Your guide to laboratory and pathology equipment in Europe € 15.– Automation & Sample Processing Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT IT Other Applications 2020 Vol. 7 Supplement FOCUS ON CHINA Power up your haemostasis lab with the newly developed CN-6000 and CN-3000, Sysmex’s next-generation haemostasis analysers. Characterised by its small footprint, CN-Series has been designed to provide a highly powerful solution in terms of productivity, services and analytical and operational performance, delivering answers to your haemostasis testing needs.

Editorial Dear readers, Welcome to the 2020 edition of the Labbook. A very special kind of seven-year itch hit us: all of a sudden our discipline – laboratory medicine – is in the spotlight. Out there on the street, you hear people discussing the specificity of PCR analytics, weighing the pros and cons of antibody tests and elaborating on the difference between DNA and RNA. Unsurprisingly, Covid-19 is a major topic in this Labbook. In addition to the feature articles, in the product section we are presenting the entire range of analytics, from antibody test kits through to diagnostic products for severely ill and hospitalised COVID-19 patients to therapy support. Beyond current medical challenges, lab medicine’s progress continues. As in recent years, the first chapter of Labbook provides an overview of automation in the medical laboratory, covering equipment such as sorters, de-cappers and re-cappers as well as complete automation solutions. For the first time you will see endpoints of a site-to site sample distribution system. Automation has reached logistics; it takes over tasks and frees time for the treatment and care of patients. Professor Thomas Streichert from Cologne, Germany, looks at the nexus between patient safety and data security: impressively, he describes the communication with POCT users torn between quick access to data and the need to protect this data from unauthorised use and from tampering. Entering a user code plus a 16-digit password on a tiny keypad in the stressful surgery prep phase, or in an emergency setting, is not going to be a solution. The take-home message? Technology is not everything, much rather intelligent processes and common sense will lead to a solution. This insight, we are sure, will also support your every-day work. We would also like to point out another first: this year, our Special FOCUS ON CHINA showcases regional and smaller manufacturers of diagnostic products. Please take a look at their offerings because we would like to continue this focus in the future editions. As in previous years, you can access a digital version of the Labbook. You will find a database with the products, the feature articles and the e-paper version under www.healthcare-in-europe.com where you can also use the contact form to request further information. Manufacturers, authors and the editorial team – we all look forward to receiving your feedback, be it praise, criticism or suggestions what you would like to find in the next edition. Enjoy reading and browsing Daniela Zimmermann Dr Markus Neumann LABBOOK 2020 1

Automation & Sample Processing A u t o m a t e d S a m p l e P r o c e s s i n g Sample Processing Robotics Automation Sample Logistics LABBOOK 2020 3

