For healthcare professionals. For you. 18 MED Software Vernetzte Geräte mit intelligenter Software-Konnektivität 29 MED Komponenten Hilfe für Gelähmte: Kompaktes und leichtes Exoskelett 33 Medizintechnik aus den Fokusregionen Projekt Listen2Future: Akustische Sensorlösungen 04 | 2023 Vol 32 ISSUE 2/23 • June 2023 THE EUROPEAN FORUM FOR THOSE IN THE BUSINESS OF MAKING HEALTHCARE WORK Cancer patients at risk Blood test detects risk of neurotoxicity from CAR T-cell therapy 3 2 0 2 r e b m e z e D Dezember 2023 92. Jahrgang ku-gesundheitsmanagement.de Evidence of a stroke (red arrows) is seen on this MRI scan of a brain of a patient who developed neurotoxic side effects after CAR T-cell therapy. © Dr Omar H. Butt of Washington University at St. Louis is an therapy Chimeric antigen receptor (CAR) T-cell im- munotherapy treatment that re- engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very ef- fective in the treatment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syn- drome (CRS) and immune effec- tor cell-associated neurotoxicity syndrome (ICANS). ICANS Researchers in Germany and in the United States have separately de- termined that high levels of serum neurofilament light chain (NfL), a protein in the blood indicative of neuroaxonal injury, are associated with complications. A simple blood test identifying NfL levels can help identify cancer pa- tients who are at risk of developing ICANS following CAR T-cell ther- apy. ICANS represents a broad spectrum of neurologic symptoms ranging from mild confusion, tremor, headaches, difficulty read- ing, difficulty concentrating, lethar- gy, and memory problems to se- vere brain swelling, seizures, coma, and even death. Between 40% to 60% of patients receiving CAR T-cell therapy develop ICANS. Two independent studies, one con- ducted at the Washington Univer- 2 In lab, a virus “infects” T cells with CARs. 1 Patient donates blood to get T cells. www.healthcare-in-europe.com Harnessing the Power of the Immune System to Fight Cancer Chimeric antigen receptor (CAR) T-cell therapy uses the child’s own immune cells to seek out and kill tumor cells. 3 CAR T cells muitiply. 4 Tests ensure safety and purity. sity at St. Louis (WUSTL) and the other by a multi-institutional Ger- man team led by researchers at Ludwig Maximilian University (LMU) of Munich, have identified that higher NfL levels in cancer pa- tients’ pre-CAR T-cell treatment correlate with the severity of sub- sequent ICANS. German multi-institutional study Principal investigator Prof Louisa von Baumgarten, MD, of LMU’s co- University Hospital, researchers that and hypothesized neuroaxonal integrity might have an important role in determining the severity of ICANS. Their hy- pothesis was based on numerous studies demonstrating that NfL serum levels correlate well with cerebrospinal fluid levels, mirror the extent of neuroaxonal injury, and predict outcomes for severe neurologic conditions, including multiple sclerosis, neurodegener- ative disorders, traumatic brain in- jury, and ischemic stroke. their serum NfL Ninety-six patients being treated at CAR T-cell therapy centres at LMU and University Hospital Heidelberg had levels measured five days before treat- ment, the day of treatment, and on the day that maximum ICANS symptoms were exhibited. NfL pre- levels were significantly higher in patients who developed moderate to severe ICANS after CAR T-cell transfusion than in patients repor- ting no or mild ICANS. Both post- treatment and pre-treatment NfL le- vels correlated with the severity of the subsequent neurotoxicity. l a t i p s o H h c r a e s e R s ’ n e r d l i h C e d u J . t S . 0 2 0 2 t h g i r y p o C © 6 CAR T cells HUNT for cancer cells, BIND to them and DESTROY them 5 CAR T cells infused into patient. Predicting severe neurotoxicity Writing in Blood Advances, the re- searchers said, ‘These findings sug- gest that measuring the level of NfL – alone or in combination with known risk factors such as tumour burden, CAR T-cell expansion, sys- temic inflammation, and immune system activation – might be useful to predict severe neurotoxicity after CAR T-cell transfusion […]. Our data imply an increased risk for more se- vere ICANS as a result of neur- oaxonal injury if NfL – pre-treatment is greater than 75 pg/ml.’ They are currently validating the predictive value of NfL levels in a prospective setting, and correlating findings with EEG, fMRI, and comprehensive neuropsychologic testing. USA study Armin Ghobadi, MD, and Beau M. Ances, MD, PhD, both of WUSTL, led a similar study, published in JAMA Oncology. They measured plasma NfL levels of 30 patients re- ceiving CAR T therapy at WUSTL and Case Western Reserve Univer- sity in Cleveland at seven time- points, starting at baseline pre-CAR T infusion to 30 days after. They analysed NfL levels in patients who developed each severity grade of ICANS and those who did not, as well as age, sex, tumour burden, history of neurologic disease, and history of neurotoxic therapies. ‘Patients who developed any grade ICANS had significant elevations in baseline NfL level,’ they write. ‘Baseline NfL level correlated with ICANS grade. No association was observed with demographic, onco- logic, neurologic, or exposure to neurotoxic risk factors, such as CRS. The risk of developing ICANS is associated with pre-existing neuroaxonal injury that was quan- tifiable with plasma NfL level in a subset of patients.’ Ongoing prospective trial WUSTL lead author Omar H. Butt, MD, PhD, tells European Hospital that the team is scaling up to wide scale testing in the near future. ‘We are also trying to determine where in the brain this injury originates, how this injury interacts with the immune system to develop symp- toms, and how long the injury lasts after symptoms along with its lin- gering consequences. All these questions are under active investi- gation with an ongoing pros- pective trial integrating advanced neuroimaging with blood and spi- nal fluid biomarkers and neuro- physiological testing in patients undergoing cellular therapy.’ ■ Report: Cynthia E. Keen CONTENTS LABORATORY ROBOTICS RADIOLOGY 1-4 5-7 8-12 www.healthcare-in-europe.com IT & INNOVATION Neue Wege wagen KOMMUNIK ATION KOMMUNIK ATION KOMMUNIK ATION Transparent kommunizieren Transparent kommunizieren Transparent kommunizieren Your guide to laboratory and pathology equipment in Europe € 22.– 2023/2024 Vol. 10 Automation & Sample Processing Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT Information Technology Other Applications Discover your topics in our healthcare journals. We offer a broad range of publications in the field of healthcare. mgo-fachverlage.de/healthcare

