Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism. Gene therapy, a technique that selectively attacks a tumour, might…
Most accidents result from ‘the human factor’ – long acknowledged in aviation. Thus all crew members receive regular safety training to help prevent errors on board and on the ground. Now experts at the German Society for Orthopaedics and Trauma (DGOU) with those from Lufthansa Flight Training have developed a similar training programme for physicians. This Interpersonal Competence Training…
New research has found that a process initiated in white blood cells known as neutrophils may lead to worse outcomes for some patients with chronic obstructive pulmonary disease (COPD). The discovery may help identify patients at higher risk for COPD progression, who might also show little benefit from standard treatments.
Pentax Medical launches a world first for endoscopy, the OPTIVISTA EPK-i7010 Video Processor, featuring both digital and optical enhancements, in the European, Middle Eastern & African (EMEA) markets. This unique enhancement combination provides detailed information for more accurate endoscopic in vivo diagnosis through improved vessel and mucosal pattern characterization.
A multicenter research team led by Columbia University Medical Center (CUMC) has discovered a new neurodevelopmental syndrome and the genetic mutations that cause it. The discovery is an important step toward creating targeted therapies for individuals with this syndrome, which causes severe developmental delays, abnormal muscle tone, seizures, and eye complications.
At a recent focus meeting held in Berlin by the Association of Accredited Laboratories in Medicine, Dr Andreas Weimann, managing director at the Laboratory Berlin – Charité Vivantes Services, spoke of the challenges that laboratories working with hospitals face due to the management of pathogens and the diagnosis of infections.
Colon cancer is one of the most common forms of cancer in Germany. Prof. Dr. med. Sebastian Zeißig, group leader at the DFG Research Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden and physician at the Department of Medicine I, University Hospital Carl Gustav Carus Dresden, has now shown a decisive role of gut bacteria in the regulation of intestinal…
Several bacterial species have pledged promise in fighting tumors. However, most of them are pathogens. In order to use them as a weapon against cancer and other diseases in humans, researchers must find a balance between their therapeutic aggressiveness and safety for the patient. To overcome this problem, researchers at the Helmholtz Centre for Infection Research (HZI) have shifted their focus…
Sepsis represents a serious complication of infection and is one of the leading causes of death and critical illness worldwide due in part to the lack of effective therapies.
A research team led by University of Arkansas chemist Jingyi Chen and University of Arkansas for Medical Sciences microbiologist Mark Smeltzer has developed an alternative therapeutic approach to fighting antibiotic-resistant infections.
Researchers have found that a combination of chemotherapy and modern radiotherapy can benefit patients with advanced nasopharyngeal cancer – a cancer that starts at the back of the nose. These cancers are very rare in the UK and so modern treatments had not been previously studied in patients with advanced disease.
Every year, tens of millions of individuals across Europe undergo endoscopic procedures to assist with the diagnosis and management of gastrointestinal diseases. However, significant variation in current endoscopy provision across Europe has been reported, with back-to-back colonoscopy studies demonstrating that a concerning 22 percent of all adenomas are missed and that a three-to-six fold…
On March 3, Radiotherapy Group clinicians at Ziekenhuis Gelderse Vallei (Ede, the Netherlands) used their Esteya electronic brachytherapy system for the first time to treat a 73-year-old male patient with a nodular basal cell carcinoma on his nose. Esteya is a form of high dose rate (HDR) brachytherapy that applies high-precision radiotherapy directly to the cancer site, minimizing radiation to…
A team of investigators from Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug to successfully eliminate lung metastases in mice.
A team of scientists at Helmholtz Zentrum München, in collaboration with Technische Universität München and the German Center for Diabetes Research (DZD), have shown in a preclinical model that specifically modified insulin mimetopes may lead to an immune tolerance. The results, published in ‘Nature Communications’, may be a step to improved prevention of type 1 diabetes.
Bioengineers and physicians at the University of California, San Diego have developed a potential new therapy for critical limb ischemia, a condition that causes extremely poor circulation in the limbs and leads to an estimated 230,000 amputations every year in North America and Europe alone to prevent the spread of infection and tissue death. The new therapy could prevent or limit amputations…
Humabs BioMed SA and the Institute for Research in Biomedicine (IRB) affiliated to the Università della Svizzera italiana announced the identification, isolation and characterization of two Ebola virus neutralizing monoclonal antibodies from the blood of a survivor of an Ebola infection.
In patients suffering from Type 1 diabetes, the immune system attacks the pancreas, eventually leaving patients without the ability to naturally control blood sugar. These patients must carefully monitor the amount of sugar in their blood, measuring it several times a day and then injecting themselves with insulin to keep their blood sugar levels within a healthy range. However, precise control…
Tumours kill off surrounding cells to make room to grow, according to new research from the University of Cambridge. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer – contrary to how many of the current chemotherapy drugs work.
Internet based cognitive behavioural therapy (CBT) can help people affected by body dysmorphic disorder, finds a study published by The BMJ today. This is the largest clinical trial of body dysmorphic disorder ever conducted, and the first to evaluate the effect of an internet based programme for the condition.
Automated latex enhanced immunoturbidimetric H-FABP assay helps emergency departments to detect MI within 30 minutes of chest pain onset, and improve the diagnostic efficiency of Troponin.
Checkpoint inhibitors can achieve a lasting treatment response in around 20% of some kinds of advanced cancer cases. ‘Immunotherapies are given the highest possible rating on the Magnitude of Clinical Benefit Scale of the European Society for Medical Oncology (ESMO), which assesses the actual clinical benefit of tumour treatments,’ emphasises Professor Christoph Zielinski MD, Head of the…
Locally applied antibiotics are a component of effective infection management in orthopaedics and trauma surgery. Successful concepts are based on patient-specific surgical and antimicrobial treatment. At the symposium “Infections and high-risk patients: solutions for joint replacements and traumatology” at this year’s Congress on Orthopaedics and Trauma Surgery (DKOU) in Berlin last…
Following a heart attack or other heart trauma, the heart is unable to replace its dead cells. Patients are often left with little option other than heart transplants, which are rarely available, or more recently cell therapies that transplant heart cells into the patient's heart.