Samplision – HENmini – Automatic blood collection tube labeler Sarstedt – Decapper DC 1200 / Recapper RC 1200 Sample Processing Dimensions: Sample throughput: No of channels: Weight: 599 × 396 × 199 mm (h × w × d) High speed over 300 tubes per hour Max. 10 inlets for different brands of tubes and sizes 15 kg Highlights: Decapper DC 1200: · Automatic decapping of all tube diameters from 11 to 16 mm · Processes a variety of tube types in mixed operation · Sample pre-sorting for the decapping process is Highlights: · Table top and mobile labeling system for blood unnecessary collection tubes with storage capacity for 140 blood collection tubes · High automation: integrated customer specific loading compartments / inlets (up to 140 tubes) · All types and sizes of blood collection tubes can be used (BD, Greiner, Sarstedt) · Immediate patient specific availability Recapper RC 1200: · Automatic recapping of all tube diameters from 13 to 16 mm · Minimises the risk of exposure · Eliminates sample contamination · Archiving cap fits most tubes from 13 to 16 mm diameter · Automated decapping enabled Sarstedt – Bulk Loader BL 1200 Sarstedt – Sample Distribution System PVS 1625 Sample throughput: Up to 1,200 tubes / h Highlights: Highlights: · Ideal in combination with any analytical platform · No sorting or handling required · Process any tube type of 80 to 110 mm length (with cap) and 11 to 16 mm diameter, including false bottom options · Suited for any sample type (serum / plasma, serum gel / plasma gel, EDTA, citrate, blood sugar, urine) · Integral ID module · Automatic sample accessioning · Customised sort rules to a variety of carrier types or bins · Safe, rapid and continous operation without error System range: · BL 1200 – Bulk to Rack · HCTS2000 MK2 – Bulk to Box The PVS 1625 is a tailor made automation system for pre- and post-analytical processing of samples. It is capable to handle any kind of rack and tray type. As an open system, it is complementary to any analytical platform or can be used independently. Loading of unracked or racked sample tubes is via the Bulk Loader Module or in racks via the loading platform, which is suitable for closed and open tubes. Full function pre- and post-analytical system · Ideal in combination with any analytical platform · Modular configuration according to customer needs with: Loading platform and / or Bulk Loader Module · ID Module / Decapper / Recapper / Aliquoter / Sorter · For all common tube types: 13 – 16 mm diameter, 65 – 100 mm length (without cap) · Compatible with most racks or carrier types LABBOOK 2020 5

Automation Beckman Coulter – DxA 5000 Dynamic inlet: Centrifuges: Decapper: Recapper: Up to 1,200 tubes / h Up to 500 tubes / h (1), Up to 1,000 tubes / h (2) Up to 1,200 tubes / h Up to 1,200 tubes / h Highlights: The DxA 5000 helps laboratories meet the challenges of today’s highly focused healthcare environment through a collection of patented innovations that deliver rapid and consistent turnaround time, provide a new level of comprehensive pre-analytical sample quality detection, and reduce the number of manual processing steps to significantly improve laboratory efficiency. Leveraging first-of-its-kind dynamic system software, the DxA 5000 utilizes Intelligent Routing to bring automated patient-centric workflow to the laboratory. By understanding the tests requested, sample volume available and real-time analyzer capacity and status, the DxA 5000 continuously calculates the most expeditious route for every patient sample — both STAT and routine. The DxA 5000 enhances Beckman Coulter’s comprehensive port- folio of scalable solutions, and is a key component of its vision to bring workflow automation to laboratories of all sizes. Horiba Medical – HELO* Solution Highlights: Horiba Medical has developed a new HELO* configu ration thanks to a new Yumizen T6000 island shape. This compact solution allows to connect analyzers (Yumizen H1500/H2500 and Yumizen SPS options) on both sides of the same track. This innovative track config- uration generates a very high result production capacity per square meter of floorspace. The HELO* Solution is therefore available in four different shapes (Linear, Angular, Workcell, Island) in order to match with many laboratory architectural constraints. *Horiba Evolutive Laboratory Organisation Improve Medical – Intelligent Blood Collection Management Solution Highlights: · Total solution for complete processes of blood collection management and sample processing · Intelligent and standardize blood collection process · Reduce errors during preanalytical phase Component: · Blood collection tube preparation system · Intelligent sorter · Multi-function blood collection table · Queuing system LABBOOK 2020 7