Content Products & Systems 3 Automation & Sample Processing 9 Chemistry & Immunochemistry 22 Hematology 29 Pathology 32 DNA 35 Microbiology 37 POCT 43 Information Technology 46 Other Applications Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Companies & Suppliers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 Imprint . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 3 Automation & Sample Processing Sample Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Automation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Sample Logistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 9 Chemistry & Immunochemistry Clinical Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Immunoassays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Immunochemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Integrated Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Urine Screening . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Rapid Testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 CSF and Alzheimer’s Disease Diagnostics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 22 Hematology Blood Cell Counter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Integrated Hematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 29 Pathology Histology Equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Information Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Sample Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2 LABBook 2023 / 2024 DNA 32 Amplification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Extraction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Research Use Only . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 35 Microbiology Automation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 POCT 37 Blood Glucose . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Blood Gases / Electrolytes / Metabolites / Oximetry . . . . . . . . . . . . . . . . . . . . . . 40 Endochrine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Clinical Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 Urinalysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 43 Information Technology LIS / Middleware / POCT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 Other Applications 46 Blood Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Saliva Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Pipette Tips . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Centrifuges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Incubators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Specialties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Index of Advertisers Sakura . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Mindray . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Hamamatsu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Hamamatsu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Beckman Coulter . . . . . . . . . . . . . . . . . . . . . . . . back cover . . m o c e b o d a k c o t s – m e h e v o n I © : r e v o c l

Sample Processing Sample Processing Beckman Coulter – AutoMate 2500 Family Sample Processing Systems Highlights: When you need to improve lab efficiency, turn to the AutoMate 2500 Family for an automation system that fits your lab’s unique requirements. The AutoMate family of sample processing systems allows you to streamline pre- and post-analytical processes to help gain optimal performance and use of resources, eliminating steps between sample receipt and analysis · Single point of entry to manage all tubes, from sample receipt to archiving · Advanced, automated sample loading and sorting, to minimize manual handling · Cap color analysis validates sample type against test ordered for error prevention · Through-the-label sample volume detection · Sorting speeds of 800–1,200 tubes per hour · Intelligent aliquoting and tube labeling to eliminate manual sample prepara- tion errors and ensure faster, more accurate secondary-tube preparation · Intuitive software to facilitate ease of use · Re-sealer for safe and convenient transfer to archiving Sample Processing SARSTEDT – BL 1200 – Sort Connect Sample Processing SARSTEDT – Bulk Sorter BL 1200 4 LABBook 2023 / 2024 Highlights: · Sort Connect – Bulk feeding of samples with universal connection to laboratory track systems · Process optimization with pre sorting and separation of tubes not destined for testing on the track · Modular design enables a range of configurations · Sample accessioning · Intelligent sample re-routing where test order is missing · Freely configured sorting platforms · Automatic distribution to all common makes of analyser racks or into bins · Can handle a large number of different tube types Highlights: · Ideal in combination with any analytical platform · Sample throughput up to 1,200 tubes / h · Process any tube type of 80 to 110 mm length (with cap) and 11 to 16 mm diameter, including false bottom options · Suited for any sample type (serum / plasma, serum gel / plasma gel, EDTA, citrate, blood sugar, urine) · Intelligent re-routing when waiting for lab order · Automatic sample accessioning · Customised sort rules to a variety of carrier types or bins System range: · BL 1200 – Bulk to Rack · HCTS2000 MK2 – Bulk to Box · Sort Connect – Bulk to Track

Highlights: Pre- and post-analytics in one system: · Processes any tube diameter from 11 to 16 mm · Sample throughput up to 900 tubes / h · Compatible with most racks or carrier types · Online or offline operation · Opens tubes with push caps, stoppers and screw caps · Can be customised to sort by tube type, material (barcode) or test request · Closes tubes with universal archiving caps · Retrofitting of decapping or recapping module is possible · Recapping with screw caps for SARSTEDT tubes with 13 or 15 mm diameter Sample Processing Sample Processing SARSTEDT – Sorter DC/RC 900 Flex Sample Processing T&O LabSystems – ATRAS Bulk Loader and Bulk / Rack Sorter – 4th generation Highlights: Cut down your process time, simplify your daily life and configure the ATRAS to fit your needs. · Cost-efficient registration and sorting of bulk material · Numerous output configurations for sorting into bulk bins, customer-specific racks and centrifuge buckets · Fast bulk-to-rack sorting on a small footprint (3000 samples / h on 1.2 m²) · Extendable by our intelligent sample transportation system InTrac Equip the ATRAS according to your requirements Features such as CapIdent, STAT Input, SIQ bin, Piston detection, Spin Check and Barcode alignment Automation Beckman Coulter – DxA 5000 Total Lab Automation System Sample throughput: up to 1,200 tubes / h Highlights: The DxA 5000 helps laboratories meet the challenges of today’s highly focused healthcare environment through a collection of patented innovations that deliver rapid and consistent turnaround time, provide a new level of comprehensive pre-analytical sample quality detection, and reduce the number of manual processing steps to significantly improve laboratory efficiency. Leveraging first-of-its-kind dynamic system software, the DxA 5000 utilizes Intelligent Routing to bring automated patient- centric workflow to the laboratory. By understanding the tests requested, sample volume available and real-time analyzer ca- pacity and status, the DxA 5000 continuously calculates the most expeditious route for every patient sample — both STAT and routine. The DxA 5000 enhances Beckman Coulter’s comprehensive port- folio of scalable solutions and is a key component of its vision to bring workflow automation to laboratories of all sizes. 6 LABBook 2023 / 2024

Automation Sample Logistics SARSTEDT – Tempus600® Connection Module Sample Logistics SARSTEDT – Tempus600® Quantit Sample Logistics SARSTEDT – Tempus600® Vita 8 LABBook 2023 / 2024 Highlights: The Tempus600® Connection Module is part of an automated one-touch handling system for sample tubes. The sample tubes are delivered from the ward to the laboratory through the dedicated point- to-point system. The sample tubes are gently slowed down before landing in the automation module. From here they are automatically transferred e. g. onto a track system. · Compatible with all lab automation systems including sorters and bulk loaders · A brake module can be fitted to increase sample throughput · and failure-free tube loading. · Up to 8 connections Highlights: The Tempus600® Quantit provides direct and fast transport of blood samples to the laboratory without batching or manual packaging steps. The samples are placed in a drawer, transported via a pipeline ø 25 mm and landed in the laboratory within seconds. Drastically reducing the total turnaround time for blood sample testing results in faster diagnosis and patient treatment. · Sending both high volume and urgent samples · Samples are always oriented the right way by the system · Compatible with all test tubes: length 80 – 110 mm, diameter 12 – 18 mm · Connectable to all lab automation, sorters and bulk loaders Highlights: The Tempus600® Vita provides dedicated, direct and fast transport of blood samples to the laboratory without batching or manual pack- aging steps. The samples are placed in the insertion point of the Vita, transported via a pipeline ø 25 mm and landed in the laboratory within seconds. Drastically reducing the total turnaround time for blood sample testing results in faster diagnosis and patient treatment. · Handles up to 810 sample tubes / hour · Compatible with all sample tubes: length 80 – 110 mm, diameter 12 – 18 mm · Connectable to all lab automation, sorters and bulk loaders

