Content Products & Systems 3 Automation & Sample Processing 16 Chemistry & Immunochemistry 37 Hematology 46 Pathology 51 DNA 59 Microbiology 64 POCT 71 Information Technology 77 Other Applications Editorial . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Companies & Suppliers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 Imprint . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86 3 Automation & Sample Processing Sample Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Automation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Sample Logistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 16 Chemistry & Immunochemistry Clinical Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Immunoassays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Integrated Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 Mass Spectrometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Electrophoresis / Chromatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Plasma Protein Testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Drug Testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Urine Screening . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Urine Microbiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Rapid Testing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 CSF and Alzheimer’s Disease Diagnostics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Research Use Only . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 37 Hematology Blood Cell Counter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 Integrated Hematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Microscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Hemostaseology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 2 LABBook 2022 / 2023 Pathology 46 Printer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Histology Equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Microscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Information Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 Sample Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48 MALDI-MS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 MALDI-MSI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 51 DNA Amplification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 Amplification / Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Extraction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Infectious Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 Sample Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 Research Use Only . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58 59 Microbiology Automation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Mass Spectrometry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Micoscopy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 64 POCT Blood Glucose . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Immunoassays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Cardiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Blood Gases / Electrolytes / Metabolites / Oximetry . . . . . . . . . . . . . . . . . . . . . . 66 Urinalysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Information Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Endochrine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Other . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 71 Information Technology LIS / Middleware / POCT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 Inventory Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76 77 Other Applications Blood Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 Pipette Tips . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Saliva Collection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Centrifuges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 Nitrogen Generators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Compressors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Incubators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Specialties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 Index of Advertisers Advanced Instruments . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Beckman Coulter . . . . . . . . . . . . . . . . . . . . inside front cover Fujifilm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Hamamatsu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Mindray . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Shimadzu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Siemens . . . . . . . . . . . . . . . . . . . . . . . . . . . cover/back cover

Sample Processing Sample Processing ASP Lab Automation – SortPro Sample sorter Sample Processing ASP Lab Automation – SortProR Rack Module Sample Processing ASP Lab Automation – SortTable Unboxing workbench 4 LABBook 2022 / 2023 Number of sorting targets: 5 to 17, free configurable Capacity input hopper: Approx. 600 tubes Processing speed: Sorting criteria: up to 3,600 tubes per hour, dependent on IT environment Barcode, Cap color, Tube type, centrifugation status, aspiration status, duplicates Highlights: ASP SortPro detects and handles samples faster than any other sorter and is the only sorter with the capability to assess the quality of the samples it handles and thereby minimizes erroneous diagnoses and downtime in analytics due to defective tubes or samples. It supports the work in the accessioning area of laboratories while remaining easily operated. SortPro provides significant increases in laboratory efficiency, reducing the workload on lab professionals and minimizing errors. Processing speed: approx. 1,800 samples/h for each rack module Number of specimen: up to 600, depending on used racks Sorting criteria: See basic device SortPro Permitted rack types: All racks commonly used in clinical laboratories fed vertically Highlights: By adding the SortProR module, your SortPro can load any racks directly during sample accessioning without any loss of time. Equipped with two of these modules, ASP SortPro achieves the same potential throughput of 3.600 tubes / hour when loading racks as it does when dispensing in bulk. This means that samples can be placed in racks just as quickly as they are registered and processed by the base unit. SortPro R has five drawers for any combination of racks that are fed vertically. Dimensions: 1970 × 1060 × 800 mm (w × h × d) Working height: 950 mm Set up in relation to base unit: Tube capacity: To the left of the unit, parallel or at right angles Up to 5,000 depending on tube dimensions Highlights: The ergonomic workstation SortTable buffers highly fluctuating sample volumes by collecting up to 5,000 samples and feeding them to the sorter without inter- ruption. Incoming submissions are unpacked here and the samples are placed directly in the buffer. From the buffer they are automatically fed to the ASP SortPro sorter for process- ing. This allows the sorter to constantly work at maximum capacity. In this way efficiency can be maximized and TAT minimized, even with heavy workloads.

Sample Processing Sample Processing EndMed – Archiving Rack & Cap Sample Processing EndMed – Recapper RC 2000 SL Sample Processing EndMed – Smart Tube Sorter TT 2000 S - IQ Vision 6 LABBook 2022 / 2023 Highlights: The archive rack and patented recap are intended to use with Recapper RC 2000 SL. While the recap is as effective at manual closing as with the recapper, the rack is also apt for archiving purposes. Cap · Patented one-size-fi ts-all recap · Closes all Ø 13 mm & 16 mm tubes · Intended for use with Recapper DC 2000 SL · Effective at manual closing Archive Rack · Simple rack for archiving · Compatible with most tube types with L 75 mm & 100 mm · Intended for use with Recapper DC 2000 SL · Ideal solution for cost-effective archiving purposes Dimension: 950 × 1600 × 900 mm (w × h × d) Sample Throughput: 1200 samples / h Highlights: · Automated recapping of Ø 13 mm & 16 mm tubes using the patented one-size- fi ts-all archive cap · Closing tubes with L 75 mm & 100 mm in our archive racks · Detecting tubes with caps & missing tubes in the rack · Two Operation Modes: Connection to LIS & stand-alone · Reading rack barcode & matching with closed tubes for sample archiving · Preventing cross-contamination from previously used caps · Minimising infection to staff by aerosol & splashing effect, and eliminating repetitive stress injury · Easy operation & minimum maintenance Dimension: 1940 × 1200 × 720 mm (w × h × d) Sample Throughput: up to 1600 samples / h Number of Channels: 12 target bins +1 error bin for default / can be confi gured from 6 to 18 target bins + 1 error bin & TT Smartline conveyor system (optional) Highlights: · Continuous bulk loading of sample tubes · Registering the samples · Sorting tubes into assigned bins and TT Smartline conveyor system · Working both with and without connection to LIS (bi-directional connection) · Built-in own proprietary software allowing easy setup of sorting rules based on the barcode, tube dia & length, blood test, cap colour, and any combinations · Responding to STAT samples · Compatible with all standard tubes, and effortless introduction of new types with its software. · Archiving photos of all processed tubes · Connection to TT Smartline for accepting & transport

Sample Processing Sample Processing Sarstedt – Bulk Sorter BL 1200 Sample Processing Sarstedt – Sample Distribution System PVS 1625 Sample Processing Sarstedt – Sorter DC/RC 900 Flex 8 LABBook 2022 / 2023 Highlights: · Ideal in combination with any analytical platform · Sample throughput up to 1,200 tubes / h · Process any tube type of 80 to 110 mm length (with cap) and 11 to 16 mm diameter, including false bottom options · Suited for any sample type (serum / plasma, serum gel / plasma gel, EDTA, citrate, blood sugar, urine) · Intelligent re-routing when waiting for lab order · Automatic sample accessioning · Customised sort rules to a variety of carrier types or bins System range: · BL 1200 – Bulk to Rack · HCTS2000 MK2 – Bulk to Box · Sort Connect – Bulk to Track Highlights: The PVS 1625 is a tailor made automation system for pre- and post-analytical processing of samples. It is capable to handle most kind of rack and tray types. As an open system, it is complementary to any analytical platform or can be used independently. Full function pre- and post-analytical system · Modular configuration according to laboratory needs with: Loading platform / ID Module / Decapper / Recapper / Aliquoter / Sorter · For all common tube types: 13 – 16 mm diameter, 65 – 100 mm length (without cap) · Aliquoter for secondary tubes or multi-wells available Highlights: Pre- and post-analytics in one system: · Processes any tube diameter from 11 to 16 mm · Sample throughput up to 900 tubes / h · Compatible with most racks or carrier types · Online or offline operation · Opens tubes with push caps, stoppers and screw caps · Can be customised to sort by tube type, material (barcode) or test request · Closes tubes with universal archiving caps · Retrofitting of decapping or recapping module is possible · Recapping with screw caps for Sarstedt tubes with 13 or 15 mm diameter

Automation Beckman Coulter installs the world’s 100th DxA Automation System at Savona Hospital Automation reimagines laboratory diagnostics service San Paolo Hospital in Savona, Italy, has upgraded its Corelab-related analytical equipment. In collaboration with Beckman Coulter, the San Paolo diagnostic laboratory has installed Beckman Coulter’s DxA 5000 Laboratory Automation System, an innovative, high-throughput automation system that rapidly increases test processing. This latest installation of Beckman Coulter’s DxA Automation System marks the 100th installation worldwide and the first in Liguria region of Italy. It will reduce manual processes, ensure consistent and rapid turnaround time, and correct pre-analyt- ical treatment errors to help deliver a higher quality of each diagnostic test result. 10 LABBook 2022 / 2023 DxA 5000 total laboratory automation system

Automation Automation Beckman Coulter – DxA 5000 Sample throughput: up to 1,200 tubes / h Highlights: The DxA 5000 helps laboratories meet the challenges of today’s highly focused healthcare environment through a collection of patented innovations that deliver rapid and consistent turnaround time, provide a new level of comprehensive pre-analytical sample quality detection, and reduce the number of manual processing steps to significantly improve laboratory efficiency. Leveraging first-of-its-kind dynamic system software, the DxA 5000 utilizes Intelligent Routing to bring automated patient-centric workflow to the laboratory. By understanding the tests requested, sample volume available and real-time analyzer capacity and status, the DxA 5000 continuously calculates the most expeditious route for every patient sample — both STAT and routine. The DxA 5000 enhances Beckman Coulter’s comprehensive port- folio of scalable solutions, and is a key component of its vision to bring workflow automation to laboratories of all sizes. Automation Beckman Coulter – DxA 5000 Fit Sample throughput: up to 375 tubes / h Highlights: At a time when up to 75 percent of lab errors take place pre- analytically, laboratories can benefit from comprehen- sive workflow automation. For this reason, Beckman Coulter developed the DxA 5000 Fit, an automation system that offers an improved approach to laboratory workflow by making intelligent automation accessible to labs of virtually any size. The DxA 5000 Fit leverages DxA 5000 technology, providing the benefit of intelligent automation to midsize labs in a compact footprint. Automation MolGen – PurePrep TTR Dimensions: Sample throughput: 1700 × 2030 × 1070 mm (d × w × h) 320 Highlights: The PurePrep TTR is a high throughput, fully automated liquid handling device able to transfer samples accurately and consistently from tubes to 96 wells Deep Well microtiter plates at up to 320 samples per hour. Optimized for processing PurePrep TL+ samples, it decreases hands on time in large scale labs due to automated decapping and capping tubes and pipetting samples from tube to plate. It reduces contamination risks as the whole process is done in a closed cabinet. Sensors ensure safe and accurate processing while barcodes offer full track-and-trace of samples and plate positions throughout the workflow. 12 LABBook 2022 / 2023

