A tomosynthesis dataset greatly reduces detection challenges associated with overlapping structures in the breast, which is the primary drawback of conventional 2D analog and digital mammography. By the end of 2015, Hologic, the leader in breast tomo- synthesis¹, had installed approxi- mately 3,600 breast tomosynthesis systems worldwide.² Many sites using the Hologic tomosynthesis system have purchased Hologic’s C-View™ software which generates a 2D image from the tomo- synthesis dataset, avoiding the need for a sepa- rate 2D exposure. Eliminating the 2D exposure saves time and makes the dose of a Hologic 3D MAMMOGRAPHY™ exam comparable to the dose of a conventional 2D exam. Clinical studies, including the landmark JAMA study, “Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography,” found that Hologic breast tomosynthesis exams resulted in a significant increase in Positive PredictiveValue (PPV) for biopsy versus conventional 2D mam- mography.³ PPV for biopsy is a widely used meas- ure of the proportion of women having a breast biopsy who are found to have breast cancer. Unfortunately, suspicious areas found with breast tomosynthesis exams may be occult in other imaging modalities (conventional 2D mammogra- phy, ultrasound, breast MRI), or better seen with tomo- Biopsing areas only seen or better seen with breast tomosynthesis Tomosynthesis is a breast cancer screening and diag- nostic modality that acquires images of a breast at multiple angles during a short scan. The individual images are then reconstructed into a series of thin, high-resolution slices typically one mm thick The lightweight Affirm upright system easily integrates onto the Hologic tomo- synthesis system in under a minute and is pre-programmed to use Hologic’s Eviva® and ATEC® biopsy needles RADBOOK 2016 92 ◼ MAMMOGRAPHY