A new study by scientists at Kyoto University and the University of Fukui may offer hope for adults who have lost their teeth. The team reports that an antibody for one gene - uterine sensitization associated gene-1 or USAG-1 - can stimulate tooth growth in mice suffering from tooth agenesis, a congenital condition. The paper was published in Science Advances. Although the normal adult mouth has…
Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patients' immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors.…
More than four in five (86%) people who were unsure or said no to a Covid-19 vaccine in December 2020 would now take one, or have already been vaccinated, finds the latest research by the Virus Watch study conducted by University College London (UCL).
From swallowing pills to injecting insulin, patients frequently administer their own medication. But they don’t always get it right. Improper adherence to doctors’ orders is commonplace, accounting for thousands of deaths and billions of dollars in medical costs annually. Researchers at the Massachusetts Institute of Technology (MIT) have developed a system to reduce those numbers for some…
BOLD-100/KP1339 is a ruthenium-based anticancer agent that has been co-developed at the University of Vienna and which has shown promising results in clinical trials in cancer patients. However, the mode of action of this metal compound has not yet been fully elucidated. Researchers from the University of Vienna and the Medical University of Vienna have now been able to demonstrate that BOLD-100…
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as…
Temperature control equipment and systems company Lauda is expanding its portfolio with its new Versafreeze product line. This consists of high-quality ultra-freezers which have been optimized for the extreme requirements of deep-freeze storage. Lauda thereby meets the requirements of vaccine producers, pharmaceutical service providers, vaccination centers and universities for the safe storage of…
The European Commission has launched a contingency plan to meet the challenge of the various mutations of the coronavirus. Karolinska Institutet and Karolinska University Hospital are contributing to a new network for the evaluation and testing of new vaccines. The network is called "Vaccelerate" and it will contribute both to the evaluation of ongoing and future vaccinations, as well…
Osteoarthritis affects more than 30 million adults and is the fifth-leading cause of disability in the United States. In a new study, scientists have discovered the cellular pathway that leads to the joint disease and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
Is there a better approach to Covid drug research? Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of Covid-19, revealing vital clues for the discovery of antiviral drugs. Researchers compared SARS-CoV-2 and the closely related virus SARS-CoV,…
University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…
Patients given preventive blood thinning drugs (prophylactic anticoagulants) within 24 hours of admission to hospital with Covid-19 are less likely to die compared with those who do not receive them, a new study finds. Clinical trials are now underway to see if prophylactic anticoagulants could be an effective treatment for Covid-19. In the meantime, the researchers say these findings provide…
One more piece of the puzzle has fallen into place behind a new drug whose anti-cancer potential was developed at the University of Alberta and is set to begin human trials this year, thanks to newly published research. “The results provide more justification and rationale for starting the clinical trial in May,” said first author John Mackey, professor and director of oncology clinical…
For the first time, scientists have come up with a precise atomic level explanation for why glulisine - a commonly used medication to treat diabetes - is faster acting than insulin. The findings, published in Scientific Reports, could have benefits for diabetes patients in ensuring that a more improved insulin can be developed for future treatment. The study was carried out by experts from the…
Even those who understand the scientific process, trust medical experts and know how important vaccines are for fighting infectious diseases might still have some questions or concerns about the new Covid-19 vaccines. Here, Thaddeus Stappenbeck, MD, PhD, helps set the record straight on 8 common questions, concerns and myths that have emerged about Covid-19 vaccines.
Before the pandemic, the lab of Stanford University biochemist Peter S. Kim focused on developing vaccines for HIV, Ebola and pandemic influenza. But, within days of closing their campus lab space as part of Covid-19 precautions, they turned their attention to a vaccine for SARS-CoV-2, the virus that causes Covid-19. Although the coronavirus was outside the lab’s specific area of expertise,…
Scientists have developed a machine-learning method that crunches massive amounts of data to help determine which existing medications could improve outcomes in diseases for which they are not prescribed. The intent of this work is to speed up drug repurposing, which is not a new concept – think Botox injections, first approved to treat crossed eyes and now a migraine treatment and top cosmetic…
In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of these findings into clinically approved treatments has progressed at a much slower rate, in part because of the challenges scientists face in delivering therapeutics across the blood-brain barrier (BBB)…
Research conducted at the Health New Orleans Neuroscience Center of Excellence at the Louisiana State University (LSU) reports that a combination of an LSU Health-patented drug and selected DHA derivatives is more effective in protecting brain cells and increasing recovery after stroke than a single drug. The findings are published in Brain Circulation.
The Covid-19 vaccine developed by Oxford University/AstraZeneca has been given regulatory approval by the Medicines and Healthcare products Regulatory Agency (MHRA) after meeting required safety, quality and effectiveness standards. Following a rigorous, detailed scientific review by the MHRA’s expert scientists and clinicians and on the basis of the advice of its scientific, independent…
Nearly a quarter of the world’s population may not have access to a covid-19 vaccine until at least 2022, warns a study published by The BMJ. A second study estimates that 3.7 billion adults worldwide are willing to have a covid-19 vaccine, highlighting the importance of designing fair and equitable strategies to ensure that supply can meet demand, especially in low and middle income countries.
A recent preclinical study from scientists at Sunnybrook Research Institute, Canadian Blood Services and the University of Toronto has demonstrated that focused ultrasound improves the delivery of intravenous immunoglobulin (IVIg), a blood product composed of antibodies from healthy donors, previously shown to have potential in treating a subgroup of patients with Alzheimer’s disease.
A study of over a thousand cancer patients treated with immunotherapy drugs has found these patients are at greater risk of heart problems, including death from heart attack or stroke. The patients had either lung cancer or malignant melanoma (a type of skin cancer), for which immune checkpoint inhibitors such as a programmed cell death-1 (PD1) inhibitors or cytotoxic T-lymphocyte-associated…
Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss,…
Researchers in Finland have developed a machine learning model that can help us treat cancer more effectively.