Researchers make bacteria produce tissue-healing hydrogel

Researchers from DTU have developed a new biopolymer for muscle tissue regeneration. They have harnessed the native bioproduction facilities in bacteria to synthesize a durable, resilient, and elastic hydrogel that may foster better therapies against traumatic muscle injuries.

Image credit: DTU

The group harnessed the native bioproduction facilities in bacteria to synthesize a new biopolymer with tissue-healing properties. They used this polymer to manufacture a durable, resilient, and elastic hydrogel for muscle tissue regeneration. The study is published in the journal Bioactive Materials and details a new biopolymer - Pantoan Methacrylate, PAMA for short - with muscle regeneration properties derived from bacteria. 

They have implemented this new hydrogel – or "bactogel" - to treat muscle injuries in rats with promising results. The in vivo study showed a significant increase in muscle tissue formation and reduced fibrous tissue. With nearly 100% mechanical recovery, good biocompatibility, and healing capacity, the PAMA bactogel presents a new path in the field. "This combination of feats is rarely encountered in the field, as most bioactive hydrogels display subpar mechanical properties that do not fit the mechanically demanding milieu of musculoskeletal tissues, such as muscles, says Associate Professor Alireza Dolatshahi-Pirouz from DTU Health Tech. "I believe that our new results could foster better therapies against musculoskeletal injuries in athletes, the elderly, as well as in wounded soldiers or others involved in accidents giving rise to traumatic muscle injuries."

Graphical abstract of the biopolymer research

Image source: Niknezhad SV et al., Bioactive Materials 2024 (CC BY-NC-ND 4.0)

With PAMA, the team has shown that they can achieve tissue regeneration in rats without using cells, and they expect much better healing by combining their bactogels with either muscle progenitor cells or stem cells. "I imagine a future where bacteria-derived polymers or put simply "bactomers" revolutionize the field of regenerative medicine. A future where bacteria in so-called regenerative bacto-baths secrete regenerative bactomers on demand to heal injured tissues in patients," says Alireza Dolatshahi-Pirouz. 

Source: Technical University of Denmark

21.08.2024

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