Cardiac Imaging in a Small Animal Model

In the last 10 years, small animal models have played an important role in cardiological research. These research models are especially important since today various cardiac illness entities can be investigated in transgene animal models. Because of the animals ease of handling and fast generation time, research projects with rats and mice are particularly interesting. Until the 1980s, experiments were overwhelmingly carried out on large animals, but cardiological research using small animal models faces specific problems. A major feature is the examination of the development of specific phenotypes in transgenic mouse models. It is important to note that even with the specific control of individual gene loci, or the production of certain transgenic mouse models, actual phenotyping cannot necessarily be predicted. Thus in dealing with such small animal models, safe, reliable and reproducible cardiac phenotyping is of utmost importance. In principle, various physiological parameters can be measured to capture the elements of cardiac function. These encompass hemodynamic measurements with the measurements of cardiac output and pressure, as well as mesurements of the heart's morphology, such as determination of wall thickness, and approximation of left ventricular function by determining the diameter of the heart cavities and their respective abbreviated ejection fractions.

Fig. 1: This figure shows an echocardiographical M-mode lead in a healthy mouse...
Fig. 1: This figure shows an echocardiographical M-mode lead in a healthy mouse (left) and a mouse following a heart infarction (right) in parasternal view. (IVS: interventricular septum; PW: posterior wall; LV: left ventricle; MI: myocardial infarction)

This article was first published in the VISIONS, issue 6/2004, a publication of Toshiba Medical Systems

13.08.2007

Read all latest stories

Related articles

Photo

sponsored solution

Vitrea Advanced Visualization

Vitrea software is a multi-modality advanced visualization system providing comprehensive applications in a variety of IT environments – from single site to multi-site standardization. Vitrea…

Photo

Medics on the move

Healthcare goes out and about

New technology being deployed across the NHS in central England is helping to deliver more secure mobile systems for healthcare professionals. The partnership between Toshiba and the Birmingham…

Photo

Experts' get-together

Toshiba Medical invites you to their MRI User Meeting 2017

Toshiba Medical proudly announces its 2nd MRI User Meeting in collaboration with Clinica Creu Blanca in Barcelona on 22 & 23 September 2017 (at Camp Nou FC Barcelona, Spain). At this MRI User…

Related products

Canon – Aceso

DR

Canon – Aceso

Canon Medical Systems Europe B.V.
Canon – Adora DRFi

Flatpanel Fluoro

Canon – Adora DRFi

Canon Medical Systems Europe B.V.
Canon – Adora DRi

DR

Canon – Adora DRi

Canon Medical Systems Europe B.V.
Canon – Advanced intelligent Clear-IQ Engine for MR

Artificial Intelligence

Canon – Advanced intelligent Clear-IQ Engine for MR

Canon Medical Systems Europe B.V.
Canon – Alphenix 4D CT

Multi Modality Suites

Canon – Alphenix 4D CT

Canon Medical Systems Europe B.V.
Canon – Alphenix Biplane

Bi-Plane

Canon – Alphenix Biplane

Canon Medical Systems Europe B.V.