sensor patch applied to a finger
A photoacoustic sensor could help clinicians diagnose tumors, organ malfunctions and more

Image source: Xiaoxiang Gao / Jacobs School of Engineering at UC San Diego (CC BY 2.0)

News • Diagnosis of tumors, organ malfunction and more

Wearable skin patch could help monitor at-risk patients

A team of engineers at the University of California San Diego has developed an electronic patch that can monitor biomolecules in deep tissues, including hemoglobin. This gives medical professionals unprecedented access to crucial information that could help spot life-threatening conditions such as malignant tumors, organ dysfunction, cerebral or gut hemorrhages and more.

“The amount and location of hemoglobin in the body provide critical information about blood perfusion or accumulation in specific locations. Our device shows great potential in close monitoring of high-risk groups, enabling timely interventions at urgent moments,” said Sheng Xu, a professor of nanoengineering at UC San Diego and corresponding author of the study. The paper is published in Nature Communications.

Design, fabrication, and working principle of the soft photoacoustic patch: the...
Design, fabrication, and working principle of the soft photoacoustic patch: the system remains operational even under various degrees of deformation (below).

Image source: Gao et al., Nature Communications 2022 (CC BY 4.0)

Low blood perfusion inside the body may cause severe organ dysfunctions and is associated with a range of ailments, including heart attacks and vascular diseases of the extremities. At the same time, abnormal blood accumulation in areas such as in the brain, abdomen or cysts can indicate cerebral or visceral hemorrhage or malignant tumors. Continuous monitoring can aid diagnosis of these conditions and help facilitate timely and potentially life-saving interventions.

With its low-power laser pulses, [the sensor patch] is also much safer than X-ray techniques that have ionizing radiation

Hongjie Hu

The new sensor overcomes some significant limitations in existing methods of monitoring biomolecules. Magnetic resonance imaging (MRI) and X-ray-computed tomography rely on bulky equipment that can be hard to procure and usually only provide information on the immediate status of the molecule, which makes them unsuitable for long-term biomolecule monitoring. “Continuous monitoring is critical for timely interventions to prevent life-threatening conditions from worsening quickly,” said Xiangjun Chen, a nanoengineering PhD student in the Xu group and study co-author. “Wearable devices based on electrochemistry for biomolecules detection, not limited to hemoglobin, are good candidates for long-term wearable monitoring applications. However, the existing technologies only achieve the ability of skin-surface detection.” 

The new, flexible, low form-factor wearable patch comfortably attaches to the skin, allowing for noninvasive long-term monitoring. It can perform three-dimensional mapping of hemoglobin with a submillimeter spatial resolution in deep tissues, down to centimeters below the skin, versus other wearable electrochemical devices that only sense the biomolecules on the skin surface. It can achieve high contrast to other tissues. Due to its optical selectivity, it can expand the range of detectable molecules, integrating different laser diodes with different wavelengths, along with its potential clinical applications. 

The patch is equipped with arrays of laser diodes and piezoelectric transducers in its soft silicone polymer matrix. Laser diodes emit pulsed lasers into the tissues. Biomolecules in the tissue absorb the optical energy, and radiate acoustic waves into surrounding media. “Piezoelectric transducers receive the acoustic waves, which are processed in an electrical system to reconstruct the spatial mapping of the wave-emitting biomolecules”, said Xiaoxiang Gao, a postdoctoral researcher in Xu’s lab and co-author of the study. “With its low-power laser pulses, it is also much safer than X-ray techniques that have ionizing radiation”, said Hongjie Hu, a postdoctoral researcher in the Xu group and study coauthor. 

Based on its success so far, the team plans to further develop the device, including shrinking the backend controlling system to a portable-sized device for laser diode driving and data acquisition, greatly expanding its flexibility and potential clinical utility. They also plan to explore the wearable’s potential for core temperature monitoring. “Because the photoacoustic signal amplitude is proportional to the temperature, we have demonstrated core temperature monitoring on ex-vivo experiments,” Xu said. “However, validating the core temperature monitoring on the human body requires interventional calibration.” They are continuing to work with physicians to pursue more potential clinical applications. 


Source: University of California, San Diego

22.12.2022

Read all latest stories

Related articles

Photo

News • Proof of concept

Tattoo-like sensors reveal blood oxygen levels

Silk-based material under skin changes color in response to oxygen, and in the future might be adapted to track glucose and other blood components.

Photo

News • As good as gold

Raman spectroscopy: a wearable chemical sensor

Researchers created a special ultrathin sensor, spun from gold, that can be attached directly to the skin without irritation or discomfort. The sensor can measure different biomarkers or substances…

Photo

News • Wearables

Personal health trackers may include smart face mask

Researchers developed two concepts of wearable smart bioelectronic devices, materials for better real-time monitoring of a person’s health, including vitals.

Related products

Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Clinical Chemistry

Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Alsachim, a Shimadzu Group Company
Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Clinical Chemistry

Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Alsachim, a Shimadzu Group Company
Beckman Coulter – Access Procalcitonin (PCT)

Immunoassays

Beckman Coulter – Access Procalcitonin (PCT)

Beckman Coulter Diagnostics
Beckman Coulter – Early Sepsis Indicator

Blood Cell Counter

Beckman Coulter – Early Sepsis Indicator

Beckman Coulter Diagnostics
Beckman Coulter – Psychiatry Antipsychotic Assays

Clinical Chemistry

Beckman Coulter – Psychiatry Antipsychotic Assays

Beckman Coulter Diagnostics
Fujifilm Wako – Autokit Total Ketone Bodies Assay

Clinical Chemistry

Fujifilm Wako – Autokit Total Ketone Bodies Assay

FUJIFILM Wako Chemicals Europe GmbH
Subscribe to Newsletter