Sample Logistics Sarstedt – Tempus600 Vita Sarstedt – Tempus600 Quantit Sarstedt – Tempus600 Connection Module Automation Automation Highlights: The Tempus600 Vita provides dedicated, direct and fast transport of blood samples to the laboratory without batching or manual pack- aging steps. The samples are placed in the insertion point of the Vita, transported via a pipeline ø 25 mm and landed in the laboratory within seconds. Drastically reducing the total turnaround time for blood sample testing results in faster diagnosis and patient treatment. · Handles up to 810 sample tubes / hour · Compatible with all sample tubes: length 80 – 110 mm, diameter 12 – 18 mm · Connectable to all lab automation, sorters and bulk loaders Highlights: The Tempus600 Quantit provides direct and fast transport of blood samples to the laboratory without batching or manual packaging steps. The samples are placed in a drawer, transported via a pipeline ø 25 mm and landed in the laboratory within seconds. Drastically reducing the total turnaround time for blood sample testing results in faster diagnosis and patient treatment. · Sending both high volume and urgent samples · Samples are always oriented the right way by the system · Compatible with all test tubes: length 80 – 110 mm, diameter 12 – 18 mm · Connectable to all lab automation, sorters and bulk loaders Highlights: The Tempus600 Connection Module is part of an automated one-touch handling system for sample tubes. The sample tubes are delivered from the ward to the laboratory through the dedicated point- to-point system. The sample tubes are gently slowed down before landing in the automation module. From here they are automatically transferred e. g. onto a track system. · Compatible with all lab automation systems including sorters and bulk loaders · A brake module can be fitted to increase sample throughput · and failure-free tube loading. · Up to 8 connections LABBOOK 2020 9

LABBOOK 2020 11

9 1 0 2 , . c n I s c i t s o n g a D e r a c h t l i a e H s n e m e i S © • 0 0 A 4 - 1 A - 7 6 6 9 - X D 1 9 A . c n I , s c i t s o n g a D e r a c h t l i a e H s n e m e i S f o k r a m e d a r t a s i a c i l l e t A Chemistry & Immunochemistry Less work. More flow. Data-driven innovation to simplify workflows s i d n a y r t n u o c o t y r t n u o c m o r f y r a v y a m y t i l i b a l i a v a t c u d o r P . s t n e m e r i u q e r y r o t a l u g e r g n i y r a v o t t c e j b u s Atellica Diagnostics IT We make IT simple Your laboratory is under pressure to manage higher sample volumes, reduce costs, and retain staff. Atellica® Diagnostics IT is a comprehensive suite of software that puts your data to work to simplify today’s complexities and prepare your lab for tomorrow’s opportunities. Innovation to unlock performance Atellica Diagnostics IT leverages data to optimize workflows and unlock your lab’s full potential. • Easy-to-use tools that simplify tasks and increase capacity • Open and scalable design to enhance visibility and centralize management • Business analytics that unify sample, process, result, and inventory data for greater insights Proven results, proven partner We’re experts at leveraging IT to automate workflows and optimize processes. We’ve used data to drive results and support clinical decisions in labs like yours for more than 20 years. 93% reduction in testing errors.1 88% 30-minute STAT turnaround compliance.2 85% increase in patient and staff satisfaction.1 Learn how Atellica Diagnostics IT can use your data to take the work out of your workflow. siemens-healthineers.com/atellica-diagnostics-it 1. Wen D, et al. Establishment and application of an autoverification system for chemistry and immunoassay tests. 69th AACC Annual Scientific Meeting Abstracts. 2017. 2. Columbus Regional Health leverages informatics and automation efficiency. Siemens Healthcare Diagnostics Inc. 30-19-13821-01-76. 2019 May. LABBOOK 2020 13

