An international research group with essential participation of the Paul-Ehrlich-Institut, has identified NLRX1, a cellular factor of the human cell that is indispensable to the replication of Human Immunodeficiency Virus (HIV-1). This factor plays a key role in attenuating the innate immune system towards HIV-1. Until now, the significance of NLRX1 for the replication of HIV-1 and the…
Many viral diseases tend to become chronic – including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently. Scientists at the University of Bonn have now identified an immune factor which is partially responsible for this. Their results give rise to hopes for new therapeutic approaches. The work, which included researchers…
Nothing could be simpler: a drop of blood is placed on a special carrier substance; after a wait of a few minutes, the slide is placed on a device that emits polarised light thanks to an inexpensive polarisation filter. It is covered with a lid containing a second polarisation filter, which blocks the light from all materials except crystalline or materials with directional properties.
A new report gives the first ever picture of global investment in Ebola research and development (R&D), reporting that this investment might have come at the expense of efforts to develop drugs, vaccines and diagnostics for other neglected diseases, which collectively cause more than six million deaths every year in developing countries.
A unique molecule developed at Duke Medicine, the University of North Carolina at Chapel Hill and MacroGenics, Inc., is able to bind HIV-infected cells to the immune system’s killer T cells. It could become a key part of a shock-and-kill strategy being developed in the hope of one day clearing HIV infection.
It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) and University…
Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS, say researchers at California Institute of Technology.
There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule – to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
Vaccination remains one of the most efficient strategies against infectious diseases, often being the best protection against infections such as hepatitis B, or influenza. European Hospital reports on expert reviews of vaccines in the pipeline and the potential of nanomedicine given during the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) annual meeting in…
The District of Columbia's needle exchange program prevented 120 new cases of HIV infection and saved an estimated $44 million over just a two-year period, according to a first-of-a-kind study published today by researchers at the Milken Institute School of Public Health (Milken Institute SPH) at the George Washington University.
A multifaceted farming intervention can reduce food insecurity while improving HIV outcomes in patients in Kenya, according to a randomized, controlled trial led by researchers at UC San Francisco.
Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia.
The European Investment Bank (EIB) has provided a EUR 10 million long-term loan to Swedish biotech company Cavidi AB for developing a next generation automated testing device for HIV viral load. This is the first transaction under InnovFin Infectious Diseases, an innovative high risk-taking financial instrument recently established within the new generation of financial products for innovative…
In collaboration with colleagues from California and New York, researchers of the Paul-Ehrlich-Institut have identified a cytosolic receptor which enables cells of the immune system to recognize HIV and to trigger an immune response. The findings of the researchers may be a useful tool for creating an effective endogenous immune response against HIV and helpful to boost vaccine responses.
Bio-Rad Laboratories, a global provider of life science research and clinical diagnostic products, announced that Bio-Rad is extending its agreement with Beckman Coulter and has named the company exclusive global distributor of Bio-Rad's Access HIV combo assay and the Access hepatitis C virus (HCV) assay in select geographies.
The question as to whether or not there is a point in using medical apps on private smartphones is being asked more frequently. Issues around medical diagnostics are among the key points here. We asked Prof. Dr. Dr. Norbert Gässler, Head of the Centre for Laboratory Diagnostics at the St. Bernward Hospital, Hildesheim, for competent advice. Interview: Walter Depner
30 years after HIV was discovered to be the cause of the acquired immune deficiency syndrome AIDS, and despite intensive research, no vaccine or cure has yet been found. An international team of scientists, in collaboration with the German Center for Infection Research (DZIF) and the University Hospital of Cologne, has now tested a new generation of antibodies in humans for the first time. They…
World-renowned experts discussed the situation of predomonant epidemics at the International Roche Infectious Disease Symposium in Barcelona.
A Birmingham hospital trust is to lead a major research study over concerns that one of the commonest sexually transmitted infections is becoming resistant to current treatment.
Robert Koch Award 2013 goes to Jeffrey I. Gordon for pioneering studies of the human microbiome; Anthony S. Fauci receives the Robert Koch Gold Medal 2013 for outstanding scientific contributions to HIV research
Over 32% of HIV+ people in Europe remain undiagnosed. This large untapped pool and the development of novel nucleic acid test (NAT) and non-NAT technology based platforms offers growth potential for HIV diagnostics manufacturers.
At the launch of the Policy Cures study ‘Saving Lives and Creating Impact: EU Investment in Poverty-Related and Neglected Diseases’ in Brussels today, DSW (Deutsche Stiftung Weltbevoelkerung) confirmed that EU funding for Global Health Research and Development (R&D) has a direct benefit on both developing countries and the European Union.
The European Congress of Radiology (ECR), the annual meeting of the die European Society of Radiology (ESR), started on Thursday in Vienna. 20,000 visitors are expected to participate in the congress which is one of the largest healthcare events worldwide.
Using a mathematical formula that carefully measures the degree to which HIV infection of immune system cells is stalled by antiretroviral therapy, AIDS experts at Johns Hopkins have calculated precisely how well dozens of such anti-HIV drugs work, alone or in any of 857 likely combinations, in suppressing the virus.
More than doubling over the last 20 years in most EU Member States, obesity has considerable implications for health, health systems and the economy. Over half our adult population is now overweight or obese, according to the joint European Commission and OECD report "Health at a Glance: Europe 2010".
