High-resolution MR imaging of embryos

Image source: University of Tsukuba

News • One hundredth of millimeter resolution

High-resolution MR imaging of embryos

Researchers from the University of Tsukuba have improved the imaging resolution of the magnetic resonance (MR) microscope, which is used to obtain high-resolution images of the interiors of small objects.

Magnetic resonance (MR) microscope has previously been used to observe chemically fixed specimens of human embryos during their early developmental stages. This tool has been instrumental in advanced studies of human embryology. MR microscopes enable researchers to visualize the development and growth of organs throughout various stages in three dimensions, leading to the creation of detailed three-dimensional morphological models. However, conventional MR microscopes are limited by their maximum spatial resolution of approximately four-hundredths of a millimeter, which occasionally results in blurred or lost small structures within human embryos. 

To address this limitation, the research team has introduced a high-resolution MR microscope capable of a spatial resolution of one-hundredth of a millimeter. This leap in resolution clarity surpasses conventional capabilities, facilitating intricate detailing of the brain, central nervous system, and other organs in human embryos. This was achieved via enhancements in hardware, imaging methods, and the integration of efficient data collection and reconstruction techniques, such as compressed sensing technology. 

The team published their findings in the Journal of Magnetic Resonance.

In magnetic resonance imaging (MRI), there is no direct correlation between the set pixel size and the actual resolution; various factors resulted in reducing the resolution of the images. However, after testing the resolution using well-defined artificial structures designed for image quality evaluation, the research team found a match between the set pixel size and the achieved resolution. Moreover, upon comparing this MRI image with an optical microscope image of a human embryo specimen from the same developmental stage, results showed that the microstructure was precisely captured. 

Such groundbreaking results emphasize that this improved resolution effectively captures the microstructure of the human embryo. This technique promises to revolutionize human embryology research, enabling the creation of a high-resolution atlas of brain and other organs. 


Source: University of Tsukuba

18.09.2023

Read all latest stories

Related articles

Photo

News • Motion artifact monitoring

Movement-detecting sensor could make MRI scans more efficient

A new prototype self-powered sensor could improve the process of medical imaging for patients and technicians by detecting movement and shutting down an MRI scan in real time.

Photo

Video • Imaging of speech disorder

MRI shows stuttering in real-time

What happens in the internal speech muscles when people are stuttering? Researchers now showed the mechanical aspects using real-time MRI. This could lead to better treatments of speech disorders.

Photo

News • Quantum sensing prototype

A sensor that detects errors in MRI scans

A new sensor prototype can detect errors in MRI scans in a way that is impossible for current electrical sensors – and hopefully pave the way for MRI scans that are better, cheaper and faster.

Related products

Subscribe to Newsletter