News • Anxiety and depression medication
Study explores mental health toll of endometriosis
Women who are later diagnosed with endometriosis have a markedly higher use of antidepressant and anxiety medication, and are far more often in contact with psychiatric hospital departments than other women.
Image source: Aarhus University/AU Foto
And this is not only the case after the diagnosis has been made. The pattern is already apparent ten years before. That is the finding of a large new Danish registry-based study from Aarhus University, based on data from 136,842 women. The findings are published in the journal Human Reproduction.
"What surprised us was how clear and persistent the pattern was, and that the difference did not diminish over time. On the contrary. Women with endometriosis consistently redeemed more prescriptions for antidepressant medication than women without the disease throughout the entire period, from ten years before to ten years after diagnosis," says Marie Josiasen, PhD student at the Department of Public Health and one of the researchers behind the study.
Specifically, women with endometriosis redeemed 29% more prescriptions for antidepressant medication and 16% more for anxiety medication in the years before diagnosis. After diagnosis, the difference rose to 40% and 46%.
The study does not provide an answer as to what causes the mental strain, but Marie Josiasen points to a couple of likely explanations: "It's possible that prolonged pain, uncertainty about the cause of the symptoms, and frustration over not being able to live the life one wants may be among the reasons. For some women, fertility problems can also be a major psychological burden," she says.
One of the study's most interesting findings, according to Marie Josiasen, is that the strain does not ease after the women receive their diagnosis. On the contrary, the difference compared with women without endometriosis becomes even more pronounced in the years that follow. "A diagnosis can be a relief, but it also involves coming to terms with having a chronic illness," says Marie Josiasen.
The study does not indicate whether an earlier diagnosis could reduce the psychological strain.
As part of her PhD project, Marie Josiasen will investigate the role that hormonal contraception plays in the mental health of women with endometriosis. "We can see that many receive medication and are in contact with psychiatric services. But we still lack an understanding of what actually helps these women. That's what I want to help find out," says Marie Josiasen.
Source: Aarhus University
18.08.2026
