Since the introduction of targeted therapies in oncology the task of the pathologist has expanded beyond histological diagnostics: today, the pathologist analyses tumour tissue samples to establish a molecular profile with tumour cell characteristics – which in turn become the targets of medication.
The ongoing debate about breast cancer diagnostics has left many women confused — particularly over what age they should get mammograms and who needs treatment. An issue with current methods is that they often identify lumps but cannot conclusively pinpoint which ones are cancerous. To help resolve this uncertainty, researchers have developed a pill that could improve imaging techniques so that…
A team of investigators from Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug to successfully eliminate lung metastases in mice.
Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.
Results from recent trials are promising: an almost 40% increased breast cancer detection rate from digital breast tomosynthesis (DBT) screening compared to conventional mammography.
A new EU-funded project HYPMED is developing a ground-breaking imaging method for more accurate detection of breast cancer and a better, more personalised, understanding of its response to therapy.
In a comprehensive modeling study, researchers from UC Davis and other institutions have found that breast cancer screening with digital mammography poses only a small risk of radiation-induced breast cancer for most women. However, the research showed increased risk for women with large breasts or breast implants, who must often receive extra screening views, increasing their radiation exposure.
Breast cancer screening has helped to detect cancer in its early stages, but it is unclear how important this contribution is to mortality reduction because treatment has greatly improved. Overdiagnosis and overtreatment remain associated risks that need to be fully assessed for screening to be of real benefit. Leading experts in this field passionately discussed these controversies in a…
Additional breast cancers found with MRI are sometimes larger and potentially more aggressive than those found on mammography, according to a study published online in the journal Radiology.
The mammography detection rate of an early-stage but potentially invasive type of breast cancer rises with age, according to a large new study from Germany published online in the journal Radiology.
A photograph may reveal how something looks, but direct observation can divulge how the objects behave. The difference can mean life or death, especially when it comes to fighting human disease. To help researchers examine exactly how human diseases work at the molecular level, Virginia Tech Carilion Research Institute scientist Deborah Kelly has developed a new set of tools to peer into the…
A magnetic resonance (MR) breast imaging technique that uses no ionizing radiation or contrast agent could reduce unnecessary biopsies by providing additional information about suspicious findings on X-ray screening mammography, according to a new study published online in the journal Radiology.
For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals. mTOR (as it’s called in mammals) plays a central role in instructing the cell to grow and divide in response to nutrients. When it’s turned down, the cell shifts into a second, tidying mode,…
American Society of Human Genetics issues recommendations on age-appropriate genetic testing in children and adolescents.
Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center have discovered a molecular mechanism that connects breast tissue stiffness to tumor metastasis and poor prognosis. The study may inspire new approaches to predicting patient outcomes and halting tumor metastasis.
Agendia co-founder and Chief Research Officer, Laura van't Veer, Ph.D., has won the European Inventor Award in the SME category. The European Inventor Award is a prestigious innovation award presented by the European Patent Office, with only 15 inventors nominated in a total of five categories worldwide.
“I am very concerned about the impact that Angelina Jolie has on the media,” Walter Rocca, professor of epidemiology and neurology at the Mayo Clinic in Rochester, Minnesota, stated. He wasn’t hinting to Jolie’s acting choices or waifish silhouette, but to the confusion surrounding her decision to remove her ovaries to prevent ovarian cancer. By Mélisande Rouger
Each year, approximately 1.6 million women in the USA have breast biopsies to diagnose or rule out cancer. Pathological diagnosis is considered the gold standard – how accurate are these diagnoses? Report: Cynthia E. Keen
Australian researchers have found that so-called 'triple-negative breast cancers' are two distinct diseases that likely originate from different cell types. This helps explain why survival prospects for women with the diagnosis tend to be either very good or very bad.
Cells have two different programs to safeguard them from getting out of control and developing cancer. One of them is senescence (biological aging). It puts cancer cells into a permanent sleep so they no longer divide and grow in an uncontrolled way. Now the research group led by Professor Walter Birchmeier (Max Delbrück Center for Molecular Medicine, MDC, Berlin-Buch) has discovered that an…
The Koning Breast CT (KBCT) system, which has been granted FDA approval, provides 3D breast of the entire breast from any orientation for diagnoses.
SOFIA is the new automated breast tomography system developed by iVu Imaging and presented at ECR 2015 by Hitachi. The system, beyond its charming name, offers some very charming features indeed which may make SOFIA the most comfortable scanner currently available on the market.
MRI is increasingly relevant to cancer management, especially to detect breast carcinoma. Professor Christiane K Kuhl from the department of diagnostic and interventional radiology at the University of Aachen, Germany, strongly advocated in favour of MRI in breast cancer screening during a dedicated Satellite Symposium organised by Bracco at ECR 2015. Report: Mélisande Rouger
It is tough enough to be a clinician reading dozens of mammograms every day to detect early signs of breast cancer. Now those same radiologists must become statisticians in order to decrypt dozens of studies, challenging whether it is worth reading mammograms in the first place. Report: John Brosky
In breast cancer care each patient receives personalised, highly effective diagnosis and treatment procedures. In breast diagnostics this mainly revolves around new MRI scanning procedures that allow the quantification of biological and physiological processes on a cellular and molecular level.