Automation Automation Siemens Healthineers – Atellica Integrated Automation Automation Sysmex Corporation – CN Track Sample Logistics Sarstedt – Tempus600 Vita 14 LABBook 2022 / 2023 Highlights: Atellica Integrated Automation provides integrated automation in 6 m2. By integrating automation into Atellica Solution* chemistry and immunoassay analyzers with little or no additional footprint, labs can automate several tasks associated with chemistry and immunoassay testing. The system provides intelligent software, decapping, and independent control over samples with the system’s revolutionary sample management, including management of samples throughout all phases of testing – from sorting through archiving. *Product availability varies by country. Sample throughput: up to 1,000 samples / h Highlights: · Automate haemostasis work area by connecting up to three CN-Series or CS-5100 analysers to a track system · Workflow automation covers sample handling, measurement and rerun · Cap-piercing capability for extra safety, or process open tubes · Modular and scalable configuration set-up allows for space- saving and adaptation to workflow needs · Smart workflow supported by software solutions Extended IPU and Caresphere(TM) · Cost-effective island solution requiring only a moderate investment · Connectable to third-party TLA systems Highlights: The Tempus600 Vita provides dedicated, direct and fast transport of blood samples to the laboratory without batching or manual pack- aging steps. The samples are placed in the insertion point of the Vita, transported via a pipeline ø 25 mm and landed in the laboratory within seconds. Drastically reducing the total turnaround time for blood sample testing results in faster diagnosis and patient treatment. · Handles up to 810 sample tubes / hour · Compatible with all sample tubes: length 80 – 110 mm, diameter 12 – 18 mm · Connectable to all lab automation, sorters and bulk loaders

Chemistry & Immunochemistry Clinical Chemistry Immunochemistry Immunoassays Integrated Systems Mass Spectrometry Electrophoresis / Chromatography Plasma Protein Testing Drug Testing Urine Screening Urine Microbiology Rapid Testing CSF and Alzheimer’s Disease Diagnostics Research Use Only

Predicting Covid-19 Predicting Co Predicting Covid-19 infection sev infection severity infection severity Report: Mark Nicholls Using mass spectrometry and chromatography techniques, UK researchers have developed an approach to predict infection severity among Covid-19 patients, as well as potential outcomes. Diagnosis of Covid-19 is normally based on the qualitative detection of viral nucleic acid sequences. Although metabolic profiles are well suited to capture host state, many of the early metabolomics studies suffered from methodical weaknesses, stated doctoral researcher Ivayla Roberts from the Institute of Systems, Molecular and Integrative Biology in the Centre for Metabolomics Research at the University of Liverpool. She said that many of the early metabolomics studies were either underpowered, measured only a restricted subset of metabolites, compared infected individuals against uninfected control cohorts that are not suitably matched, or did not provide a compact pre- dictive model. Roberts outlined how the study team had created a well-powered study focused on ‘untargeted metabolomics of Covid-19 patient serum’ and validated their findings in a separate blind study on an additional 90 patients. Metabolomic profiling High resolution untargeted LC-MS (liquid chromatography-mass spectrometry) analysis was performed on patient serum using both positive and negative ionisation modes. A subset of 20 intermediary metabolites predictive of severity and outcome were selected based on univariate statistical significance and a multiple predictor Bayesian logistic regression model. The predictors were selected for their relevant biological function and include deoxycytidine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) among others. The study was launched in 2020 in the earlier stages of the coronavirus pandemic. Roberts said: ‘Our aim was to explore how metabolomic profiles can predict disease severity and outcome in infection. The demographic reflects known trends in Covid-19 infection with cases predominant in males and poor outcomes more likely in the elderly.’ Delegates heard that 74% of patients 18 LABBook 2022 / 2023 i h h S u y n e Y / k c o t s r e t t u h S involved in the trial were eventually discharged. The expert explained that the trial started with 9,000 compounds and looked at ways of reducing the number of predictors, initially down to 900, and then down to 20 compounds, with a known biological function. Inflammatory process Roberts reported that some of these markers were found to be predictive of the inflammatory process in patients. She said pyrimidine metabolism changes in severe cases and poor outcome was likely to be an indicator of higher viral replication activity, while fatty acid beta oxidation indicates energy metabolism differences and are in higher levels in more severe cases of Covid- 19 in patients and those with poor outcome. Another finding of the study was that the tryptophan/kynurenine degradation was a sign of host immune response. With untargeted metabolomics of Covid-19 patient serum revealing potential prognostic markers of both severity and outcome, the research- ers believe that following the findings of the study that prognos- tic tests based on the markers could help lead to improvement in the planning of Covid-19 patient treatment. PROFILE Ivayla Roberts is doctoral researcher at the Institute of Systems, Molec- ular and Integrative Biology in the Centre for Metabolomics Research at the University of Liverpool. Originally with a computer science background, she transitioned to molecular biology research. Her research interests are metabolomics, mass spectrometry and the application of statistical and machine learning computational approaches to metabolomics. Her PhD is focused on metabolomics in Covid-19.

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry Beckman Coulter – HbA1c Advanced Beckman Coulter – Psychiatry Antipsychotic Assays Highlights: The fully automated HbA1c Advanced assay enables mid- to high-volume laboratories to provide physicians with state-of-the-art precision and accuracy for diagnosing diabetes mellitus, monitoring long-term glucose control in individuals with diabetes mellitus and identifying pa- tients who may be at risk of developing diabetes mellitus. · National Glycohemoglobin Standardization Program (NGSP) certifi ed/DCCT standardized and precise, providing clinically relevant results for diagnosing and monitoring diabetes · Unaffected by common hemoglobin variants, mini- mizing misdiagnosis or missed diagnosis for patients with these blood conditions · Easy to implement and integrate into the laboratory’s existing chemistry testing practices, providing work- fl ow effi ciency · Available in a single all-in-one kit for Beckman Coulter DxC 700 AU analyzers Assays: Clozapine, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Paliperidone Highlights: Antipsychotic drug monitoring provides healthcare professionals accurate and vital information. Testing of antipsychotic drugs can help manage patient therapy by providing greater clarity on the causes of treatment failure (i.e., adherence, drug resistance, drug- drug interactions and drug metabolism) and may help to establish the right medication at the right dose more quickly. Liquid, ready-to-use reagents for immediate and easy use to provide faster, actionable insights across the care continuum for patients with serious mental illness Psychiatry antipsychotic assays integrate seamlessly into established workfl ows with no special training required and can be performed on any of Beckman Coulter’s Clinical Chemistry AU and DxC/AU systems. Clinical Chemistry ELITechGroup – Selectra Mach5 Clinical Chemistry ELITechGroup – Selectra ProM Dimensions: Weight: Sample throughput: 1050 × 650 × 700 mm (w × h × d) 110 kg 250-500 tests/hour (workfl ow dependent) Dimensions: Weight: Sample throughput: Assays: Selectra Reagents Line; Anaemia, Cardiac, Diabetes, General Chemistry, Specifi c Proteins, Special Chemistry Assays: 1220 × 750 × 610 mm (w × h × d) 95 kg Typically 180 tests/hour; Up to 266 ISE tests/hour (optional ISE) Selectra Reagents Line; Anaemia, Cardiac, Diabetes, General Chemistry, Specifi c Proteins, Special Chemistry Highlights: · Economical fully automated benchtop solution · Effi ciency through consolidation of routine and special Highlights: testing · Up to 65 barcode readable reagent positions · Accessible sample area with 85 primary tube positions; 65 barcode readable · Sustainability through optimized water consumption, LED-based photometric cartridges and reusable cuvette rotor · Broad reagent menu and state-of-the-art analytical quality with Selectra Reagents · A fully automated integrated chemistry solution · Effective use of consumables to reduce operational cost · Reusable economical cuvette rotor with washer and optical systems · 62 sample positions; 50 barcode readable for positive sample identifi cation · 32 cooled reagent positions for extended onboard stability · A smart choice when growing into a midsized laboratory · Board menu and state-of-the-art analytical quality with Selectra Reagents 20 LABBook 2022 / 2023

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry Fujifi lm Wako – Autokit Total Ketone Bodies Assay Greiner – Vacuette CAT Serum Fast Tube Assays: Quantitative determination of total ketone bodies [acetoacetate (AcAc) + 3-hydroxy- butyrate (3-HB)] in serum or plasma Highlights: · Enzymatic colorimetric test, applicable to clinical properties of serum Highlights: · Tube combines the speed of a plasma tube with the chemistry analyzers · Recognition of pediatric metabolic disorders · Monitoring of liver transplants · Monitoring of diabetic patients · Reliable results without interference from ascorbic acid and bilirubin · Shorter preanalytical process · Full coagulation in just 5 minutes · Improved turnaround time · Blood collection can be performed shortly before transport of the blood samples · Quicker lab results with on-site analysis Clinical Chemistry Clinical Chemistry Mindray – BS-240Pro Clinical Chemistry Analyzer Mindray – BS-430 Clinical Chemistry Analyzer Dimensions: Weight: Sample throughput: 860 × 550 × 660 mm (w × h × d) 115 kg Constant 240 tests / h, up to 400 tests / h with ISE Highlights: · Constant throughput with 240 photometric tests / h, up to 400 tests / h with ISE module Dimensions: Sample throughput: 1050 × 1150 × 720 mm (w × h × d) Constant 420 tests / h, up to 625 tests / h with ISE · Large and fl exible capacity: up to 100 sample / reagent Highlights: · Large loading capacity: positions (50 fi xed + 50 interchangeable) · Reduced reagent consumption: 100 μl minimum reaction volume · Intelligent probe with liquid level detection, V&H collision detection, inventory monitoring, reagent pre-heating and optional clog detection · Grating photometer with 12 wavelengths, dual-diaphragm and dual-lens · HbA1c smart-sampling function, automatic hemolysis 92 reagent positions, 102 sample positions · Whole blood HbA1c: supports HbA1c onboard hemolysis · Advanced software platform: auto QC, auto refl ex, substrate depletion & enzyme linearity extension, etc. · Quick start-up time: 5 minutes system initialization, 1 minute system wake-up · Low reagent consumption: minimal 100μl reaction volume 22 LABBook 2022 / 2023

