New research has found that neurons deep inside the brain could hold the key to...
New research has found that neurons deep inside the brain could hold the key to accurately diagnosing bipolar disorder and depression. Picture showns an MRi of the amygdala.

Credit: Dr Mayuresh Korgaonkar    

Fighting misdiagnosis

Brainscans help to distinguish bipolar disorder from depression

New research from the Westmead Institute for Medical Research and the University of Sydney has found that neurons deep inside the brain could hold the key to accurately diagnosing bipolar disorder and depression.

The research team used sophisticated MRI scanning to see how the amygdala—a set of neurons that play a key role in processing emotions—reacts as a patient processes facial expressions such as anger, fear, sadness, disgust and happiness. The research showed that this key structure within the brain responds differently depending on whether the person has bipolar disorder or depression.

In people with bipolar disorder, the left side of the amygdala is less active and less connected with other parts of the brain than in people with depression. The findings from this study had 80% accuracy in making this distinction. Lead researcher Dr. Mayuresh Korgaonkar said these differences could potentially be used in the future to differentiate bipolar disorder from depressive disorders. "Mental illness, particularly bipolar disorder and depression, can be difficult to diagnose as many conditions have similar symptoms," Dr. Korgaonkar said.

"Mental illness, particularly bipolar disorder and depression, can be difficult to diagnose as many conditions have similar symptoms."

Dr. Mayuresh Korgaonkar

"These two illness are virtually identical except that in bipolar individuals also experience mania." This means distinguishing them can be difficult and presents a major clinical challenge as treatment varies considerably depending on the primary diagnosis. The wrong diagnosis can be dangerous, leading to poor social and economic outcomes for the patient as they undergo treatment for a completely different disorder. Identifying brain markers that could reliably tell them apart would have immense clinical benefit. "Such a marker could help us better understand both these disorders, identify risk factors for developing these disorders, and potentially enable clear diagnosis from early onset," Dr. Korgaonkar said. Approximately 60% of patients with bipolar disorder are initially misdiagnosed as major depressive disorder. Alarming, it can take up to a decade for these patients to be accurately diagnosed with bipolar disorder.

Bipolar disorder often first presents in the depressive phase of the illness and bipolar depression is similar to major depression in terms of clinical symptoms. Emotion processing is a core problem underlying both these disorders. Dr. Korgaonkar and his team are now running phase 2 of this study, which aims to further characterise these identified markers in a larger cohort of patients.

Source: Westmead Institute for Medical Research

06.09.2018

Read all latest stories

Related articles

Photo

Obsessive compulsive disorder

Targeted deep brain stimulation reduces OCD symptoms

The debilitating behaviours and all-consuming thoughts which affect people with severe obsessive compulsive disorder (OCD), could be significantly improved with targeted deep brain stimulation,…

Photo

At age 2

AI and MRIs at birth can predict cognitive development

Researchers at the University of North Carolina School of Medicine used MRI brain scans and machine learning techniques at birth to predict cognitive development at age 2 years with 95 percent…

Photo

Restored brain waves

Brain stimulation improves depression symptoms

With a weak alternating electrical current sent through electrodes attached to the scalp, UNC School of Medicine researchers successfully targeted a naturally occurring electrical pattern in a…

Related products

allMRI GmbH – MRI vacuum immobilisation for head coils

Accessories / Complementary systems

allMRI GmbH – MRI vacuum immobilisation for head coils

allMRI GmbH
allMRI GmbH – MRI wheelchair – foldable

Accessories / Complementary systems

allMRI GmbH – MRI wheelchair – foldable

allMRI GmbH
allMRI GmbH – MRI wheeled waste bin – 90 liters

Accessories / Complementary Systems

allMRI GmbH – MRI wheeled waste bin – 90 liters

allMRI GmbH
Block Imaging

3 Tesla

Block Imaging

Block Imaging
Canon – Vantage Elan

1.5 Tesla

Canon – Vantage Elan

Canon Medical Systems Europe B.V.
Canon – Vantage Galan 3 T

3 Tesla

Canon – Vantage Galan 3 T

Canon Medical Systems Europe B.V.