In a symposium organised by Bayer Schering Pharma at the 2009 European Congress of Radiology (ECR), the audience heard a series of four presentations on the potential advantages of high-signal-intensity contrast agents for MRI, focusing on gadobutrol (Gadovist). During the discussion, several claims made by the speakers were challenged and debated by ECR delegates.
Although its standard description is simple: Photo detection at low light levels where single photon absorption events are counted, according to an internationally renowned medical imaging scientist, in terms of X-ray imaging, counting photons may really be the way to see the light.
With 16 years’ experience in developing contrast media power injectors, Medtron AG recently launched the Accutron HP-D, which, the firm reports, is the only totally wireless, high pressure double-head injector dedicated to all vascular diagnostic and interventional procedures.
The Accutron HP-D - the first dual head contrast media power injector for angiography, intervention and computed tomography.
What was initially viewed with scepticism developed into an integral and indispensable part of modern imaging diagnostics
Early suspicions of cancer, either from clinical evidence or medical imaging, are often followed up on biopsy. However, the removal of tissue for histological analysis can be uncomfortable for patients.
The belief that iodinated contrast agents can induce nephropathy has been held for many years, even though most of the clinical literature has not been able to distinguish contrast-induced nephropathy from other causes of the condition.
Last October the Food and Drugs Administration (FDA) added a black box warning on ultrasound (US) contrast agents used in echocardiogram imaging examinations, around 200 reports of serious allergic reactions were received. Problems included cardiac arrest as well as breathing difficulty and seizures; seven of the cases resulted in death.
The idea of measuring tissue stiffness using ultrasound is nothing new. But lately the field sets a rapid pace. “Real-time, hand-held elastography is now a commercial reality,” asserts Jonathan Ophir from the University of Texas Medical School.
Tiny lipid-shelled microbubbles injected in vessels may serve as an new ultrasound contrast agent to evaluate microvascular blood flow. By this microbubbles US-researcher devised a ultrasound imaging technique that can spot early signs of PAD.
Andrea Martini and Joerg Larsen, of the Institute for Roentgendiagnostics, Braunschweig Teaching Hospitals, Germany, discuss nanotechnology, hybrid imaging and the quest for a personalised medicine.
Apart from spending a year at Johns Hopkins University Hospital, Baltimore, USA, the professor has never worked anywhere other than at the Radiology Department at the University Hospital of Cattinara Hospital, Trieste, of which she is Chairman. Daniela Zimmermann asked her about what women can achieve in this field, as well as the professor's own multifarious roles and research activities.
By Professor Robert D Speller, Head of the Radiation Physics Group, University College London, and Dr Alessandro Olivo, of the Medical Physics & Bioengineering Dept. University College London
Molecular imaging aims at the in vivo quantitative visualisation of molecules and molecular events that occur at cellular level. The potential towards clinical translation is huge, because the same modalities used in medical imaging are used in molecular imaging investigations.
ulrich medical, established 25 years ago, is an independent medium-size medical technology firm with worldwide sales. Among its products are contrast agent injectors for contrast agents used in computer and magnetic resonance tomography.
Early functional evaluation of new treatments in oncology is of major importance. Overall survival rate is the best criterion for assessing treatment, but unfortunately it calls for lengthy follow-up whereas treatment efficacy must be ascertained as soon as possible. The morphological criteria normally used (WHO or RECIST) do not lend themselves easily to new therapies which often induce lesion…
The use of state-of-the-art helical CT scanners allows for ultra fast examination of larger regions of the body. Due to the short examination time, optimum utilization of the intravenous contrast medium bolus is of extreme importance. The Sure Start function grants this in a very simple way.
The introduction of a new generation of microbubbles has created opportunities for ultrasound, and this is particularly true in the liver, where study of the arterial, venous and sinusoidal phases with an agent such as SonoVue at low ultrasound power levels (Iow mechanical index, MI) provides unique information. Similar diagnostic advantages can be obtained in diseases of the kidneys, spleen and…
There are a number of problems in contrast imaging using LevovistTM contrast agent. In Doppler mode, the problems are poor resolution and large areas of blooming. In 2nd harmonic imaging and pulse inversion imaging, there are problems related to tissue harmonic imaging (THI) because Levovist requires a high mechanical index (MI). THI increases under high-MI conditions, and THI interferes with…
Case 1 50-year-old male with a colorectal cancer. Greyscale imaging clearly shows the lesion, as an echogenic 3 cm mass (Fig.l a), which must be considered as suspicious for a metastasis from his colorectal cancer but benefit of the doubt must be given. Colour Doppler (Fig. 1b) is not helpful. At 33 seconds after SonoVue injection (early sinusoidal phase), Vascular Recognition Imaging (VRI)…
Vascular Recognition Imaging (VRI) is a low MI broadband colour Doppler method that images the interactions of Sonovue with microbubbles in a non-destructive manner as perfusion images of a quality never before achieved. The perfusion image represents the low velocities of unmoving or barely moving microbubbles as green-coded tissue perfusion, while the higher velocities of the veins and arteries…
Over the last years Toshiba has actively participated in the development of Contrast Harmonic Imaging. Around 1996 one of the first agents that became available on the European market was Levovist TM (Schering AG, Berlin, Germany). This was a galactose-based contrast agent. Levovist could be used as a Doppler signal enhancer throughout the entire vascular system. With the development of these…
Intravascular contrast medium is essential for enhancement of vessels and parenchyma. In this way the relation between vessels and tumours can be detected. Factors that influence the time required for a contrast bolus are the cardiac output of a patient, body weight, hydration status and the condition of the vessels. When a main vessel is occluded because of thrombosis, embolia or trauma a…
Ultrasound contrast agents (USCA) or echo enhancers consist of minute gas containing microbubbles that have a high reflectivity when exposed to an ultrasound field. The history of USCA started in the mid of the 1960s. The cardiologist Joyner performed echo cardiography during the injection of saline solution into the aortic root via a catheter. During the injection he observed bright signals on…