Chemistry & Immunochemistry Blood test detects risk of neuro- toxicity from CAR T-cell therapy Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that re-engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very effective in the treat- ment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Report: Cynthia E. Keen Researchers in Germany and in the United States have sepa- rately determined that high levels of serum neurofilament light chain (NfL), a protein in the blood indicative of neuroaxonal injury, are associated with ICANS complications. A simple blood test identifying NfL levels can help identify cancer patients who are at risk of developing ICANS following CAR T-cell therapy. ICANS represents a broad spectrum of neurologic symptoms ranging from mild confusion, tremor, headaches, difficulty read- ing, difficulty concentrating, lethargy, and memory problems to severe brain swelling, seizures, coma, and even death. Between 40% to 60% of patients receiving CAR T-cell therapy develop ICANS. Two independent studies, one conducted at the Washington University at St. Louis (WUSTL) and the other by a multi-insti- tutional German team led by researchers at Ludwig Maximilian University (LMU) of Munich, have identified that higher NfL levels in cancer patients’ pre-CAR T-cell treatment correlate with the severity of subsequent ICANS. Evidence of a stroke (red arrows) is seen on this MRI scan of a brain of a patient who developed neurotoxic side effects after CAR T-cell therapy. © Dr Omar H. Butt of Washington University at St. Louis 10 LABBook 2023 / 2024 German multi-institutional study Principal investigator Prof Louisa von Baumgarten, MD,of LMU’s University Hospital, and co-researchers hypothesized that neu- roaxonal integrity might have an important role in determining the severity of ICANS. Their hypothesis was based on numerous studies demonstrating that NfL serum levels correlate well with cerebrospinal fluid levels, mirror the extent of neuroaxonal injury, and predict outcomes for severe neurologic conditions, including multiple sclerosis, neurodegenerative disorders, traumatic brain injury, and ischemic stroke. Ninety-six patients being treated at CAR T-cell therapy centres at LMU and University Hospital Heidelberg had their serum NfL levels measured five days before treatment, the day of treat- ment, and on the day that maximum ICANS symptoms were exhibited. NfL pre-levels were significantly higher in patients who developed moderate to severe ICANS after CAR T-cell transfusion than in patients reporting no or mild ICANS. Both post-treatment and pre-treatment NfL levels correlated with the severity of the subsequent neurotoxicity. Writing in Blood Advances, the researchers said, ‘These findings suggest that measuring the level of NfL – alone or in com- bination with known risk factors such as tumour burden, car T-cell expansion, systemic inflammation, and immune system activation – might be useful to predict severe neurotoxicity after CAR T-cell transfusion […]. Our data imply an increased risk for more severe ICANS as a result of neuroaxonal injury if NfL – pre-treatment is greater than 75 pg/ml.’ They are currently validating the predictive value of NfL levels in a prospective setting, and correlating findings with EEG, fMRI, and comprehensive neuropsychologic testing. USA study Armin Ghobadi, MD, and Beau M. Ances, MD, PhD, both of WUSTL, led a similar study, published in JAMA Oncology. They measured plasma NfL levels of 30 patients receiving CAR T

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry Beckman Coulter – Antipsychotic Drug Monitoring Beckman Coulter – AU5800 Series Clinical Chemistry Analyzers Assays: Clozapine, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Paliperidone Highlights: Antipsychotic drug monitoring provides healthcare professionals accurate and vital information. Testing of antipsychotic drugs can help manage patient therapy by providing greater clarity on the causes of treatment failure (i.e., adherence, drug resistance, drug-drug inter- actions and drug metabolism) and may help to establish the right medication at the right dose more quickly. Liquid, ready-to-use reagents for immediate and easy use to provide faster, actionable insights across the care continuum for patients with serious mental illness Psychiatry antipsychotic assays integrate seamlessly into established workfl ows with no special training required and can be performed on any of Beckman Coulter’s Clinical Chemistry AU and DxC/AU systems. Dimensions: Weight: Sample throughput: Power consumption: 1260 × 2600 × 1580 mm (h × w × d) 1,070 kg 2,000 – 9,800 / h 200 – 240 W Highlights: The AU5800 series represents the highest throughput and fastest turnaround time in the Beckman Coulter AU Chemistry Analyzer Family. With true random-access capabilities, the AU5800 series is available in four different scalable models, which are designed to meet the needs of the high-volume core hospital laboratories, as well as the ultra-high-volume commercial laboratory market segment. · Maximize throughput with an intelligent sample man- agement system that optimizes the processing of racks based on the tests ordered · Ensure quick turnaround time for critical patients with STAT priority testing and auto-repeat of abnormal results Clinical Chemistry Clinical Chemistry Beckman Coulter – DxC 700 AU Chemistry Analyzer ELITechGroup – Selectra Mach5 Dimensions: Weight: Sample throughput: Power consumption: 1300 × 1250 × 890 mm (h × w × d) 460 kg 800 – 1,200 / h 200 – 240 W Highlights: Designed to meet the needs of mid- to high-volume clinical laboratories, the DxC 700 AU Chemistry Analyzer reduces the number of test-processing steps by 30% due to its intuitive user-interface that allow operators to spend less time on daily tasks and more time producing the quality results that empower better decision-making. · Simple, intuitive design of the DxC analyzer with the robust throughput capabilities of the AU analyzer · Confi gurable with a total laboratory solution option to connect the Analyzer with pre-analytical automation, immunoassay and clinical IT Dimensions: Weight: Sample throughput: 1050 × 650 × 700 mm (w × h × d) 110 kg 250-500 tests/hour (workfl ow dependent) Assays: Selectra Reagents Line; Anaemia, Cardiac, Diabetes, General Chemistry, Specifi c Proteins, Special Chemistry Highlights: · Economical fully automated benchtop solution · Effi ciency through consolidation of routine and special testing · Up to 65 barcode readable reagent positions · Accessible sample area with 85 primary tube positions; 65 barcode readable · Sustainability through optimized water consumption, LED-based photometric cartridges and reusable cuvette rotor · Broad reagent menu and state-of-the-art analytical quality with Selectra Reagents 12 LABBook 2023 / 2024

