News • Elusive variants
Rare genetic markers of drug-resistant tuberculosis identified
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
Antibiotic resistance
Article • Antimicrobial resistance development
AMR and climate change: a worrying dual threat to global health
Climate change and antimicrobial resistance (AMR) are forming an alarming alliance: Global warming creates new breeding grounds for resistant bacteria. A serious and very real threat to public health – but not quite the doomsday scenario some might make it out to be, says Prof Sabiha Essack from the University of KwaZulu-Natal in Durban, South Africa.
Article • Drug dose optimisation
Antibiotics: no more ‘dosing in the dark’
Finding the right antibiotic dose is akin to a Goldilocks problem: give too little, and the infection will persist; too much, and side-effects will override the benefits of the therapy. To get it “just right”, Prof Dr Birgit Koch talks about dosing optimisation in the clinical setting.
News • Deep learning approach
'Curvy' bacteria as telltale sign of drug resistance?
Researchers find that drug-resistant bacteria can be distinguished from non-resistant bacteria based on structural changes evident in electron microscope images with high accuracy using deep learning.
News • Evolution tactics in E.coli
Antibiotic resistance: (Population) size matters
An international team of scientists have shown that small and large bacterial populations follow qualitatively different evolutionary paths to develop antibiotic resistance.
News • Before clinical use of antibiotics
Superbug MRSA arose in hedgehogs
A type of the antibiotic resistant superbug MRSA arose in nature long before the use of antibiotics in humans and livestock, which has traditionally been blamed for its emergence.
Article • Mending medication mismanagement
Antibiotic resistance: Gaining back lost ground
For many years, antibiotic consumption in France was at an alarming level, resulting in a worryingly constant increase in antibiotic resistance However, a newly-enforced strict national plan appears to be having effect.
Article • A potentially devastating impact
Covid-19 alters antibiotic use
The long-term impact of the coronavirus pandemic on antimicrobial resistance remains difficult to predict. Infectious diseases consultant Professor Alison Holmes reflects on Covid-19's effect on antibiotic use in hospitals and beyond.
News • Nosocomial infections
Forcing a 'cease-fire' on resistant germs
To counteract the spread of resistant germs, researchers have developed new drug candidates that are able to render one of the most important hospital germs harmless.
News • Hazardous materials
Microplastic pollution aids antibiotic resistance
According to scientists at Rice University’s George R. Brown School of Engineering, discarded polystyrene broken down into microplastics provides a cozy home not only for microbes and chemical contaminants but also for the free-floating genetic materials that deliver to bacteria the gift of resistance.
News • Finding solutions
$ 1.8 million to stop AMR
Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.
News • Sharper than ever
High-res image of bacterial bumps gives clues to antibiotic resistance
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
News • Resistance mechanism discovered
How staphylococci protect themselves against antibiotics
The skin bacterium Staphylococcus aureus often develops antibiotic resistance. It can then cause infections that are difficult to treat. Researchers at the University of Bonn have uncovered an ingenious way in which a certain strain of Staphylococcus aureus protects itself against the important antibiotic vancomycin. The results have now been published in the journal Microbiology Spectrum.
News • Fighting antibacterial resistance
Continued COVID levels of hygiene could transform infection control
Making recommendations for change, academics analyzed global data into the prevalence of antimicrobial resistance in urban areas—the rise of which is threatening the lifesaving role of the medications.
News • Repurposing bacteria
‘Living medicine’ could treat drug-resistant infections
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
News • Combined with antibiotics
Bacteria-killing viruses to fight antibiotic-resistant bacteria
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Sponsored • Tools for the lab
Speeding up diagnostics to detect antibiotic resistance
Infectious disease diagnostics are notoriously slow. The gold standard for laboratory diagnosis of bacterial and fungal infection involves growing the pathogen from a clinical specimen – an overnight event, or even longer. The healthcare focus is on improving the use of antibiotics for better patient outcomes and reducing the environmental pressures that drive antibiotic resistance. To impact…
News • Population bottlenecks
Random effects make it difficult to optimise antibiotic therapy
Antibiotic-resistant pathogens have become one of the greatest threats to public health. The basic mechanisms of resistance evolution have been well studied experimentally and are an important research field at Kiel University. An important factor in this context, but one that has received little attention so far, is the population size of the respective pathogen. Over the course of an infection…
Article • AMR Insights platform
Antibiotic resistance: a global problem in urgent need of solutions
Antibiotics have been at the heart of modern healthcare since the 1950s. They are prescribed prior to an operation to minimise the risk of infection after the operation. Or antibiotics are prescribed to fight an infection. This practice, which might seem straightforward at first glance, has proven to cause a number of problems itself: Over the last twenty years, it has become increasingly clear…
Article • Antibiotic resistance
Five-minute MRSA detection with aptasensor swabs
An international research team from Saudi Arabia, Germany, and Jordan has developed a novel pathogen aptasensor swab designed to qualitatively detect, within five minutes, any methicillin-resistant Staphylococcus aureus (MRSA) contamination that remains in a hospital isolation room or other surface following standard decontamination and cleaning.
News • Bacteriophage
Trained viruses fight antibiotic resistance
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
News • Resistence
Higher doses of antibiotic may strenghten certain bacteria
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
News • Hydrogel wound covering
New material to protect against antibiotic resistant bacteria
Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers great hope for combating a growing global problem. The World Health Organization describes antibiotic-resistant bacteria as one of…
News • A new tool to combat superbugs
Defeating antibiotic resistant bacteria with 'molecular tweezers'
Antibiotic resistant bacteria are a looming super threat – heralding a time when our drugs will no longer be effective against prevalent infections. Hospitals are already coping with treatment-resistant bacterial infections. Cognizant of the threat and thinking outside the box, BGU scientists and German and American colleagues have developed a pair of 'molecular tweezers' to destroy the biofilm…
News • Spread of drug-resistance
WHO reports global shortage of innovative antibiotics
The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to a new report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria.…
