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Personalised implants are transforming complex skull reconstruction surgery. This issue features an in-depth interview on how digital planning has shifted cranioplasty from intraoperative improvisation to preoperative precision, with experts discussing material choices between titanium and PEEK. Further topics include Denmark's successful elimination of congenital syphilis, the role of certified cardiac arrest centres in improving survival after out-of-hospital cardiac arrest, and how radiotherapy may boost immunotherapy in pancreatic cancer. Enjoy reading! 

Interview • Personalised implants in CMF surgery

Digital planning in skull reconstruction: from benefit to necessity

Whenever cranioplasty is discussed, the conversation usually centres on the implant material: titanium or PEEK. However, for Prof. Thomas Schouman, a CMF surgeon at the AP-HP Pitié-Salpêtrière Hospital in Paris, and Maarten Zandbergen, Market ...

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News • 10 years without a single case

"Farvel", congenital syphilis: how Denmark eliminated mother-to-child transmission

Congenital syphilis is on the rise across Europe, nearly doubling in a single year. Yet Denmark has marked a full decade without a single case. How one country managed what many others haven't.

Article • Acute cardiovascular care

Saving lives with timely transfers to cardiac arrest centres

Networks of certified cardiac arrest centres could dramatically improve survival and neurological outcomes for patients who suffer out-of-hospital cardiac arrest. At the ESC 2026 congress in Munich, experts debated how hub-and-spoke models in acute ...

News • Promising treatment synergies

Pancreatic cancer radiotherapy could also boost immunotherapy

Radiotherapy may be able to do far more than simply destroy tumor cells. A review explores how combining radiotherapy with immunotherapy could improve outcomes for patients with pancreatic cancer.

Article • Digital Health

Insulin infusions: calculating the safety check

Manually calculating intravenous insulin infusion rates is a time-consuming, error-prone process. A Turkish hospital addresses these issues with bedside software built in-house by a clinician who saw the problem firsthand on the ward. The tool ...

News • Immunotherapy first, surgery afterwards

Glioblastoma: treatment sequence matters

In glioblastoma, the treatment order matters: a new study shows that administering cell immunotherapy before surgery to remove a brain tumour is significantly more effective than the other way around.

News • Prophylactic post-treatment

MRI surveillance after SCLC helps patients avoid brain irradiation

After treatment for small-cell lung cancer (SCLC), patients often undergo prophylactic radiotherapy to prevent metastases in the brain. Now, a new study shows that MRI surveillance alone is enough, with fewer side-effects.

News • Collagen-targeted protein CA

New MRI agent to earlier detect lung cancer, hidden metastases

A research team has developed a new class of protein-based MRI contrast agent that detects invasive lung cancer and metastatic disease at earlier stages than conventional imaging approaches.

News • Environmental exposure

Researchers explore link between microplastics and lung cancer

People with lung cancer are more likely to have microplastics in their lungs and to have larger quantities of microplastics in their lungs, according to new research.

News • Beyond antibiotics

3D micro-bladder model to test phage therapy on recurrent UTIs

A new study shows that phage therapy could help reduce recurrent infections, which happen when the bacteria responsible for UTIs ‘hide’ in the tissue of the bladder.

News • Study challenges long-held assumptions

C. diff: not so harmless for the infant gut

Clostridioides difficile does not cause symptoms in infants – but that does not mean the bacteria are harmless: research links colonization to serious long-term consequences for the developing gut.

News • Impact on healthy tissues uncovered

Study explores cost of childhood chemotherapy

For many childhood cancers, chemotherapy is the only treatment option. A study explores the trade-off between life-saving treatment at a young age, and delayed side effects unfolding over a lifetime.

Events

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ASTRO 2026 Annual Meeting (American Society for Radiation Oncology)
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Annual Meeting of the European Association for the Study of Diabetes (EASD 2026)
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