Sepsis—the body's own immune response gone against it—is a major health problem worldwide. It is basically a "hyper" immune response by the body to infection or injury, and is characterized by hyperinflammation, immune system paralysis, cell death, liver and kidney failure, blood clots, and even hemorrhage. An estimated 30 million people suffer from sepsis every year, of which 20%…
The Government and the UK’s Chief Scientific Adviser have backed the UK’s leading clinicians and scientists to map how COVID-19 spreads and behaves by using whole genome sequencing. Through a £20 million investment, the consortium will look for breakthroughs that help the UK respond to this and future pandemics, and save lives. COVID-19 Genomics UK Consortium - comprised of the NHS, Public…
Scientists from the German Cancer Research Center (DKFZ) and the Hebrew University in Jerusalem demonstrated in mice that intestinal bacteria reprogram DNA activity in cells of the gut mucosa and thus have a considerable impact on the development of the healthy gut.
Evonetix, a synthetic biology company developing a desktop platform for scalable, high-fidelity and rapid gene synthesis, announced it has partnered with imec, a world-leading research and innovation hub active in the fields of nanoelectronics and digital technologies, to increase production of Evonetix’s proprietary microelectromechanical systems (MEMS)-based silicon chips, enabling the…
Getting a good night’s sleep is important and insufficient sleep has been linked to poor health in many studies. Analysing data collected from wearable trackers, researchers from the SingHealth Duke-NUS Institute of Precision Medicine (PRISM) and the National Heart Centre Singapore (NHCS) recently demonstrated that chronic sleep deprivation is associated with increased cardiovascular disease…
For almost any conceivable protein, corresponding antibodies can be developed to block it from binding or changing shape, which ultimately prevents it from carrying out its normal function. As such, scientists have looked to antibodies as a way of shutting down proteins inside cells for decades, but there is still no consistent way to get them past the cell membrane in meaningful numbers. Now,…
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology – CRISPR-Cas9 and a reverse transcriptase – into a single machine. The system, called “prime editing,” is capable of directly editing human cells in a precise, efficient, and highly versatile fashion.
Scientists at St George’s, University of London, in collaboration with researchers from Germany, the USA, Tunisia and Iran have identified a new gene associated with the neuromuscular disorder, hereditary spastic paraplegia (HSP). The study, published in Nature Communications, also highlights a potential mechanism for the disease, which is already being targeted in drug trials for Alzheimer’s…
When it comes to genetics, Estonia is considered a trailblazer, as the ambitious Estonian Genome Project (Eesti Geenivaramu) shows. Its objective is to test the genome of every citizen for the risk of diseases. Dr Jaanus Pikani talks about the initial difficulties which the genome project encountered and about its potential for Estonian – and possibly worldwide – healthcare.
Genes alone cannot be used to determine an individual’s sexual orientation. A study published in the journal Science found only five out of hundreds of thousands genetic variants occurred somewhat more often in people who had had same-sex partners. This suggests human sexuality is influenced by a complex mix of genetic and environmental factors, according to the researchers. The study is based…
Researchers at ETH Zurich have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously. The biotechnological method CRISPR-Cas offers a relatively quick and easy way to manipulate single genes in cells, meaning they can be precisely deleted, replaced or modified. Furthermore, in recent years,…
A group of scientists from Vilnius University have developed the world’s fastest DNA testing method, reducing DNA testing costs by 90%. It identifies changes in chromosomes, genes, or proteins to determine a genetic condition or eliminate the chance of the formation or passing on of a gene-based disorder amongst humans and animals. At present, the sole method of genetic testing is the DNA…
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves.
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…
Olympus and Cytosurge AG, developer of the disruptive and patented FluidFM technology, announced their collaboration to significantly expand the awareness and availability of the FluidFM BOT* – a cutting-edge system for single cell manipulation and live cell imaging – in Europe, the Middle East and Africa (EMEA). By pooling together each other’s world-class competences and by listening to…
Having a child with a developmental disorder can cause parents to worry about the outcome of further pregnancies. In cases where the genetic mutation causing the disorder is not present in either parent it is assumed to be a one-off event with a very small chance of recurrence. But in some families, the risk of having another affected child is as high as 50%. Identifying such high-risk families…
A quick and easy test to detect cancer from blood or biopsy tissue could eventually result in a new approach to patient diagnosis. The test has been developed by University of Queensland researchers Dr Abu Sina, Dr Laura Carrascosa and Professor Matt Trau, who have discovered a unique DNA nanostructure that appears to be common to all cancers. Cancer is an extremely complicated and variable…
Of course every lab needs a spectrophotometer to measure its DNA, RNA or protein concentrations. In most cases, this is a small and easy-to-use instrument. Normally you pipette approximately 1 µl of your liquid onto a pedestal, close the lid to cover your drop of liquid and, after pressing the measuring button, you will know the concentration of your sample. Since the procedure is so simple and…
In a joint collaboration, researchers from Denmark and Switzerland have shown that bacteria produce a specific stress molecule, divide more slowly, and thus save energy when they are exposed to antibiotics. The new knowledge is expected to form the basis for development of a new type of antibiotics. All free-living organisms are under constant pressure to survive. Darwin dubbed this…
Today, on the occasion of the international DNA day, imec, a world-leading research and innovation hub in nanoelectronics and digital technologies, and its partners revealed their Genome Analytics Platform (GAP) platform, a unique platform that can perform a full genome analysis of 48 samples in only 48 hours and at an acceptable cost. The platform paves the way to genome sequencing as a daily…
Scientists from King's and Cambridge have developed a catalogue of DNA mutation ‘fingerprints’ that could help doctors pinpoint the environmental culprit responsible for a patient’s tumour – including showing some of the fingerprints left in lung tumours by specific chemicals found in tobacco smoke. Our DNA, the human genome, comprises of a string of molecules known as nucleotides. These…
“We are facing a technological revolution, but we still struggle with actually implementing these new technologies in healthcare institutions”: Professor Jacob Moran-Gilad, MD, MPH, speaks about the gap between the potential of new generation sequencing methods such as WGS and the clinical reality where these technologies have not yet arrived.
In the last six years, a tool called CRISPR-Cas9 has transformed genetic research, allowing scientists to snip and edit DNA strands at precise locations like a pair of tiny scissors. But sometimes, it takes more than scissors to do the job. Now, a collaborative international team has unveiled a new CRISPR-based tool that acts more like a shredder, able to wipe out long stretches of DNA in human…
Pathological infertility is a condition affecting roughly 7% of human males, and among those afflicted, 10-15% are thought to have a genetic cause. However, pinpointing the precise genes responsible for the condition has been difficult, due to the extensive number involved in generating and developing sperm cells. In a new paper appearing in Science Signaling, a Japanese team reports unravelling…
Binge and heavy drinking may trigger a long-lasting genetic change, resulting in an even greater craving for alcohol, according to a Rutgers-led study in the journal Alcoholism: Clinical & Experimental Research. “We found that people who drink heavily may be changing their DNA in a way that makes them crave alcohol even more,” said Distinguished Professor Dipak K. Sarkar, senior author of…