Chemistry & Immunochemistry Clinical Chemistry Clinical Chemistry Sarstedt – S-Monovette GlucoExact Sarstedt – S-Monovette Lithium Heparin Gel+ Highlights: · The S-Monovette GlucoExact stands for precise Highlights: · Laboratory results influence therapy decisions by determination of glucose and stabilizes the glucose concentration immediately for up to 96 hours at room temperature. · It meets the Gestational Diabetes Guidelines of the German Diabetes Association (DDG) and the German National Disease Management Guidelines (NVL) for type 2 diabetes. · Gold standard for glucose determination. 70 to 85 percent. For both the doctor and the patient, it is important that laboratory results are incorporated into therapy decisions quickly and without compromise. · The S-Monovette Lithium Heparin Gel+ guarantees reliable sample quality at a reduced TAT: The centri- fugation time is reduced by up to 50 percent which enables faster therapy decisions. Also the equipment utilization is optimized at an improved workflow. Clinical Chemistry Clinical Chemistry Sarstedt – S-Monovette – Venous Blood Collection Sarstedt – Microvette – Capillary Blood Collection Highlights: · S-Monovette – the Revolution in blood collection. A blood collection system that combines two blood collection techniques – the aspiration technique and the vacuum technique. · The S-Monovette is suitable for all vein conditions and achieves an optimal sample quality, thereby producing the best results. · The aspiration technique is a gentle technique for routine blood collection. Using the vacuum technique, a “fresh” vacuum is always available. · Suitable for all ages, from young to old, the S-Monovette is as individual as your patients. Highlights: · Flexible capillary blood collection systems such as the Microvette – tailor-made to the individual needs of each patient group. · Different patient groups and collection techniques require different collection systems. · With a nominal volume range from 100 – 500 µl, the capillary blood collection systems product range is one of the most extensive in the entire market. · Depending on the requirements, our portfolio in- cludes Microvettes with conical or round bottom inner tubes and the option for various different collection techniques, end-to-end or with a collection rim. 24 LABBook 2022 / 2023

Chemistry & Immunochemistry Immunoassays Immunoassays Beckman Coulter – UniCel DxI 800 Access Immunoassay System DRG Instruments – DxDATA Dimensions: Weight: Sample throughput: Assays: 1700 × 1710 × 970 mm (h × w × d) 630 kg up to 400 tests / h > 50 preprogrammed, bar-coded immunoassay methods Highlights: The UniCel DxI 800 includes proven chemiluminescent technology and one of the highest throughput systems available on the market. High volume labs can decrease process steps and improve turnaround time by simplifying and automating immunoassay testing to a single platform. · Beckman Coulter’s immunoassay instruments have common software interfaces and consumables across the whole family, enabling operators to train more quickly, minimize inventory, and ensure consistency in results across platforms Dimensions: Weight: Number of Channels: 610 × 410 × 520 mm (h × w × d) 35 kg 8 Highlights: DxDATA is an automated chemiluminescence enzyme- linked immunosorbent assay (CLIA) and magnetic particle separation Analyzing System that uses indirect chemiluminescence based on a chemiluminescent substrate (APS-5) and alkaline phosphatase for quali- tative or quantitative testing. It offers a wide range of applications, and it can aid the detection of analytes in human serum, plasma, and whole blood samples for a variety of diseases, Iike TBI (Traumatic Brain Injury), COVID-19, Cytokine Storm, Infl ammation, Cardiovas- cular & Cerebrovascular Disease, Diabetes, and many more. Immunoassays Immunoassays Beckman Coulter – Access High Sensitivity Troponin I (hsTnI) Fujifi lm Wako – Autokit CH50 Assay Highlights: The Access hsTnI assay provides the advanced diagnostic capabilities necessary to aid physicians in diagnosing at risk patients for acute myocardial infarction earlier and discharging non-acute patients faster. In comparison to standard troponin assays, high-sensi- tivity assays demonstrate signifi cantly improved preci- sion at and below the 99th percentile upper reference limit (URL), allowing better discrimination of small differ- ences in troponin values between serial measurements. · Aids in rapid diagnosis of AMI and confi dently excludes AMI in as little as one hour after patient presentation · Provides optimal precision at concentrations about 10x lower than previous generation troponin assays. Improved precision at the clinical cutoff reduces chance of misclassifying patients in the Emergency Department 26 LABBook 2022 / 2023 Assays: Quantitative determination of total complement activity (CH50) in human serum Highlights: · In vitro diagnostic homogeneous liposome immunoassay · Applicable to automated analyzers · Precise and accurate · Stable, extended calibration stability · Good correlation with Mayer’s hemolytic method

Chemistry & Immunochemistry Integrated Systems Integrated Systems Mindray – M1000 Chemistry and Immunoassay Integrated System Mindray – SAL 6000 Modular System Dimension: Throughput: CC: 2450 × 1150 × 1300 mm (w ×h × d) IM: 2305 × 1150 × 1180 mm (w × h × d) CC: 2,000 tests/h, up to 24,00 tests/h with ISE IM: up to 500 tests/h Number of Parallel Tests: CC: up to 69 tests IM: up to 36 tests Highlights: M1000 is a chemistry and immunoassay integrated system for large laboratories, with high effi ciency and accuracy. It supports up to 600 samples continuous loading at one time, and creative sample auto de-capping function. It adopts innovative technologies like 360-degree sample barcode scanning, PDR optical platform, HIL.L SI solution, timely environment pressure and CO2 monitoring, VU-Mix and FS-sampling, whole blood HbA1c with auto sample increment tests, delivering high effi ciency and reliable patient reports in a short TAT. Sample throughput: No of channels: Assays: Chemistry up to 1,200 t ests / h (including ISE), Immunology up to 240 tests / h 68 (Chemistry) / 36 (Immunology) 132 Highlights: The SAL 6000 is a high performance chemistry and immu- nology integrated system, combining BS-800 chemistry analyzer, CL-2000i immunology analyzer and the SPL 1000 sample process line. The system offers a large capacity of 300 samples with continuous loading by racks. It supports onboard sample pretreatment for HbA1c testing. Integrated Systems Integrated Systems Mindray – SAL 9000 Modular System Siemens Healthineers – Atellica Solution Sample throughput: No of channels: Assays: Chemistry up to 2,200 tests / h (including ISE), Immunology up to 480 tests / h 67 (Chemistry) / 36 (Immunology) 132 Highlights: Highlights: The SAL 9000 is a high performance chemistry and immu- nology integrated system, combining BS-2000 chemistry analyzer, CL-6000i immunology analyzer and the SPL 1000 sample process line. The system offers a large capacity of 300 sample positions and supports non-stop continuous sample loading. It offers a large capacity of 600 samples with continuous sample loading by racks, dedicated STAT channel, and sample tray direct loading and offl oading. Seamlessly integrating immunoassay and clinical chemistry analysis— Atellica Solution analyzers allow for over 300 customizable confi gurations for unmatched fl exibility, independent control over every specimen, including STAT and precious samples, inte- grated automation (Atellica Integrated Automation) of manual tasks (e.g. decapping), and a redesigned user interface that’s as intuitive and easy to use as a smartphone. Experience workfl ow excellence combined with data-driven insights to enhance overall clinical value – in just 6m2 . Product availability will vary by country. 30 LABBook 2022 / 2023

Chemistry & Immunochemistry Mass Spectrometry Mass Spectrometry Shimadzu – LCMS-8060 CL (IVD) / LCMS-8060 (RUO) Shimadzu – LCMS-8050 CL (IVD) / LCMS-8050 (RUO) Dimensions: Weight: 1180 × 540 × 610 mm (w × d × h) 140 kg Dimensions: Weight: 1180 × 540 × 610 mm (w × d × h) 140 kg Highlights: Highlights: The LCMS-8060 CL delivers the highest sensitivity and fastest analysis speed of any LCMS on the market today. A newly developed UF-Qarray boosts ion intensity but suppresses noise. By improving the ion sampling device, the ion guide, and vacuum efficiency, Shimadzu has achieved an unprecedented sensitivity in quantitative analysis by LC / MS / MS while keeping high robustness for daily analysis. Triple Quadrupole Mass Spectrometry is the method of choice for quantification of trace-level analytes in complex samples for a variety of applications including clinical research, forensic, toxicology, pharmacokinetics. Combined with our world-leading UHPLC systems, and maintaining Shimadzu’s proprietary ultrafast technologies (UFMS), which include high-speed MRM transitions, MS / MS acquisition, and ultra-high speed polarity switching, the LCMS-8050 can dramatically improve analytical throughput. Mass Spectrometry Mass Spectrometry Shimadzu – LCMS-8045 CL (IVD) / LCMS-8045 (RUO) Shimadzu – nSMOL Antibody BA Kit Assays: 100 Dimensions: Weight: 1180 × 540 × 610 mm (w × d × h) 140 kg Highlights: Highlights: The LCMS-8045 offers the proven high sensitivity, high speed and robustness of Shimadzu’s UFMS series to provide highly reliable data for applications that demand the sensitivity and speed of a mass spectro- meter, such as for simultaneous analysis used in the clinical research field. Due to the heated-ESI probe and UFsweeper II collision cell, it offers the highest sensitivity in the middle-range class (UFsensitivity). nSMOL is a proprietary, innovative technique from Shimadzu, enabling selective proteolysis of the Fab region of monoclonal antibodies. The nSMOL Antibody BA Kit is a ready-to-use reagent kit for collecting monoclonal antibodies from blood or other biological samples using immunoglobulin collection resin, and then performing selective proteolysis of the Fab region of these antibodies via FG beads Trypsin DART. Fab-derived peptide fragments produced by limited digestion can then be quantified via LC-MS / MS. 32 LABBook 2022 / 2023