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry Mindray – BS-430 Clinical Chemistry Analyzer Mindray – BS-600M Chemistry Analyzer Dimensions: Sample throughput: 1050 × 1150 × 720 mm (w × h × d) Constant 420 tests / h, up to 625 tests / h with ISE Highlights: · Large loading capacity: 92 reagent positions, 102 sample positions · Whole blood HbA1c: supports HbA1c onboard hemolysis · Advanced software platform: auto QC, auto refl ex, substrate depletion & enzyme linearity extension, etc. · Quick start-up time: 5 minutes system initialization, 1 minute system wake-up · Low reagent consumption: minimal 100μl reaction volume Dimension: Throughput: Number of Parallel Tests: 1380 × 1200 × 860 mm ( w × d × h) 600 photometric tests per hour, up to 800 tests per hour with ISE up to 77 photometric tests + 3 ISEs + 3 serum indices Highlights: BS-600M is a powerful yet effi cient chemistry analyzer. It can deliver a maximized throughput in a minimal footprint of 1.2 m2, helping laboratories perform more tests in a smaller space and with a shorter TAT. It also features continuous sample loading, whole-blood HbA1c function, STAT Priority, integrated ISE module. With excellent sigma metric performance, BS-600M helps deliver reliable chemistry test results. Clinical Chemistry Clinical Chemistry Mindray – BS-800M Clinical Chemistry Analyzer Randox – Acusera Quality Control Dimensions: Weight: Sample throughput: No of parallel samples: 1600 × 1200 × 1015 mm (w × h × d) ≤ 450 kg for analytical unit, 150 kg for SDM Constant 800 tests / h, up to 1,200 tests / h with ISE up to 68 on-board chemistry tests Highlights: · Modular system: fl exible connection · Whole Blood HbA1c, automatic hemolysis · Accurate: high pipetting precision, coolant circulation reagent refrigeration, direct solid-heating system, effective mixing unit and intelligent clot detection · Innovative: reagent bubble detection, dot light source and water quality Monitoring · Cost-effi cient: large capacity with SDM racking system, 100 μl minimum reaction volume, one key STAT, Onboard reagent loading and unloading · Original calibrators with traceability 14 LABBook 2023 / 2024 Highlights: Randox specialises in Quality Control, crafting high-qual- ity materials that streamline procedures and save labs time and resources, no matter their size or budget. Our diverse products include third-party quality controls & calibrators, interlaboratory data management, exter- nal quality assessment, calibration verifi cation, and molecular IQC/EQA for infectious disease testing. Trusted by 60,000 users worldwide, Randox consistently delivers reliable results.

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry SARSTEDT – Microvette® – Capillary Blood Collection SARSTEDT – S-Monovette® cfDNA Exact Highlights: · Flexible capillary blood collection systems such as the Microvette® – tailor-made to the individual needs of each patient group. · Different patient groups and collection techniques Highlights: · Reliable sample stabilisation: up to 14 days at 4 °C to require different collection systems. · With a nominal volume range from 100 – 500 µl, the capillary blood collection systems product range is one of the most extensive in the entire market. · Depending on the requirements, our portfolio in- cludes Microvettes with conical or round bottom inner tubes and the option for various different collection techniques, end-to-end or with a collection rim. 37 °C · No gDNA input from nucleated cells – unaltered and exact analysis results · Lowest haemolysis – best possible sample quality – reliable results · The S-Monovette® cfDNA Exact standardises the pre-analysis of liquid biopsy samples and guarantees excellent sample quality. Clinical Chemistry Clinical Chemistry SARSTEDT – S-Monovette® GlucoExact SARSTEDT – S-Monovette® LightPROTECT Highlights: · Light Protection – from blood collection to archiving · Sustainable by avoiding aluminium foil · Process-compliant pre-analytics Light protection is provided by the special white coating on the S-Monovette® tubes and is guaranteed from the time of blood collection to opening the specimen in the laboratory. This S-Monovette® can be labelled and processed as normal. Direct legibility and therefore the usual convenient specimen identification are maintained. The S-Monovette® Serum Gel LightPROTECT eliminates the inconvenience of wrapping the blood sample, e.g. in aluminium foil/aluminium foil + tape. This also enables an effortless contribution to greater sustainability in the workplace by saving resources (aluminium foil). Highlights: · The S-Monovette® GlucoExact stands for precise determination of glucose and stabilizes the glucose concentration immediately for up to 96 hours at room temperature. · It meets the Gestational Diabetes Guidelines of the German Diabetes Association (DDG) and the German National Disease Management Guidelines (NVL) for type 2 diabetes. · Gold standard for glucose determination. 16 LABBook 2023 / 2024

Chemistry & Immunochemistry Immunoassays Immunoassays Beckman Coulter – UniCel DxI 800 Access Immunoassay System Mindray – CL-900i Chemiluminescence Immunoassay Analyzer Dimensions: Weight: Sample throughput: Assays: 1700 × 1710 × 970 mm (h × w × d) 630 kg up to 400 tests / h > 50 preprogrammed, bar-coded immunoassay methods Highlights: It includes proven chemiluminescent technology and one of the highest throughput systems available on the market. High-volume labs can decrease process steps and improve turnaround time by simplifying and automating immunoassay testing to a single platform. Beckman Coulter’s immunoassay instruments have common software interfaces and consumables across the whole family, enabling operators to train more quickly, minimize inventory, and ensure consistency in results across platforms. Dimensions: Weight: Sample throughput: Reagent Positions: Assays: 860 × 740 × 560 mm (w × h × d) 130 kg up to 180 tests / h 15 79 Highlights: · High throughput up to 180 tests per hour · One of the smallest benchtop CLIA analyzer · Reagent capacity with 15 positions · Single cuvette system · Dual substrate and automatically switch the empty one · Intuitive software interface, easy access to all functions · Continuously loading of lntelligent consumables management Immunoassays Immunoassays Mindray – CL-1000i / 1200i Chemiluminescence Immunoassay Analyzer Mindray – CL-2000i Chemiluminescence Immunoassay Analyzer Dimensions: Weight: Sample throughput: Reagent Positions: Assays: 1400 × 760 × 600 mm (w × h × d) 225 kg up to 180 tests / h 25 79 Highlights: · High throughput up to 180 tests per hour · Benchtop analyzer · Large reagent capacity with 25 positions · Sample rack system · STAT lane · Single cuvette system · Dual substrate and automatically switch the empty one Dimensions: Weight: Sample throughput: Reagent position: Assays: 2150 × 1020 × 1200 mm (w × h × d) 750 kg up to 240 tests / h 36 79 Highlights: · up to 240 tests per hour · Measurement principle: enhanced ALP-AMPPD method · Reagent carousel: 36 reagent positions with non-stop refrigerating · Sample handling: up to 300 samples can be loaded in one batch, sample loading and offl oading continuously by sample racks, fast prioritizing STAT samples · Continuously loading of reagents, substrate, cuvettes, wash buffer and waste bags 18 LABBook 2023 / 2024

