News • Genetic dystrophy repair
Using mRNA to improve muscle strength
An ECRC research team has introduced CRISPR-Cas9 into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.
Musculoskeletal
Sponsored • Orthopaedics
Periprosthetic joint infection: a complex issue
Periprosthetic joint infection (PJI) can be an enormous challenge for orthopaedists and trauma surgeons. Antibiotic-loaded bone cement is an important element in a prevention strategy.
News • Is it broken?
AI accurately detects fractures on x-rays, alerts doctors
A new study has found that AI can help physicians in interpreting x-rays after an injury and suspected fracture. This has the potential to improve diagnostic performance and efficiency.
News • Negative volume segmentation
Novel 3D image segmentation for literal ‘jaw-dropping’
Researchers at the Skolkovo Institute of Science and Technology (Skoltech) led by Professor Dylov and their colleagues from First Pavlov State Medical University of St. Petersburg, Russia, have developed a brand-new approach to the task of 3D image segmentation — figuring out the contours of the constituent parts in a complex structure. While their so-called negative volume segmentation…
News • Scaffold-free approach
Researchers create cartilage tissue out of stem cells
Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage. Cartilage acts as a shock absorber in joints, but it is susceptible to damage through daily wear-and-tear, or trauma from sports injuries and falls.
News • Bioengineering
Lab-grown muscle offers insights for neuromuscular diseases
In the fight against diseases like amyotrophic lateral sclerosis (ALS), biomedical engineering researchers at the University of Southern California have created a powerful lab model to better see how our muscles and neurons connect.
News • Titanium-alloy knee plates
3D printing simplifies high tibial osteotomy
3D metal printing technology is producing personalised medical-grade titanium-alloy plates that perfectly fit individuals suffering arthritis of the knee. Engineers at the University of Bath’s Centre for Therapeutic Innovation (CTI) working with 3D Metal Printing Ltd, are using the TOKA (Tailored Osteotomy for Knee Alignment) treatment to improve the surgical procedure and fit of high-tibial…
News • Orthopaedics
Iliac crest reconstruction: 15 patients recruited into GreenBRIC study
GreenBone Ortho, a company specialising in bone regeneration, announces that it has achieved its aim of recruiting 15 patients into the GreenBRIC study. GreenBRIC study is a prospective, open label, single-arm, First-in-Human clinical investigation, in male and female patients, aged between 18 and 70 years, undergoing surgery to correct bone defects using GreenBone Implant, specifically for iliac…
News • Self-powered implant
New device to speed up bone healing
Researchers know that electricity can help speed up bone healing, but “zapping” fractures has never really caught on, since it requires surgically implanting and removing electrodes powered by an external source. Now, researchers at the University of Wisconsin–Madison have expanded on this principle and developed a device to speed up bone healing.
Article • Implantation of cartilage or stem cells
Remarkable cartilage regeneration
Joint cartilage usually regenerates very poorly. The matrix of cartilage (scaffolding) contains very few cells in deep layers. Moreover, joint cartilage is highly isolated: there are neither regenerative cells in the immediate vicinity that could migrate into the site of the defect and trigger repair, nor vessels that could transport regenerative cells to the cartilage. Unsurprisingly,…
News • From the brain to the joints
Common anti-depressant could also treat osteoarthritis
Osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to the joint disease and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
News • New regeneration method
Healing skeletal injuries with synthetic bone
Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone. The study, published in the research journal Science Advances, was conducted on rats, but the researchers think that the method in various combinations will soon be…
News • Osteoarthritis research
New treatment target could halt knee cartilage degeneration
There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that…
News • Muscle dystrophy
Duchenne: "Crosstalk" between muscle and spleen
Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance. Characteristic is a progressive muscular atrophy. The disease often results in death before the third decade of life. Researchers of the Universities of Maynooth (Ireland) and Bonn have found a connection between dystrophic muscles and the lymphatic system in mice…
News • Outstanding radiologist
International recognition for Dr Jamie MacKay