Chemistry & Immunochemistry such as IgM and IgG specifi c assays designed to identify antibodies associated with both short-term and long-term immune responses will help us monitor and prevent the spread of the pandemic. Confi rming suspected COVID-19 cases as early as possible is critical in isolating patients to slow the spread of disease. Fighting the coronavirus pandemic drives you, and we’re in this fi ght together. Find resources for help in navigating the SARS- CoV-2 virus crisis and learn more about Beckman Coulter’s Access SARS-CoV-2 Assays at beckmancoulter.com/coronavirus. References: 1 Saplakoglu Y. Coronavirus ‘spike’ protein just mapped, leading way to vaccine. LiveScience.com. https://www.livescience.com/coronavirus-spike-protein-structure.html. February 19, 2020. [Accessed May 1, 2020] 2 Pappas S. Scientists fi gure out how new coronavirus breaks into human cells. Live Science. March 11, 2020. https://www.livescience.com/how-coronavirus-infects-cells. html. [Accessed: May 1, 2020] 3 McAndrews, K., Dowlatshahi, D., Dai, J., Becker, L., Hensel, J., Snowden, L., . . . Kalluri, R. (2020, August 14). Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications on COVID-19 immunity. Retrieved August 26, 2020, from https://doi.org/10.1172/jci.insight.142386 CONTACT Beckman Coulter, Inc. 250 S. Kramer Boulevard, Brea, CA 92822, USA phone: +1 714 993 53 21 PANEUMarketing@beckman.com www.beckmancoulter.com LABBOOK 2020 15 Though the coronavirus uses many different proteins to replicate and invade cells, the spike protein (S protein) is the major surface protein that it uses to bind to a receptor. After the spike protein binds to the human cell receptor, the viral membrane fuses with the human cell membrane, allowing the genome of the virus to enter human cells and begin infection.1 The coronavirus spike protein mediates entry into host cells by attaching to a receptor on respiratory cells called angiotensin- converting enzyme 2, or ACE2.2 Not all antibody tests are equal – some SARS-CoV-2 antibody tests on the market target the N-protein rather than the S-protein. Doing so can potentially lead to weaker neutralizing capacity. A recent study found that 12 percent more individuals exhibited neutralizing capacity with S-RBD binding antibodies than with N-protein antibodies.3 The case for separate IgM and IgG assays Common serology testing for COVID-19 can be separated into two groups: a total IgG and IgM antibody test, where the patient is administered a single test for both assays; and separate IgG and IgM antibody tests, where a patient is administered two tests at different stages in their infection timeline. The hardship with total IgG and IgM assays lies with the diffi culty distinguishing between earlier (IgM) and later (IgG) antibody responses. A positive result in the combined assay may prompt a clinician to refl ex – resulting in re-testing testing with a PCR test, IgG test, or both. As with any serology test, the use of high-quality assays is key for accuracy. It’s important to ensure the antibody test you utilize has high sensitivity, or the ability of the test to detect SARS-CoV-2 antibodies in patients who have antibodies, and high specifi city, or the ability of the test to correctly identify those who do not have antibodies. Opportunities for COVID-19 serology testing going forward Plasma, the liquid component of blood, contains vital antibodies that could boost a person’s ability to fi ght the disease. Plasma containing neutralizing antibodies may be administered to reduce symptoms, prevent death and speed recovery among the seriously ill with a specifi c infection. Plasma transfusions can be made available to patients right away, while a vaccine or new drugs could take an extended amount of time to be available. COVID-19 requires multiple analytic tools to help determine the health status of an individual. High-quality separate antibody assays,

