News • Study
Safety concerns over new female sterilization device
Women who undergo implant based female sterilization have a significantly heightened risk of reoperation following complications, suggests a large study published in The BMJ.
News • Protein DART
New shock-and-kill strategy against HIV
A unique molecule developed at Duke Medicine, the University of North Carolina at Chapel Hill and MacroGenics, Inc., is able to bind HIV-infected cells to the immune system’s killer T cells. It could become a key part of a shock-and-kill strategy being developed in the hope of one day clearing HIV infection.
News • Neurotransmitters
Coordinating traffic down the neuronal highway
An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells. Their findings open up new avenues for design of drugs for ataxia, a motor coordination disorder.
News • Innovation
3D bone marrow made from silk biomaterials generates platelets
Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3-dimensional (3D) tissue-engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).
News • Discovery
Viruses flourish in guts of healthy babies
Bacteria aren’t the only nonhuman invaders to colonize the gut shortly after a baby’s birth. Viruses also set up house there, according to new research at Washington University School of Medicine in St. Louis. All together, these invisible residents are thought to play important roles in human health.
News • Hours at a computer
Short walk can reverse vascular dysfunction
Across the country, many employees are seated at desks for the majority of an eight-hour workday. As technology creates an increase in sedentary lifestyles, the impact of sitting on vascular health is a rising concern. Now, researchers from the University of Missouri School of Medicine have found that when a person sits for six straight hours, vascular function is impaired — but by walking for…
News • Course of infections
Cell marker enables prognosis
When a pathogen invades the body, specific cells in the human immune system are ready to take immediate action in order to destroy it. The molecular characteristics of these killer cells were unknown until recently. Now, for the first time, a team from the Technical University of Munich (TUM) has managed to create a molecular profile of the protective cells. By studying these immune cells from…
News • PointMan DNA
Enrichment technology for highly sensitive lung cancer mutation detection
EKF Diagnostics, the global in vitro diagnostics company, announces that two research posters supporting the application of its PointMan DNA enrichment technology, for rapid and sensitive detection of lung cancer mutations, have been delivered at key conferences.
News • Experts Advise
Routinely screen those older than 70 for brain health
A panel of world experts in aging convened at Saint Louis University recommended that everyone 70 and older should have their memory and reasoning ability evaluated annually by a doctor or health care provider.
The mechanism that impairs blood flow with aging
With the world’s elderly population expected to double by 2050, understanding how aging affects the body is an important focus for researchers globally. Cardiovascular disease, the No. 1 cause of death worldwide, often is associated with aging arteries that restrict blood flow. Now, University of Missouri researchers have identified an age-related cause of arterial dysfunction, a finding that…
News • Science
New molecule can prevent preterm birth
Premature births are intimately linked with inflammation of the uterine tissue, a biological response which induces contractions and preterm labor. In their search for a mean to prevent this phenomenon and complications related to deliveries occurring before 37 weeks of gestation, researchers at CHU Sainte-Justine and University of Montreal discovered an agent that shows efficacy in inhibiting…
News • Study
Spheroid stem cell production sows hope for IPF treatment
In a small pilot study, researchers from North Carolina State University have demonstrated a rapid, simple way to generate large numbers of lung stem cells for use in disease treatment. This method of harvesting and growing a patient’s own lung stem cells shows promise in mice for treating idiopathic pulmonary fibrosis (IPF), and could one day provide human IPF sufferers with an effective, less…
News • Cancer Treatments
The DNA damage response goes viral
Every organism—from a seedling to a president—must protect its DNA at all costs, but precisely how a cell distinguishes between damage to its own DNA and the foreign DNA of an invading virus has remained a mystery. Now, scientists at the Salk Institute have discovered critical details of how a cell’s response system tells the difference between these two perpetual threats. The discovery…
News • Discovery
Researchers reveal cellular clockwork underlying inflammation
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer.
News • DNA
Keeping the cellular production line on track
When our cells copy their DNA to grow and replicate, it’s vital the process runs smoothly. To get this right, cells use a complex “machine”, made from many hundreds of components. This machine is built afresh, moment by moment as it’s needed during the copying process. This assembly–de-assembly is vital to accurate and efficient copying.
News • Research
Link between diabetes and bone health
Diabetes, which now affects almost 30 million Americans, can cause serious health complications, including heart disease, blindness, kidney failure and lower-extremity amputations. A lesser-known but equally grave complication is the effect of diabetes on bone health.“Clinical trials have revealed a startling elevation in fracture risk in diabetic patients,” says Liyun Wang, associate…
News • Fighting AIDS
Targeting HIV in semen to shut down AIDS
There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule – to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
News • mTOR
Cells in limbo hold clues for tackling cancer and ageing
For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals. mTOR (as it’s called in mammals) plays a central role in instructing the cell to grow and divide in response to nutrients. When it’s turned down, the cell shifts into a second, tidying mode,…
News • Microorganisms
Guidelines aimed at preventing build-up of dangerous biofilms
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms, which contribute to antimicrobial resistance.
Article • Data sharing
The LAW of the Lab
First they fixed the cables to hard-wire a faster data transfer from laboratory instruments. Now a coalition of the largest manufacturers of lab equipment for patient diagnostic tests have agreed on shared protocols for how software should report results. This is the first update to international standards in 20 years.
Article • Gold standard
Giant aims to inflate microbiology
At Europe’s largest meeting for clinical laboratories, Beckman Coulter stepped forward to welcome a new class of customers looking for familiar and reliable instruments. Report: John Brosky
Article • Pathology
Unlocking imaging potential
Automated image analysis shows significant potential within histopathology to help identify novel and subtle prognostic features. UK expert Dr Peter Caie also believes such image analysis can turn aspects of histopathology from a traditionally semi-quantitative field into a fully quantifiable and standardised science. However, he also points out that challenges remain before the full potential is…
Article • Danish experience
A national digital pathology system
A national digital pathology system across Denmark has helped to significantly improve efficiency and raise levels of patient safety. It has used advanced computer software systems and created a countrywide database to optimise the assessment of patients’ specimens. Report: Mark Nicholls
Article • Digital Pathology
CAD in pathology
Computer-aided diagnosis could soon play a greater role in digital pathology. Dr Jeroen van der Laak, an Assistant Professor in Digital Pathology at Radboud University, believes a breakthrough that would increase the speed and accuracy of diagnoses and prognoses is closer than many observers think Report: Mark Nicholls
Article • Infectious diseases
Developing vaccines and nanotechnology
Vaccination remains one of the most efficient strategies against infectious diseases, often being the best protection against infections such as hepatitis B, or influenza. European Hospital reports on expert reviews of vaccines in the pipeline and the potential of nanomedicine given during the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) annual meeting in…