Chemistry & Immunochemistry Integrated Systems Integrated Systems Mindray – SAL 6000 Modular System Mindray – SAL 9000 Modular System Sample throughput: No of channels: Assays: Chemistry up to 1,200 t ests / h (including ISE), Immunology up to 240 tests / h 68 (Chemistry) / 36 (Immunology) 132 Sample throughput: No of channels: Assays: Chemistry up to 2,200 tests / h (including ISE), Immunology up to 480 tests / h 67 (Chemistry) / 36 (Immunology) 132 Highlights: The SAL 6000 is a high performance chemistry and immu- nology integrated system, combining BS-800 chemistry analyzer, CL-2000i immunology analyzer and the SPL 1000 sample process line. The system offers a large capacity of 300 samples with continuous loading by racks. It supports onboard sample pretreatment for HbA1c testing. Highlights: The SAL 9000 is a high performance chemistry and immu- nology integrated system, combining BS-2000 chemistry analyzer, CL-6000i immunology analyzer and the SPL 1000 sample process line. The system offers a large capacity of 300 sample positions and supports non-stop continuous sample loading. It offers a large capacity of 600 samples with continuous sample loading by racks, dedicated STAT channel, and sample tray direct loading and offloading. Urine Screening Rapid Testing SARSTEDT – NFT Urine collection system SARSTEDT – Blood gas Monovette® and capillaries The first enclosed urine collection system from SARSTEDT for hygienic and needle-free sample collection (NFT = Needle Free Transfer). Highlights: Highlights: · A needle is no longer needed – the Urine-Monovette® easily pierces the innovative NFT membrane for closed urine transfer · No risk of needlestick injury · No sharps container needed to dispose of the NFT products · Available as Urine Cup NFT and 3-litre Urine Container NFT · Blood gas collection systems for arterial, venous and capillary sampling with the smallest sample volumes and Ca2+ balanced heparin. · The Ca2+ balanced heparin in spray-dosed droplet form enables rapid and optimal mixing of blood and anticoagulants. The Blood gas Monovette® is available in 1 and 2 ml options and has been designed for venous and arterial blood collection. The blood gas capillaries offer a nominal volume range of 100 – 175 µl. 20 LABBook 2023 / 2024

Hematology Blood Cell Counter Integrated Hematology

Hematology Detecting and measuring nanoplastics in blood Plastics are a part of everyday life, and an increasingly concerning factor of global environmental pollution. They also have infi ltrated our bodies as microparticles (MPs) and nanoparticles (NPs), found even in placentas supporting foetal life. And they are in our blood. Now, researchers in Spain have developed a new method to detect and measure nanoparticles in human peripheral blood that is faster and more accurate than some current techniques being used. method. Flow cytometry is a laser-based technique used to detect and analyze the chemical and physical characteristics of cells or particles. The researchers’ method, described in MethodX, is based on the fluorescent staining of Nile red, a dye that binds to the surface of plastics and neural lipids. Lead author Roser Salvia and colleagues used the lipophilic dye Nile Red, in combination with fluorescence techniques and nanocytometry to determine the presence in human peripheral blood of the four most common plastics produced in the world. 196 people living in the Metropolitan Area of Barcelona donated blood, ranging in age from new-borns to age 90. The donor cohort included 37 healthy individuals, 36 new-born infants, Report: Cynthia E. Keen Plastic MPs and NPs are ingested through oral intake of food and liquids, air inhalation, and exposure to the skin, such as bathing and using personal care products containing nanopar- ticles. Ranging in size up to 5 mm for MPs and from 1 nm to 1000 nm for NPs, they most commonly enter the body through food, drinking water, and use of plastic food contact materials. Microplastics and nanoplastics are now known to induce inflammation, oxidative stress, immune response, and cell death through apoptosis and necrosis. When nanoplastics reach the blood stream, they circulate throughout the body. Because almost all blood from the intestinal tract transfers through the liver, this is a particularly vulnerable organ. Accumulations of plastic particles in the liver can penetrate the epithelial barrier. A study conducted by Chinese researchers at Shandong University’s Institute of Toxicology in Jinan, determined that that polystyrene nanoparticles increased blood-brain barrier (BBB) permeability and accumulated in the brains of mice. This accumulation triggered activation of microglia, the cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. The researchers reported that their study revealed that polystyrene nanoparticles induced microglia activation and neuron damage in the mouse brain. Barcelona study reveals prevalence of plastics in the blood Although more than a decade has been spent in intensive global research, the extent of harm plastic particles can cause to the human body is still unknown. Tens of thousands of variables are involved in terms of assessing exposure, hazards, and effects on human anatomy. Accurate and reproducible detection and measurement techniques are essential for all research. A Universitat Autònoma de Barcelona research team has devel- oped a simple, fast, robust, and reproducible method to detect nanoplastics in human peripheral blood using a flow cytometry 24 LABBook 2023 / 2024 © Adobe Stock / VectorMine

Hematology Blood Cell Counter Blood Cell Counter Mindray – BC-700 Series Hematology Analyzers with ESR Mindray – BC-6200 / 6000 Auto Hematology Analyzer Sample throughput: CD (CBC + DIFF): 80 t/h CD + ESR: 40 t/h Sample throughput: up to 110 t / h Highlights: · Revolutionary hematology analyzers integrated with Highlights: · Unique SF Cube 3D cellular analysis technology ESR measurement function. · Adopting the high-end SF-Cube 3D analysis techno- logy, delivering extraordinary performance in reliable counting and differentiation of abnormal samples. · The innovative parameter – optical PLT-H in every CBC & DIFF test, delivering reliable platelet counts event with interference. for WBC 6-part diff count including IMG · NRBC in every CBC+DIFF result · Automatic rerun & reflex in case of abnormal results · BC-6200 with RET channel can provide optional Reticulocytes and PLT-O parameters and perform automatic 8-times PLT-O counting for thrombo- cytopenia samples. Blood Cell Counter Blood Cell Counter Mindray – BC-6800Plus Auto Hematology Analyzer SARSTEDT – Microvette® APT – for routine capillary blood analysis Sample throughput: CBC+DIFF 200 t / h, RET 120 t / h, BF 40 t / h Highlights: BC-6800Plus is currently the fastest standalone hematology analyzer in the world, which can process 200 CBC+DIFF samples / h and 120 RET samples / h. Notably, the ERP channel can provide more research parameters such as MCHr and HDW, which can help early diagnosis of various types of anemia. 26 LABBook 2023 / 2024 Highlights: · Capillary blood collection system specially developed for automated processing in blood count analysis systems · Greater flexibility thanks to two collection techniques – precise filling volume with end-to-end capillary (250 µl) and entire collection rim (250 – 500 µl) for optimum mixing with a K2 EDTA preparation · Meets all the important processing requirements for a primary container and has a leak-proof cap with pierce- able membrane for save transportation and shipping · Improves the turn-around time in capillary blood anal- ysis and reduces the need for repeated blood collection · Available in ISO and EU colour code

Hematology Integrated Hematology Beckman Coulter – wDxH 900 Hematology Analyzer with Reagent Preparation Instrument (RPI) Dimensions: 755.7 × 1740 × 828 mm (w × h × d) Weight: 254 kg Sample throughput: up to 100 samples / h Power consumption: 520 W Highlights: Ideal for mid- to high-volume clinical laboratories perform- ing complete blood counts and white blood cell differential tests while minimizing repeat testing, allowing the right results to be delivered the fi rst time as well as achieving superb RBC, PLT, and WBC differentials through near na- tive-state cellular characterization and precise fl agging. · Optimized processes help your laboratory maximize staff time through fewer slide reviews, automated QC, longer walkaway and system uptime · Most reportable results per sq m with industry-leading 93% fi rst-pass yield and a > 40% smaller footprint than competitive instruments · Exclusive Early Sepsis Indicator: a one-of-a-kind FDA- cleared hematologic biomarker designed to help ED physicians identify sepsis sooner · The analyzer features a variety of workcell confi gura- tions to match laboratory workload, with a mounted user interface, onboard power computer and wireless peripherals, eliminating the need for extra hardware · Newly introduced, the DxH Concentrated ECO Diluent reduces both the number of diluent box reloads and storage space by 94%, minimizing daily lab tasks · DxH Concentrated ECO Diluent uses an RPI with a convenient built-in water purifi cation system and an intuitive software system that alerts when the cubitieres need changing p r o d u c s a l s n l i n e F i n d a l For more information, visit healthcare-in-europe.com

