News • Developing Nations
Researchers turn bubble wrap into tiny test tubes
Inexpensive packing material pops up as an alternative to high-cost glass lab equipment for simple diagnostic tests, a potential boon in developing nations.
Article • Therapy
Molecular imaging mines deeper
The view across the Atlantic – it fills Professor Fabian Kiessling, Chair of Experimental Molecular Imaging at the RWTH Aachen (Rhine-Westphalia Institute of Technology Aachen), with optimism. The USA offers more opportunities for molecular imaging. Only recently, new tracers for Alzheimer’s were accepted as reimbursable in some centres, whilst the development of new diagnostics in Europe…
News • Preclinical Alzheimer's disease
Omega-3 supplements and antioxidants may help
New research in The FASEB Journal suggests that clinical trials of omega-3 and antioxidant supplementation should be undertaken for people with Alzheimer's disease with mild clinical impairment.
Novel DNA repair mechanism brings new horizons
A group of researchers, lead by Vasily M. Studitsky, professor at the Lomonosov Moscow State University, discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases. The article describing their discovery is published in AAAS' first open access online-only journal Science Advances.
News • ADAM17
Fight against cancer: Researchers map important enzyme
Danish researchers from the University of Copenhagen have discovered what controls the enzyme that aids the growth of cancer tumours. These findings could be of great value to cancer treatments and has just been published in the renowned journal, Nature Communications.
Fructose produces less rewarding sensations in brain
Fructose not only results in a lower level of satiety, it also stimulates the reward system in the brain to a lesser degree than glucose. This may cause excessive consumption accompanied by effects that are a risk to health, report researchers from the University of Basel in a study published in the scientific journal PLOS ONE. Various diseases have been attributed to industrial fructose in…
News • Gene defects
Cancer brake failure leads to brain cancer
Tumor suppressor genes protect against cancer. Until now, scientists have had to perform complex experiments to detect whether or not a mutation or loss of this gene type does, in fact, cause cancer. Scientists from the German Cancer Research Center (DKFZ) have now used a new gene technology method called CRISPR/Cas9 technology for this detection.
Article • Gentle intervention
Endoscopy jumps the boundaries
‘Health insurers should keep a tighter rein on the quality of endoscopic interventions because, mostly, they represent a gentler alternative to surgery,’ asserts international expert Horst Neuhaus, during an EH interview. Report: Daniela Zimmermann/Juliane Dannert
News • Figthing cancer
Triple treatment keeps cancer from coming back
Lung cancer is the leading cause of cancer death worldwide, responsible for some 1.59 million deaths a year. That figure is due, in part, to the fact that the cancer often returns after what, at first, seems to be successful treatment. And the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission. According to new research by the Weizmann…
News • Technology
Diabetes: Smart insulin patch could replace painful injections
Painful insulin injections could become a thing of the past for the millions of Americans who suffer from diabetes, thanks to a new invention from researchers at the University of North Carolina and NC State, who have created a “smart insulin patch” that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream whenever needed.
News • Molecular Genetics
How a Bacterial Cell Recognizes its Own DNA
It may come as a bit of a surprise to learn that bacteria have an immune system – in their case to fight off invasive viruses called phages. And like any immune system – from single-celled to human – the first challenge of the bacterial immune system is to detect the difference between “foreign” and “self.” This is far from simple, as viruses, bacteria and all other living things…
Article • UTI pathogen
Boosting the Body’s Natural Ability to Fight Urinary Tract Infections
Urinary tract infections (UTIs) are common, and widespread antibiotic resistance has led to urgent calls for new ways to combat them. Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report that an experimental drug that stabilizes a protein called HIF-1alpha protects human bladder cells and mice against a major UTI…
News • Neurology
Balanced behavior with IRBIT
Hyperactivity and social abnormalities are defining characteristics of ADHD and autism, two developmental disorders that parents and scientists around the world are struggling to understand. At the RIKEN Brain Science Institute in Japan, researchers have identified the protein IRBIT as a key player in preventing these behaviors from developing.
Article • Infection control
From alcohol to cancer detection
Clinical trials are under way at two NHS hospitals in England to assess breathalyser technology to detect lung cancer. Phase I clinical trials of a diagnostic breathalyser developed by Cambridge-based Owlstone Ltd have shown accurate identification of 12 lung cancer biomarkers in breath specimens. A Phase II trial is now targeting development of a small, handheld device that can be used in GP…
Article • Diabetes I
Diabetology news
The focus of the 2015 Diabetes Congress held in Berlin this May was ‘Personalised diabetes treatment: innovative – individual – sustained’. EH reports on points aired during the supporting press briefing. Report: Bettina Döbereiner
Article • Funding black holes
Curbing the use of agency nurses
New figures for the UK’s key National Health Service (NHS) Trusts have revealed their total deficit of more than €1.1 billion for the year 2014-15. This rise on the previous year’s deficit of €160m comes against a backdrop of health authorities being required to find ‘efficiency savings’ of almost €1.4bn over the last five years. The NHS was also a major issue in the recent UK…
Article • New Study
Seeking to identify what causes death
A new study group that aims to establish guidelines on forensic microbiology sampling and encourage increased communications between European and global organisations, has been launched by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID).
Article • Antimicrobial stewardship
A diagnostic marker reduces antibiotics use
Since 2009, as part of diagnostic and antimicrobial stewardship strategies, Hampshire Hospitals National Health Service (NHS) Trust has used serum procalcitonin (PCT) – an innovative and highly specific marker to diagnose clinically relevant bacterial infections and sepsis. Report: Mark Nicholls
Placenta-on-a-chip
National Institutes of Health (NIH) researchers and their colleagues have developed a "placenta-on-a-chip" to study the inner workings of the human placenta and its role in pregnancy.
First full genome of a living organism assembled
Researchers in Canada and the U.K. have for the first time sequenced and assembled de novo the full genome of a living organism, the bacteria Escherichia Coli, using Oxford Nanopore's MinIONTM device, a genome sequencer that can fit in the palm of your hand.
Study finds gene mutations sensitize tumors to specific cancer drugs
Mutations in ARID1a, which are common in many cancer types, disrupt DNA damage repair in cancer cells, allowing the cancer to progress. This gene may also be an Achilles' heel when treating certain tumors, according to a team of researchers at The University of Texas MD Anderson Cancer Center.
New imaging technique pinpoints changes in brain connectivity following mTBI
A new imaging technique can identify the specific changes in neural communication that can disrupt functional connectivity across the brain as a result of mild traumatic brain injury (mTBI).
Unique bacterial fingerprint identified in systemic sclerosis
The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) Press Conference showed that people with systemic sclerosis (SSc) have a unique bacterial signature in their colon, when compared with healthy people.
News • Microbiology
ESCMID launches study groups for forensic and veterinary microbiology
The ESCMID Study Group for Forensic and Postmortem Microbiology will create a new network of microbiologists, virologists, anthropologists and archaeologists working in the field of forensic medicine. Professor Amparo Fernandez-Rodriguez, from the National Institute of Toxicology and Forensic Sciences, Madrid, is the head of ESGFOR and stresses the importance of this group in facilitating…
News • HIV
Identification of a molecule that recognizes HIV in immune cells
In collaboration with colleagues from California and New York, researchers of the Paul-Ehrlich-Institut have identified a cytosolic receptor which enables cells of the immune system to recognize HIV and to trigger an immune response. The findings of the researchers may be a useful tool for creating an effective endogenous immune response against HIV and helpful to boost vaccine responses.