News • Sepsis
New technology could prevent a leading cause of death
What do Casey Kasem, Christopher Reeve and Muhammad Ali have in common? They all died of sepsis: a rapid, potentially deadly reaction that affects millions each year.
Bacteria
News • tumor-fighting
Swarms of magnetic bacteria could deliver drugs to tumors
Researchers funded in part by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have recently shown that magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs.
News • Infection
Why does MRSA ‘superbug’ kill influenza patients?
Researchers have discovered that secondary infection with the Methicillin-resistant Staphylococcus aureus (MRSA) bacterium (or “superbug”) often kills influenza patients because the flu virus alters the antibacterial response of white blood cells, causing them to damage the patients’ lungs instead of destroying the bacterium. The study suggests that inhibiting this response may help treat…
News • Molecular troublemakers
How proteins prevent communication between bacteria
They may be slimy, but they are a perfect environment for microorganisms: biofilms. Protected against external influences, here bacteria can grow undisturbed, and trigger diseases. Scientists at Kiel University, in cooperation with colleagues at the Hamburg University of Technology (TUHH) in Hamburg-Harburg, are researching how it can be possible to prevent the formation of biofilms from the…
News • Staphylococcus aureus
Women more likely to die within 30-days from bacterial blood infection
Clinicians around the world have long suspected that bacteraemia due to Staphylococcus aureus has a worse outcome in women compared to men, but direct evidence has been elusive. A study just published confirms that significantly more women than men diagnosed with Staphylococcus aureus bacteraemia (SAB) – a blood infection of the common bacteria – die within 30 days.
News • Bacteria
New discovery could change ICU care
No one knows for sure how they got there. But the discovery that bacteria that normally live in the gut can be detected in the lungs of critically ill people and animals could mean a lot for intensive care patients.
Protein fragment could provide a defense when antibiotics fail
Bacterial infections that don't respond to antibiotics are of rising concern, as is sepsis - the immune system's last-ditch, failed attack on infection that ends up being lethal itself. Reporting online in "Nature", researchers at Boston Children's Hospital describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.
Article • Infection control
Scientists gain ground against resistance
The mechanism by which drug-resistant bacteria maintain a defensive barrier has been identified by researchers at England’s University of East Anglia (UEA) and their findings could result in a new wave of drugs that can bring down those defensive walls rather than attack the bacteria – thus they may not develop drug-resistance at all.
News • Therapy
New way to predict COPD progression
New research has found that a process initiated in white blood cells known as neutrophils may lead to worse outcomes for some patients with chronic obstructive pulmonary disease (COPD). The discovery may help identify patients at higher risk for COPD progression, who might also show little benefit from standard treatments.
News • Bacteria
Revolutionary antibiotics will save the world
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
Interview • Tumour triggers
Can cancer be contagious?
No self-respecting TV crime series is without a pathologist – but the fictitious pathologist who incessantly solves crimes has little to do with reality.
News • Breakthrough
Gut bacteria drive growth of stem cells in colon cancer
Colon cancer is one of the most common forms of cancer in Germany. Prof. Dr. med. Sebastian Zeißig, group leader at the DFG Research Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden and physician at the Department of Medicine I, University Hospital Carl Gustav Carus Dresden, has now shown a decisive role of gut bacteria in the regulation of intestinal…
News • E. coli
Using harmless bacteria to fight cancer
Several bacterial species have pledged promise in fighting tumors. However, most of them are pathogens. In order to use them as a weapon against cancer and other diseases in humans, researchers must find a balance between their therapeutic aggressiveness and safety for the patient. To overcome this problem, researchers at the Helmholtz Centre for Infection Research (HZI) have shifted their focus…
News • Bacteria
3D images of megaenzymes may improve antibiotics
Taking clear pictures of megaenzymes isn’t easy. But it’s definitely worth it. These proteins play an active role in creating many common antibiotics. They are in constant motion, with sections that flip around acrobatically to carry out necessary tasks. Now, for the first time, McGill researchers have been able to take a series of 3D images of a large section from one of these…
News • E. coli
Identify most dangerous strains of often-deadly bacteria
A multi-disciplinary group of researchers at the University of Maryland School of Medicine (UM SOM) have for the first time determined the genetic makeup of various strains of E. coli, which every year kills hundreds of thousands of people around the world.
News • Respiratory infection
Under the weather? A blood test can tell if antibiotics are needed
Researchers at Duke Health are fine-tuning a test that can determine whether a respiratory illness is caused by infection from a virus or bacteria so that antibiotics can be more precisely prescribed.
News • Oncology
Scientists use dead bacteria to kill colorectal cancer
Led by Professor Teoh Swee Hin, scientists from Nanyang Technological University (NTU Singapore) have successfully used dead bacteria to kill colorectal cancer cells. Harvesting the Clostridium sporogenes bacteria found commonly in soil, the NTU team was able to harness the bacteria in its dead form, and its secretions, to destroy colon tumours cells effectively.
Article • Infection
Trial pitches MGB-BP-3 against clostridium difficile
Scientists at the University of Strathclyde in Glasgow have been working to identify compounds with important anti-infective activity and suitable for treating serious infectious diseases caused by bacteria and parasites, such as Clostridium difficile. Their work has led to the creation of the new drug known as MGB-BP-3 (MGB = minor groove binder). Report: Mark Nicholls
News • WHO
Public misunderstanding about antibiotic resistance
As the World Health Organization (WHO) ramps up its fight against antibiotic resistance, a new multi-country survey shows people are confused about this major threat to public health and do not understand how to prevent it from growing.
News • Linac Coherent Light Source
A glimpse into live bacteria
A group of scientists in Sweden has taken an important step towards the goal of peering inside a working cell. They are among researchers around the globe who are seeking a method that enables the observation of proteins, lipids and DNA inside individual cells, as well as gaining a better understanding of how this intricate and interconnected system changes with time.
Article • Politics
Spain’s response to EU directive
Increasingly resistant bacteria are a global problem and require innovative action from all parties concerned, says Jesús Rodriguez-Baño, President of the Scientific Committee of the annual meeting of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), which unfolded last May in Seville. EH asked him why the creation of a national plan has become necessary to tackle…
News • bacterial communities
What’s lurking in your lungs?
With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs – the community of microscopic organisms that are…
News • Molecular Genetics
How a Bacterial Cell Recognizes its Own DNA
It may come as a bit of a surprise to learn that bacteria have an immune system – in their case to fight off invasive viruses called phages. And like any immune system – from single-celled to human – the first challenge of the bacterial immune system is to detect the difference between “foreign” and “self.” This is far from simple, as viruses, bacteria and all other living things…
Article • Infectious diseases
Carrying home a nosocomial infection
About 6-8% of Spanish patients will develop an infection during or after a hospital stay. Can these infections be avoided? How is Spain facing up to the challenge? Dr Juan Pablo Horcajada, Head of the Department of Infectious Diseases at Hospital del Mar, Barcelona, and spokesperson of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), assessed the situation and…
News • Microscope technique
Speeding identification of deadly bacteria
A new way of rapidly identifying bacteria, which requires a slight modification to a simple microscope, may change the way doctors approach treatment for patients who develop potentially deadly infections and may also help the food industry screen against contamination with harmful pathogens, according to researchers at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon,…