Osseosurface electronic devices, which attach directly to the bone, could one...
Osseosurface electronic devices, which attach directly to the bone, could one day help physicians monitor bone health. It is applied to a synthetic bone in the Gutruf Lab at the University of Arizona.

Courtesy of Gutruf Lab

Osteoporosis

An ultra-thin 'computer on the bone'

A team of University of Arizona researchers has developed an ultra-thin wireless device, called osseosurface electronic, that grows to the surface of bone and could someday help physicians monitor bone health and healing over long periods.

"As a surgeon, I am most excited about using measurements collected with osseosurface electronics to someday provide my patients with individualized orthopedic care – with the goal of accelerating rehabilitation and maximizing function after traumatic injuries," said study co-senior author Dr. David Margolis, an assistant professor of orthopedic surgery in the UArizona College of Medicine – Tucson and orthopedic surgeon at Banner – University Medical Center Tucson.

Fragility fractures associated with conditions like osteoporosis account for more days spent in the hospital than heart attacks, breast cancer or prostate cancer. Although not yet tested or approved for use in humans, the wireless bone devices could one day be used not only to monitor health, but to improve it, said study co-senior author Philipp Gutruf, an assistant professor of biomedical engineering and Craig M. Berge faculty fellow in the College of Engineering.

"Being able to monitor the health of the musculoskeletal system is super important," said Gutruf, who is also a member of the university's BIO5 Institute. "With this interface, you basically have a computer on the bone. This technology platform allows us to create investigative tools for scientists to discover how the musculoskeletal system works and to use the information gathered to benefit recovery and therapy."

Because muscles are so close to bones and move so frequently, it is important that the device be thin enough to avoid irritating surrounding tissue or becoming dislodged, Gutruf explained.

"The device's thin structure, roughly as thick as a sheet of paper, means it can conform to the curvature of the bone, forming a tight interface," said Alex Burton, a doctoral student in biomedical engineering and co-first author of the study. "They also do not need a battery. This is possible using a power casting and communication method called near-field communication, or NFC, which is also used in smartphones for contactless pay."

Ceramic adhesive grows to bone

Photo
The device is as thin as a sheet of paper and roughly the size of a penny.
Source: Courtesy of Gutruf Lab

The outer layers of bones shed and renew just like the outer layers of skin. So, if a traditional adhesive was used to attach something to the bone, it would fall off after just a few months. To address this challenge, study co-author and BIO5 Institute member John Szivek – a professor of orthopedic surgery and biomedical engineering – developed an adhesive that contains calcium particles with an atomic structure similar to bone cells, which is used to secure osseosurface electronics to the bone.

"The bone basically thinks the device is part of it, and grows to the sensor itself," Gutruf said. "This allows it to form a permanent bond to the bone and take measurements over long periods of time."

For instance, a doctor could attach the device to a broken or fractured bone to monitor the healing process. This could be particularly helpful in patients with conditions such as osteoporosis since they frequently suffer refractures. Knowing how quickly and how well the bone is healing could also inform clinical treatment decisions, such as when to remove temporary hardware like plates, rods or screws.

Some patients are prescribed drugs designed to speed up bone healing or improve bone density, but these prescriptions can have side effects. Close bone monitoring would allow physicians to make more informed decisions about drug dosage levels.

The devices are described in a paper published in Nature Communications.

26.11.2021

Read all latest stories

Related articles

Photo

Multi-component procedure

SULEEI: extending the functional lives of biological heart valve prostheses

For decades now, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing processes and systems for cleaning, sterilization, and surface…

Photo

Nuclear magnetic resonance relaxometry

Hydration sensor could improve dialysis

For patients with kidney failure who need dialysis, removing fluid at the correct rate and stopping at the right time is critical. This typically requires guessing how much water to remove and…

Photo

Innovation

Taiwan at Medica 2018: virtual solutions for real problems

Jhy-Wey Shieh sees the link between Taiwan and Germany as obvious: ‘The word “trade” – of central importance for Medica – starts with “t” for Taiwan and contains “de” for Germany…

Related products

Fujifilm Wako – Autokit Total Ketone Bodies Assay

Clinical Chemistry

Fujifilm Wako – Autokit Total Ketone Bodies Assay

FUJIFILM Wako Chemicals Europe GmbH
Intermedical – "New" Radius XP with flat panel

Surgical Flat Panel C-Arms

Intermedical – "New" Radius XP with flat panel

INTERMEDICAL SRL
Siemens Healthineers - teamplay myCare Companion

Business Intelligence

Siemens Healthineers - teamplay myCare Companion

Siemens Healthineers
Stephanix – Omniscop DReam S

Surgical Flat Panel C-Arms

Stephanix – Omniscop DReam S

STEPHANIX