Pathology Histology Equipment Information Technology Sakura Finetek – Tissue-Tek Genie Advanced Staining System Clinisys – DaVinci Dimensions: Weight: 1650 × 1600 × 750 mm (w × h × d) 585 kg Highlights: · Pay-per-slide pricing ensures transparent cost management. · Unique standard 2hr 45min TAT for Sakura’s RTU biomarkers to support an efficient workflow. · 130+ ready-to-use antibodies and probes. · A closed system limits exposure to chemicals and allows easier IVDR compliance. · 30 fully independent stations allow maximum flexibility, with limited downtime, and no case splitting. · GenieOnline partnership ensures worry-free stock management and easy verification of new biomarkers. · Optimal, ready-to-use reagents. Sample Collection SARSTEDT – Digitising Pre-Analytics with S4DX System Highlights: Clinisys DaVinci – user- friendly solution designed by pathologists for increased productivity With our anatomical pathology solution you can optimise your pathology processes, and your employees can work more effi ciently and more collaboratively. Results are available quicker and, of course, this benefi ts the patients. Our solution supports all traditional pathology processes, with user-friendly and task-oriented workfl ows – starting from order communication and registration all the way to the delivery of the results. LABBOOK 2023 Please visit us at healthcare-in-europe.com Highlights: Established pre-analytical quality monitoring · Document transport time and temperature · Monitor sample quality digitally according to ISO 15189 · Link pre-analytical data such as the time of sampling, the verification of the patient and, if necessary, his or her condition to the diagnostic process Optimised work processes and reduce laboratory costs · Reduce costs in sample logistics · Automate sample receipt procedures · Minimise repeated measurements · Reduce training outlay for collection sites · Optimise customer communication Reduced pre-analytical errors · Avoid errors such as “wrong patient”, “wrong blood in tube” and “missing material” 30 LABBook 2023 / 2024

DNA Amplifi cation Extraction Research Use Only

DNA Amplifi cation Extraction SARSTEDT – White Multiply PCR Plates Promega – Maxwell® CSC Instrument Highlights: In addition to a generally improved quality, SARSTEDT now offers optimized white color variants for better detection sensitivity in qPCR. In addition, we have ex- panded our PCR plate range with high-purity EtO-treated variants (Biosphere plus quality) as well as DNA & protein low binding variants. With our Biosphere plus variants, we offer the maximum and unsurpassed purity standard for an absolutely reliable absence of DNA or other bio- molecules. The low binding variants are our contribution to the increasing use of PCR consumables for other applications, e.g. for sample storage of smallest volumes or for preparing dilution series so that all biomolecules can be recovered from the wells. Dimensions: Weight: Sample througput: Assays: 330.2 × 299.7 × 345.2 mm (w × h × d) 11 kg up to 16 samples / 25 – 75 minutes Blood, FFPE, buffy coat, bone marrow, cells, serum, stool, urine etc. (CE-IVD) or tissue, food, and many more (RUO) Highlights: Automated DNA and RNA extraction – IVDR-compliant · Generates consistent, high-quality nucleic acid for use in downstream diagnostic amplifi cation assays · Works with multiple sample types, e.g., blood, FFPE, tissue, buccal swabs etc. (CE-IVD) or cells, saliva, food, plants and many more (RUO) · Paramagnetic particle use = no cross-contaminations · Reliable sample tracking with integrated barcode scanner · Flexible, dual-mode software with separate RUO mode for research-based DNA & RNA extractions · Designed and manufactured under cGMP Extraction Research Use Only Promega – Maxwell® CSC 48 Instrument SARSTEDT – Low DNA Binding Micro Tubes Dimensions: Weight: Sample throughput: Assays: 533.4 × 355.6 × 533.4 mm (w × h × d) 27 kg up to 48 samples / 25 – 75 minutes Blood, FFPE, buffy coat, bone marrow, buccal swabs, stool, urine etc. (CE-IVD) or tissue, food, and many more (RUO) Highlights: Automated nucleic acid extraction – IVDR-compliant · Extraction of high-quality nucleic acid with minimal hands-on time · Processes different sample types for downstream applications in molecular diagnostics · Paramagnetic particle use = no cross-contaminations · Integrated vision system for error prevention · Reliable sample tracking with integrated barcode reader · Dual-mode software for both molecular diagnostics (IVD-mode) and research applications (RUO-mode) · Designed and manufactured under cGMP 34 LABBook 2023 / 2024 Highlights: As the trend towards decreasing sample volumes continues, it is increasingly important to minimize potential interaction between the analyte and tube. Our low protein and new low DNA binding micro tubes are specifically designed to meet the require- ments in protein and DNA analytics while maximizing recovery rates.

Microbiology Automation Beckman Coulter – DxM Autoplak Automation Dimensions: Weight: 1850 × 2000 × 920 mm (w × h × d) 500 kg Highlights: Robust microbiology automation in a fl exible and compact footprint Increased Productivity · Inoculate and streak up to 125 plates per hour · Load up to 120 samples in various sizes continuously with random access capability Automated Process · De-cap and re-cap multiple specimen containers · Implement plate streaking with various streaking patterns to fi t your laboratory needs Reduced Errors and Improved Effi ciency · Ensure standardized technique and improve colony isolation with automated streaking Minimize cross-contamination with loop incineration, HEPA fi ltration and one-way sample fl ow YOUR ADVERTISEMENT OR ADVERTORIAL Please cnac ur media cnsulan Julia Lutz Tel.: +49 (0)9221 949407 j.lutz@mgo-fachverlage.de

