Detailed map of immune cells

The Human Blood Atlas: a mighty new tool to fight deadly diseases

A first-ever map of the human body’s immune cells has been created by scientists at SciLifeLab, providing medical research with a detailed description of the proteins in human blood. The open-access database offers medical researchers an unprecedented resource in the search for treatments for diseases.

Published in the journal Science, the Blood Atlas resource is the latest database to be released by the Human Protein Atlas program, which is based at the Science for Life Laboratory (SciLifeLab), a joint research center aligned with KTH Royal Institute of Technology, Karolinska Institutet, Stockholm University and Uppsala University.

Image source: Human Protein Atlas

KTH Professor Mathias Uhlén, director of the Human Protein Atlas, says that this open-access resource will facilitate future efforts to combat disease. “The immune cells are involved in fighting all human diseases – in particular cancer, infectious diseases and autoimmune diseases,” Uhlén says. “With a comprehensive map identifying all proteins in these blood cells, researchers around the world will be able to deepen their understanding of human biology and develop new, more effective therapies targeting these diseases.”

The Blood Atlas provides a detailed view of the proteins in individual blood cells in relationship to the presence of these proteins in the other parts of the body, determining which proteins are unique to different types of blood cells. A thorough analysis of blood cell RNA expression profiles has enabled the identification of approximately 1,500 genes with elevated expression in various immune cells, confirming well-known immune proteins, but also identifying new targets for in-depth analysis. Uhlén says the corresponding proteins are interesting to study further in order to explore the biological functions linked to the function of each blood cell type.

This resource is very important for anyone interested in understanding the function of individual genes, for example in patients with primary immune deficiency diseases

Petter Brodin

To illustrate the usefulness of this resource in understanding the function of specific genes across cells and tissues, the paper describes the cellular distribution of genes known to cause primary immunodeficiencies. Co-author Petter Brodin, a researcher in the Department of Women’s and Children’s Health at Karolinska Institutet and SciLifeLab says: “This resource is very important for anyone interested in understanding the function of individual genes, for example in patients with primary immune deficiency diseases.”

The results are presented in an updated version 19 of the Human Protein Atlas, providing an open-access knowledge resource to allow exploration of the expression profiles across human immune cell populations and all major tissues and organs. The Blood Atlas also contains information about the proteins actively secreted by various cells into human blood as reported recently by Uhlén and research colleagues in Science Signaling.


Source: KTH Royal Institute of Technology Stockholm

23.12.2019

More on the subject:
Read all latest stories

Related articles

Photo

Coronavirus research

How type 1 interferon deficiency hints at severe forms of COVID-19

Which patient will develop a severe form of COVID-19? This is an essential question which must be answered in order to improve the individual management and the prognosis of these patients. In a…

Photo

Dracula debunked

The medical science behind ancient vampire myths

The vampire myth is likely related to a medical condition with symptoms that may explain many elements of centuries-old folklore. The concept of a vampire predates Bram Stoker’s tales of Count…

Photo

Antithrombotic approach

A new way to detect blood clots

Biomedical engineering researchers at Texas A&M University designed a medical device that mimics blood vessels to design and monitor drugs for patients with clotting disorders. This approach…

Related products

AB Medical – V-Tube EDTA K2, K3

Blood Cell Counter

AB Medical – V-Tube EDTA K2, K3

AB Medical V-Tube
Analyticon Biotechnologogies – Hemolyzer 3 NG / Hemolyzer 5 NG

Blood Cell Counter

Analyticon Biotechnologogies – Hemolyzer 3 NG / Hemolyzer 5 NG

Analyticon Biotechnologies AG
BD Vacutainer UltraTouch Push Button Blood Collection Set

Blood Collection

BD Vacutainer UltraTouch Push Button Blood Collection Set

BD – Becton Dickinson
Beckman Coulter – DxH 520 Hematology Analyzer

Blood Cell Counter

Beckman Coulter – DxH 520 Hematology Analyzer

Beckman Coulter, Inc.
Beckman Coulter – Early Sepsis Indicator

Blood Cell Counter

Beckman Coulter – Early Sepsis Indicator

Beckman Coulter, Inc.
Eppendorf – Mastercycler nexus X2

Research Use Only (RUO)

Eppendorf – Mastercycler nexus X2

Eppendorf AG