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Clinicial chemistry
News • Swiss Army Knife for Laboratories
Liquid Chromatography Tandem Mass Spectrometry
During the past 15 years, liquid chromatography tandem mass spectrometry (LC-MS/MS) has evolved into a vital technology used to perform routine tests in many clinical laboratories. Historically, LC-MS/MS had been used primarily by research, pharmaceutical, or commercial laboratories; however, advances in the technology, decreasing costs for basic systems, intelligible software, an increased…
Article • Event
US-American clinical lab specialists meet today
Did you know that we offer around 1200 features on laboratory medicine? No? Then you might want to browse through our compilation of interesting articles on pathology, chemistry or management and many more.
Article • Switzerland
Clinical chemistry is broad ranging
The field is neither tedious nor monotonous; it’s fascinating every day, Professor Katharina Rentsch emphasises, when explaining the need to attract students to this often overlooked but intreguing and varied discipline.
News • Oncology
Easier Detection of Colorectal Cancer
Chemists at Caltech have developed a new sensitive technique capable of detecting colorectal cancer in tissue samples—a method that could one day be used in clinical settings for the early diagnosis of colorectal cancer.
Article • POCT
Evolutionary POCT
A growing number of clinical tests are being delivered in community hospitals with more patients receiving quicker, accurate diagnoses closer to home, without stays in acute hospital beds. Professor Daniel Lasserson, an Associate Professor in the Nuffield Department of Primary Care Health Sciences at Oxford University, shares the opinion that using point-of-caretesting (POCT) to facilitate high…
Sponsored • Bad blood
Haemolysis must be avoided
Blood sampling via intravenous catheters frequently occurs because patients in intensive care already have intravenous catheters in place, and patients admitted to accident and emergency units are immediately set up with intravenous catheters – providing easy access to blood.
Article • Research
Genetic alterations
This article discusses examples of applications of genetic analyses in coagulation disorders and haematological and oncological diseases. Professor Christine Mannhalter highlights the impact changes have on the occurrence and severity of diseases and their influence on therapy response. Report: Christine Mannhalter
Article • Antimicrobial stewardship
A diagnostic marker reduces antibiotics use
Since 2009, as part of diagnostic and antimicrobial stewardship strategies, Hampshire Hospitals National Health Service (NHS) Trust has used serum procalcitonin (PCT) – an innovative and highly specific marker to diagnose clinically relevant bacterial infections and sepsis. Report: Mark Nicholls
Interview • Mass Spectrometry
Connected components are not enough
Bringing liquid chromatography and tandem mass spectrometry (LC-MS/MS) testing into clinical laboratories has been a slow process but continues to show promise to help improve patient care. The medical device industry is on the edge of fundamental breakthroughs that can help drive the adoption into more mainstream clinical laboratories. We recently sat down with Dr Bori Shushan, Mass Spectrometry…
Article • MALDI-TOF
Identifying a single isolate in minutes
When trialled in Swansea, Wales, Matrix Assisted Laser Desorption Ionisation – Time of Flight (MALDI-TOF) demonstrated sufficient advantages over conventional methods to be introduced into routine practice.
Article • Cancer diagnostics II
New nanoparticle could enhance MRI scanning
Scientists in the UK have designed a new self-assembling nanoparticle that targets tumours and could lead to quicker diagnosis of cancer. Researchers at Imperial College London report that a new self-assembling nanoparticle can adhere to cancer cells, thus making them visible in MRI scans and possibly eliminate the need for invasive tissue biopsies. Report: Mark Nicholls
Article • Norms & standards
IT communication fosters unified standards
Looking back, the founding fathers of laboratory medicine were doctors who carried out the historic medical practice of uroscopy in the Middle Ages, explains Professor Klaus Kohse MD, Director of the Institute for Laboratory Medicine in Oldenburg Clinical Centre at Oldenburg University Medical Faculty. Report: Walter Depner
Article • Laboratory Medicine
‘Kissed by Europe’
They are not such strange bedfellows, say Walter Depner (Frankfurt) and Professor Norbert Gässler (Hildesheim), who find themselves ‘kissed by the European lab muse’ and were prompted to ask: What links literature and laboratory medicine at a European level? Commentary: Walter Depner, Prof. Norbert Gässler
Strategic lab control
Managing physicians’ test requests is a key ingredient of modern lab management. However, doctors and nurses still do not provide the clinical reasons for orders to all labs.
Epigenetic drugs
‘All human body cells contain the same DNA, but every type of cell – for example a muscle cell compared to that of a nerve – has a different gene expression pattern’, said Dr Sonja Stadler, speaking at the 2012 congress of DGKL (German Society for Clinical Chemistry).
Mass spectrometry
‘Mass spectrometry has developed into a successful routine procedure,’ according to Dr Christoph Seger (Univ. Doz.), technical head of the Mass Spectrometry and Chromatography division at the Central Institute of Medical and Chemical Laboratory Diagnostics, Innsbruck University Hospital, Austria.
First on-site evaluation of the cobas 8000 clinical analyser
The Poole Hospital NHS Foundation Trust has become the first site, worldwide, to evaluate the full serum work area (SWA) capabilities of the cobas 8000 high throughput clinical analyser.
Article • Research, diagnostics, therapy
Laboratory medicine in focus
The medical laboratory is a supporting pillar of modern healthcare. Laboratory findings with analyses of blood, urine and other body fluids provide valuable insights from infection diagnostics and innovative screening procedures to therapy monitoring. Here you will find information on sample management, pre- and postanalytics, clinical chemistry, haematology and much more.
Article • More than just a subdiscipline
Spotlight on clinical chemistry
Clinical chemistry has evolved far beyond its beginnings of blood and urine analysis. Advanced techniques such as enzyme measurement, electrophoresis, and immunoassays have made their impact on the field, expanding its diagnostic capabilities. Keep reading for advances in automation and clinical chemistry applications for toxicology, urinalysis and much more.
