Prof. Dirk Haller and his team found out that it is not cell stress alone that...
Prof. Dirk Haller and his team found out that it is not cell stress alone that leads to tumour growth, but rather the cooperation of stress and microbiota - here in the analysis of tissue sections with the scientists Sandra Bierwirth (left) and Olivia Coleman.

Source: A. Heddergott/TUM

Dickdarmkrebs

The microbiota in the intestines fuels tumour growth

The team of Professor Dirk Haller at the Technical University of Munich (TUM) made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumour growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases.

"With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation," explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM. "However, the surprising result for us was the discovery that bacteria together with stress in cells caused tumours (exclusively in the colon) and without the involvement of inflammation".  

The investigations were initially carried out using the mouse model.  In germ-free (i.e. sterile) animals, in which the activated transcription factor ATF6 regulated stress in the intestinal mucosa (intestinal epithelium), no change could be observed.  But as soon as the microbiota, i.e. all the microorganisms in the intestine, were transplanted back into germ-free animals, tumours developed in the colon of the mice. Using Koch's postulates, Haller and his team were able to show that microorganisms are involved in the development of cancer in the colon.

ATF6 incidence found to be increased in colon cancer patients

The transcription factor ATF6 regulates stress in cells, and the intensity and duration of activation is increased with diseases. "However, it is not cell stress alone that leads to tumour growth, but the combination of stress and microbiota that favours cancer growth," says Haller, head of ZIEL - the Institute for Food & Health at TUM.  

Subsequently, in cooperation with the clinic on the right side of the Isar, the data of 541 patients with colon cancer were examined. In those cases where the level of transcription factor ATF6, which triggers cell stress, was significantly increased, the recurrence rate after surgery increased: About ten percent of patients were at risk of getting colon cancer a second time.  

"In certain patients, the protein ATF6 could serve as a diagnostic marker for an increased risk of colon cancer and could indicate the start of therapy at an early stage," said Prof.  Haller - "a microbial therapy is conceivable, when we know more about the composition of the bacterial flora.  What now became clear, however: Chronic inflammation has no effect on cancer development in the colon." 

Source: Technische Universität München

25.09.2018

Read all latest stories

Related articles

Breakthrough

Gut bacteria drive growth of stem cells in colon cancer

Colon cancer is one of the most common forms of cancer in Germany. Prof. Dr. med. Sebastian Zeißig, group leader at the DFG Research Center for Regenerative Therapies Dresden (CRTD) - Cluster of…

Brain cancer

Typical mutation in cancer cells stifles immune response

The exchange of a single amino acid building block in a metabolic enzyme can lead to cancer. In addition, it can impair the immune system. It thus blocks the body’s immune response in the battle…

Promising research

Could senescence be the key to stopping cancer?

Canadian researchers have found a promising way to stop tumour cells from multiplying. In disrupting the composition of ribosomes, the team from Université de Montréal (UdeM) discovered a direct…

Related products