Chemistry & Immunochemistry Genrui – GS100 Genrui – GE500 Sample throughput: Dimensions: Weight: Up to 120 tests / h 350 × 350 × 605 mm (w × h × d) 25 kg Highlights: The most integrated one among its competitors, GS100 serves its customers with considerate all-in-one solution (build-in PC, printer, easy-to-use UI), and yet it makes no compromise on the performance. By bringing easeful experience of a small automatic analyzer, it fits in various healthcare settings especially in primary care, and makes the work in these department more efficient as a further development. Sample throughput: Dimensions: Weight: Highlights: K+, Na+, Cl-, Li+, Ca2+, pH, Mg2+ 235 × 439 × 330 mm (w × h × d) Device, 230 × 125 × 245 mm (w × h × d) Auto loader 7.5 kg Device / 2.0 kg Auto loader The simplest-to-the-best one GE500 has considerate integrated solution both for its analyzer (auto-loader for sampling) and reagent (reagent pack by tests). What’s more, it offers automation and reliable perfor- mance with minimal hands-on time through its inno- vative UI. Aiming at small to medium sized labs, with its proven quality and easier operation, it leaves a pleasant impression on technicians. Not available for sale in the U.S. / Product availability varies by countries Not available for sale in the U.S. / Product availability varies by countries Greiner – Vacuette CAT Serum Fast Tube Mindray – BS-240Pro Clinical Chemistry Analyzer Highlights: · Tube combines the speed of a plasma tube with the properties of serum · Shorter preanalytical process · Full coagulation in just 5 minutes · Improved turnaround time · Blood collection can be performed shortly before transport of the blood samples · Quicker lab results with on-site analysis Sample throughput: Dimensions: Weight: Constant 240 tests / h, up to 400 tests / h with ISE 860 × 550 × 660 mm (w × h × d) 115 kg Highlights: · Constant throughput with 240 photometric tests / h, up to 400 tests / h with ISE module · Large and flexible capacity: up to 100 sample / reagent positions (50 fixed + 50 interchangeable) · Reduced reagent consumption: 100 μl minimum reaction volume · Intelligent probe with liquid level detection, V&H collision detection, inventory monitoring, reagent pre-heating and optional clog detection · Grating photometer with 12 wavelengths, dual-diaphragm and dual-lens · HbA1c smart-sampling function, automatic hemolysis LABBOOK 2020 17

Chemistry & Immunochemistry Sarstedt – S-Monovette Lithium Heparin Gel+ Sentinel – Sentifit 270 Analyzer (Sysmex) Sample throughput: Dimensions: Weight: Assays: Up to 270 samples / h 625 × 870 × 670 mm (h × w × d) 120 kg Faecal Immunochemical Testing (FIT) and Faecal Calprotectin (fCAL) Highlights: · The Sentifit 270 Analyzer is a fully automatic system dedicated to faecal testing · Continuous sample loading · Automatically detects appropriate buffer level in tube · Integrated sensor prevents blocking of the sampling needle · Automatically detects prozone and high concentration samples, which can be automatically diluted and rerun · High on-board reagent capacity for up to 1,250 tests · Refrigerated reagent positions for long storage stability · Highly stable latex reagents · Integrated barcode reader Highlights: · Laboratory results influence therapy decisions by 70 to 85 percent. For both the doctor and the patient, it is important that laboratory results are incorporated into therapy decisions quickly and without compromise. · The S-Monovette Lithium Heparin Gel+ guarantees reliable sample quality at a reduced TAT: The centri- fugation time is reduced by up to 50 percent which enables faster therapy decisions. Also the equipment utilization is optimized at an improved workflow. Immunochemistry DRG Instruments – DRG:Hybrid-XL Sarstedt – ELISA Plates / Micro test plates for immunoanalytics Sample throughput: 40 fully automated tests per run Assays: SARS-CoV-2 (RBD) Total Ab SARS-CoV-2 (RBD) IgG (quantitative) Brand New: AMH (Anti-Mullerian Hormone) Unique Stool Diagnostic Test: Pancreatic Elastase, Calprotectin Tests for Celiac Diseases: Anti-tTG, Anti-DGP More unique assays: Hepcidin-25, Salivary Cortisol, 17-OH Progesterone Dimensions: 600 × 600 × 630 mm (h × w × d) Highlights: DRG:Hybrid-XL is a fully-automated bench top analyzer with high flexibility and an intuitive user interface, that simplifies daily work. This unique technology allows the simultaneous determination of immunoassays, immu- noturbidimetry, as well as clinical chemistry tests in the same sample. Calibration is provided via barcoded master curve and a two-point re-calibration set. Calibration as well as reagent cartridges offers a long stability. Highlights: One of the analyses most commonly used is the Enzyme-Linked Immunosorbent Assay (ELISA). With this method, even the smallest concentrations of a range of substances (proteins, peptides, antibodies, hormones etc.) can be detected and quantified from complex solutions. LABBOOK 2020 19

