Scientists from the German Cancer Research Center (DKFZ) have been studying how the immune system succeeds in keeping pathogens in check. For the first time, the researchers have now discovered antibodies that are capable of disarming not only one specific bacterium but a whole variety of microorganisms at once. The newly discovered antibodies recognize a tiny sugar structure found on the surface…
Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects. Now, a…
A little-explored group of immune cells plays an important role in the regulation of intestinal bacteria. Changing metabolic states of the microbes have an effect on defense cells at different stages of alert or rest, as researchers from the Department of Biomedicine at the University and University Hospital of Basel report in the journal "Mucosal Immunology." It is known that the…
A Vanderbilt team took the next leap forward in using a little-known bacteria to stop the spread of deadly mosquito-borne viruses such as Zika and dengue. Wolbachia are bacteria that occur widely in insects and, once they do, inhibit certain pathogenic viruses the insects carry. The problem with using Wolbachia broadly to protect humans is that the bacteria do not normally occur in mosquitoes…
Partners who could hardly be further apart – yet have a lot in common – have united to fight resistant pathogens. The International Consortium for Anti-Infective Research (iCAIR) is based in Germany and Australia – separated by nearly 16,000 km as the crow flies. This has not stopped the research cooperation from achieving its objectives: the development of new agents against infections.
Beta-lactam antibiotics, including penicillin, are one of the most widely used classes of antibiotics in the world. Though they’ve been in use since the 1940s, scientists still don’t fully understand what happens when this class of drugs encounters bacteria. Now, researchers at the University of Notre Dame have elucidated how an enzyme helps bacteria rebound from damage inflicted by…
Researchers from the University of Illinois at Chicago and Nosopharm, a biotechnology company based in Lyon, France, are part of an international team reporting on the discovery of a new class of antibiotics. The antibiotic, first identified by Nosopharm, is unique and promising on two fronts: its unconventional source and its distinct way of killing bacteria, both of which suggest the compound…
While gastritis and gastric ulcer disease used to be put down to stress and dietary factors, it was discovered in the 1980s that the actual culprit is infection with a bacterium, H. pylori. This pathogen is now classed as a type I carcinogen by the WHO, as it is the major risk factor for development of gastric carcinoma. Attempts to develop a vaccine against H. pylori have been unsuccessful and…
Mologic Ltd, which develops powerful, personalised diagnostics to improve the lives of patients, and Fraunhofer Centre for Applied Photonics (Fraunhofer CAP), a world-leading centre in the field of applied laser research and development, announced they are working together to develop a rapid, point-of-care test to immediately diagnose bacterial urinary tract infections (UTIs) and any associated…
WHO’s first release of surveillance data on antibiotic resistance reveals high levels of resistance to a number of serious bacterial infections in both high- and low-income countries. WHO’s new Global Antimicrobial Surveillance System (GLASS) reveals widespread occurrence of antibiotic resistance among 500 000 people with suspected bacterial infections across 22 countries.
Bacteria are stealthy organisms. They can multiply in minutes and evolve to survive what we throw at them—including antibiotics. The World Health Organization calls antibiotic resistance “one of the biggest threats to global health, food security, and development today.” Each year, about 2 million people in the United States become infected with antibiotic-resistant bacteria, according to…
Joint replacement surgery carries the risk of developing an infection in the replaced joint, which can lead to a so-called revision or re-do of the joint replacement. However, current diagnostic practices can fail to detect bacteria in 30-50 percent of clinical cases, complicating or delaying appropriate treatment. Thomas Jefferson University researchers have found that genomic analysis using…
Bacteria not only develop resistance to antibiotics, they also can pick it up from their rivals. In a recent publication, Researchers from the Biozentrum of the University of Basel have demonstrated that some bacteria inject a toxic cocktail into their competitors causing cell lysis and death. Then, by integrating the released genetic material, which may also carry drug resistance genes, the…
An SLAS Technology review article by Yiyan Li, Xing Yang and Weian Zhao of University of California, Irvine highlights and synthesizes representative emerging micro- and nanotechnologies, as well as automated systems for bacterial identification (ID) and antibiotic susceptibility testing (AST), including both phenotypic and molecular methods and those at the point-of-care (POC) setting. Also…
Antibiotic resistant bacteria lead to infections that are difficult to treat, particularly in hospitals. Multidrug-resistant Escherichia coli bacteria which have developed special enzymes that render antibiotics ineffective frequently cause such infections. DZIF scientists from Gießen University examined these bacteria more precisely and discovered a strain of Escherichia coli that has been…
CAU research team proves, for the first time, that there is close cooperation between the nervous system and the microbial population of the body.
Chronic lung infections caused by the bacterium Pseudomonas aeruginosa require complex and, in most cases, long-term treatment with antibiotics—new medication is badly needed.
Researchers at the Swedish Medical Nanoscience Center at Karolinska Institutet have developed an innovative way of hacking conducting plastics so as to prevent bacterial growth.
‘The literature on hand washing, while extensive, often contains conflicting data, and key variables are only superficially studied, or not studied at all. Some hand washing recommendations are made without scientific support, and agreement between recommendations is limited,’ explained Professor Donald W Schaffner at Rutgers University, New Jersey, USA, who has led a team of researchers to…
While new agents to fight virulent pathogens are in the pipeline, a new study pinpoints where a recent addition is already being applied in the clinic.
Survival of mass extinctions helps to explain near indestructible properties of hospital superbugs.
The majority of women suffering with pain when urinating, or needing to urinate often or urgently probably do have a bacterial infection, even when nothing is detected by standard urine testing.
SpeeDx Pty. Ltd., a developer of innovative molecular diagnostic solutions, has signed an agreement with Thermo Fisher Scientific, the world leader in serving science. The announcement was made at the 27th European Congress of Clinical Microbiology and Infectious Disease (ECCMID) in Vienna to submit its ResistancePlus MG Test for the detection of Mycoplasma genitalium to the US Food & Drug…
Foods should be investigated as a potential source of spread of Clostridium difficile, according to research presented at the 27th ECCMID [1].
Following a top level EU report showing antimicrobial resistance (AMR) remains high, Professor Mike Catchpole, Chief Scientist at the European Centre for Disease Prevention and Control (ECDC), has warned that stricter use of antibiotics is critical.