Silicon

Research center combine electronics and photonics in neural probes

At the IEEE International Electron Devices Meeting 2015, world-leading nanoelectronics research center imec, KU Leuven, and Neuro-Electronics Research Flanders (NERF, set up by VIB/KU Leuven and imec) presented a set of silicon neural probes that combine 12 monolithically integrated optrodes using a CMOS compatible process.

Probe tip with activated light output.
Probe tip with activated light output.
Source: imec

The probes enable optical stimulation and electronic detection of individual neurons, based on optogenetics techniques. They pave the way to a greater understanding of the brain and towards novel treatments for brain disorders such as Alzheimer’s, schizophrenia, autism, and epilepsy.

The enormous burden that brain disorders pose on affected individuals and health care systems calls for new ways to prevent, treat and cure these diseases. Currently available devices for recording neural activity to study the functioning of the brain typically have a limited number of electrical channels. Additionally, the brain is composed of many genetically and functionally distinct neuron types, and conventional probes cannot disambiguate recorded electrical signals with respect to their source. Imec’s and KU Leuven’s novel neural probes tackle these challenges, set a path towards greater understanding of the brain, and enable novel treatment options for brain disorders.

Imec’s and KU Leuven’s novel probes combine electronics and photonics to perform extremely sensitive measurements. The fully integrated implantable neural microsystems have advanced capabilities to detect, process and interpret neural data at a cellular scale. The systems feature a very high density of electrodes and nanophotonic circuits (optrodes). Such optrodes are used to optically stimulate single neurons using optogenetics, a technology in which neurons are genetically modified to make them light-sensitive and thus susceptible to stimulation through light pulses.

This research is supported by the Agency for Innovation by Science and Technology in Flanders (IWT) through the OptoBrain project.


Source: imec, KU Leuven and NERF

28.12.2015

Read all latest stories

Related articles

Photo

News • Myelin visualisation

New MRI procedure makes multiple sclerosis visible

The loss of myelin sheaths in the brain is a hallmark of multiple sclerosis. Swiss researchers have now developed an MRI method that maps the condition of this nerve insulation layer more accurately.

Photo

News • LDIR in neurology

The therapeutic potential of low-dose radiation for TBI and stroke

Neuroscientists recently discovered that low-dose ionizing radiation (LDIR) can reduce lesion size and reverse motor deficits in TBI and ischemic stroke mice, demonstrating its therapeutic potential.

Photo

News • Imaging white matter damage

Advanced MRI detects brain changes after Covid-19

Using diffusion MRI technology, researchers in Sweden have found differences in brain tissue structure between patients with persisting symptoms after Covid-19 and healthy people.

Related products

Subscribe to Newsletter