Chemistry & Immunochemistry Urine Screening Urine Microbiology Sarstedt – Urine V-Monovette, Monovette, tubes & containers Greiner – Vacuette Urine CCM Tube Sarstedt NFT Urine collection system The fi rst enclosed urine collection system from Sarstedt for hygienic and needle-free sample collection (NFT = Needle Free Transfer). Highlights: Highlights: · A needle is no longer needed – the Urine-Monovette easily pierces the innovative NFT membrane for closed urine transfer · No risk of needlestick injury · No sharps container needed to dispose of the NFT products · Available as Urine Cup NFT and 3-litre Urine Container NFT · For use in microbiology testing · Stabilizes sample for up to 48 hours at room temperature · Easily soluble powder additive · Immediate stabilization of sample after gentle mixing Rapid Testing CSF and Alzheimer’s Disease Diagnostics Sarstedt – Blood gas Monovette and capillaries Sarstedt – CSF false-bottom tube Highlights: · Excellent recovery thanks to low-binding properties · Routine-use primary container for sample collection and automated analytics · Patient-friendly sample volume of 2.5 ml · Cost-effective alternative to PET scan · Reliable pre-analytics for optimum sample integrity The new CSF false-bottom tube (art. no.: 63.614.625) meets the require- ments for reliable pre-analytics in Alzheimer’s disease diagnostics. The tube combines optimum low binding properties with standardized 75 × 13 mm dimensions for ideal handling and processing of this very special sample material. Thanks to the special low binding property, the high-quality material prevents the binding of Alzheimer’s disease biomarkers and allows for maximum recovery in the sample material for reliable dementia diagnostics. The CSF false-bottom tube is recommended as standard in the pre- analytical consensus protocol and has already been validated for the new immunoassay generation from Roche. Highlights: · Blood gas collection systems for arterial, venous and capillary sampling with the smallest sample volumes and Ca2+ balanced heparin. · The Ca2+ balanced heparin in spray-dosed droplet form enables rapid and optimal mixing of blood and anticoagulants. The Blood gas Monovette is available in 1 and 2 ml options and has been designed for venous and arterial blood collection. The blood gas capillaries offer a nominal volume range of 100 – 175 µl. 34 LABBook 2022 / 2023

Chemistry & Immunochemistry Research Use Only Shimadzu – MALDImini-1 Dimensions: Weight: 309 × 385 × 320 mm (w × d × h) 25 kg Highlights: With its simple configuration and compact size, it is possible to install the MALDImini-1 in places where mass analysis devices could not previously be used. Through ingenious engineering and innovation its footprint has been reduced to the size of a piece of paper. The MALDImini-1, with ist MS3 capabilities, can be used in research facilities, educational organizations and private structures involved in biomedical science or which carry out research on the structure of glycans. Integrated solution management for your laboratory dr. neumann kindler & www.labcore.de 36 LABBook 2022 / 2023

Hematology Blood Cell Counter Beckman Coulter – DxH 690T Dimensions: 755.7 × 1740 × 828 mm (w × h × d) Weight: 254 kg Sample throughput: up to 100 samples / h Power consumption: 520 W* Blood Cell Counter Beckman Coulter – Early Sepsis Indicator Highlights: The DxH 690T offers all the benefi ts of Beckman Coulter’s fl agship DxH 900 hematology analyzer to mid-size labs, including an industry leading 93 % fi rst pass yield and the Early Sepsis Indicator. The only FDA-cleared hematology biomarker for sepsis, the ESId measures monocyte distribution width to support early detection of life-threatening sepsis for patients in the ED. · Automate QC processes to complete tasks with 75 % fewer steps, and 40 % faster software response time, than previous generation mid-volume hematology analyzers · Apply extensive sample-specifi c rule-writing capabili- ties to automate analysis and standardize SOP sample handling – without the need for middleware Highlights: A fi rst-of-its-kind, hematology-based cellular biomarker, the FDA cleared Early Sepsis Indicator is designed to help emergency department physicians identify patients with sepsis or at risk of developing sepsis within 12 hours of ED presentation. · Results are automatically reported as part of a routine complete blood count (CBC) with differential for adult emergency department patients · Combined with clinical signs and symptoms and WBC results, the Early Sepsis Indicator can inform critical decision making in adults in the emergency care setting Blood Cell Counter Greiner – Vacuette EDTA Tube Blood Cell Counter Mindray – BC-700 Series Hematology Analyzers with ESR Highlights: · Vacuette K2E K2EDTA tubes and K3E K3EDTA tubes are used for testing whole blood in haematology. · Evacuated tubes for a clearly defi ned quantity of blood sample material · Nominal volume between 2 and 9 ml according to the application · Made out of virtually unbreakable PET plastic · Selected tubes are available as premium tubes with screw thread for a safe sample transfer and easy opening. Several premium tubes can also be ordered with transparent labels. · The colour coded caps fi t the international standard according to ISO 6710. 38 LABBook 2022 / 2023 Sample throughput: CD (CBC + DIFF): 80 t/h CD + ESR: 40 t/h Highlights: · Revolutionary hematology analyzers integrated with ESR measurement function. · Adopting the high-end SF-Cube 3D analysis techno- logy, delivering extraordinary performance in reliable counting and differentiation of abnormal samples. · The innovative parameter – optical PLT-H in every CBC & DIFF test, delivering reliable platelet counts event with interference.

Hematology Blood Cell Counter Blood Cell Counter Sarstedt – S-Monovette ThromboExact – Pseudothrombocytopenia Sarstedt – Microvette APT – for routine capillary blood analysis Highlights: The S-Monovette ThromboExact has been developed especially for anticoagulant-induced pseudothrombo- cytopenia. Generally, pseudothrom bocytopenia is caused by thrombocyte aggregation. Early detection avoids the consequences of a thrombo- cytopenia misdiagnosis. This blood collection tube is validated internally by Sarstedt and externally at the Universiy Hospital Rostock, Germany. Highlights: · Capillary blood collection system specially developed for automated processing in blood count analysis systems · Greater flexibility thanks to two collection techniques – precise filling volume with end-to-end capillary (250 µl) and entire collection rim (250 – 500 µl) for optimum mixing with a K2 EDTA preparation · Meets all the important processing requirements for a primary container and has a leak-proof cap with pierce- able membrane for save transportation and shipping · Improves the turn-around time in capillary blood anal- ysis and reduces the need for repeated blood collection · Available in ISO and EU colour code Blood Cell Counter Blood Cell Counter Siemens Healthineers – Advia 360, 560, and 560 AL Hematology Systems Siemens Healthineers – Advia 2120i Hematology System Dimensions: Sample throughput: Parameters: 360 × 316 × 492 mm (h × w × d) 520 × 410 × 490 mm (h × w × d) approx. 60 tests / h 22 – 26 parameters* 3- or 5-part white cell differential Highlights: The ADVIA 360, 560, and 560 AL Hematology Systems provide laboratories with intuitive, easy-to-use, and scalable hematology solutions designed to offer the right fit for every lab. Each system delivers fast, reliable, and accurate CBC and white cell differential testing with the performance and adaptability that low- and mid- volume labs need. The optional autoloader on the ADVIA 560 AL System streamlines automatic sampling for even greater workflow efficiency. *Not all parameters are available in the U.S. Dimensions: Sample throughput: Parameters: 860 × 1410 × 680 mm (h × w × d) up to 120 samples / h CBC incl. NRBC, 6-part white cell differential, reticulocytes, body fluids, and comprehen- sive morphology results Highlights: The ADVIA 2120i Hematology System with Autoslide streamlines workflow by eliminating the majority of manual steps commonly performed to maximize productivity. Its unique testing methodology optimizes results while offering the simplicity and flexibility you need for easy integration into your lab. With connec- tivity to Aptio Automation, it supports accurate, fast, sample processing with fully customizable, user- defined features. 40 LABBook 2022 / 2023

Hematology Integrated Hematology Beckman Coulter – DxH 900 Hematology Analyzer Dimensions: 755.7 × 1740 × 828 mm (w × h × d) Weight: 254 kg Sample throughput: up to 100 samples / h Power consumption: 520 W Highlights: The DxH 900 hematology analyzer is ideal for mid- to high-volume clinical laboratories performing complete blood count and white blood cell differential tests while minimizing repeat testing, allowing you to deliver the right results the fi rst time. Achieve superb RBC, PLT and WBC differentials through near native-state cellular characterization and precise fl agging · Optimized processes help your laboratory maximize staff time through fewer slide reviews, automated QC, and longer walkaway and system uptime · Most reportable results per square meter with indus- try-leading 93 percent fi rst-pass yield and a > 40 percent smaller footprint than competitive instruments · Exclusive Early Sepsis Indicator: a one-of-a-kind FDA cleared hematologic biomarker designed to help emer- gency department physicians identify sepsis sooner · The analyzer features a variety of workcell confi gura- tions to match laboratory workload, with a mounted user interface, onboard power computer and wireless peripherals, eliminating the need for extra hardware, such as a cart. Integrated Hematology Mindray – CAL 6000/8000 Cellular Analysis Lines Dimensions: Weight: Sample throughput: Depending on confi guration Depending on confi guration CBC+DIFF: up to 1000 samples / h SC-120: up to 240 slides / h MC-80: up to 120 slides / h Highlights: · Fully Integrated with Mindray hematology analyzers, slide maker & stainer and new digital cell morphology analyzer · For digital cell morphology · The cell images look more three-dimensional, sharper in color, · Flexible confi guration with buffer module, start / stock yard and clearer and turn module · Automatically choose the optimal mode for pre-classifi cation · Accurate results of abnormal cells with advanced detection of cells with higher effi ciency technology SF-Cube · up to 60 slides/h · Streamlined laboratory workfl ow with automatic rerun and refl ex measurement 42 LABBook 2022 / 2023