Chemistry & Immunochemistry Immunoassays Beckman Coulter – SARS-CoV-2 Assays Beckman Coulter – Access Interleukin-6 (IL-6) Access SARS-CoV-2 IgM Highlights: Access SARS-CoV-2 IgG Highlights: The Access SARS-CoV-2 Assays are qualitative immuno- assay tests that detect IgG or IgM antibodies. Both the IgM and IgG assays can identify antibodies even in as- ymptomatic individuals can be used to provide clinicians with useful information. Access SARS-CoV-2 IgG · The test has a confirmed 100 % Positive Agreement (sensitivity) at 18 days post PCR confirmed positive test and 99.6 % Negative Agreement (specificity) Access SARS-CoV-2 IgM · The test has confirmed 98.3 % positive percent agree- ment (sensitivity) at 15-30 days post symptom onset and 99.9 % negative percent agreement (specificity) The Access Interleukin-6 (IL-6) assay is a fully automated immunoassay designed to measure the IL-6 level in serum and plasma which can be used to assist in identifying severe inflammatory response in patients with confirmed COVID-19 illness to aid in determining the risk of intu- bation with mechanical ventilation, in conjunction with clinical findings and the results of other laboratory testing. · Preliminary studies have shown that IL-6 levels are elevated in patients with severe COVID-19 and IL-6 may contribute to the severe inflammatory response, also sometimes referred to as cytokine storm.1 · Elevated levels of IL-6 may be an early indicator that a patient is at risk of cytokine storm and acute respiratory distress 2 3 1 https://www.immunology.ox.ac.uk/covid-19/literature-digest-old/the-poten- tial-role-of-il-6-in-monitoring-severe-case-of-coronavirus-disease-2019 2 https://link.springer.com/article/10.1007/s00134-020-05991-x 3 Maurizio, C at al. “Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection 4 Mehta P, McAuley DF Beckman Coulter – Prostate Health Index (phi) Beckman Coulter – Access High Sensitivity Troponin I (hsTnI) Highlights: The Prostate Health Index (phi) is a calculation that uses a combination of three blood tests to produce a “phi score”. The “phi score” provides additional information as to what elevated PSA levels might mean and the probability of finding detectable prostate cancer on biopsy. The phi results are intended to be used as an aid in determina- tion of the risk of prostate cancer from benign prostatic conditions in men 50 years of age and older with total PSA results in the ≥2 to ≤10 ng/mL, with a negative DRE findings that is not suspicious for cancer. When combined with the patients’ clinical risk factors and family history, the phi score can help determine individualized patient management decisions. Prostatic biopsy is required for diagnosis of cancer. Highlights: The Access hsTnI assay provides the advanced diagnostic capabilities necessary to aid physicians in diagnosing at risk patients for acute myocardial infarction earlier and discharging non-acute patients faster. In comparison to standard troponin assays, high-sensi- tivity assays demonstrate significantly improved preci- sion at and below the 99th percentile upper reference limit (URL), allowing better discrimination of small differ- ences in troponin values between serial measurements. · Aids in rapid diagnosis of AMI and confidently excludes AMI in as little as one hour after patient presentation · Provides optimal precision at concentrations about 10x lower than previous generation troponin assays. Improved precision at the clinical cutoff reduces chance of misclassifying patients in the Emergency Department LABBOOK 2020 21

