Spanish researchers are challenging the validity of many past and ongoing clinical trials and stress the importance of working with raw or preprocessed data in genetic information study.
Value in Health, the official journal of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), has announced the publication of new research indicating that testing for variants in 7 cancer-associated genes (versus the usual process of testing in just 2 genes) followed by risk-reduction management could cost-effectively improve life expectancy for women at risk of…
The one-size-fits-all approach to early stage breast cancer creates a paradox: Millions of dollars are spent on unnecessary surgeries and radiation to treat women with low-risk ‘in situ’ lesions, an estimated 85% of which would never progress to invasive cancers. Meanwhile, the standard conservative treatment is insufficient for many early-stage tumors that have progressed past the in situ…
High concentrations of the stress hormone, Cortisol, in the body affect important DNA processes and increase the risk of long-term psychological consequences. These relationships are evident in a study from the Sahlgrenska Academy on patients with Cushing’s Syndrome, but the findings also open the door for new treatment strategies for other stress-related conditions such as anxiety, depression…
Curetis, a developer of next-level molecular diagnostic solutions, today announced that the Company has established Ares Genetics GmbH, a wholly owned subsidiary of Curetis GmbH. Ares Genetics builds on GEAR GEnetic Antibiotic Resistance and Susceptibility Database and associated assets recently acquired for Siemens. The Company will use GEAR to investigate the genetic foundations of antibiotic…
European Hospital reports a new approach in molecular diagnostics introduced during the IASLC World Conference in Vienna.
The Technion breathalyzer would give pathology groups and medical laboratories unprecedented ability to support physicians in diagnosing and treating cancers, chronic diseases, and other illnesses.
Methyl labels in the DNA regulate the activity of our genes and, thus, have a great influence on health and disease. Scientists from the German Cancer Research Center and from the Saarland cancer registry have now revealed that an altered methylation status at only ten specific sites in the genome can indicate that mortality is increased by up to seven times. Smoking has a particularly…
An algorithm based on levels of metabolites found in a blood sample can accurately predict whether a child is on the Autism spectrum of disorder (ASD), based upon a recent study. The algorithm, developed by researchers at Rensselaer Polytechnic Institute, is the first physiological test for autism and opens the door to earlier diagnosis and potential future development of therapeutics.
Short men may have an increased risk of becoming bald prematurely. An international genetic study under the leadership of the University of Bonn at least points in this direction. During the study, the scientists investigated the genetic material of more than 20,000 men. Their data show that premature hair loss is linked to a range of various physical characteristics and illnesses. The work has…
An international research team from the University Hospital of Munich (LMU), Newcastle University and the University of Liverpool has identified a gene mutation that causes a hereditary skeletal muscle disorder. The study is published in the "American Journal of Human Genetics".
Lifestyle tests that pretend to be medical procedures are inherently problematic in terms of clinical, medical and privacy issues.
Angelina Jolie received widespread media attention in 2013 when she told the public that she'd tested positive for BRCA1, a gene associated with an increased risk of breast and ovarian cancers, and subsequently had a double mastectomy. Now research shows a spike in genetic tests for breast cancer after actress’ public disclosure, but no corresponding increase in mastectomies.
Experts at the European Committee on Antimicrobial Susceptibility Testing (EUCAST), who define the optimal drug concentrations to inhibit the growth of pathogens, have found that genetic methods cannot yet be used to test for susceptibility in a number of important bacterial species.
The ability to digitise results from patient samples has been one of the key enabling technologies that make personalised medicine possible now, says Dr Fiona Carragher, the Deputy Chief Scientific Officer for NHS England.
Artificial intelligence and bioprinting will be the central topics of the "Emerging Technologies In Medicine" (ETIM) congress, to be held at the University Hospital, Essen, Germany, on 10-11 February 2017.
In the largest study of its kind, UT Southwestern Medical Center researchers and colleagues in Europe identified a gene variant that suppresses the desire to drink alcohol.
After nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children’s Hospital Medical Center have created the first mouse model for the most common form of infant leukemia. Their discovery could hasten development and testing of new drug therapies.
Menarini-Silicon Biosystems announced the company’s DEPArray single-cell isolation technology played a key role in a study conducted by researchers from The University of Manchester to develop a model for predicting whether small-cell lung cancer patients will be sensitive or resistant to initial chemotherapy treatment.
n type 1 diabetes, the body attacks its own insulin-producing cells. Scientists at Helmholtz Zentrum München, partner in the German Center for Diabetes Research, and their colleagues at Technical University of Munich have now reported in the journal ‘PNAS’ about a mechanism used by the immune system to prepare for this attack. They were able to inhibit this process through targeted…
Cancer thrives when mutated cells undergo frequent division. Most anti-cancer drugs work by inserting themselves in between the DNA base pairs that encode our genetic information. This process is known as intercalation, and it can result in subtle changes to the DNA molecule’s geometric shape or tertiary structure. These structural changes interfere with the DNA’s transcription and a cell’s…
There are a couple strains of herpes so common that researchers estimate 90% of the human population have them. These strains, human herpes 6 and human herpes 7, usually do not cause severe symptoms when people acquire them. But researchers know that under certain circumstances, dormant herpes viruses in the body can unexpectedly come roaring back and cause complications not typically associated…
As men appear to have higher risk of cardiovascular disease (CVD) than women of a similar age – with vascular calcification a strong predictor of mortality and morbidity from CVD – a team from the University of Edinburgh hopes that exploration of a link between gender and calcification could help unlock the pathway to new therapies. The researchers have been looking at whether sex hormones…
Cancer patients today can benefit from much better drugs providing treatments tailor-made to specific mutations. However, broad application is still hampered by a considerable bottleneck: fast, reliable, and cost-effective diagnosis. Agena's MassARRAY platform is addressing this bottleneck with an elegant new solution.
The Ligand PD-L1 is one of the most important targets for cancer immunotherapy with checkpoint inhibitors. But not all tumors have sufficient quantities of PD-L1 ligands on their surface. Scientists from the German Cancer Consortium (DKTK) have now shown that different types of cancer possess different quantities of PD-L1-Gen copies. Genetic analysis of the PD-L1 gene may in the future help to…