New EU-funded project CoSTREAM targets the common mechanisms and pathways of stroke, Alzheimer’s disease to improve disease prevention and treatment, by combining clinical, genetic, epidemiologic, metabolic and radiologic research to develop an organ-on-a-chip in vitro model for the blood-brain connection that will revolutionise drug-development.
Georgetown University researchers are reporting the first case of Alzheimer’s disease diagnosed in an HIV-positive individual. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when Alzheimer’s risk begins to escalate.
Neurologists are gaining new insights into dementia imaging by harnessing the latest opportunities offered by Positron Emission Tomography (PET).
An international public-private research consortium has identified and validated a cellular role of a primary Parkinson’s disease drug target, the LRRK2 kinase. This important finding illuminates a novel route for therapeutic development and intervention testing for Parkinson’s, the second most common neurodegenerative disease after Alzheimer’s.
Proteins are like a body’s in-house Lego set. These large, complex molecules are made up of building blocks called amino acids. Most of the time, proteins fold correctly, but sometimes they can misfold. This misfolding causes the proteins to get sticky, and that can promote clumping, or aggregation, which is the hallmark of several neurodegenerative diseases such as ALS, Alzheimer’s and…
More than five million Americans are living with Alzheimer's disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid.
NIH-funded study highlights the possible role of glial brain cells in neurological disorders.
Retrograde amnesia is the inability to recall established memories. In humans, amnesia is associated with traumatic brain injury, Alzheimer’s disease, and other neurological conditions. Whether memories lost to amnesia are completely erased or merely unable to be recalled remains an open question. Now, in a finding that casts new light on the nature of memory, researchers from the RIKEN-MIT…
Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia.
A group of researchers, lead by Vasily M. Studitsky, professor at the Lomonosov Moscow State University, discovered a new mechanism of DNA repair, which opens up new perspectives for the treatment and prevention of neurodegenerative diseases. The article describing their discovery is published in AAAS' first open access online-only journal Science Advances.
New research in The FASEB Journal suggests that clinical trials of omega-3 and antioxidant supplementation should be undertaken for people with Alzheimer's disease with mild clinical impairment.
Degeneration of the white matter of the brain may be an early marker of specific types of Alzheimer's disease (AD), including early-onset AD, according to results of a new study published in the journal Radiology.
Low-frequency alternating magnetic fields such as those generated by overhead power lines are considered a potential health risk because epidemiological studies indicate that they may aggravate, among other things, neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). However, a recent study by researchers at the Institute of Pathobiochemistry at the…
Working with lab animals and human heart cells, scientists from Johns Hopkins and other institutions have identified what they describe as "the long-sought culprit" in the mystery behind a cell-signaling breakdown that triggers heart failure.
The ELEKIN research group of the UPV/EHU-University of the Basque Country is working to develop various non-invasive methodologies for the early detection of Alzheimer's disease.
New insights into the ways the human brain functions – that is the promise of mapping the entire web of connections in the brain, the so-called connectome. New developments in connectome imaging are one of the major topics at this year’s European Congress of Radiology (ECR).
According to Molly Polen, at the AACC, great opportunities lie ahead for laboratory medicine and, to seize them, ‘meeting with colleagues and learning about new technologies is a critical first step. The 2013 AACC will provide these and other opportunities, such as informative sessions and live demonstrations of new technology.’
‘We finally have tools to non-invasively study the human brain in normal subjects and diseased patients,’ says Professor Stefan Sunaert, Head of Translational MRI at the Department of Imaging & Pathology, Leuven University Hospital (Belgium)
“We finally have tools to non-invasively study the human brain in normal subjects and diseased patients,” says Professor Stefan Sunaert, Head of Translational MRI at the Department of Imaging & Pathology at Leuven University Hospital (Belgium).
PredictAD is an EU-funded research project that develops objective and efficient methods for enabling earlier diagnosis of Alzheimer's disease. Diagnosis requires a holistic view of the patient combining information from several sources, such as, clinical tests, imaging and blood samples.
Researchers the world over are advancing positron emission tomography (PET) as an effective method of early detection for Alzheimer’s disease, a currently incurable and deadly neurological disorder. Three studies presented at SNM’s 58th Annual Meeting are providing new insights into the development of Alzheimer’s disease while opening the door to future clinical screening and treatments.
Scientists at the University of Strathclyde in Glasgow are developing a technique based on a new discovery which could pave the way towards detecting Alzheimer’s disease in its earliest stages - and could help to develop urgently-needed treatments.
More than doubling over the last 20 years in most EU Member States, obesity has considerable implications for health, health systems and the economy. Over half our adult population is now overweight or obese, according to the joint European Commission and OECD report "Health at a Glance: Europe 2010".
Researchers at Karolinska Institutet have shown that they may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic acid levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator of aging and age-related diseases of the CNS.
How the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. Brain imaging can offer a window into risk assessment into for diseases such as Alzheimer’s disease. A recent study demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD.