Checkpoint inhibitors can achieve a lasting treatment response in around 20% of some kinds of advanced cancer cases. ‘Immunotherapies are given the highest possible rating on the Magnitude of Clinical Benefit Scale of the European Society for Medical Oncology (ESMO), which assesses the actual clinical benefit of tumour treatments,’ emphasises Professor Christoph Zielinski MD, Head of the…
Locally applied antibiotics are a component of effective infection management in orthopaedics and trauma surgery. Successful concepts are based on patient-specific surgical and antimicrobial treatment. At the symposium “Infections and high-risk patients: solutions for joint replacements and traumatology” at this year’s Congress on Orthopaedics and Trauma Surgery (DKOU) in Berlin last…
Following a heart attack or other heart trauma, the heart is unable to replace its dead cells. Patients are often left with little option other than heart transplants, which are rarely available, or more recently cell therapies that transplant heart cells into the patient's heart.
A leading cause of cancer deaths worldwide, colon cancer is famously resistant to treatment. There are many reasons for this, but one has to do with a group of persisting cancer cells in the colon that cause relapses. Conventional therapies against them are mostly ineffective. EPFL scientists have now identified a biological mechanism that can be exploited to counteract colon cancer relapses.
Multiple sclerosis (MS) may be triggered by the death of brain cells that make the insulation around nerve fibers, a surprising new view of the disease reported in a study from Northwestern Medicine and The University of Chicago.
Findings demonstrate that testosterone is a metabolic hormone as well as a sex hormone, University at Buffalo researchers say.
A discovery about how the body deals with the cholesterol contained within its dying cells has suggested an exciting new approach to control people’s cholesterol levels – and thus their risk of developing heart disease.
In the world of technology, the term Industry 4.0 is already well known. Univ-Prof. Dr. rer. nat. Bernhard Wolf has reveals a comparable development in medicine. Smart systems and personalisation have enormous potential, the Professor for Medical Electronics at the Technical University of Munich is convinced.
Every year, worldwide, over a million patients have a pacemaker or defibrillator implanted. Home monitoring systems can significantly improve the safety and quality of life for these patients, says Professor Gerhard Hindricks, head physician in the rhythmology department at Leipzig’s Heart Centre. Report: Sascha Keutel
First-of-its-kind study by the University of Iowa shows kids with hearing loss benefit from early intervention.
Engineers at the University of California, Berkeley, are developing a new type of bandage. Thanks to advances in flexible electronics, the researchers have created a new "smart bandage" that uses electrical currents to detect early tissue damage from pressure ulcers, or bedsores, before they can be seen by human eyes - and while recovery is still possible.
Warts aren’t just for witches and goblins. According to member dermatologists from the American Academy of Dermatology, children and teens, people who frequently bite their nails, and people with a weakened immune system are more prone to getting warts than others.
A photograph may reveal how something looks, but direct observation can divulge how the objects behave. The difference can mean life or death, especially when it comes to fighting human disease. To help researchers examine exactly how human diseases work at the molecular level, Virginia Tech Carilion Research Institute scientist Deborah Kelly has developed a new set of tools to peer into the…
Hearing loss is one of the most common birth defects, with more than 12,000 children in the United States affected each year. Three students in Wichita State University's biomedical engineering program recognized this issue and designed their senior project to create a therapeutic toy to provide early intervention therapy for children with auditory disabilities.
In a discovery that could lead to more targeted and effective treatments for certain lung and prostate cancers, researchers at the University of Virginia School of Medicine have identified two new cancer-causing gene mutations – mutations that may be particularly susceptible to cancer-fighting drugs already approved by the federal Food and Drug Administration. One of the gene mutations also may…
Some six million people in the U.S. suffer from scoliosis, a sideways curvature of the spine. These include approximately 2 to 3% of adolescents who are diagnosed each year with idiopathic scoliosis, which is usually identified during puberty and progresses until skeletal maturity. One in 500 children today require treatment using spine braces and 1 in 5,000 need spinal surgery. The typical spine…
A unique molecule developed at Duke Medicine, the University of North Carolina at Chapel Hill and MacroGenics, Inc., is able to bind HIV-infected cells to the immune system’s killer T cells. It could become a key part of a shock-and-kill strategy being developed in the hope of one day clearing HIV infection.
University of Virginia School of Medicine researchers have discovered a new strategy for attacking cancer cells that could fundamentally alter the way doctors treat and prevent the deadly disease. By more selectively targeting cancer cells, this method offers a strategy to reduce the length of and physical toll associated with current treatments.
People with Parkinson’s disease (PD) tend to slow down and decrease the intensity of their movements even though many retain the ability to move more quickly and forcefully. Now, in proof-of-concept experiments with “joysticks” that measure force, a team of Johns Hopkins scientists report evidence that the slowdown likely arises from the brain’s “cost/benefit analysis,” which gets…
Scientists at the University of California, San Diego School of Medicine have elucidated a genetic interaction that may prove key to the development and progression of glaucoma, a blinding neurodegenerative disease that affects tens of millions of people worldwide and is a leading cause of irreversible blindness.
A gap in scientific knowledge about a family of drugs that are used to treat Type 2 diabetes has been highlighted in a new study.
Fetuses with enlarged ventricles--the fluid-filled cavities inside the brain--may be less likely than their counterparts to benefit from surgery in the womb to treat spina bifida, according to a study supported by the National Institutes of Health.
Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS, say researchers at California Institute of Technology.
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer.
There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule – to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