Radiologist Dr Jamie MacKay has achieved international recognition for his research using advanced imaging to help patients with osteoarthritis and other musculoskeletal conditions. MacKay, who is a radiologist at the Norfolk and Norwich University Hospital (NNUH) and lecturer at University of East Anglia (UEA), has been elected as a Junior Fellow of the International Society for Magnetic…
News • Surgical material research
Patching skull injuries with eggshells
A bioactive polymer-ceramic composite for fixing implants and restoring bone defects in the skull was developed by an international group of materials scientists from the Russian National University of Science and Technology (NUST) MISIS Center for Composite Materials. An innovative composition of the material based on eggshell-derived bioceramic provides increased strength and biointegration of…
News • Joint study shows
Endoprothetic risk: Metals from implants can accumulate in bone tissue
Using highly complex analytical techniques, a group of researchers from Charité – Universitätsmedizin Berlin were able to observe in detail how different metals are released from joint implants and accumulate in the surrounding bone tissue. Findings showed a steady release of metals from various implant components. In contrast to previous assumptions, this was not related to the degree of…
News • Fossilised findings
Study shows: Even dinosaurs had cancer
A collaboration led by the Royal Ontario Museum (ROM) and McMaster University has led to the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur. Examples of malignant cancers are very rare in the fossil record. The paper was published in the journal The Lancet Oncology. The cancerous bone in question is the fibula (lower…
News • Congenital defect reconstruction
Pectus Excavatum: First-in-human trial of novel reconstruction scaffold
Medtech company BellaSeno announced the initiation of a first-in-human trial of its novel, absorbable soft tissue reconstruction scaffold (Senella). A patient with Pectus Excavatum congenital defect has undergone surgery at Princess Alexandra Hospital in Brisbane, Australia, earlier this month. The procedure was performed by Dr. Michael Wagels, Principal Investigator of the trial and Plastic and…
Article • Perfect musculoskeletal imaging
Radiography: Correct patient positioning is critical
Dr Francis Zarb, senior radiography lecturer at the University of Malta, outlined challenges in correctly positioning patients needing musculoskeletal imaging. During our interview, he also offered a brief insight into the use of artificial intelligence (AI) in radiography today.
News • Algorithmic enhancement
Improved MRI scans could aid in development of arthritis treatments
An algorithm that analyses MRI images and automatically detects small changes in knee joints over time could be used in the development of new treatments for arthritis. A team of engineers, radiologists and physicians, led by the University of Cambridge, developed the algorithm, which builds a three-dimensional model of an individual’s knee joint in order to map where arthritis is affecting the…
News • Bone cement research
Developing self-healing bone replacements
Our body is able to treat many injuries and wounds all by itself. Self-healing powers repair skin abrasions and enable bones to grow back together. However, doctors often have to lend a helping hand to repair bones after a fracture or due to a defect. Increasingly, bone replacement materials are being used, which partially or completely restore the form and function of the bone at the site of the…
News • Diabetes-related diseases
3D printed implants for personalized treatment of bone defects
BellaSeno GmbH, a company developing absorbable scaffolds using additive manufacturing technologies, announced a collaboration with Charité – Universitätsmedizin Berlin under the recently established SyMBoD consortium. Under the agreement, BellaSeno will design and manufacture personalized, 3D-printed, absorbable implants suitable for the treatment of diabetes patients with bone defects. The…
News • Skeletal reconstruction
New stem cells discovery could pave the way to generate new bone
A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the University of Connecticut (UConn) School of Dental Medicine. In the journal Stem Cells, lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, postdoctoral fellows Dr. Sierra Root and Dr. Natalie Wee, and collaborators at Harvard, Maine Medical Research…
News • Finding new treatment options
Cancer cachexia: Help against muscle loss
Cancer cachexia often occurs in cancer patients in an advanced state. This metabolic wasting syndrome leads to severely reduced muscle mass and fat tissue, which cannot be reversed by nutritional support. Furthermore, muscle regeneration is affected during cancer cachexia due to impaired muscle stem cell function. A problem that also occurs often in the aging process. Cancer cachexia is…