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Interactive CVD risk calculator

KardioKompassi: Individualised cardiac disease prevention with genomic data

With KardioKompassi, researchers from the University of Helsinki have developed an interactive web tool that aims to predict and prevent cardiovascular disease.

The application for patients and doctors uses traditional health information combined with genome information, including 49,000 DNA variations associated with the disease. Using this data, the risk calculator evaluates the risk of cardiac disease more precisely, motivating users to make better lifestyle choices. 

KardioKompassi can be accessed here: http://www.kardiokompassi.fi/

Cardiovascular disease (CVD) continues to be a major reason for mortality among working-age Finns, even though the risk factors are currently very well known. Identifying high-risk persons and targeting preventative measures in time would be of vital importance in terms of both the wellbeing of the individual and costs to society.

Users can independently find out as much information as possible about their risk of illness and see how changes in their lifestyle would influence the risk

Elisabeth Widén

Coronary artery disease (CAD) is a good example of a case where lifestyle choices have a major impact on the likelihood of contracting the illness. The KardioKompassi web app takes a more individualised approach to support health behaviour changes. The calculator evaluates and interprets personal risk for contracting CAD during the coming ten years for each user. Using the interactive interface, users can also test how different lifestyle changes, such as quitting smoking, impact their risk.

KardioKompassi has been developed by a group of experts in genomic medicine and biostatistics from the Institute for Molecular Medicine Finland FIMM, the Institute for Molecular Medicine Finland (HiLIFE Unit), who have spent several years working on the application under the leadership of Samuli Ripatti and Elisabeth Widén. In addition, the current team includes Project Manager Johanna Aro and Kari Pitkänen, a biotechnology veteran tasked with business development.

The risk calculator is based on a statistical algorithm using the latest genomic research data from the FINRISK study. The algorithm was developed by Samuli Ripatti’s research group. “From the very beginning, our goal has been to create an easy-to-use tool where users can independently find out as much information as possible about their risk of illness and see how changes in their lifestyle would influence the risk,” says Elisabeth Widén.

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When it comes to genetics, Estonia is considered a trailblazer, as the ambitious Estonian Genome Project (Eesti Geenivaramu) shows. Its objective is to test the genome of every citizen for the risk of diseases. Dr Jaanus Pikani talks about the initial difficulties which the genome project encountered and about its potential for Estonian – and possibly worldwide – healthcare.

The usability and significance of the risk data is currently being analysed in the extensive GeneRISK research project. More than 7,300 people from the Helsinki Metropolitan Area and the Kymenlaakso region have participated in the study. All study participants were also invited to the first follow-up study 18 months after the launch of the research.

Based on the sampling from the first follow-up study, nine out of ten participants felt that the information about the risks motivated them to take better care of their health. Results on lifestyle changes are similarly promising: 13% of participants had managed to permanently lower their body weight, while 14% of smokers had stopped smoking. The group with the highest genetic risk had made the most positive changes to their health behaviour.

This means that in a research setting, the KardioKompassi has been found to be an easy and accessible way of finding information about people’s personal risk of illness. The team has explored the potential of commercialising the concept with the New Business from Research Ideas funding from Business Finland, which ended in August 2019. This funding was granted to the University and the project during summer 2017 with the help from Helsinki Innovation Services HIS. With this funding, KardioKompassi is currently piloted in clinical settings, both in Finland and abroad.


Source: University of Helsinki

29.10.2019

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