Hematology Hemostaseology Hemosteasology Siemens Healthineers – Atellica COAG 360 System* Siemens Healthineers – Sysmex CS-5100 System Sample throughput: Dimensions: Weight: Highlights: PT and APTT: 350 (simultaneous analysis) 1858 × 1042 × 1415 mm (w × h × d), without LAS connection 2156 × 1042 × 1415 mm (w × h × d), with LAS connection 600 kg (without LAS connection) 617 kg (with LAS connection) The Atellica COAG 360 System* offers high-volume specialty hemostasis labs a transformative array of capabilities to streamline and unify hemostasis testing · Five methodologies–clotting, chromogenic, immu- nologic, platelet aggregation and high-sensitivity immunoassay (LOCI) testing · Primary-tube sample-volume checks, advanced assay-specific sample quality checks for hemolysis, icterus and lipemia (HIL) interference. · Intelligent reagent and consumable management *Not available for sale in the US Dimensions: Sample throughput Weight: approx. 1280 × 1,576 × 1150 mm (h × w × d) approx. 400 simultaneous PT / APTT tests / h approx. 362 kg Highlights: The Sysmex CS-5100 System offers high-volume and multisite labs smartly designed PSI technology and automation connectivity for streamlined workflow and high-quality test results on the first run. Simultaneous, multiwavelength PSI technology helps labs to identify and manage unsuitable test specimens prior to analysis. The Sysmex CS-5100 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays). Hemosteasology Hemosteasology Siemens Healthineers – Sysmex CS-2500 System Siemens Healthineers – Sysmex CA-600 Systems Dimensions: Sample throughput Weight: approx. 685 × 1113 × 895 mm (h × w × d) approx. 180 simultaneous PT / APTT tests / h approx. 140 kg Highlights: The Sysmex CS-2500 System offers mid-volume and multisite hemostasis labs smartly designed technolo- gies for improved efficiency, exceptional accuracy, and reliable first-run results. Equipped with next-gen- eration PSI technologies, the system takes hemostasis testing to the next level. The Sysmex CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument. Dimensions: Sample throughput: Weight: approx. 490 × 566 × 490 mm (h × w × d) approx. 60 PT tests / h approx. 43 kg Highlights: The Sysmex CA-600 Systems – with the smallest foot- print in their class – are built on a history of proven reliability and provide scalable options for routine and specialty* coagulation testing. · Features clotting, chromogenic*, and immunologic* measurements with true random access · Enables critical tests to be processed at any time via STAT sample processing · Offers the most frequently requested routine and specialty tests, including INNOVANCE D-Dimer* *Sysmex CA-660 System only. 44 LABBook 2022 / 2023

Pathology Printer Histology Equipment Microscopy Information Technology Sample Collection MALDI-MS MALDI-MSI

Pathology Microscopy Information Technology Olympus – UC90 4K Microscopy Clinisys – Clinisys Anatomical Pathology Laboratory Highlights: · Up to 4K UHD image capturing · One Camera for Multiple Applications · 9-megapixel CCD camera Highlights: The 9-megapixel UC90 camera captures it all: brightfi eldimages of superior quality, and up to 4K UHD imaging. Whatever your imaging needs are, expect no less than exceptional results in image quality, sensitivity, dynamic range, and color fi delity. The UC90 offers fl uid sample navigation and focusing, making it effortless and convenient to locate regions of interest right on your screen. Excellent microscope imaging has never been as easy and versatile as with the UC90. Clinisys Anatomical Pathology Laboratory – user- friendly solution designed by pathologists for increased productivity With our anatomical pathology solution you can optimise your pathology processes, and your employees can work more effi ciently and more collaboratively. Results are available quicker and, of course, this benefi ts the patients. Our solution supports all traditional pathology processes, with user-friendly and task-oriented workfl ows – starting from order communication and registration all the way to the delivery of the results. Sample Collection Sarstedt – Digitising Pre-Analytics with S4DX System Powering modern laboratories Clinisys’ intelligent informatics solutions and expertise redefine the modern laboratory across healthcare, life sciences and public health. clinisys.com 48 LABBook 2022 / 2023 Highlights: Established pre-analytical quality monitoring · Document transport time and temperature · Monitor sample quality digitally according to ISO 15189 · Link pre-analytical data such as the time of sampling, the verifi cation of the patient and, if necessary, his or her condition to the diagnostic process Optimised work processes and reduce laboratory costs · Reduce costs in sample logistics · Automate sample receipt procedures · Minimise repeated measurements · Reduce training outlay for collection sites · Optimise customer communication Reduced pre-analytical errors · Avoid errors such as “wrong patient”, “wrong blood in tube” and “missing material”

Professional knowledge for Developers and Designers of Medical Devices – qualifi ed, practical and up-to-date! The trade journal MED engineering supports developers and designers of medical devices in their daily work. MED engineering provides important news from following topics: • medical electronics • hardware and software device components • development of endoprostheses and exoprostheses • metrology • software tools Opt now for a subscription of the trade journal MED engineering with seven issues per year plus three special issues (International version + MED engineering Market + MED engineering career) at a price of 71 Euros abroad (incl. VAT and shipping) med-eng.de

DNA . m o c k c o t S e b o d A - y l f y t t i k © The complexities of drug testing The complexities of drug testing in urine and hair in urine and hair Report: Cynthia E. Keen Urine screening tests using only immunoassays are the most common procedures used to identify drug abuse. They are inexpensive, automated, and produce rapid results. But they may produce false-positive or false-negative results, which vary based on the drug, drug class, and the assay used. Hair toxicology analysis is another form of drug testing, which unlike urine tests, enable analysis of drug use over a period of time. Hair toxicology tests complement urine tests but can be just as challenging to interpret. Mass spectrometry, specifically liquid chromatography with tandem mass spectrometry (LC-MS/MS), is a powerful tool for toxicology analysis. Although more labour intensive, more time consuming, and much more expensive that hair and urine tests, LC-MS/MS is recommended for drug confirmation testing following a positive or inconclusive immunoassay screen. It is highly complex and requires significant expertise but provides definitive results due to its superior sensitivity and specificity. As part of a scientific session on unusual toxicology at the 2022 AACC Annual Scientific Meeting in Chicago, Joe M. El-Khoury, PhD, director of the Clinical Chemistry Laboratory at Yale-New Haven Health and Associate Professor of Laboratory Medicine at Yale School of Medicine in New Haven, Connecticut, discussed the challenges of interpreting complex urine toxicology cases. ‘When in doubt, mass spec it out’ El-Khoury discussed a routine urine test ordered for a patient prescribed opioids and other medications for multiple, chronic, and complex medical problems. Her physician wanted to verify that this patient was not taking additional types of painkillers. The test results were positive for heroine, but other findings were contradictory and confusing. ‘Immunoassay screening may not produce accurate results, because antibodies used in the assays for the targeted drug may exhibit cross-reactivity toward other closely related compounds,’ said El-Khoury. ‘Patients maintained on chronic opioids are often at risk of false positives. The LC-MS/ MS test determined that the patient was only taking exactly what she’d been prescribed. When in doubt, mass spec it out.’ He noted that patients taking Suboxone, a drug widely used for treatment of patients with opioid use disorder, are high-risk, and may attempt to stimulate compliance by spiking the pill in urine to pass the screening test. Immunoassays are not specific enough to detect this sample adulteration and patients may get away with it. El-Khoury recommends that quantitative LC-MS/ MS testing be the only method used for assessing adherence in patients taking Suboxone. When concentrations of drugs in urine are high, he advised the audience to make sure to rule out pharmaceutical impurities, and to rule out enzyme inhibitors when metabolite patterns are unusual. Hair toxicology: useful, but not perfect Jacqueline Hubbard, PhD, the Laboratory Director of Three Rivers Diagnostics in Pittsburgh, Pennsylvania, gave deeper insights into hair toxicology analysis. Hair grows an average of 1 cm each month. When hair samples are segmented into sections, it is pos- sible to obtain a detailed historic profile of an individual’s drug exposure over a specified amount of time. However, the accuracy of the analysis may be impacted by ultraviolet light exposure and diffusion of sweat, which may occur at any time. Cosmetic hair treatments may strip analytes or increase environmental contamination. A person with higher melanin may show a greater accumulation of drugs compared to a person with low melanin, so this needs to be considered when testing dark hair. Hubbard explained that the Society of Hair Testing (SHT) recom- mends that hair first be segmented prior to decontamination. The Society recommends use of aqueous washes and an organic 52 LABBook 2022 / 2023

DNA Amplifi cation Sarstedt – White Multiply PCR Plates Amplification / Detection MolGen – MoaA kit Highlights: In addition to a generally improved quality, Sarstedt now offers optimized white color variants for better detection sensitivity in qPCR. In addition, we have expanded our PCR plate range with high-purity EtO-treated variants (Biosphere plus quality) as well as DNA & protein low binding variants. With our Biosphere plus variants, we offer the maximum and unsurpassed purity standard for an absolutely reliable absence of DNA or other biomol- ecules. The low binding variants are our contribution to the increasing use of PCR consumables for other applica- tions, e.g. for sample storage of smallest volumes or for preparing dilution series so that all biomolecules can be recovered from the wells. Highlights: The MolGen MoaA kit is a 1 well, sensitive multiplex RT-qPCR targeting the most common respiratory viral threats, such as Influenza A and B virus, Respiratory syncytial viruses (RSV) type A and B and SARS-CoV-2. Requiring only one PCR reaction to detect any of these highly infectious diseases, saves time and money. Utilizing PlexZyme technology for high specificity it is compatible with the ABI QuantStudio and ABI 7500 platforms and commercial magnetic bead extraction systems such as the PurePrep 96. Amplifi cation / Detection Amplifi cation / Detection Quidel – Savanna – Multiplex Real-time PCR technology Singuway – AccuRa-32 - Fast Real-Time Quantitative PCR System Dimensions: Weight: 316 × 340 × 220 mm (w × d × h) 8 kg Dimensions: 254 × 254 × 210 mm (w × d × h) – small size Sample Throughput: 32 Samples/h (4×8 wells, dual module) Test panels: RVP4 (SARS-CoV-2, Influenza A, Influenza B, RSV), RVP11*, GI Panel*, STI Panel* *New test in development Highlights: · True sample to result platform with no up-front sample or reagent preparation · One sample with multiple results · Fast turnaround time (<25 min RVP4) with test select feature – select parameters now and recall other results within 48 hours · Delivering customized rapid, molecular results · Effi cient nucleic acid isolation via magnetic beads · Room temperature storage · Low capital and disposable costs Number of Channels: 4 Highlights: The AccuRa-32 is specifically designed for rapid nucleic acid testing in applications such as clinical, food, environmental and research. It is supported by highly sensitive fluorescence measurements in real time. The instrument can test 32 samples simultaneously. Up to 4 fluorescence detection channels enable multiplex PCR. Effective reduction of “crosstalk” interference and edge effects, no ROX correction required. New optical scanning detection system Method: Magnetic Bead Suitable sample types: Whole blood, serum, plasma, nasal swab, throat swab, puncture fluid, etc. 54 LABBook 2022 / 2023

