Heart Attacks

Potential Breakthrough in Determining Who’s at Risk

Researchers are revisiting their views on the relative dangers soft and hard atherosclerotic plaque deposits pose to heart health. Findings of a new study by researchers at the Intermountain Medical Center Heart Institute may be a “game-changer” for determining who’s at risk of a heart attack, they say.

Researchers are revisiting their views on the relative dangers soft and hard...
Researchers are revisiting their views on the relative dangers soft and hard atherosclerotic plaque deposits pose to heart health. Findings of a new study by researchers at the Intermountain Medical Center Heart Institute may be a “game-changer” for determining who’s at risk of a heart attack, they say.
Source: Intermountain Medical Center

The notion that soft plaque is more likely to rupture and cause heart attacks than hard calcium deposits in coronary arteries may be wrong, according to the new study that was presented at the American College of Cardiology Scientific Sessions in Washington, D.C., on March 18.

Atherosclerosis is caused when plaque builds up in the arteries, narrowing and hardening them.

“We previously thought the lipid-laden soft plaque was more likely to rupture and cause heart attacks, but based on our new research, it’s more the calcified plaque that appears to be associated with adverse cardiovascular events” said Brent Muhlestein, MD, one of the study’s authors and co-director of cardiology research at the Intermountain Medical Center Heart Institute in Salt Lake City.

Intermountain Medical Center Heart Institute researchers had earlier teamed with Johns Hopkins School of Medicine and National Institutes of Health scientists to analyze the composition of plaque from 224 patients who had diabetes, but no heart symptoms.
 
This new research reflects more long-term findings after patients were followed for an average of nearly seven years to see if their plaque composition had predicted whether they’d have a cardiac event. 
 
In this study, through careful quantitative evaluation, the composition of coronary artery plaque identified in the subjects through CT coronary angiography was stratified proportionately into amounts of soft, calcified, and fibrous plaque and compared with future risk of unstable angina, heart attack or death. 
 
Unexpectedly, proportionately higher quantities of calcified plaque best predicted major adverse coronary events, while soft plaque did not, researchers found. 
 
Dr. Muhlestein said further studies are needed to verify the findings, but results from his team’s research may represent a potential paradigm shift. “We need further validation to gauge the importance of why the coronary calcium score is so predictive,” he said.
 
Although a build-up of coronary calcium doesn’t go away, doctors can successfully treat the patient aggressively with statins. They know no one gets coronary calcium if they don’t have plaque, even if it hasn’t been seen, so anyone with coronary calcium also has atherosclerosis.
 
“It’s a disease marker, not a risk marker. And we think it’s possibly a very important predictor,” said Dr. Muhlestein, who noted that having a calcium score of zero is like having a five-year warranty against heart attack — even with high levels of low-density lipoprotein, also known as LDL or bad, cholesterol.
 
“The finding potentially could mean a lot of patients may not require statin therapy, even though they have high cholesterol,” he said. “Maybe we can find and identify them. If there’s no atherosclerosis, you’re not going to have a heart attack. So the coronary calcium score may allow us to much more effectively select who we treat.”
 
The next step for the researchers is to complete more of the scans to see if the finding holds up, which will make findings more robust.

Source: newswise

24.03.2017

Read all latest stories

Related articles

Photo

News • Smart device

Dissolving pacemaker communicates with body-area sensor

Wireless bioresorbable pacemaker bypasses need to extract non-biodegradable leads, eliminating additional risk to the patient.

Photo

News • Cardiology research

Covid-19 vaccine technique could also save tissue after heart attack

A method for delivering genetic material to the body that has proven useful in Covid-19 vaccination is now being tested as a way to repair damaged heart muscle after a heart attack.

Photo

News • In cardiac cells

Pop-up sensors measure electronic signals

A tiny ‘pop-up’ sensor monitors the electrical activity inside heart cells. The device could provide new insights into cardiac diseases, including myocardial infarction and arrhythmias.

Related products

Canon – Alphenix Biplane High Definition Detector

Bi-Plane

Canon – Alphenix Biplane High Definition Detector

Canon Medical Systems Europe B.V.
Canon – Alphenix Core

Single Plane

Canon – Alphenix Core

Canon Medical Systems Europe B.V.
Canon – Alphenix Core+

Single Plane

Canon – Alphenix Core+

Canon Medical Systems Europe B.V.
Canon – Alphenix Core+ High Definition Detector

Single Plane

Canon – Alphenix Core+ High Definition Detector

Canon Medical Systems Europe B.V.
Canon – Vitrea Advanced Visualization

Reading

Canon – Vitrea Advanced Visualization

Canon Medical Systems Europe B.V.
Subscribe to Newsletter