Backup from BARDA

Sepsis early detection algorithm receives development funding

Beckman Coulter, Inc. announced that it has initially been awarded a contract of $1.25 million, with potential to be awarded an additional $6.5 million if all contract options are exercised, from the DRIVe (Division of Research, Innovation, and Ventures) established by the Biomedical Advanced Research and Development Authority (BARDA), under the Office of the Assistant Secretary for Preparedness and Response (ASPR), within the United States Department of Health and Human Services (HHS).

The contract will enable Beckman Coulter, in collaboration with Dascena, Inc, to develop and commercialize a novel machine-learning-based sepsis detection algorithm. By combining novel laboratory test parameter values with electronic health record information, the objective for this next-generation analytic algorithm will be to accurately predict and detect sepsis earlier, with the goals of reducing sepsis mortality through earlier intervention and reducing the total cost of care.

3d rendering of red blood cells with infection

Image source: Shutterstock/Phonlamai Photo

Sepsis, defined as dysregulated immune response to infection, is a high-priority health concern accounting for the deaths of approximately 250,000 Americans and millions globally each year, and is the most expensive medical condition encountered in most hospitals,” said Elliott Crouser, M.D., of The Ohio State University Wexner Medical Center, and principal investigator in the clinical trial for Beckman Coulter’s Early Sepsis Indicator. “Delays in the detection and treatment of sepsis during its early phases can contribute significantly to adverse outcomes. The objective of this project will be to deliver earlier and more accurate sepsis detection. The resulting predictive analytic algorithm for sepsis detection is expected to have a major global impact.”

The creation of the algorithm is part of DRIVe’s mission to accelerate the development and availability of transformative technologies and approaches to protect Americans from health security threats such as sepsis. Beckman Coulter and Dascena will collaborate in the commercialization of the solution.

“This project integrates the novel laboratory parameters generated on the Beckman Coulter DxH 900 hematology analyzer into Dascena’s best-in-class sepsis prediction and detection algorithm,” said David Persing, M.D., Ph.D., chief scientific officer for the Danaher diagnostics platform. “We aim to leverage the unique ability of the DxH 900 to detect changes in monocyte distribution width and combine the results, along with other diagnostic parameters and vital-sign data, with a multi-modal algorithm expected to achieve unprecedented levels of performance.”

“We are proud to partner with BARDA and to further our shared mission of advancing healthcare by improving early detection for sepsis patients,” said Chris Riley, president of Beckman Coulter Diagnostics. “By combining the power of Beckman Coulter’s Early Sepsis Indicator and Dascena’s capabilities into a digital diagnostic solution, we believe we will facilitate earlier and more effective detection and intervention and help hospital systems counteract this deadly and expensive condition.”


Source: Beckman Coulter

30.10.2019

Read all latest stories

Related articles

Photo

Hematology

Early sepsis indicator helps identifying patients at risk

The critical element of testing for sepsis lies not so much in the location but in the timing and rapidity of results, according to Professor Jeannine T. Holden from Beckman Coulter Early…

Photo

Innovation

Hematology: Advancements and future trends

While the role of the laboratory in disease diagnosis and management has expanded in recent years, causing an overwhelming rise in testing demands, the availability of skilled technologists and…

Photo

Molecular diagnostics

A one-step system for faster turnaround of hospital samples

A new molecular diagnostics system is revolutionising analysis of hospital samples across an area of northern Italy. The Greater Romagna Area Hub Laboratory has recently installed the Beckman Coulter…

Related products

Beckman Coulter – Access 25(OH) Vitamin D Total

Immunoassays

Beckman Coulter – Access 25(OH) Vitamin D Total

Beckman Coulter, Inc.
Beckman Coulter – Access 2 Immunoassay System

Immunoassays

Beckman Coulter – Access 2 Immunoassay System

Beckman Coulter, Inc.
Beckman Coulter – Access Active B12

Immunoassays

Beckman Coulter – Access Active B12

Beckman Coulter, Inc.
Beckman Coulter – Access Procalcitonin (PCT)

Immunoassays

Beckman Coulter – Access Procalcitonin (PCT)

Beckman Coulter, Inc.
Beckman Coulter – Anti-Mullerian Hormone (AMH)

Immunochemistry

Beckman Coulter – Anti-Mullerian Hormone (AMH)

Beckman Coulter, Inc.