DNA Extraction MolGen – PurePrep 24D Extraction MolGen – PurePrep 96 Dimensions: Sample throughput: 700 × 500 × 470 mm (w × h × d) 24 – 144 Dimensions: Sample throughput: 650 × 530 × 700 mm (w × h × d) 96 – 576 Highlights: PurePrep 24D is a convenient bench top, open system for DNA and RNA purification that uses magnetic beads separation technology of various matrices, such as blood, cultured cells or bacteria, tissues, body fluids and plant samples and can be used in low-medium through- put settings. The PurePrep 24D leverages special sample strips for 5 or 10 ml sample volume and a separate 2 ml tube for elution and is capable of extracting 1~24 samples per run. Used in combination with our PurePrep kits, it offers an extraction protocol of 15~40 minutes per cycle depending on sample type and method. Highlights: PurePrep 96 is a user-friendly, automated DNA/RNA purification system, suitable for high throughput workflows featuring 96 wells and a wide volume range of 50 – 1000 μL. The high-speed, high-quality device uses magnetic separation technology for various matrices and has an extraction protocol of 15~40 minutes – per cycle depending on sample and method. It’s accurate temperature control system (±1°C) ensures stability purification performance while its open, multi-function design provides more methods for reagent optimization. The PurePrep 96 is compatible with MolGens extraction kits and can be used in a wide range of laboratories, such as diagnostic, agricultural, biotech and animal diagnostic- or research laboratories. Extraction Molzym – SelectNAplus Extraction Promega – Maxwell CSC Instrument Dimensions: Weight: Sample througput: 650 × 600 × 690 mm (w × h × d) 60 kg flexible: 1 to 12 samples / run Highlights: SelectNAplus is Molzym’s unique bench top instrument for the automated enrichment and isolation of bacterial & fungal DNA from complex specimens. · Walk-away pathogen DNA isolation · Human DNA depletion (MolYsis technology) for enhanced sensitivity · For body fl uids, tissue biopsies and swabs · DNA-free consumables & reagents Extracted DNA is suitable for all downstream appli- cations such as NGS-based Microbiome and Metage- nome sequencing, PCR and Real-Time PCR. For clinical routine diagnostics Molzym offers a CE IVD marked kit including the broad-range detection of bacteria and fungi. Dimensions: Weight: Sample througput: Assays: 330.2 × 299.7 × 345.2 mm (w × h × d) 11 kg up to 16 samples / 25 – 75 minutes Blood, FFPE, buffy coat, bone marrow, cells, serum, urine etc. (CE-IVD) or stool, tissue, food, and many more (RUO) Highlights: Automated DNA and RNA extraction – IVDR-compliant · Generates consistent, high-quality nucleic acid for use in downstream diagnostic amplifi cation assays · Works with multiple sample types, e.g., blood, FFPE, tissue, buccal swabs etc. (CE-IVD) or cells, saliva, food, plants and many more (RUO) · Paramagnetic particle use = no cross-contaminations · Reliable sample tracking with integrated barcode scanner · Flexible, dual-mode software with separate RUO mode for research-based DNA & RNA extractions · Designed and manufactured under cGMP 56 LABBook 2022 / 2023

DNA Sample Collection MolGen – Saliva Collector Research Use Only Sarstedt – Low DNA Binding Micro Tubes Highlights: Part of our MegaPrep workflow, the MolGen Saliva Collector is an easy-to-use device that collects saliva through a one-way tube. Locally produced, it’s available as a complete collection kit or as a stand alone product, and is CE-IVD marked. The Saliva Collector contains a transport lysis buffer, the PurePrep TL-Pro, which lysate the sample during transport and keeps the sample stable up to 6 days at 4°C post sampling. At room tem- perature, it has a 1-year shelf life and features a colour addition for safety and quality control. Highlights: As the trend towards decreasing sample volumes continues, it is increasingly important to minimize potential interaction between the analyte and tube. Our low protein and new low DNA binding micro tubes are specifically designed to meet the require- ments in protein and DNA analytics while maximizing recovery rates. 58 LABBook 2022 / 2023

Mass Spectrometry Visualisation of DNA methylation: Markers on DNA can increase or decrease certain expressions in the cell and leave a corresponding signature on the DNA. Image source: EUTOPS/Uni Innsbruck New test detects four women’s cancers from cervical screening samples What if a test analysing cervical cells from a gynaecological swab could be used to detect four different female cancers at an early stage and also predict cancer risk over a healthy woman’s lifetime? Researchers at the European Translation- al Oncology Prevention and Screening (EUTOPS) Institute in Innsbruck, Austria, are developing tests to do just that for breast, ovarian, cervical, and endometrial cancer detection. Report: Cynthia E. Keen These four cancers account for more than 50% of all cancers in women in Europe. Globally, the World Health Organization’s International Agency for Research on Cancer reports that breast cancer was the world’s leading cause of cancer incidence in 2020, with an estimated 2.3 million new cases and 685,000 deaths. It also estimated 604,000 new cases of cervical cancer, 417,000 of endometrial cancer, and 314,000 of ovarian cancer. Ovarian cancer is especially deadly because it tends to be asymptomatic until reaching an advanced stage, when the cancer has spread within the abdominal cavity or beyond. Over half of ovarian cancer patients die within fi ve years after their initial diagnosis. 60 LABBook 2022 / 2023

Microbiology Automation Automation Beckman Coulter – DxM Autoplak Automation Beckman Coulter – DxM 1096 MicroScan WalkAway system Dimensions: Weight: 1850 × 2000 × 920 mm (w × h × d) 500 kg Highlights: Robust microbiology automation in a fl exible and compact footprint Increased Productivity · Inoculate and streak up to 125 plates per hour · Load up to 120 samples in various sizes continuously with random access capability Automated Process · De-cap and re-cap multiple specimen containers · Implement plate streaking with various streaking patterns to fi t your laboratory needs Reduced Errors and Improved Effi ciency · Ensure standardized technique and improve colony isolation with automated streaking Minimize cross-contamination with loop incineration, HEPA fi ltration and one-way sample fl ow Dimensions: Weight: 977 × 939 × 863 mm (w × h × d) 186 kg Highlights: The DxM MicroScan WalkAway system uses direct MICs, providing greater confi dence in results and the broadest breadth of fi rst-time reporting. Automated ID and AST testing for a fi nal report Flexible use of different panel types · ID and MIC separately or combined as Combo-Panel · One system for automation of rapid and conventional tests · Easy-to-view external LED indicators show status at a glance · Continuous loading 96 Panels Bi-directional connectivity to LIS systems Mass Spectrometry Mass Spectrometry Shimadzu – Axima iDplus Assurance Shimadzu – Axima iDplus Confi dence Dimensions: Weight: 700 × 1920 × 850 mm (w × h × d) 330 kg, excluding data system Highlights: Axima Assurance – fl exibility and quality: The Axima Assurance is designed with the general analytical and life science laboratory in mind. Incorporating a variable repetition rate 50 Hz N2 laser, the system provides high quality and high sensitivity rapid MALDI mass spectra and is particularly suited to identifi cation in the microbiology fi eld. Positive and negative ion modes are included as standard, allowing greater fl exibility and extending the compound categories that may be analysed. Dimensions: Weight: 700 × 1920 × 850 mm (w × h × d) 330 kg, excluding data system Highlights: iDplus Confi dence – sensitivity and fl exibility: · Rapid microbial identifi cation for research use · Identifi es and classifi es strains based on phenotype characteristics · SuperSpectra reduce the incidence of false positives and ensure robustness and reproducibility · Open system allows addition of new species / entries to the database or the creation of new databases · Clustering allows molecular profi ling and tracking of change or evolution · High performance MS for large molecule analysis · MS / M 62 LABBook 2022 / 2023

POCT Blood Glucose Immunoassays Cardiology Blood Gases / Electrolytes / Metabolites / Oximetry Urinalysis Information Technology Endochrine Clinical Chemistry Other

POCT Cardiology Cardiology Siemens Healthineers – Atellica VTLi Analyzer Siemens Healthineers – Stratus CS 200 Acute Care Diagnostic System Assays: Dimensions: hs-cTnI 85 × 52 × 250 mm (w × h × d) Weight: 0.46 kg Assays: Dimensions: Troponin I, D-dimer, NT-proBNP, CKMB, hsCRP, Myoglobin, bhCG 460 × 580 × 710 mm (w × h × d) Weight: 68 kg Highlights: The Atellica VTLi Patient-side Immunoassay analyzer delivers lab-comparable, hs-cTnI results in 8 minutes on a fingerstick sample at the point of care. Leverage cardiac solutions that offer both speed and accuracy from the laboratory to the point of care. Not available for sale in the U.S. Product availability varies from country to country and is subject to local regulatory requirement. Highlights: The Stratus CS 200 Acute Care Diagnostic System delivers lab-quality results at the point of care with the speed that is needed for cardiac patients. Its broad menu of tests helps physicians to make more timely assessments, enabling rapid decision making for better patient care. Not available for sale in the U.S. Product availability varies from country to country and is subject to local regulatory requirement. Blood Gases / Electrolytes / Metabolites / Oximetry Blood Gases / Electrolytes / Metabolites / Oximetry KABE Labortechnik – Consumables for blood gas analysis KABE Labortechnik – Pipette-Adapter for Capillaries (PAC) Highlights: The best sampling system in every situation Plastic blood gas capillary: · Unbreakable plastic · Fast drawing · Crystal clear · Numerous drawing volumes and diameters available · Minimum gas permeability for oxygen and carbon dioxide · Comprehensive range of accessories Blood gas tube: · Rapid anticoagulation thanks to liquid preparation · Optimal filling with special piston geometry · Individual sterile packing Both sampling systems are prepared with balanced heparin and are ideal for blood gas and electrolyte analyses on all common blood gas systems. 66 LABBook 2022 / 2023 Highlights: Assists in the handling of capillaries and their targeted draining on POCT-analysers and test strips or into vessels · Suitable for different capillaries regarding measure- ments and preparations · Available individually or completed with capillary Handling: · Fix capillary in the PAC while using oneway gloves · The capillary is filled as usual – afterwards the thump is put gently on the upper mouth of the PAC · The (dropwise) draining is carried out by generating a slight gauge pressure with the thumb

