Helminths

Worm infestation in the gut can lower viral defenses

Infection with parasitic intestinal worms (helminths) can apparently cause sexually transmitted viral in-fections to be much more severe elsewhere in the body. This is shown by a study led by the Universities of Cape Town and Bonn.

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Section from the genital tract of a female mouse. The immune messenger Interleukin-33 indirectly ensures the maturation of granulocytes.

© Pia Vornewald (CEMIR, IKOM, NTNU; Trondheim, Norway)

According to the study, helminth-infected mice developed significantly more severe symptoms after infection with a genital herpes viruses (Herpes Simplex Virus). The researchers suspect that these results can also be transferred to humans. The results have now appeared in the journal Cell Host & Microbe.

In sub-Saharan Africa, both worm infections and sexually transmitted viral diseases are extremely common. These viral infections are also often particularly severe. It is possible that these findings are related. At least, this is the conclusion suggested by the current findings from mice. The scientists involved in the study investigated how an infestation with helminths affects the course of a herpes infection of the female genital tract in the animals. "The results themselves surprised us in their clarity," explains Prof. William Horsnell PhD., of the Institute of Infectious Diseases and Molecular Medicine at the University of Cape Town. "Genital herpes disease is often accompanied by scarring of the vagina, known as necrosis. In our study, this serious symptomatology occurred twice as often as normal after helminth infestation."

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This is a remote effect of helminth infection that was not known before

Laura Layland

The finding is also surprising because the worms themselves never infest the female genital tract. They are parasites that are ingested with food or through the skin and eventually migrate to the intestines. "So this is a remote effect of helminth infection that was not known before," explains Dr. Laura Layland of the Institute of Medical Microbiology, Immunology and Parasitology at Bonn University Hospital.

The researchers were able to show that a specific group of immune cells, the eosinophil granulocytes, is responsible for the necrotization. These are white blood cells that are specialized in fighting worms and other parasites. They are armed with cell-decomposing enzymes that they carry around inside them. However, these are not freely available - they are too dangerous for that. Instead, they are packed in so-called granules (hence the name "granulocytes"). Upon contact with a parasite, the cells channel these granules to the outside, where they release their deadly cargo. "In our case, however, the worm infestation in the intestine causes eosinophilic granulocytes to accumulate in the vagina during a concurrent genital herpes infection," Horsnell points out. "They then secrete their cell-damaging enzymes there, even though no helminths are present. And it's this misdirected immune response that leads to the serious damage in the mucosa of the vagina that we've observed."

A specific immune messenger, interleukin-33, appears to play an important role in this process, indirectly causing the accelerated maturation of granulocytes in the vagina. "We inhibited IL-33 with a specific compound," Horsnell explains. "The mice then developed significantly less tissue damage in the genital tract." The scientists are now looking for potential drugs that are also suitable for use in humans and that can be produced inexpensively.


Source: University Hospital Bonn

19.04.2021

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