in the world, and, for the first time, female breast cancer is the most commonly diagnosed cancer, overtaking lung cancer, according to a collaborative report, Global Cancer Statistics 2020, from the American Cancer Society (ACS) and the International Agency for Research on Cancer (IARC). Data show that 1 in 5 men and women worldwide…
Covid-19 patients who suffer a cardiac arrest either in or out of hospital are far more likely to die than patients who are not infected with the coronavirus. In particular, women have the highest risk of dying: they are nine times more likely to die after suffering a cardiac arrest in hospital, according to research published in the European Heart Journal.
Engineers at EPFL’s Center for Artificial Muscles have developed a silicone aorta that can reduce how hard patients’ hearts have to pump. Their breakthrough could offer a promising alternative to heart transplants. “Over 23 million people around the world suffer from heart failure. The disease is usually treated with a transplant, but because donated hearts are hard to come by, there is an…
The continuing corona virus epidemic has impacted strongly on cancer care and research, including the delay of treatments and diagnoses as well as on trials of new therapies, and the shift in research to develop a Covid-19 vaccine. However, the session ‘Cancer research and Covid-19’, during the National Cancer Research Institute (NCRI) Virtual Showcase (online 2-3 November) looked at how UK…
A team of neuroscientists has identified a potential means to address the loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis in mice. Their findings, reported in the journal Science Signaling, reveal that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation.
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals such as mice is difficult to do, because their…
Evidence is emerging that vitamin D – and possibly vitamins K and A – might help combat Covid-19. A new study from the University of Bristol published in the journal of the German Chemical Society Angewandte Chemie has shown how they – and other antiviral drugs – might work. The research indicates that these dietary supplements and compounds could bind to the viral spike protein and so…
The emergence of SARS-CoV-2 virus variants that are adding twists in the battle against COVID-19 highlight the need for better genomic monitoring of the virus, says Katia Koelle, associate professor of biology at Emory University.
Researchers from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes…
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles' heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
As the pandemic has continued to spread globally, studies indicate the COVID-19 virus may be contained in aerosols that can be generated and spread through breathing, coughing, sneezing, or talking by infected individuals. Researchers are increasingly focused on developing tools and methods to assist in decontaminating surfaces and spaces.
Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development.
Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases.
Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pain.