Image source: Shutterstock/create jobs 51

Early detection

Blood-based methylation test offers promising data on lung cancer detection

In-vitro diagnostics company Universal Diagnostics (UDX) announced promising new data for its investigational blood-based lung cancer test.

The data, presented at the IASLC 2020 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (#WCLC20), held virtually 28th-31st January 2021, used methylation status measurement of the tumour-derived portion from cell-free DNA (cfDNA) in plasma for patient classification. Results of the study show the potential of the test to detect different lung cancer sub-types early, with high sensitivity and specificity, and indicate the potential of using blood-based screening for wider population regardless of the smoking-status of the patient.

“These initial results from our lung cancer test study are promising, particularly for detecting cancer at the early stages. With current methods for lung cancer screening being limited, with the majority of patients being detected too late, we believe there is a significant opportunity to improve outcomes for lung cancer patients using a simple and accurate blood-based test for early detection through mass screening,” said Juan Martínez-Barea, Co-Founder and President of Universal Diagnostics. “We will now build on these preliminary results and plan to move forward with test development, including starting clinical sample collection studies and further improving the panel and its performance. Beyond this, the results demonstrate our ability to leverage our technology for other cancer tests.”

In the study (P46.06 – “Cell-Free DNA (cfDNA) Methylation Assay Allows for Early Detection and Identification of Lung Cancer”), plasma samples of 37 lung cancer patients and 71 asymptomatic age, gender and smoking-history matching controls were assessed using UDX’s 10 methylation marker panel. The panel exhibited good lung cancer detection potential, with sensitivity for detecting lung cancer of 73% (27/37) at 90% (64/71) specificity. A total of 82% of adenocarcinoma (9/11), 80% of squamous cell carcinoma (8/10), 73% of small cell lung cancer (8/11) and 40% of other rare lung cancer subtypes (2/5) were correctly identified. Notably, the sensitivity for stage I cancers was 73% (11/15).


Source: Universal Diagnostics

02.02.2021

Read all latest stories

Related articles

Photo

New sensor tech

A more reliable way to early detect lung tumours

People who are at high risk of developing lung cancer, such as heavy smokers, are routinely screened with computed tomography (CT), which can detect tumors in the lungs. However, this test has an…

Photo

Early detection of coronavirus presence

Covid-19 wastewater testing: new quantification kit launched

Life science research and clinical diagnostics company Bio-Rad Laboratories announced the launch of its PREvalence ddPCR SARS-CoV-2 Wastewater Quantification Kit, a tool to detect the virus that…

Photo

Oncology early detection tool

Blood test for 50+ types of cancer promising for screening

Final results from a study of a blood test that can detect more than 50 types of cancer have shown that it is accurate enough to be rolled out as a multi-cancer screening test among people at higher…

Related products

Beckman Coulter – Access Interleukin-6 (IL-6)

Immunoassays

Beckman Coulter – Access Interleukin-6 (IL-6)

Beckman Coulter, Inc.
Beckman Coulter – DxA 5000

Sample Processing

Beckman Coulter – DxA 5000

Beckman Coulter, Inc.
Beckman Coulter – SARS-CoV-2 Assays

Immunoassays

Beckman Coulter – SARS-CoV-2 Assays

Beckman Coulter, Inc.
Creative Biosciences - Colosafe

Creative Biosciences - Colosafe

Creative Biosciences (Guangzhou) Co., Ltd.
Subscribe to Newsletter