POCT Blood Gases / Electrolytes / Metabolites / Oximetry Urinalysis Siemens Healthineers – RapidPoint 500e Blood Gas System Siemens Healthineers – Clinitek Status Connect System Parameters: Dimensions: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, tHb, CO-oximetry, Neonatal Total Bilirubin 300 × 550 × 420 mm (w × h × d) Weight: 16.55 kg Highlights: The RAPIDPoint 500e Blood Gas System features a redesigned user interface and upgraded hardware and software in a cartridge-based, no maintenance ana- lyzer. It incorporates Siemens Healthineers proprietary Integri-sense Technology to deliver confi dence with every result and elevates your blood gas solutions to a new level, allowing more time for patient care. Product availability varies by country. Assays: Dimensions: Weight: Highlights: Albumin, Bilirubin, Creatinine, Glucose, Ketone, Leukocytes, Nitrite, pH, Protein, Specifi c gravity, Urobilinogen, Albumin- to-creatinine, hCG 171 × 185 × 272 mm (w × h × d) 2.3 kg The CLINITEK Status Connect System with Auto-Checks Technology simplifi es and streamlines your daily opera- tions. This automated point-of-care urinalysis and hCG pregnancy testing solution eliminates the subjectivity of a visual read, helps improve accuracy, saves time, and allows for increased productivity. This system provides fl exible data management and connectivity through bi-directional connectivity and on-board Wi-Fi with expanded network compatibility.* * Feature not available in all countries. Urinalysis Information Technology Siemens Healthineers – Atellica 1500 Automated Urinalysis System Siemens Healthineers – POCcelerator Data Management System Sample Throughput: Assays: Dimensions: Weight: Highlights: 106 – 240 samples /h Bilirubin, Clarity, Color, Glucose, Ketone, Leukocyte esterase, Nitrite, Occult blood, pH, Protein, Specifi c gravity, Urobilinogen, Albumin, Albumin-to-creatinine ratio, Creatinine, Protein-to-creatinine ratio 1260 × 625 × 680 mm (w × h × d) 114 kg Highlights: Combining the CLINITEK Novus Analyzer and the Atellica UAS 800 Analyzer* into one completely automated unit, the Atellica 1500 Automated Urinalysis System sets the new standard for accuracy and effi ciency. It is a truly digital automated urinalysis system, and lets you manage more samples with less staff in shorter time, while never compromising on high-quality results. Not available for sale in the U.S. Product availability varies by country. 68 LABBook 2022 / 2023 Connect securely with an open, reliable POC informatics platform. Gain vendor independence and free choice in selecting the appropriate POCT device to meet your clinical requirements. Confi rm that your POC devices are online, operational, and properly maintained with immediate oversight and control. Includes data analytics, operator management, quality assurance, and eLearning integration. Create a long-term solution that saves time and money by simplifying the complexity and cost of maintaining multiple IT systems. Product availability varies by country.

POCT Other Other Sarstedt – Minivette POCT / Capillary Blood Collection Sense Biodetection – Veros Covid-19 Highlights: · Collection devices for Point-of-Care tests · Easy sample recovery · Precise and dispensing of small whole blood volumes · Prevents spillage during transfer · Volume range: 10 µl – 200 µl · Preparations: neutral, heparin and EDTA Highlights: Molecular test with lab-quality results with no instrument. Veros Covid-19 is the only fully integrated molecular diagnostic test that provides laboratory-quality molecular results in about 15 minutes, right at the point of care. · In about 15 minutes · 97.9% accuracy · Easy-to-use, single-use test Product is CE marked and available in select EU markets. Other Other Siemens – Clinitest Covid-19 Antigen Test Siemens – Clinitest Covid-19 + Influenza A/B Antigen Test Highlights: The lateral flow Clinitest Rapid Covid-19 Antigen Test, distributed by Siemens Healthineers, is so easy to use that any trained professional can administer it in virtually any setting, without special equipment, at a fraction of the cost of laboratory PCR testing. When used as part of a comprehensive strategy, the Clinitest Rapid Covid-19 Antigen Test can help communities stay ahead of the spread of Covid-19, even in the face of emerging variants. Highlights: One swab, three results—know with confidence Reliable results in 15 minutes to facilitate immediate patient treatment. When your patients present with a fever, cough, and other common respiratory symptoms, choosing the appropriate treatment requires determining the cause of their illness. The Clinitest Rapid Covid-19 + Influenza Antigen Test, distributed by Siemens Healthineers, enables you to detect and differentiate infections involving any combination of these three respiratory viruses at the point of care. 70 LABBook 2022 / 2023

Information Technology Earlier disease prediction and identification The potential of AI in routine blood testing By Dr Raj Gopalan Clinical laboratories have transformed over the years, becoming more efficient, accurate, and consistent. These advances have helped clinicians to better manage large volumes of lab test results, enabling them to more quickly identify results that require further review. The lab’s role in offering decision support to physicians, predominantly, has not expanded much beyond providing basic reference intervals and highlighting the results that fall outside of those intervals.2 The development and implementation of more nuanced clinical decision support in the laboratory remains a tremendous oppor- tunity with the potential to help identify risk of diseases sooner and ultimately support physicians in enhanced triage, advanced testing, and management of patients’ conditions. Clinical decision support (CDS) as a potential aid in patient management and triage protocols The biochemical process of any disease is a complex mechanism, and the early signs of many diseases are often evident by changes in blood parameters that occur even before the first symptoms appear. Combined changes in the parameters of commonly ordered routine blood panels may offer clues to underlying disease processes, in order to provide an opportunity for clini- cians to consider specific additional tests to confirm or rule out potential diseases. With the help of artificial intelligence (AI) and machine learning (ML) technologies, it may be possible, for example, to develop and implement algorithms that automatically compare the results of various defined analytes and aggregate that data with the patient’s age and gender (or other dimensions) to generate more advanced insight into a patient’s condition. Taking this example a step further, such an advanced algorithm could potentially generate disease-specific likelihood scores to help the clinician focus on the most probable potential diagnoses or further inform the probability of risks for specific diseases. The increasing prevalence of widespread cancers, progressive chronic diseases, and acute infections underscores the need for such models. It isn’t long ago that various countries were forced to grapple with the awful decisions of how best to triage thousands of Covid-19 patients flooding hospital EDs and ICUs in the face of inadequate supplies and limited clinical care space. It was clear that physicians and hospitals could have then benefited PROFILE Dr Raj Gopalan, Chief Medical Informatics Officer and Global Head of Clinical Decision Support, Siemens Healthineers, Diagnostics It’s widely known that more than 70% of today’s medical decisions involve the results of laboratory tests1, but the insights clinicians derive from these tests today may only be scratching the surface of their potential. Routine blood tests may also offer opportunities for earlier identification of patients at risk for complex diseases such as cancer, oth- er silent chronic diseases, acute life-threatening infections, and severe Covid-19. 72 LABBook 2022 / 2023

Information Technology LIS / Middleware / POCT LIS / Middleware / POCT Beckman Coulter – DxONE Command Central Workstation Beckman Coulter – Remisol Advance Highlights: Beckman Coulter’s DxONE Command Central remote monitoring system helps manage lab workflow and improve decision-making steps. The system can connect up to 18 instruments or automation systems, and up to five networked DxONE Command Central workstations within a single laboratory, allowing the operator to place DxONE Command Central workstations in prime laboratory locations for increased flexibility. DxONE Command Central maximizes workflow efficien- cies by providing lab technicians with a real-time view of laboratory systems from a single point of control. DxONE Command Central works with data managers such as Remisol Advance to achieve workflow efficiencies, or can serve as a stand-alone product for users to monitor automation and / or multiple analyzers and quickly respond to any instrument issues. LIS / Middleware / POCT Clinisys – Clinical Laboratory Highlights: Remisol Advance is an enterprise data management solution that can help improve sample workflow through consolidated management, drive consistency through network standardization across multiple sites, create efficiency through autoverification, and improve reli- ability by integrating quality control management. It is a unique software product that consolidates patient test information from multiple instruments in the lab or from multiple labs in the hospital network. Remisol Advance features virtualization capability to help reduce failure points and increase uptime. Highlights: Clinisys Clinical Laboratory - high efficiency, rapid communication of results, standardised workflows Our clinical laboratory solutions are high-performance laboratory information systems (LIS) that allow you to organise and automate all processes exactly as you want them: from order entry and instrument control to results reporting, invoicing and statistics. Thanks to the rich functionality of our solutions your laboratory can work more efficiently. You save costs and resources, while offering an enhanced service for requesters and patients – today and tomorrow. Integrated solution management for your laboratory dr. neumann kindler & www.labcore.de 74 LABBook 2022 / 2023

Information Technology LIS / Middleware / POCT LIS / Middleware / POCT Siemens Healthineers – Atellica Process Manager Siemens Healthineers – Atellica Data Manager Highlights: Uncover inefficiencies and optimize clinical operations with built-in analytics and business intelligence. Identify and resolve pre-analytic, analytic and post-analytic problems with advanced performance metrics. Increase productivity with centralized oversight to control systems*, view reagent levels and review exceptions from one screen. Deliver transparent, predictable TAT using rules and at-risk sample alerts. *Instruments require VNC or Remote Desktop capability. Not available on all systems. Highlights: Open, scalable, easy-to-use solution with powerful rules to standardize testing, enhance QC and streamline result management. Enhance visibility, automate process- es, autoverify results and centralize management of analyzers, automation, sites and networks to increase productivity. Reduce errors and process variation with consistent review/reporting. Sharpen clinical focus with details needed to make informed, accurate decisions. Product availability varies by country. Inventory Management Siemens Healthineers – Atellica Inventory Manager Powering modern laboratories Clinisys’ intelligent informatics solutions and expertise redefine the modern laboratory across healthcare, life sciences and public health. clinisys.com Highlights: Get the right materials at the right time — Atellica Inventory Manager* provides automated, real-time control of reagents and consumables across multiple locations to reduce costs, save time, and improve lab quality. *Product availability varies by country. 76 LABBook 2022 / 2023

