A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns. Published in the journal mBio, the findings highlight the need to develop new drugs and treatment regimens for the lethal brain infection, which kills around 180,000 people each year. Cryptococcal…
Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections. The discovery is important as it is directly related to the development of Staphylococcus aureus diseases, known popularly as staph infections, which…
T2 Biosystems, Inc., a leader in the development and commercialization of medical diagnostic products, and CARB-X, a global non-profit partnership dedicated to accelerating R&D innovation to address the rising global threat of drug-resistant bacteria, announced the granting of a CE mark to the T2Resistance Panel. With the CE mark, T2 Biosystems has met the requirements of the In-Vitro…
Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial agents is becoming increasingly smaller as resistance rates rise.
Nosocomial infections cause more deaths than traffic accidents – a stunning discovery made in a recent German study. Worse: infectious diseases long thought eradicated in Europe, such as measles, tuberculosis (TB) and, more recently, syphilis, are also implicated. The increasing number of patients places an additional financial burden on healthcare. But – and this might be the good news –…
PHE’s latest English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) report shows that there were an estimated 61,000 antibiotic resistant infections in England during 2018, a 9 percent rise from 2017.[i]
Scientists from Scotland are developing a low cost, rapid diagnostic sensor test which aims to show the susceptibility of bacteria to antibiotics within 45 minutes. Laboratory testing of samples can take up to two days and the new test aims to allow doctors to be able to prescribe the correct antibiotic to a patient for an infection more quickly. In a research paper published in the journal…
Many life-threatening bacteria are becoming increasingly resistant to existing antibiotics. Swiss researchers co-headed by the University of Zurich have now discovered a new class of antibiotics with a unique spectrum of activity and mechanism of action. By disrupting outer membrane synthesis, the antibiotics effectively kill Gram-negative bacteria. According to the World Health Organization…
Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients. Helicobacter pylori is a bacterial pathogen carried by 4.4 billion people worldwide, with the highest prevalence in Africa, Latin America and the Caribbean. Although the majority of infections show no symptoms,…
Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins…
Scientists at the University of Surrey have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria...
T2 Biosystems and CARB-X announced that the T2Resistance Panel is the first diagnostic to graduate from CARB-X’s portfolio.
Bacteria are becoming increasingly resistant to common antibiotics. Often, resistance is mediated by resistance genes, which can simply jump from one bacterial population to the next. It’s a common assumption that the resistance genes spread primarily when antibiotics are used, a rationale backed up by Darwin's theory: only in cases where antibiotics are actually being used does a resistant…
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…
New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections, are spreading through hospitals in Europe. Certain strains are resistant to the carbapenem antibiotics that represent the last line of defence in treating infections and are therefore regarded as extremely drug resistant (XDR).
Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.
In view of the increase of multidrug-resistant organisms (MDRO), the WHO has declared antibiotic resistance one of the biggest threats to global health. MDROs have become a major problem particularly in hospitals. Professor Dr Georg Häcker from the Institute for Microbiology and Hygiene at the University Hospital Freiburg, explains some strategies to prevent hospital-acquired infections (HAIs).
Many countries across the world are challenged with a rising number of incidences of multi-drug resistant (MDR) organisms infecting the population, and for several years, a clear pattern of increased resistance has emerged in southern and eastern European countries. For example, in countries such as Italy, a reduced number of therapeutic options remain available for highly pathogenic infections,…
As leaders gather for the International Ministerial Conference on antimicrobial resistance (AMR), hosted by the government of The Netherlands and organised in close cooperation with the FAO, OIE and WHO, experts and responsible manufacturers are calling for a 'One Health' approach to AMR and recognition of the impact of antibiotic production on the environment. "With two thirds of the worlds…
A new benchtop automated reading and incubation system is now available in Europe for antimicrobial susceptibility testing (AST). The new instrument provides microbiology laboratories with the accurate MIC results that clinicians need to confidently select an effective antibiotic for critically-ill patients while safeguarding future patient care through more successful antimicrobial stewardship.…
Bacteria have fascinating properties. They adapt excellently to their respective environment, and they existed long before humans. Their toughness has led to the fact that bacteria have successfully spread all over the world for three billion years – even in places where humans could not survive, for example in the hottest springs and in the coldest places on earth. However, they were only…
Imperial medical students have helped to devise a new type of ‘decoy’ drug to tackle infections that are resistant to antibiotics. In lab tests on bacterial cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden. When the bacteria fight against the first ‘decoy’ antibiotic, this action…
A team of researchers from Versailles Saint-Quentin-en-Yvelines University (UVSQ), Inserm and Pasteur Institute has been able to provide for the first time an accurate estimate of both the incidence (annual number of new cases) and added direct cost of infections due to antibiotic-resistant bacteria in patients hospitalised in French hospitals during 2015 and 2016.
In a joint collaboration, researchers from Denmark and Switzerland have shown that bacteria produce a specific stress molecule, divide more slowly, and thus save energy when they are exposed to antibiotics. The new knowledge is expected to form the basis for development of a new type of antibiotics. All free-living organisms are under constant pressure to survive. Darwin dubbed this…
When the first antibiotics were discovered in the early 20th century, the rate of death from infectious diseases fell dramatically. But the emergence of multidrug-resistant bacteria as a result of antibiotic misuse is raising fears that by 2050, these same diseases will once again become the leading cause of death worldwide. In a bid to boost the arsenal available to tackle this threat,…