News • Finding solutions
$ 1.8 million to stop AMR
Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.
Antibiotic resistance
News • Sharper than ever
High-res image of bacterial bumps gives clues to antibiotic resistance
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
News • Resistance mechanism discovered
How staphylococci protect themselves against antibiotics
The skin bacterium Staphylococcus aureus often develops antibiotic resistance. It can then cause infections that are difficult to treat. Researchers at the University of Bonn have uncovered an ingenious way in which a certain strain of Staphylococcus aureus protects itself against the important antibiotic vancomycin. The results have now been published in the journal Microbiology Spectrum.
News • Fighting antibacterial resistance
Continued COVID levels of hygiene could transform infection control
Making recommendations for change, academics analyzed global data into the prevalence of antimicrobial resistance in urban areas—the rise of which is threatening the lifesaving role of the medications.
News • Repurposing bacteria
‘Living medicine’ could treat drug-resistant infections
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
News • Combined with antibiotics
Bacteria-killing viruses to fight antibiotic-resistant bacteria
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Sponsored • Tools for the lab
Speeding up diagnostics to detect antibiotic resistance
Infectious disease diagnostics are notoriously slow. The gold standard for laboratory diagnosis of bacterial and fungal infection involves growing the pathogen from a clinical specimen – an overnight event, or even longer. The healthcare focus is on improving the use of antibiotics for better patient outcomes and reducing the environmental pressures that drive antibiotic resistance. To impact…
News • Population bottlenecks
Random effects make it difficult to optimise antibiotic therapy
Antibiotic-resistant pathogens have become one of the greatest threats to public health. The basic mechanisms of resistance evolution have been well studied experimentally and are an important research field at Kiel University. An important factor in this context, but one that has received little attention so far, is the population size of the respective pathogen. Over the course of an infection…
Article • AMR Insights platform
Antibiotic resistance: a global problem in urgent need of solutions
Antibiotics have been at the heart of modern healthcare since the 1950s. They are prescribed prior to an operation to minimise the risk of infection after the operation. Or antibiotics are prescribed to fight an infection. This practice, which might seem straightforward at first glance, has proven to cause a number of problems itself: Over the last twenty years, it has become increasingly clear…
Article • Antibiotic resistance
Five-minute MRSA detection with aptasensor swabs
An international research team from Saudi Arabia, Germany, and Jordan has developed a novel pathogen aptasensor swab designed to qualitatively detect, within five minutes, any methicillin-resistant Staphylococcus aureus (MRSA) contamination that remains in a hospital isolation room or other surface following standard decontamination and cleaning.
News • Bacteriophage
Trained viruses fight antibiotic resistance
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
News • Resistence
Higher doses of antibiotic may strenghten certain bacteria
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
News • Hydrogel wound covering
New material to protect against antibiotic resistant bacteria
Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers great hope for combating a growing global problem. The World Health Organization describes antibiotic-resistant bacteria as one of…
News • A new tool to combat superbugs
Defeating antibiotic resistant bacteria with 'molecular tweezers'
Antibiotic resistant bacteria are a looming super threat – heralding a time when our drugs will no longer be effective against prevalent infections. Hospitals are already coping with treatment-resistant bacterial infections. Cognizant of the threat and thinking outside the box, BGU scientists and German and American colleagues have developed a pair of 'molecular tweezers' to destroy the biofilm…
News • Spread of drug-resistance
WHO reports global shortage of innovative antibiotics
The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to a new report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria.…
News • M.O. of Darobactin unveiled
Novel antibiotic deceives bacteria through mimicry
An increasing number of bacterial pathogens are resistant to antibiotics. And the most dangerous pathogens share a common feature: a double membrane that is difficult to penetrate. Even when antibiotic agents are able to break into this shell, the bacteria just pump them right out again. But a recently discovered compound called Darobactin manages to circumvent these protective measures and kill…
News • Covid-19 impact on vaccination
Antibiotic resistance could make diphtheria ‘major global threat’ again
Diphtheria – a relatively easily-preventable infection – is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India. The researchers, led by scientists at the University of Cambridge, say that the impact of Covid-19 on diphtheria vaccination schedules, coupled with a rise in…
News • Infection research
Mutations help bacteria resist antibiotic treatment
Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…
News • Revealing the mechanisms
Unlocking ‘the shape of water’ to fight antibiotic resistance
New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause — and possible solution — of antibiotic resistance. The findings of the new study are published in the journal Nature Chemical Biology. Pathogenic germs become resistant to antibiotics when they develop the ability to…
News • Faster testing
Device rapidly detects antibiotic-resistant bacteria
Bacterial infections have become one of the biggest health problems worldwide, and a recent study shows that COVID-19 patients have a much greater chance of acquiring secondary bacterial infections, which significantly increases the mortality rate.
News • Solving a mystery
How the TB bacterium develops rapid resistance to antibiotics
For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.
Article • Antimicrobial Resistance Action Fund
AMR research gains $1 billion funding
A unique, ground-breaking global campaign, which has seen major pharmaceutical companies unite to fight antibiotic resistant infections, has been launched with a one-billion-dollar investment fund. The Antimicrobial Resistance (AMR) Action Fund aims to help save the collapsing antibiotic pipeline and make 2-4 new antibiotics available within a decade.
News • MRSA, E.Coli & co
New compound kills antibiotic resistant superbugs
Researchers at the University of Sheffield have developed a new compound that is able to kill both gram-positive and gram-negative antibiotic-resistant bacteria.
News • Antibacterial cellulose
A wound dressing that kills bacteria
In order to combat bacterial wound infections, Empa researchers have developed cellulose membranes equipped with antimicrobial peptides. Initial results show: The skin-friendly membranes made of plant-based materials kill bacteria very efficiently. If germs invade a wound, they can trigger a long-lasting infection that may fail to heal or even spread throughout the body, leading to…
News • Peptide synthesis
Making drug-resistant bacteria sensitive to antibiotics again
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.