Lung Diseases

Researchers find new treatment to reverse COPD and other lung diseases

In a study conducted on mice, researchers found a receptor that could reverse inflammatory responses and combat chronic obstructive pulmonary disease (COPD) and other lung diseases.

Lung X-Ray
Lung X-Ray
Source: Shutterstock: sfam_photo

The findings, published in The FASEB Journal, found that the helpful receptor is one characterized for advanced glycan end-products (RAGE)-specific antagonist chemical compound, FPS-ZM1.

"RAGE disturbances in pulmonary disorders are precise and effective strategies with beneficial clinical effects," said Se-Ran Yang, PhD, an author on the study and an associate professor at the Department of Thoracic and Cardiovascular Surgery in the School of Medicine at Kangwon National University in Gangwon, Korea. "Blockade of RAGE as a novel clinical therapeutic for COPD ameliorates emphysema/COPD development and progression."

The researchers investigated the efficacy of the receptor in both vivo and in vitro COPD models to see what the molecular mechanism by which RAGE influences COPD.

They found that RAGE was association with the up-regulation of DAMP-related signaling pathways. FPS-ZM1 also reversed emphysematous lung symptoms in the mice by a significant margin.

"No one expected the pathogenic roots of COPD to be simple, and this study gives us an indication of the complexity involved.," said Thoru Pederson, PhD, editor-in-chief of  The FASEB Journal. "The current pharmacological armamentarium is limited, and studies like this are thus extremely valuable as a foundation."

Source: Radiology Business

21.02.2017

Read all latest stories

Related articles

Photo

News • Extra risk for asthma, COPD patients

Climate change: an even greater hazard for people with lung conditions

Heatwaves, wildfires, flooding: effects of climate change will further exacerbate breathing difficulties for millions of people living with lung conditions, new research finds.

Photo

News • Microfluidics and electrochemical transduction

Paper-based device for rapid diagnosis of lung diseases

A new device that combines microfluidics on paper, electrochemical transduction and immunoassays on magnetic nanoparticles is useful for easy and rapid diagnosis of lung diseases.

Photo

News • Heart failure and organ fibrosis

RNA therapeutics: potential far beyond Covid-19

RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic…

Related products

contextflow Advance Chest CT *

Artificial Intelligence

Dedalus · contextflow Advance Chest CT *

Dedalus HealthCare GmbH
ImageVision

Reading

medigration · ImageVision

medigration GmbH
Sarstedt · Low DNA Binding Micro Tubes

Research Use Only

Sarstedt · Low DNA Binding Micro Tubes

SARSTEDT AG & CO. KG
Subscribe to Newsletter