The new blood test has the potential to dramatically improve early detection of the disease.

Early diagnosis

New blood test detects early stage ovarian cancer

Research on a bacterial toxin first discovered in Adelaide has led to the development a new blood test for the early diagnosis of ovarian cancer - a disease which kills around 150,000 women globally each year.

The new blood test has the potential to dramatically improve early detection of the disease, although it will require further testing before it is available for clinicians. A research team from the University of Adelaide and Griffith University have been studying the interactions between the toxin and an abnormal glycan (sugar) expressed on the surface of human cancer cells and released into the blood. The team has now engineered a harmless portion of the toxin to enhance its specificity for the cancer glycan and used this to detect it in blood samples from women with ovarian cancer.

A paper published this month in Biochemical and Biophysical Research Communications has shown that the new test detected significant levels of the cancer glycan in blood samples from over 90% of women with stage 1 ovarian cancer and in 100% of samples from later stages of the disease, but not in any of the samples from healthy controls.

Ovarian cancer is notoriously difficult to detect in its early stages, when there are more options for treatment and survival rates are better. Our new test is therefore a potential game changer,” says Professor James Paton, Director of the University of Adelaide’s Research Centre for Infectious Diseases.

Professor Michael Jennings, Deputy Director of the Institute for Glycomics at Griffith University, said: “Detection of this tumour marker may also play a role in a simple liquid biopsy to monitor disease stage and treatment.”

The team is currently seeking scientific and commercial partners to further test the technology with larger numbers of patient samples and to adapt it for mass screening.

Source: University of Adelaide

22.11.2018

Read all latest stories

Related articles

Photo

Rare cancer

A simple blood tests could improve diagnosis of myeloma

A pioneering study into myeloma, a rare cancer, could lead to General Practicianer (GPs) using simple blood tests to improve early diagnosis. The study investigated the best combination of blood…

Photo

Hormones

Stress accelerates breast cancer metastasis

It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking…

Photo

Immuno-oncological biomarkers

Seeking to augment the value of tumour infiltrating lymphocytes

Measuring tumour infiltrating lymphocytes (TILs) is gaining importance in immunotherapy, but other variables must also be considered to boost prognosis and prediction accuracy, a leading pathologist…

Related products

i-Solutions Health – LabCentre

LIS, Middleware, POCT

i-Solutions Health – LabCentre

i-SOLUTIONS Health GmbH
KABE Labortechnik – Consumables for pathology / histology

Histology Equipment

KABE Labortechnik – Consumables for pathology / histology

KABE LABORTECHNIK GmbH
Medat – Laboratory Information System

LIS, Middleware, POCT

Medat – Laboratory Information System

Medat Computer-Systeme GmbH
SARSTEDT - Microvette - Capillary Blood Collection

Blood collection

SARSTEDT - Microvette - Capillary Blood Collection

SARSTEDT AG & CO. KG
SARSTEDT - S-Monovette - Venous Blood Collection

Blood collection

SARSTEDT - S-Monovette - Venous Blood Collection

SARSTEDT AG & CO. KG