The past several years, interventions using ultrasound for real-time image monitoring in diagnostic and therapeutic procedures have increasingly been integrated into the daily clinical routine. Limitations due to image-distorting physical effects, such as the total reflection at the soft tissue/lung boundary, are associated with the use of ultrasound. CT fluoroscopy on the other hand enables real-time monitoring throughout the entire body with a high degree of geometric precision, which usually is not accompanied by any significantly disturbing artifacts. This increases the accuracy level of reaching the target, shortens intervention time and improves the biopsy yield. CT-supported interventions do not necessarily imply high patient dose. On the contrary, a variety of features efficiently reduce the radiation exposure for both physician and patient. CT fluoroscopy has become a safe and effective instrument for all diagnostic and therapeutic, percutaneous interventions.