Other Applications Blood Collection Blood Collection Greiner – MiniCollect Capillary Blood Collection System Greiner – Vacuette Safety Blood Collection Sets Highlights: · A gentle way to collect small blood samples for a wide range of analyses · Perfectly suited for young children, geriatric patients as Highlights: · Specially developed for blood collection from patients well as patients with fragile veins · Small quantities are sufficient to enable a variety of parameters to be tested · For delicate vein conditions, patients who often have blood samples taken, or people with severe burns · The MiniCollect® safety lancets are available with a wide range of puncture depths and blade sizes / needle gauges to ensure that the puncture wound can be kept as small as possible while achieving the targeted sample volume with difficult vein conditions · Protection from the risk of needlestick injuries · Simple activation of safety mechanism · Transparent view window provides clear vein entry indication · Particularly safe due to activation of the safety mechanism while the needle is still in the vein · More flexibility due to assorted tube lengths for blood collection · Optional use as an infusion set Blood Collection Blood Collection KABE Labortechnik – Capillary Blood Collection GK KABE Labortechnik – Primavette S and V Highlights: Capillary Blood Collection GK – for small amounts of blood The system offers special advantages for the collection of blood samples from new-borns, children, elderly people and emergency patients, thus everywhere, where only small amounts of blood are available · The test vessel is prepared on the entire inner surface. Besides it can be used as centrifugal vessel · The capillary is coated on the entire inner surface and guarantees an exact filling volume · The attached stopper, which is optionally available with an integrated elastically resealable rubber membran, offers perfect tightness · Different measurements and preparations are available Highlights: The safe and variable blood collection system · Gentle – aspiration technique suitable for all vein conditions · Safe – unbreakable, high quality plastic ensures maximum user and patient safety · Clean – the high grade rubber membrane closure guarantees absolute tightness · Flexible – vacuum technique possible · Versatile – available in different tube sizes and preparations · Comprehensive – offered with a broad range of accessories 78 LABBook 2022 / 2023

Other Applications Centrifuges Hettich – Mikro 220 | 220 R Dimensions: 330 × 420 × 313 mm (w × h × d) Weight: 21 kg / 42 kg Rotational frequency: 18,000 min-1 Relative centrifugal force: 31,514 Centrifuges Hettich – Universal 320 | 320 R Dimensions: 401 × 529 × 346 mm (w × h × d) Weight: 31 kg / 52 kg Rotational frequency: 16,000 min-1 Relative centrifugal force: 24,900 Highlights: · Compact, high-performance microlitre centrifuge · Choice of seven rotors · IvD-conform according to directive 98 / 79 / EC · Impulse key for short cycle mode · Nine program memories for more individuality · Nine individual acceleration and deceleration stages · Model 220 R coolable from –20 to +40 °C with pre-cooling function · Max. number of tubes: 60 × 2.0 ml Highlights: · The universal choice among the benchtop centrifuges · Choice of 18 rotors · IvD-conform according to directive 98 / 79 / EC · Impulse button for short centrifugation · Impulse key for short cycle mode · Nine program memories · Nine individual acceleration and ten deceleration stages · Model 320 R coolable from –20 to +40 °C with pre-cooling function · Max. number of tubes: 4 × 200 ml / 6 × 94 ml Centrifuges Sarstedt – SC 2700 Centrifuge Centrifuges Hettich – Rotina 420 | 420 R Dimensions: 506 × 650 × 423 mm (w × h × d) Weight: 75 kg / 108 kg Rotational frequency: 15,000 min-1 Relative centrifugal force: 24,400 Highlights: · Centrifugation at up to 2,700 x g with swing-out rotor · Easy operation with pre-installed programs · Variable program for individual settings is available · High quality and quiet Highlights: · High-performance with fi rst-class equipment · Choice of fi ve rotors · IvD-conform according to directive 98 / 79 / EC · Max. noise level of 51 dB(A) with rotor 4790-A · 98 program memories for more individuality · Nine individual acceleration and deceleration stages · Model 420 R coolable from –20 to +40 °C with pre-cooling function · Max. number of tubes: 4 × 600 ml The SC 2700 centrifuge has been specially designed for use in physician’s consultancies or small laboratory units and can be used with all standard samples tubes. Intuitive operation to centrifuge the most common types of sample materials at the push of a button is guaranteed by pre-set programs for blood and urine. The settings tailored to the specifi c sample materials of blood and urine make it virtually impossible to operate the centrifuge incorrectly. 80 LABBook 2022 / 2023

y r t s i m e h c o n u m m I & y r t s i m e h C ■ y r t e m o r t c e p S s s a M ■ ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ l y g o o n h c e T n o i t a m r o f n I ■ s n o i t a c i l p p A r e h t O ■ T C O P ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ A u t o m a t e d S a m p l e P r o c e s s i n g Companies & Suppliers Advanced Instruments 2 Technology Way 02062 Norwood, USA phone: +1 800-225-4034 orders@aicompanies.com www.aicompanies.com ASP Lab Automation AG Heinrich-Hertz-Straße 32 25336 Elmshorn, Germany phone: +49 4121 264 731-0 info@asplabauto.com www.asplabauto.com Beckman Coulter Diagnostics 22, Rue Juste-Olivier 1260, Nyon, Switzerland phone: +41 22 365 38 08 EUPublicRelations@beckman.com www.beckmancoulter.com Chromalytic LTD Cranleigh Road Fareham PO16 9DR phone: +49 7142 9022-0 office@chromalytic.com www.chromalytic.com Clinisys Deutschland GmbH Am Klingenweg 6 65396 Walluf, Germany phone: +49 6123 7016-222 info-de@clinisys.com www.clinisys.com DRG Instruments GmbH Frauenbergstraße 18 35039 Marburg, Germany phone: +49 6421 1700-0 drg@drg-diagnostics.de www.drg-diagnostics.de DTM Medical Mainzer Straße 131 65187 Wiesbaden, Germany phone: +49 611 92777-0 info@dtm-medical.eu dtm-medical.eu Dürr Technik GmbH & Co. KG Pleidelsheimer Straße 30 74321 Bietigheim-Bissingen, Germany phone: +49 7142 9022-0 office@duerr-technik.de www.duerr-technik.com ELITechGroup B.V. Van Rensselaerweg 4 6956 Spankeren, The Netherlands phone: +31 313 430 500 sales.ecsnl@elitechgroup.com www.elitechgroup.com 82 LABBook 2022 / 2023

y r t s i m e h c o n u m m I & y r t s i m e h C ■ y r t e m o r t c e p S s s a M ■ ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ l y g o o n h c e T n o i t a m r o f n I ■ s n o i t a c i l p p A r e h t O ■ T C O P ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ Companies & Suppliers MolGen Traverse 2 3905 Veenendaal, The Netherlands phone: +31 85 200 7431 info@molgen.com www.molgen.com Molzym GmbH & Co. KG Mary-Astell-Str. 10 28359 Bremen, Germany phone: +49 421 6961620 info@molzym.com www.molzym.com Nova Biomedical 200 Prospect Street Waltham, MA 02454-9141, USA phone: +1 781 894-0800 info@novabio.com www.novabiomedical.com Olympus Europa SE & Co. KG Amsinckstraße 63 20097 Hamburg, Germany phone: +49 40 23773-0 ScientificSolutions@olympus-europa.com www.olympus-lifescience.com Promega GmbH Gutenbergring 10 69190 Walldorf, Germany phone: +49 6227 6906-129 martin.rossmanith@promega.com www.promega.com Quidel Germany GmbH Leibnizstraße 11 70806 Kornwestheim, Germany MarketingEurope@quidel.com www.quidel.com SARSTEDT AG & Co. KG Sarstedtstraße 1 51588 Nümbrecht, Germany phone: +49 2293 305-0 info@sarstedt.com www.sarstedt.com www.tempus600.com Sense Biodetection, Ltd. 29 and 30 The Quadrant, Abingdon Science Park Abingdon, Oxfordshire phone: 0800-640-4554 customersupport@sense-bio.com www.sense-bio.com SHIMADZU Europa GmbH Albert-Hahn-Straße 6-10 47269 Duisburg, Germany phone: +49 203 7687-0 shimadzu@shimadzu.eu www.shimadzu.eu 84 LABBook 2022 / 2023

Imprint Mediengruppe Oberfranken Fachverlage GmbH & Co. KG E.-C.-Baumann-Straße 5 95326 Kulmbach, Germany Phone: +49 9221 949-311 Managing Directors Walter Schweinsberg, Bernd Müller Editor-in-Chief Markus Neumann Dr. Neumann & Kindler GmbH & Co. KG Herner Straße 324 44807 Bochum, Germany Phone: +49 234 9571969-0 info@labcore.de · www.labcore.de Production Management Sonja Buske s.buske@mgo-fachverlage.de Advertising Director Ralf Mateblowski r.mateblowski@mgo-fachverlage.de Art Director Friedrich Oertel Subscription Simone Sesselmann kundenservice@mgo-fachverlage.de Subscription rate: € 20.– plus postage Printed by mgo360 GmbH & Co. KG, Bamberg Disclaimer The information and opinions expressed in artic- les and product entries published in LABBook are solely those of the manufacturers / companies, their authors and contributors, for which the publisher holds no responsibility. All trademarks, product names, company names and logos in this publication are the property of their respective holders. Users must obtain permission from those holders before copying or using the owner’s trademarks, product and company names or logos. Errors and omissions excepted. Not all products are available in all European countries. Medical devices placed on the market in the EU must bear a CE mark. Information on their clas- sification, notified body number and authorised European representative can be obtained from the respective manufacturer. Please note that the manufacturers’ websites may contain further product disclaimers. © 2022 by Mediengruppe Oberfranken, Fachverlage GmbH & Co. KG. All rights reserved. A brand of Mediengruppe Oberfranken 86 LABBook 2022 / 2023

Notes 88 LABBook 2022 / 2023

6 7 - 0 6 9 1 - 2 2 - 1 3 . o N r e d r O Continuous innovation for a lifetime of answers · . c n I s c i t s o n g a D e r a c h t l i a e H s n e m e i S y b d e h s i l b u P Integrated, intelligent, and fully customizable solutions to enhance diagnostic potential—for every patient and clinical environment 2 2 0 2 , . c n I s c i t s o n g a D e r a c h t l i a e H s n e m e i S © · 2 2 0 2 - 8 0 At every stage of life, diagnostic medicine provides a better understanding of our health, offering deeper insight into our bodies, and helping us live the best life possible. Enhanced system integration. Advanced digitalization and automation. AI-powered intelligence. These are the promises of diagnostics’ future. And when delivered with total customization—capable of meeting the specific needs of any user in any clinical environment— vital patient information can be delivered more efficiently. Digital solutions seamlessly connect across entire networks, standardized and infused with data- driven insights to better support the ultimate mission of providing patients with the most beneficial therapies, at the best possible time. Our portfolio is continuously evolving to accelerate innovation via smarter technology, increased integration, and greater customization. Because when you expand the power of choice within industry-leading solutions— improving operational efficiency and enhancing clinical insight at every opportunity—you can push the boundaries of what’s possible in diagnostics. siemens-healthineers.com/laboratory-diagnostics