Molecular electronics

Biosensor chips for infection surveillance and more

Roswell Biotechnologies, Inc., a manufacturer of molecular electronics sensor chips, and imec, a research and innovation hub in nanoelectronics and digital technologies, announced a partnership to develop the first commercially available molecular electronics biosensor chips.

micro chip
Source: Roswell Biotechnologies, Inc.

These chips are the brains behind Roswell Technologies' new platform for DNA sequencing, to support precision medicine, molecular diagnostics, rapid infectious disease testing, and DNA data storage. “The urgent need for a new generation of rapid, low-cost, consumer surveillance and diagnostics tools has been made extremely clear in the current COVID-19 pandemic,” said Roswell President & CEO Paul Mola. “In that area, the Roswell molecular electronic platform will transform the way infectious diseases are detected, with powerful new capabilities that enable, rapid screening of many infectious diseases at once, or many viral strains, with portable or handheld devices."

One of the significant hurdles to commercializing molecular electronics is the need for costly customized solutions for large scale manufacturing

Barry Merriman

The Roswell platform is the first to deliver molecular electronic sensing, to support a full spectrum of DNA sequencing and biosensing applications. This includes the spectrum of tests necessary for the detection and containment of infectious diseases, such as COVID-19, including sequencing, nucleic acid detection, antigen detection and antibody detection. The platform was also designed with the scalability to provide the solution for rapid, low-cost whole genome sequencing in precision medicine, for treating cancer and other diseases, as well as for reading massive amounts of digital data stored in DNA, which is envisioned as the future of archiving data at the global scale.

Molecular electronic sensor chips integrate single molecules as electrical sensor elements on standard semiconductor chips, making electronic biosensor devices massively scalable. While electronic biosensors have seen gradual adoption in DNA sequencing and other areas of testing, there have been no major innovations in the basic sensor technology. The Roswell molecular electronics sensors represent an entirely new class of sensors, specifically designed to be maximally compatible with modern CMOS chip technology, delivering a technological breakthrough that significantly increases performance and lowers costs. This advance allows low-cost, high speed biomedical tests, including DNA sequencing and other forms of biomarkers sensing essential to modern medical diagnostics, to be deployed on simple portable or handheld devices.

“Although molecular electronics has long been hailed as a scientific breakthrough, its commercial viability required the technology to be put on a standard semiconductor chip," said Roswell Chief Science Officer Dr. Barry Merriman. "One of the significant hurdles to commercializing molecular electronics is the need for costly customized solutions for large scale manufacturing. Imec has overcome those challenges by utilizing state-of-the-art semiconductor manufacturing technology coupled with its deep experience in biosensor technology to commercialize molecular electronics using standard tools. We are excited to be partnering with imec on this effort."

Imec and Roswell have successfully completed key proof-of-concept work and are now focused on final process development. The initial products are expected to be commercially available in 2021. “Building on its leadership in advanced process development for the semiconductor industry, imec has pushed the limits of what is possible. This next-generation sensor, poised to disrupt bio-sensing, benefits from our broad expertise to solve the manufacturing hurdles,” said Dr. Ashesh Ray Chaudhuri,  team leader of life science technologies at imec.

Dr. Simone Severi, program director for life science technologies at imec, added, “Our partnership with Roswell is a great example of how imec is leveraging its leadership in state-of-the-art semiconductor manufacturing technology to make next-generation life-science instrumentation possible. We are very excited to collaborate with Roswell on the integration of their molecular electronics sensor and developing the fastest route to achieving large scale commercial manufacturing of their sensor chips. It is especially motivating to use our skills to make a direct impact in important areas of medicine, such as genome sequencing and infectious disease monitoring, as well as to open up new sectors such as DNA storage of Exabyte scale DNA."


Source: Roswell Biotechnologies, Inc./imec

06.05.2020

Read all latest stories

Related articles

Photo

Evonetix and imec team-up

Collaboration for next generation DNA synthesis platform

Evonetix, a synthetic biology company developing a desktop platform for scalable, high-fidelity and rapid gene synthesis, announced it has partnered with imec, a world-leading research and innovation…

Photo

Development of a highly sensitive analytical workflow

Collaboration for infectious disease diagnosis and patient monitoring

Thermo Fisher Scientific and NanoPin Technologies, Inc. have entered into a collaborative relationship to advance blood-based infectious disease detection technology through the development of highly…

Photo

Pathogenic microbes

Cigarette smoke makes MRSA superbug bacterium more drug-resistant

Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of…

Related products

Agena Bioscience - MassARRAY Colon Panel

Amplification/Detection

Agena Bioscience - MassARRAY Colon Panel

Agena Bioscience GmbH
Atlas Genetics - Atlas Genetics io system

Infectious diseases testing

Atlas Genetics - Atlas Genetics io system

Atlas Genetics Ltd
BD/QIAGEN PAXgene Blood ccfDNA Tube

Liquid Biopsy

BD/QIAGEN PAXgene Blood ccfDNA Tube

BD – Becton Dickinson
Eppendorf – BioSpectrometer fluroescence

Research Use Only (RUO)

Eppendorf – BioSpectrometer fluroescence

Eppendorf AG
Eppendorf – Mastercycler nexus X2

Research Use Only (RUO)

Eppendorf – Mastercycler nexus X2

Eppendorf AG