Carl Borrebaeck, professor at the department of Immunotechnology at Lund...
Carl Borrebaeck, professor at the department of Immunotechnology at Lund University.

Source: Apelöga

Oncology

Blood test detects early stage pancreatic cancer

Pancreatic cancer is currently very difficult to detect while it is still resectable. A new blood test developed by researchers at Lund University in Sweden, Herlev Hospital, Knight Cancer Center and Immunovia AB, can detect pancreatic cancer in the very earliest stages of the disease.

Due to diffuse symptoms, pancreatic cancer is usually diagnosed very late in the disease progression. Therefore, despite pancreatic cancer representing less than 3% of all cancer cases, more people currently die from it than breast cancer. By 2030, pancreatic cancer is expected to be the second deadliest type of cancer in the world.

"Our test can detect pancreatic cancer with 96% accuracy at stage I and II, while there is still the possibility of successful surgical intervention. There is currently no cure and few treatment options for advanced pancreatic cancer, which is the late stage when pancreatic cancer is usually diagnosed", explains Carl Borrebaeck, professor at the department of Immunotechnology at Lund University.

The study used samples from patients in both Denmark and the US, at different stages of the disease. The blood test is developed on a so-called antibody microarray that consists of hundreds of recombinant antibody fragments. These antibody fragments are specific for a number of immune-regulatory proteins, cancer-associated antigens, and so on.

Since the immune system is the first to respond to threats like complex diseases, such as cancer, autoimmune diseases and infections, the microarray was designed to mirror this early response. This provides information about the development of tumours long before being visible on CT or detected by ctDNA. From those hundreds of markers, 29 markers were selected to detect pancreatic cancer with 96% accuracy at stage I and II.

In the future, the screening method could be used to screen people who are at a higher risk of developing pancreatic cancer, such as those with a hereditary risk, newly onset diabetes patients and patients with chronic inflammation of the pancreas.

The next step has already been initiated, which is a large US prospective study for high risk individuals.

Source: Lund University

20.09.2018

Read all latest stories

Related articles

CancerSEEK

Single blood test screens for 8 cancer types

Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer. The test, called CancerSEEK, is…

Rare cancer

A simple blood tests could improve diagnosis of myeloma

A pioneering study into myeloma, a rare cancer, could lead to General Practicianer (GPs) using simple blood tests to improve early diagnosis. The study investigated the best combination of blood…

Oncology

Blood test spots tumor-derived DNA in early-stage cancers

In a bid to detect cancers early and in a noninvasive way, scientists at the Johns Hopkins Kimmel Cancer Center report they have developed a test that spots tiny amounts of cancer-specific DNA in…

Related products

Infectious diseases testing

Atlas Genetics - Atlas Genetics io system

Atlas Genetics Ltd

Clinical chemistry

DiaSys Diagnostic Systems - InnovaStar

DiaSys Diagnostic Systems GmbH

Mobile RIS/PACS viewer

IMAGE Information Systems - iQ-4VIEW

IMAGE Information Systems Europe GmbH

Blood collection

SARSTEDT - S-Monovette - Venous Blood Collection

SARSTEDT AG & CO.