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News • False positive results

Accuracy of rapid covid test may be lower than previously suggested

The accuracy of a rapid finger-prick antibody test for SARS-CoV-2, the virus responsible for covid-19 infection, may be considerably lower than previously suggested, finds a study published by The BMJ. The results suggest that if 10% of people given the test had previously been infected, around 1 in 5 positive test results would be incorrect (false positive results). These conclusions contrast…

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Interview • Quality aspects

Lab automation – economic aspects and Covid-19

The academic teaching Karlsruhe Hospital, at the University of Freiburg, is the largest hospital providing tertiary care in the Middle Upper Rhine Valley. Every year, 63,000 in-patients and 180,000 out-patients are treated in the 1,500-bed facility with 50 departments and 30 out-patient clinics. Inevitably, a hospital of this size has a central lab. We spoke with Dr Horst Mayer, managing senior…

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Sponsored • Product of the Month

Needlestick Injuries are history

Injuries due to contaminated puncture devices are still the most frequent cause of accidents in hospitals. This is a significant source of danger for many employees in the healthcare industry. At this moment in time, there are already more than 20 bloodborne pathogens that we know of. The most dangerous are HBV, HCV and HIV. Recent studies show that it is up to ten times more likely for more…

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News • Using virus particles in exhaled breath

New SARS-CoV-2 test to deliver results in under 5 minutes

Research and innovation hub Imec announced that it has started developing a groundbreaking SARS-CoV-2 test. Unlike current approaches (using blood, saliva, or a nasopharyngeal swab), the new test will identify SARS-CoV-2 virus particles in a person’s exhaled breath. The solution promises the accurate identification of a contagious case in less than five minutes.

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Article • Mass spectrometry-based metabolomics

A new technique to understand metabolic pathways

Mass spectrometry-based metabolomics has emerged as a powerful tool to help study chemical ecology. Recent advances in the technique make it possible to study microbial interactions from complex communities. Laia Castaño-Espriu outlined the role and benefits of MS in this context in her presentation ‘Analysis of microbial ecology by mass spectrometry-based metabolomics techniques’, at the…

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Interview • Rapid diagnostics

The clinical potential of POCT

In 2019, the Central Laboratory of the Institute for Clinical Chemistry and Pathobiochemistry at the Klinikum rechts der Isar of the Technical University Munich, headed by Professor Peter B Luppa, organised the 4th of the internationally renowned Munich Point-of-Care Testing Symposiums. Dr Andreas Bietenbeck is senior physician at the Institute which for many years has been focusing on…

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News • Revealing innovation potential of new antibiotics

Using proteomic profiling to accelerate drug development

The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents. The aim is to identify substances that attack the pathogens in a truly novel way. The team at the Center for Systems-Based Antibiotic Research (Cesar) at Ruhr-Universität Bochum (RUB) has described in two publications how assess if a new antibiotic…

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Sponsored • Challenges in acute care

POCT: Understanding sources of error

In an emergency, point-of-care-testing can provide results in minutes. However, sources of error must be understood to ensure result accuracy and confident diagnosis (particularly important during the current pandemic). Medical teams frequently use POCT devices to assess acutely ill patients; a hospital’s diagnostic laboratory is responsible for the analysers, plus training non-laboratory…

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News • POCT for the head

New device detects traumatic brain injury 'on the spot'

A method for detecting traumatic brain injury at the point of care has been developed by scientists at the University of Birmingham. Using chemical biomarkers released by the brain immediately after a head injury occurs, researchers are able to pinpoint when patients need urgent medical attention. This saves time in delivering vital treatment and avoids patients undergoing unnecessary tests where…

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News • Simulation model for pathological mechanisms

Understanding the progress of viral infections

It is only 120 millionths of a millimetre in size but can bring entire countries to a standstill: the Corona virus. Even if it were to disappear one day, viral infections will still be among the most frequent and difficult-to-treat diseases in humans. Even decades of research have only produced a few standardized vaccines and strategies for treatment to combat just a small number of viruses. Nor…

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News • Testing strategy re-evaluated

COVID-19 testing at random? Here's a better idea

As COVID-19 infections begin to rise again, a novel testing strategy proposed by researchers at the University of Oxford at the start of the pandemic has become urgent once again. The strategy aims to bring the virus’s reproduction number (‘R’) down to below 1, by concentrating testing resources on particular groups in the population that are most likely to spread the infection to others,…

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Article • Antimicrobial Resistance Action Fund

AMR research gains $1 billion funding

A unique, ground-breaking global campaign, which has seen major pharmaceutical companies unite to fight antibiotic resistant infections, has been launched with a one-billion-dollar investment fund. The Antimicrobial Resistance (AMR) Action Fund aims to help save the collapsing antibiotic pipeline and make 2-4 new antibiotics available within a decade.

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Article • Information channel

Digital pathology special

From glass slides to the realm of ones and zeros: Digitising pathology offers many benefits to the specialty. Read our information channel for some of the most exciting applications.

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Article • Overcoming the barriers to AI in digital pathology

‘You can’t do AI on glass slides’

As Artificial Intelligence continues to impact on the development of digital pathology, potential users are still slow to implement key enabling technologies to harness the benefits, according to Dr David McClintock, who will detail critical steps for pathology departments to transition practice from glass (analogue) to digital (whole slide imaging) and embrace AI, to the 6th Digital Pathology…

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Article • High-capacity digital image analysis

Spatial statistics extract subvisual features

Spatial analytics offers greater clarity in the assessment of tumours beyond routine microscopic analysis. High-capacity digital image analysis enables new methods of spatial statistics to extract features not immediately distinguishable by visual inspection. These subvisual features reflect complex properties, such as intratumour heterogeneity and have the additional benefit that they can target…

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Sponsored • Histology/cytology equipment

Optimise pathology workflow with Hamamatsu whole slide imaging solutions

Hamamatsu Photonics understand the benefits and challenges of whole slide imaging systems. For over 15 years, we have been working to deliver robust and reliable scanners with optimal image quality. Our NanoZoomer whole slide scanner series quickly transform entire histology and cytology glass slides into diagnostic-quality digital images for duplication, annotation, storage, retrieval, and image…

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Article • Tissue analysis

Infrared spectroscopy as a diagnostic tool

New techniques of infrared-based technology are showing strong potential for cost-effective tissue analysis. Peter Gardner, Professor of Analytical and Biomedical Spectroscopy at the University of Manchester, outlined how hyperspectral imaging coupled with sophisticated computer algorithms can identify and grade cancerous tissue, as well as offer an indication of prognosis. The technique, he…

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Article • Need for modernisation

Digital pathology: Luxury or necessity?

The anatomical pathologist faces a crisis. Public and private labs suffer increasing caseloads, whilst pathologist numbers diminish for various reasons, including greater cancer prevalence associated with aging populations as well as improved cancer screening programs. Precision medicine typically involves more genetic testing and extensive use of immunohistochemistry to classify cancer and…

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