Image source: Shutterstock/zlikovec

News • RadClip

AI tool for MRI could transform prostate cancer surgery, treatment

Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer.

The tool, called RadClip, uses AI algorithms to examine a variety of data, from MRI scans to molecular information. The research team included Cleveland Clinic, University Hospitals and the Louis Stokes Cleveland Veterans Administration Medical Center.

Photo
Overall workflow and pipeline (click to enlarge). T2WI = T2-weighted magnetic resonance imaging; ADC = apparent diffusion coefficient

Image source: Li et al., EBioMedicine 2021 (CC-BY-ND 4.0)

“This tool can help urologists, oncologists and surgeons create better treatment plans so that their patients can have the most precise treatment,” said Lin Li, a doctoral student in Case Western Reserve’s Biomedical Engineering Department and a member of the CCIPD team that developed the tool. “RadClip allows physicians to evaluate the aggressiveness of the cancer and the response to treatment so they don’t overtreat or undertreat the patient.” Li is first author on a study used to validate the tool, which appeared in The Lancet’s EBioMedicine journal. While other studies on prostate cancer have examined data from single sites, the CCIPD study included MRI scans from Cleveland Clinic, The Mount Sinai Hospital, University Hospitals and the Hospital of the University of Pennsylvania. The multi-institutional study applied RadClip AI tool to pre-operative scans from nearly 200 patients whose surgeons removed their prostate gland because of cancer, then compared its results of other predictive approaches—as well as the patients’ outcomes in succeeding years.

Recommended article

Photo

Article • Improving detection accuracy

Fighting prostate cancer with over 1.5 million MRI images

Men die about five years earlier than women across the world. As initiatives to boost awareness of men’s health unfolded in November, an international project is bringing the forefront of AI research to tackle prostate cancer (PC), the second most frequent type of cancer in men and the third most lethal in Europe.

One of the critical questions in managing prostate cancer in men undergoing surgery is identifying which are at highest risk of recurrence and prostate cancer-specific mortality so they can be identified early for additional therapy. While RadClip has been shown to be able to predict the risk of disease recurrence, clinical trials will be needed to demonstrate that the tool can also help identify men undergoing surgery who would also benefit from additional therapy. The approach involved using AI to identify subtle differences in heterogeneity and texture patterns inside and outside the tumor region on pre-operative MRI to predict patient outcome following surgery. 

portrait of Anant Madabhushi
Anant Madabhushi
Source: Case Western

“We’re bringing together and connecting a variety of information, from radiologic scans like MRI to digitized pathology specimen slides and genomic data, for providing a more comprehensive characterization of the disease,” said Anant Madabhushi, CCIPD director, Donnell Institute Professor of Biomedical Engineering at Case Western Reserve and the study’s senior author.

Madabhushi added that the study demonstrates the value of imaging data, showing that RadClip provides better prognostic information than other commonly used tools, such as the Cancer of the Prostate Risk Assessment (CAPRA) score and the genomic-based Decipher Prostate Cancer Test. “Genomic-based tests cost several thousand dollars and involve destructive testing of the tissue,” Madabhushi said. “Prognostic predictions from an MRI scan provide a non-invasive method for making both short-term and long-term decisions on treatment.”

Data generated from the AI algorithms can be used to address two important clinical areas—prostate surgery and post-operative management. Information obtained from pre-operative MRI images can help predict the existence and extent of cancer on the margins of tumors, which would allow surgeons to make informed decisions about how much tissue to remove. Data also can predict the risk of cancer recurrence so oncologists can determine whether a patient needs adjuvant treatments after surgery, such as radiation therapy or chemotherapy. “Having this information before surgery,” Li said, “provides surgeons and oncologists the time and space to adjust treatment plans and come up with a plan that’s best suited to the patient.”


Source: Case Western Reserve University

15.01.2021

Read all latest stories

Related articles

Photo

News • AI-based imaging and reporting solutions for MRI

Philips partners with imaging biomarker specialist Quibim

Philips and Quibim have signed a multi-year agreement to work on an integrated solution including an AI-based software to automate real-time prostate gland segmentation in MR images.

Photo

News • Medical technology presentation

United Imaging showcases EU presence, AI-driven solutions at ECR 2024

United Imaging showcased its full portfolio of AI-empowered products at the ECR 2024 in Vienna. The company highlighted its significant EU growth since establishing its regional HQ in 2019.

Photo

News • Imaging equipment

Fujifilm presents new MRI scanner at ECR 2024

Fujifilm Healthcare Europe will present its Echelon Synergy MRI system at the European Congress of Radiology 2024. The 1.5 T scanner employs AI features to enhance image quality and scanning speed.

Related products

Subscribe to Newsletter