A genetic study identifies neuronal circuits responsible for ultrasonic calls uttered by mouse pups. The cries of human babies may well depend on similar connections, which could also be impaired in speech disorders.
The calls of new-born mice draw the attention of their mother. A group of neuronal cells in the brain stem is essential for this process. Without these cells, the mice are mute. These are the results of a study by a research team at the Max Delbrück Center in Berlin. Almost immediately after birth, mouse pups that are separated from their mother are able to make calls that summon her. The generation of these calls requires the coordinated activity of two muscle groups. This is achieved by neurons in the brainstem, according to a study by Carmen Birchmeier's lab at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC).
Importance of vocalization
Newborn mice need to be close to their mother and indicate this to her. As soon as a newborn mouse pup escapes the safety of the nest it emits salvos of four to six calls with a frequency of 75 kHz. These sounds are not audible to the human ear. During each call, the newborn mouse exhales deeply. The mother of the mouse, however, responds immediately: she goes looking for her lost progeny and reunites it with the rest of the litter. Even when she hears recorded ultrasound calls, she sets off in pursuit. If a baby mouse in distress is unable to emit these calls, the mother ignores it.
“We suspect that the calls are an evolutionarily conserved signal that indicates the offsprings' fitness and health,” Carmen Birchmeier says. “The mute mice are also a model for investigating the importance of vocalization for the interaction between mother and baby,” first-author Luis Hernandez-Miranda says. Another idea is that the nucleus could be involved in the development and manifestation of speech disorders, which are often seen in patients after strokes, those who have a tumor or are suffering from neurodegenerative diseases.
Source: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft