News • Research
Stuttgart researchers enhance CRISPR for cellular analysis
University of Stuttgart scientists develop enhanced CRISPR technique that makes genetic loss-of-function analyses more efficient and reproducible for medical research.
Search for: "Nobel Prize in Chemistry" - 25 articles found
News • Good killer cells
Cellular immunotherapy: a new approach against cancer
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. Now, lymphoma specialists in Essen are investigating the possibility of a different approach.
News • For discoveries leading to mRNA vaccines against Covid-19
Nobel Prize in Medicine goes to Katalin Karikó and Drew Weissman
For their contributions to developing mRNA vaccines to fight Covid-19, Katalin Karikó, PhD, and Drew Weissman, MD, PhD, have been jointly awarded the 2023 Nobel Prize in Physiology or Medicine.
News • Genome instability
Gene editing via CRISPR/Cas9 can lead to cell toxicity
Researchers identify critical spots on the genome where gene editing could cause an unwanted response, and they provide recommendations for safer approaches.
News • Fire and Ice
Nanomedicine: more effective tumor treatment
Researchers have succeeded in using metal oxide nanoparticles as "radiosensitizers" – and in producing them on an industrial scale.
News • Biological image analysis
Machine learning accelerates super-resolution microscopy
Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.
News • Genome editing
Using CRISPR to speed up Covid-19 testing
A research team led by scientists in the labs of Jennifer Doudna, David Savage and Patrick Hsu at the University of California, Berkeley, is aiming to develop a rapid Covid-19 diagnostic test that is much faster and easier to deploy than qRT-PCR. It has now combined two different types of CRISPR enzymes to create an assay that can detect small amounts of viral RNA in less than an hour. Doudna…
News • COVID-19
CRISPR test uses smartphone to detect SARS-CoV-2
Scientists at UC Berkeley and Gladstone Institutes have developed a new CRISPR-based COVID-19 diagnostic test that, with the help of a smartphone camera, can provide a positive or negative result in 15 to 30 minutes.
Article • MEDICA session
PCR tests excel during Covid-19 pandemic
In early 1990, at Analytica, in Munich, a young US-American researcher Kary B Mullis received the award for biochemical analytics for his 1983 invention: the polymerase chain reaction (PCR) – a success topped in 1993 by the Nobel Prize for chemistry. Mullis’ work revolutionised DNA copying, a process which, before PCR, had taken weeks. Whilst initially PCR was used to create digital…
News • For the development of CRISPR/Cas9
Nobel Prize in Chemistry goes to Emmanuelle Charpentier and Jennifer A. Doudna
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2020 to Emmanuelle Charpentier from the Max Planck Unit for the Science of Pathogens, Berlin, Germany, and Jennifer A. Doudna from the University of California, Berkeley, USA, “for the development of a method for genome editing”, more commonly known as the 'gene scissors' CRISPR/Cas9.
News • New mechanism discovered
UPR: Stress raises cancer cells' chemo resistance
Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism of chemoresistance which has now been published in "Nature Communications". It is driven by…
Video • Adaptation to oxygen availability
Nobel Prize in Medicine goes to William G. Kaelin Jr, Sir Peter J. Ratcliffe, and Gregg L. Semenza
The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.
Interview • Shimadzu Europa 50th anniversary
Mass spectrometry and ever more…
As Shimadzu celebrates its 50th anniversary in Europe, we spoke with Stéphane Moreau, Manager of LC-MS & Life Sciences at the Marketing Europe/Analytical Business Unit of Shimadzu Europa GmbH, about today’s and many more decades of exciting clinical developments.
Video • New treatment options
Unlocking the secrets of cell communication
Portland State University (PSU) researchers have made a significant breakthrough by developing the 3-D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer. The PSU research team, led by chemistry professor Steve Reichow, used a multimillion-dollar microscope and a…
News • Brain tumors
Researchers find missing immune cells that could fight glioblastoma
Glioblastoma brain tumors can have an unusual effect on the body's immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body's defenses. Where the T-cells go has been unclear, even as immunotherapies are increasingly employed to stimulate the body's natural ability to fight invasive tumors. Now researchers have tracked the missing T-cells in…
Interview • Combined power
LC-MS research and routine use
LC/MS, i.e. the combination of liquid chromatography (LC) with mass spectrometry (MS) – an analytical method developed primarily for environmental analysis and live science – remains a keen topic in the medical laboratory. In recent European Hospital issues, we have outlined various reasons why this procedure is in increasingly popular in the medical lab. Here we continue with an interview…
Article • Contrast enhancement
Sonic boom with bubbles
Illuminating blood vessels, opening the blood-brain barrier and delivering drugs. What will be the next big thing that tiny microbubbles can do?
Suitable protein tags for nanoscopy
Scientists of the Göttingen Cluster of Excellence CNMPB and the EMBL describe efficient fluorescence tag for super-resolution microscopy.
Long-standing mystery in membrane traffic solved
Researchers discovered that NSF unravels a single SNARE complex using one round ATP turnover by tearing the complex with a single burst, contradicting a previous theory that it unwinds in a processive manner.
Sponsored • Celebration
Japanese firm celebrates 140 successful years
The son of a craftsman making Buddhist altars, he was driven to create instruments for physics and chemistry. Attending the Physics and Chemistry Research Institute he gained experience with a variety of technologies and fields of expertise. He was convinced that Japan, as a should work towards becoming a leader in science. At the dawn of the industrial revolution and scientific age in 1875 he…
Article • History
Radiology on the Frontline 1914-1918
100 years ago Marie Curie personally brought radiology to the battlefield creating the first mobile x-ray unit and training an army of women as field technicians. Report: John Brosky
Shimadzu combines two vital strengths to create new molecular imaging technologies
Molecular imaging, a new science that emerged from molecular biology, is unlike traditional imaging. Whilst the latter can, for example, show the differences in proton density or water content on MRI, molecular imaging uses biomarkers (probes) that interact selectively with molecules within an area and then generate the image according to fine molecular alterations occurring inside (e.g. within a…
Healthcare sector to fight ATB over-consumption
Czech hospitals are seeking powerful inspiration regarding antibiotics (ATB) consumption from France, where a recent public campaign helped to decrease ATB consumption by 30%.
Why European laboratorians benefit from the AACC Annual Meeting
When asked to write a brief note on why I found it important to attend the AACC Annual Meeting, particularly from the European perspective, my mind returned to the first time I attended an AACC meeting.
Interview • Nuclear imaging
SPECT-CT versus PET-CT: The 'little sister'?
When it was suggested, during our interview with Dr Torsten Kuwert, Director and Professor of Clinical Nuclear Medicine, Clinic of Nuclear Medicine, at Friedrich-Alexander University Hospital, Erlangen, that SPECT-CT is the little sister of PET-CT, and that he might have preferred to install the ‘big brother’, Dr Kuwert pointed out the greater cost of PET, explaining: ‘The isotopes are more…
