The MALDI Tissuetyper is a system that records spatially resolved mass spectra directly from tissue. This allows the direct measurement of proteins, lipids and other molecular classes without the need for antibodies or molecular probes. This results in highly multiplexed datasets in which hundreds or thousands of compounds are measured simultaneously.
Pathologists have been largely diagnosing disease the same way for the past 100 years, by manually reviewing images under a microscope. But new work suggests that computers can help doctors improve accuracy and significantly change the way cancer and other diseases are diagnosed. A research team from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) recently developed…
Professor Klaus Kayser, former Head of the Institute of Pathology at Heidelberg University Hospital’s Thorax Clinic, may be retired but he continues to be a leading figure in his discipline, a visionary, famous for this critical and ‘out of the box’ thinking. During the run-up to the European Congress on Digital Pathology (ECDP), we asked the expert about telemedicine and standards and,…
Strictly speaking, digital pathology has not yet resulted in any groundbreaking changes for clinical diagnostics. The conventional light microscope introduced to pathology around 100 years ago continues to be the most important tool for pathologists.
Healthcare is going digital. No doubt about it, Prof. Hufnagl predicts. Information and communication technologies have gone beyond moving data from one place to the other; they are triggering stellar improvements in healthcare: diagnoses are becoming ever more precise, therapies ever more personalised. The extent to which the individual clinical disciplines have progressed in their technological…
Mobile technology could prove an important catalyst in helping take digital pathology onto a new level in delivering clinical diagnostics.
Histopathologists play key roles in diagnosing disease entities and determining biomarkers related to the prognosis and response to specific therapy of malignant tumours. Report: Bela Molnar
A UK-based neuropathologist has highlighted how the digitisation of pathology will play a pivotal role in taking patient care on to a new and more efficient level. Speaking in a recent Webinar under the heading The Adoption and Benefits of Digital Pathology for Primary Diagnosis, Dr Daniel du Plessis also noted how the digital era would raise the profile of pathology and ‘bring it out of the…
As laboratories in Europe shift to systems for digital pathology, they must ensure the technology not only works, but works for them, says Dr Liron Pantanowitz, director of pathology informatics at University of Pittsburgh Medical Center (UPMC).
Carol - I. Geppert MD, from the Institute for Pathology at Erlangen University Hospital, Friedrich Alexander University Erlangen-Nuremberg, debates the impact of digitisation on pathology.
In a study of 436 breast cancer cases with 28 years of survival data histo-pathologists from Karolinska Institute, Stockholm, Sweden shows that protein tissue-based biomarker data are at least as good as gene expression assays.
Pathologists in Utrecht step away from the microscope as the first fully digital workflow goes live for primary diagnostics. ‘The whole world wants to stop by and see the show,’ said Paul van Diest MD, who leads the Department of Pathology at the Utrecht University Medical Centre.
Harnessing the potential of digital pathology is taking research into new and more efficient biomarkers to a new level. By combining strategic planning with the latest digital pathology technology, high quality tissue microarrays for biomarker research are being produced.
Whilst digital pathology has the potential to deliver more precise diagnostics, there remain a number of barriers to its widespread implementation.
Compressing and storing digital images in pathology remains technically challenging but there are many options that can both help reduce costs and improve efficiency, a Spanish expert will explain in a dedicated talk during ECDP in Berlin.
The equivalent of HD or Ultra-HD for home television and video is now entering the world of medicine. Although 4K technology with its high-resolution display quality is already used in radiology, there are areas that do not yet benefit from this advanced technology.
No self-respecting TV crime series is without a pathologist – but the fictitious pathologist who incessantly solves crimes has little to do with reality.
Since the introduction of targeted therapies in oncology the task of the pathologist has expanded beyond histological diagnostics: today, the pathologist analyses tumour tissue samples to establish a molecular profile with tumour cell characteristics – which in turn become the targets of medication.
Imaging research is one step closer to giving clinicians a way to do high-resolution scans of malignant cells in order to diagnose cancer and help identify useful therapies. If this technology were to prove successful in clinical studies, it might change how anatomic pathologists and radiologists diagnose and treat cancer.
Although tuberculosis (TB) is commonly thought of as being a disease that mainly affects nineteenth century poets and Victor Hugo characters, it is still the second-most common cause of mortality from an infectious disease in the world, killing nearly three people every minute.
Since 2012, at least 1,500 individuals have developed Middle East respiratory syndrome (MERS), resulting in more than 500 fatalities. Only now are results being reported of the first autopsy of a MERS patient, which was performed in 2014. Not only do these findings, published in The American Journal of Pathology, provide unprecedented, clinically-relevant insights about how MERS progresses, they…
Post mortems are now rarely carried out within UK hospitals – according to a study that examined all acute NHS Trusts within England, NHS Boards in Scotland and Wales and Social Care Trusts in Northern Ireland, and found that the process has disappeared completely in around a quarter (23%) of NHS trusts. In 2013, the average autopsy rate (percentage of adult in-patient deaths that undergo…
The field is so new that the annual Digital Pathology Congress (3-4 December in London) was held for only the second time. Yet, Philips Healthcare could announce a world-first – in partnership with the Netherlands-based LabPON, the company has created the first clinical pathology laboratory to be completely converted to digital diagnosis.
Collaborating with colleagues locally and globally using telepathology can be successful for facilities both financially and clinically, says Dr. Liron Pantanowitz, director of pathology informatics at University of Pittsburgh Medical Center (UPMC). Pantanowitz, who also serves as a consultant to Onyx, a company that provides digital pathology technology and is joint venture between GE Healthcare…
Increasing requirements for specialisation and diagnostic quality in pathology on the one hand and the importance of pathology findings for treatment planning on the other hand call for new solutions in pathomorphological diagnostics. One important starting point is the fast-paced opportunity for digitalisation along with communication systems which facilitate the storage and transfer of large…