Golden helpers

Nanoparticles could allow for faster, better medicine

Gold nanoparticles could help make drugs act more quickly and effectively, according to new research conducted at Binghamton University, State University of New York.

Nanoparticles are microscopic particles that are bigger than atoms but smaller than what the eye can see. They are unique for their large surface area-to-volume ratio and their fairly ubiquitous nature. A new study, co-conducted by Binghamton University Assistant Professor of Biomedical Engineering Amber Doiron, is one of the first of its kind to look deeper into these nanoparticles in regards to health. “Nanoparticles are a huge area of research in the scientific community right now. However, they’re not yet well understood for their impact on human health,” said Doiron.

Binghamton University Assistant Professor of Biomedical Engineering Amber...
Binghamton University Assistant Professor of Biomedical Engineering Amber Doiron, is one of the first of its kind to look deeper into these nanoparticles in regards to health.
Credit: Binghamton University, State University of New York

“Nanoparticles have unique properties and, because of that, are used in many applications. They’re in your food and may get into your bloodstream through environmental exposure. Eventually, they may be used for helping to get drugs to tissues or as imaging agents. We wanted to investigate how nanoparticles interact with human cells,” added Doiron.

Doiron and her team looked specifically at the effects that gold nanoparticles have on the health of a cell. They found that nanoparticles can change cells, but only if the particles are a very specific size. “The nanoparticles have to be around 20 nanometers. Nothing bigger or smaller worked,” said Doiron.

It has to be exact, otherwise changing the permeability of veins too much could be extremely dangerous

Amber Doiron

Their research found that when the cells that line arteries or veins are exposed to these nanoparticles, the vascular permeability changes. This could potentially help in more effective medication delivery. However, the researchers are also aware of some limitations to nanoparticles being used in this way. “It has to be exact, otherwise changing the permeability of veins too much could be extremely dangerous,” said Doiron.


Source: Binghamton University, State University of New York

21.11.2017

Read all latest stories

Related articles

Photo

Drug delivery research

Nanoparticles to help cross the blood-brain barrier

Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood–brain barrier. As a result, the doses administered must be high and only a…

Photo

Crossing the blood-brain barrier

Nanoparticle drug-delivery system to treat brain disorders

In the past few decades, researchers have identified biological pathways leading to neurodegenerative diseases and developed promising molecular agents to target them. However, the translation of…

Photo

Triple-negative breast cancer

Target validation for drug development against aggressive breast cancer

At around 30.5 percent, breast cancer is the most common cancer among women in countries of the industrialized world. The number of cases has doubled since the 1980s: about 69,000 times a year women…

Related products

Shimadzu – LCMS-8060NX (RUO)

Mass Spectrometry

Shimadzu – LCMS-8060NX (RUO)

Shimadzu Europa GmbH
Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Clinical Chemistry

Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Alsachim, a Shimadzu Group Company
Alsachim – Dosimyco immunosupressant reagent kit (RUO)

Clinical Chemistry

Alsachim – Dosimyco immunosupressant reagent kit (RUO)

Alsachim, a Shimadzu Group Company
Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Clinical Chemistry

Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Alsachim, a Shimadzu Group Company
ASP Lab Automation – Bench-top Decapper DeCap Pro

Sample Processing

ASP Lab Automation – Bench-top Decapper DeCap Pro

ASP Lab Automation AG
ASP Lab Automation – Recapper KapSafe

Sample Processing

ASP Lab Automation – Recapper KapSafe

ASP Lab Automation AG
Subscribe to Newsletter