POCT First-tier rapid serology First-tier rapid serology testing for Lyme disease testing for Lyme disease Lyme disease, the most common tick-transmitted bacterial infection in the world, is challenging to diagnose. Initial early stage symptoms may include skin rash, fever, headache, fatigue, swollen lymph nodes, and/or body and joint aches. However, these symptoms are also associated with many other diseases and medical conditions. Report: Cynthia E. Keen In many cases, Lyme disease can be diagnosed based on clinical findings and a history of a tick bite or probable exposure. Labora- tory testing is problematic, both with respect to confirming and ruling out the disease. Lyme disease serologic testing measures the levels of antibodies generated by the body in response to the infection. However, these antibodies may take several weeks to develop to a level where they can be reliably detected. Conse- quently, both false negative tests and false positive tests are a problem with first-tier Lyme serological assays. For this reason, a second-tier laboratory test is needed to confirm initial positive findings. An on-site, point-of-care, rapid testing system that produces first-tier testing results within 3-15 minutes alleviates delays associated with initial analysis by an external laboratory. This rapid test, utilizing an advanced immunofluorescence-based lateral-flow technology (Quidel Sofia 2 Lyme+Fluorescent Immunoassay with CE Mark), has been available for clinical use in Europe since 2018, and also in the United States (Quidel Sofia 2 Lyme Fluorescent Immunoassay) (FIA). Treating early stage localized Lyme disease with antibiotics Positive test results help reinforce a physician’s decision to pre- scribe antibiotics while awaiting the results of a second-tier test, especially if the physician believes that a patient may have been exposed to ticks. Antibiotics are very effective in treating early stage localised Lyme disease, and to prevent it from developing into second and third stages that are more difficult to cure and can cause serious medical problems. The rapid test is also useful for patients who presented with Lyme disease symptoms but had negative test results, and who have returned weeks later for a follow-up test to definitively confirm the initial results. ‘In my opinion, the rapid FIA test’s primary benefit is actually to rule out Lyme disease, not diagnose it, because it has a high negative predictive value (NPV),’ says Professor of Laboratory Medicine and Pathology Elitza S. Theel, PhD, who also co-directs Mayo Clinic’s Vector-Borne Diseases Laboratory Service Line in Rochester, Minnesota, US. Researchers at Massachusetts General Hospital in Boston are the first to formally evaluate the performance of this single-use cartridge-based assay using lateral flow technology with an instrument reader, comparing it with a next-generation polyvalent enzyme immunosorbent assay (EIA) testing system (Zeus ELISA Borrelia VlsE1/pepC10 IgG/IgM (Zeus VlsE, Zeus Scientific), currently in use at the hospital. They report in the American Journal of Clinical Pathology that both of these first-tier serology assays show excellent agreement when combined with second tier immunoblot tests as a part of a standard two-tier testing protocol.1 1 Evaluation of the Rapid Quidel Sofia 2 Lyme Immunoassay as a First-Tier Test in a Two-Tier Testing Algorithm for Lyme Disease: Comparison to the Zeus ELISA Borrelia VlsE1/pepC10 IgG/IgM Assay Followed by Immunoblot Get access Arrow; https://doi.org/10.1093/ajcp/aqad007 38 LABBook 2023 / 2024

POCT Blood Glucose Blood Gases / Electrolytes / Metabolites / Oximetry Nova Biomedical – StatStrip Glucose / Ketone* Nova Biomedical – Prime Plus Critical Care Analyser Highlights: The only glucose meter technology cleared by the US FDA across all professional and healthcare settings, including critical care. · Measures and corrects glucose errors caused by abnormal haematocrit levels · Measures and corrects errors caused by electro- chemical interferences · Measures blood beta-hydroxybutyrate, the preferred ketone for diagnosing ketoacidosis · Available as a fully connected, wi-fi meter, or a smaller Xpress* style meter *StatStrip Glucose only in the US Assays: PO2, PCO2, pH, Hct, tHb, MCHC, Na, Cl, K, iCa, TCO2, iMg, Glu, Lac, Urea (BUN), Creat, ePV, SO2%, O2Hb, COHb, MetHb, HHb, HbF*, tBil* Highlights: Stat Profile Prime Plus offers a complete test menu panel in about one minute, along with bidirectional connectivity, a robust data management system, and comprehensive cybersecurity protection. This comprehensive critical care menu includes iMg, urea and creatinine and calculated tests for ePV, MCHC and OI. *Not available in the US or Canada Endocrine Clinical Chemistry Nova Biomedical – Allegro* – a fast simple capillary blood analyser Nova Biomedical – StatSensor Creatinine Assays: HbA1c, Lipids panel, PT/INR, CRP, blood glucose and creatinine, urine albumin and creatinine Highlights: Allegro* offers a clinically important menu of 10 mea- sured and individually selectable tests, plus 7 calculated tests. All tests are measured with disposable, ready-to- use cartridges or test strips, and are easily performed by non-technical personnel. · Capillary fingerstick samples for all blood tests · Immediate test results during the patient visit · Reduces patient follow-up visits and costs *Not available in the US or Canada Highlights: Fingerstick capillary testing for creatinine The StatSensor Creatinine is a handheld analyser and miniaturized, single-use biosensor for whole blood creatinine testing. StatSensor Creatinine’s advanced technology enables simple, rapid, and accurate assessment of renal function by fingerstick capillary blood sampling at the point of care. Available as a fully connected meter, or a smaller Xpress* style meter. · Capillary sampling · Creatinine and eGFR results in 30 seconds · 1.2uL sample · Calculates eGFR by CKD-EPI and MDRD equations *Not available in the US and Canada 40 LABBook 2023 / 2024

POCT Other Urinalysis SARSTEDT – Minivette® POCT / Capillary Blood Collection Beckman Coulter – DxU Iris Workcell Automated Urinalysis Solution Highlights: · Collection devices for Point-of-Care tests · Easy sample recovery · Precise and dispensing of small whole blood volumes · Prevents spillage during transfer · Volume range: 10 µl – 200 µl · Preparations: neutral, heparin and EDTA Highlights: Using proprietary Digital Flow Morphology technology with Auto Particle Recognition Software which delivers standardized results using AI to rec- ognize particles, the DxU Workcell helps isolate, identify and characterize urine particles on the screen to virtually eliminate the need for manual microscopy. · Minimizes operator intervention and interruptions · Intuitive user interface software · Improves efficiency of urinalysis testing and reduces manpower with iWARE Integrated Urinalysis Software, providing onboard validation and result verification in a single step. · Improves clinical information. The Body Fluid module on the DxU microscopy is the only FDA-cleared urinalysis system and with linearity down to zero. The results are streamlined, as there is no need to interrupt the analyzer to switch to body fluid mode. Provides a standardized, fully automated method for the analyses of RBC count and nucleated cell count in cerebrospinal, synovial and serous fluids. · Increases productivity MED engineering International The trade journal for designers and developers of medical therapy and diagnostic devices Request your free sample booklet at kundenservice@mgo-fachverlage.de

