Meyenburg Award

A high distinction for a pioneer in liquid biopsy

Nitzan Rosenfeld from Cancer Research UK in Cambridge is being honored with the 2017 Meyenburg Award, which carries a €50,000 monetary prize. He receives the award for his excellent work on the detection of tumor DNA in the blood.

Photo
Nitzam Rosenfeld.
Source: DKFZ

Rosenfeld has made seminal contributions to advancing a method for detecting cancer DNA in the blood to applicability in cancer medicine.
The Meyenburg-Award will be presented at a symposium held at the German Cancer Research Center (DKFZ). DNA from all cell types of the body continuously circulates in our blood. 

When a person has cancer, fragments of tumor cell DNA are also amongst them. Since cancer cells often exhibit typical genetic alterations, one can differentiate cancer DNA from genetic material of healthy cells.

Nitzan Rosenfeld’s work has been instrumental in advancing the detection of tumor DNA in blood samples

Christof von Kalle

Detecting cancer DNA in blood samples, a method known as liquid biopsy, opens a host of new possibilities for physicians. Nitzan Rosenfeld, a physicist by education, has made pioneering accomplishments in this field. One milliliter of blood contains about 10,000 floating DNA molecules from healthy cells and only a few dozens from cancer cells. Rosenfeld has developed techniques to amplify, sequence and identify cancer DNA fragments even if only traces of them are found.

Physicians will be able to use these methods in order to track whether the tumor responds to therapy. Since liquid biopsy can be repeated without problems at monthly intervals, the non-invasive method can also be used to monitor whether a tumor has returned after initial treatment. Optimistic medical experts even expect that in the future it will be possible to detect cancer using blood sample tests alone.

“Nitzan Rosenfeld’s work has been instrumental in advancing the detection of tumor DNA in blood samples from an experimental technique to a method opening a multitude of new options in cancer medicine,” says Christof von Kalle, who is a board member of the Meyenburg Foundation. He continues: “For many common cancer types, colleagues could already show in large studies what liquid biopsy can do. For example, a recurrence of bowel cancer could be detected based on a rise in cancer DNA in patient blood ten months earlier than by medical imaging. In lung cancer cases, colleagues were able to show how therapy resistance develops.”


Source: German Cancer Research Center

28.11.2017

Related articles

Datasets

Benefits from The Cancer Genome Atlas

Last year, scientists at the University of California San Francisco (UCSF) revealed that by measuring the proportion of both immune and cancerous cells in tumours, or ‘tumour purity,’ clinicians…

Discovery

‘Hijacker’ drives cancer in some patients with high-risk neuroblastoma

Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome “hijacks” DNA that regulates other…

Animal testing

Can mice really mirror humans when it comes to cancer?

A new Michigan State University study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings, now published…

Related products

Research use only (RUO)

Eppendorf - Mastercycler nexus X2

Eppendorf AG

Liquid biopsy

Streck – Cell-Free DNA BCT

Streck

Amplification/Detection

Agena Bioscience - MassARRAY Colon Pane

Agena Bioscience GmbH

Amplification/Detection

Agena Bioscience - MassARRAY Dx Analyzer 4

Agena Bioscience GmbH

Amplification/Detection

Agena Bioscience - MassARRAY Dx Lung Panel

Agena Bioscience GmbH