Information Technology LIS / Middleware / POCT LIS / Middleware / POCT Beckman Coulter – DxONE Information Management Solutions Beckman Coulter – Remisol Advance DxONE Command Central: The system can connect up to 18 instruments or automation systems and up to 5 networked DxONE Command Central workstations within a single laboratory, allowing operators to place DxONE Command Central workstations in prime laboratory locations for increased flexibility. DxONE Command Central maximizes workflow efficiencies by providing a real-time view of laboratory systems from a single point of control. DxONE Inventory Manager: The automated, end-to-end software appli- cation increases operational efficiency by automatically recording, track- ing, and optimizing a laboratory’s consumables. With the manual tasks of receiving stock, monitoring system consumption, and reordering, now managed efficiently by the DxONE Inventory Manager laboratory inventory management system, laboratory staff can focus on the more demanding work required of a lab for ever more accurate patient test results. Highlights: Remisol Advance is an enterprise data management solution that can help improve sample workflow through consolidated management, drive consistency through network standardization across multiple sites, create efficiency through auto verification, and improve reli- ability by integrating quality control management. It is a unique software product that consolidates patient test information from multiple instruments in the lab or from multiple labs in the hospital network. Remisol Advance features virtualization capability to help reduce failure points and increase uptime. LIS / Middleware / POCT Clinisys – GLIMS LIS / Middleware / POCT Clinisys – GLIMS Genetics Highlights: Clinisys GLIMS – the most widely used LIS in Europe Clinisys GLIMS is a high-performance laboratory information system (LIS) that allows you to organise and automate all processes exactly as you want them: from order entry and instrument control to results reporting, invoicing and statistics. Thanks to the rich functionality of Clinisys GLIMS your laboratory can work more efficiently. You save costs and resources, while offering an enhanced service for requesters and patients – today and tomorrow. Highlights: Clinisys GLIMS Genetics – digital workflows for the entire genetic spectrum Our genetics laboratory solution covers the entire genetic spectrum including the latest methods such as next-generation sequencing. It can be used as a standalone solution with a gene panel and variant results management, interconnected with other LIS systems and essential interfaces to all common expert systems. It can also be configured as part of a complete diagnostics LIS or be connected to order entry and result reporting systems such as Clinisys CyberLab. 44 LABBook 2023 / 2024

Other Applications Blood Collection Saliva Collection Pipette Tips Centrifuges Incubators Specialties

Other Applications Pipette Tips SARSTEDT – Refi ll Revolution Pipette Tips SARSTEDT – Sarpette® M Highlights: ONE SYSTEM – FOUR OPTIONS For over 45 years, we have been manufacturing tailor-made pipette tips. Based on this experience as well as our technical competence and using ultra-modern production methods, we have developed a revolutionary re-fi lling system for you. Suited to your applications and workfl ow. Robust and resource-sparing. Safe and reliable. Highlights: Finally: Tips AND pipettes from SARSTEDT SARSTEDT introduces next-generation pipetting with the new Sarpette® M. The Sarpette® M manual piston pipette is designed for comfort, with its uniquely placed ejection button allowing for a particularly ergonomic workfl ow. With its user-friendly design, precise handling, and lightweight, durable construction, the Sarpette® M sets the benchmark in microliter pipettes – and is also compatible with a wide range of pipette tips. The Sarpette® M pipette is a perfect fi t for any lab with its outstanding performance at a very attractive price and is available for immediately delivery. Try it now. Centrifuges Hettich – Mikro 220 | 220 R Dimensions: 330 × 420 × 313 mm (w × h × d) Weight: 21 kg / 42 kg Rotational frequency: 18,000 min-1 Relative centrifugal force: 31,514 Centrifuges Hettich – Universal 320 | 320 R Dimensions: 401 × 529 × 346 mm (w × h × d) Weight: 31 kg / 52 kg Rotational frequency: 16,000 min-1 Relative centrifugal force: 24,900 Highlights: · Compact, high-performance microlitre centrifuge · Choice of seven rotors · IvD-conform according to directive 98 / 79 / EC · Impulse key for short cycle mode · Nine program memories for more individuality · Nine individual acceleration and deceleration stages · Model 220 R coolable from –20 to +40 °C with pre-cooling function · Max. number of tubes: 60 × 2.0 ml Highlights: · The universal choice among the benchtop centrifuges · Choice of 18 rotors · IvD-conform according to directive 98 / 79 / EC · Impulse button for short centrifugation · Impulse key for short cycle mode · Nine program memories · Nine individual acceleration and ten deceleration stages · Model 320 R coolable from –20 to +40 °C with pre-cooling function · Max. number of tubes: 4 × 200 ml / 6 × 94 ml 48 LABBook 2023 / 2024

y r t s i m e h c o n u m m I & y r t s i m e h C ■ l y g o o n h c e T n o i t a m r o f n I ■ s n o i t a c i l p p A r e h t O ■ T C O P ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ Companies & Suppliers Beckman Coulter Diagnostics 22, Rue Juste-Olivier 1260, Nyon, Switzerland phone: +41 22 365 38 08 EUPublicRelations@beckman.com www.beckmancoulter.com Clinisys Deutschland GmbH Am Klingenweg 6 65396 Walluf, Germany phone: +49 6123 7016-222 info-de@clinisys.com www.clinisys.com ELITechGroup B.V. Van Rensselaerweg 4 6956 Spankeren, The Netherlands phone: +31 313 430 500 sales.ecsnl@elitechgroup.com www.elitechgroup.com Andreas Hettich GmbH & Co. KG Föhrenstraße 12 78532 Tuttlingen, Germany phone: +49 7461 705-0 info@hettichlab.com www.hettichlab.com Mesalvo GmbH Heinrich-von-Stephan-Str. 25 79100 Freiburg, Germany phone: +49 761 2928 99-0 info@mesalvo.com www.mesalvo.com SHENZHEN MINDRAY Bio-Medical Electronics Co., LTD. Mindray Building, Keji 12th Road South, High-tech Industrial Park, Nanshan 518057 Shenzhen, China intl-marcom@mindray.com www.mindray.com Nova Biomedical 200 Prospect Street Waltham, MA 02454-9141, USA phone: +1 781 894-0800 info@novabio.com www.novabiomedical.com Promega GmbH Gutenbergring 10 69190 Walldorf, Germany phone: +49 6227 6906-129 martin.rossmanith@promega.com www.promega.com RANDOX 55 Diamond Road Crumlin, County Antrim, BT29 4QY, UK marketing@randox.com www.randox.com 50 LABBook 2023 / 2024

Imprint mgo fachverlage GmbH & Co. KG E.-C.-Baumann-Straße 5 95326 Kulmbach, Germany Phone: +49 9221 949-311 Managing Directors Walter Schweinsberg, Eva-Maria Bauch, Bernd Müller Editor Sonja Buske s.buske@mgo-fachverlage.de Advertising Director Julia Lutz j.lutz@mgo-fachverlage.de Art Director Friedrich Oertel, Melitta Cipes Subscription Simone Sesselmann kundenservice@mgo-fachverlage.de Subscription rate: € 22.– plus postage Printed by mgo360 GmbH & Co. KG, Bamberg Disclaimer The information and opinions expressed in artic- les and product entries published in LABBook are solely those of the manufacturers / companies, their authors and contributors, for which the publisher holds no responsibility. All trademarks, product names, company names and logos in this publication are the property of their respective holders. Users must obtain permission from those holders before copying or using the owner’s trademarks, product and company names or logos. Errors and omissions excepted. Not all products are available in all European countries. Medical devices placed on the market in the EU must bear a CE mark. Information on their clas- sification, notified body number and authorised European representative can be obtained from the respective manufacturer. Please note that the manufacturers’ websites may contain further product disclaimers. © 2023 by mgo fachverlage GmbH & Co. KG. All rights reserved. A brand of Mediengruppe Oberfranken 52 LABBook 2023 / 2024