Chemistry & Immunochemistry Fujifilm Wako – µTASWako i30 Genrui – PA120 Dimensions: Weight: Sample throughput: Assays: 520 × 550 × 600 mm (w × h × d) 71 kg 25 tests / h AFP / AFP-L3, DCP Highlights: · Electrokinetic Analyte Transport Assay (EATA) · High sensitive fluorescence detection · Assay precision less than 3% CV for AFP-L3 · Increased sensitivity of liver cancer (HCC) detection by combined use of AFP, AFP-L3 and DCP · Unique system to calculate the GALAD score (Gender, Age, AFP-L3, AFP, DCP) for outstanding p erformance regarding early HCC recognition · Improved chance of detecting HCC early during surveillance of patients at risk Highlights: Trustable at its accuracy: PA120 is an auto specific protein analyzer with high efficiency and accuracy. Based on proven nephelometry, PA120 has great performance. Also, the large touch screen, one-press operation and multi-item combinations will offer you a fast and conve- nient testing experience. Currently following tests are available: HbA1c, FDP, D-Dimer, NGAL, RBP, ß2-MG, CYS-C, mALB, CRP, hs-CRP, SAA, IgA, IgM, IgG, IgE, C3, C4, ASO, RF, CCP, PG I, PG II More tests are in development Mindray – CL-900i Chemiluminescence Immunoassay System Mindray – CL-1000i / 1200i Chemiluminescence Immunoassay System Sample throughput: No of channels: Assays: Dimensions: Weight: Up to 180 tests / h 15 68 860 × 740 × 560 mm (w × h × d) 130 kg Sample throughput: No of channels: Assays: Dimensions: Weight: Up to 180 tests / h 25 68 1,400 × 760 × 600 mm (w × h × d) 225 kg Highlights: · High throughput up to 180 tests per hour · One of the smallest benchtop CLIA analyzer · Reagent capacity with 15 positions · Single cuvette system · Dual substrate and automatically switch the empty one · Intuitive software interface, easy access to all functions · Continuously loading of lntelligent consumables manage- ment reagents and consumables Highlights: · High throughput up to 180 tests per hour · Benchtop analyzer · Large reagent capacity with 25 positions · Sample rack system · STAT lane · Single cuvette system · Dual substrate and automatically switch the empty one LABBOOK 2020 23

Chemistry & Immunochemistry Siemens Healthineers – Dimension EXL Integrated Chemistry Systems Siemens Healthineers – Atellica Solution Sample throughput: Up to 440 photometric tests, 187 IMT tests and 167 immunoassay tests per hour Highlights: The Dimension EXL systems integrate chemistry and immunoassay testing to drive results. Simplify lab operations in any location with a compact system performing a comprehensive menu of chemistry and immunoassays. Improve workflow efficiency with the ability to load any tube, any place, any time. Gain better outcomes with fast assay times for critical results, such as High-Sensitivity Troponin I in only 10 minutes and electrolytes in < 1 minute. Product availability varies by country. Highlights: Atellica Solution: Flexible, scalable, automation-ready immunoassay and chemistry analyzers engineered to deliver control and simplicity so you can drive better outcomes. Experience the power of the Atellica Solution, featuring patented bidirectional magnetic sample transport technology, the flexibility to create over 300 customizable configurations, and a broad assay menu with proven detection technologies. Product availability will vary by country. Mass Spectrometry Shimadzu – LCMS-8060NX (RUO) Shimadzu – LCMS-8060 CL Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8060NX delivers high sensitivity and ultra fast analysis speed together with robustness and high flexibility. Developed on the base of the LCMS-8060, it incorporates a newly designed ionsource IonFocus to boost ion transfer to the masss spectrometer and increase even more the robustness of the system for complex biological matrices in daily analysis . The system perfectly suits to high sensitivity applications like steroids, catecholamines, and metabolomics studies in clinical research. Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8060 CL delivers the highest sensitivity and fastest analysis speed of any LCMS on the market today. A newly developed UF-Qarray boosts ion intensity but suppresses noise. By improving the ion sampling device, the ion guide, and vacuum efficiency, Shimadzu has achieved an unprecedented sensitivity in quantitative analysis by LC / MS / MS while keeping high robustness for daily analysis. LABBOOK 2020 25

Chemistry & Immunochemistry Plasma Protein Testing Siemens Healthineers – BN II System Siemens Healthineers – Atellica NEPH 630 System Sample throughput: Effective: Approx. 130 tests / h Sample throughput: Effective: Approx. 65 tests / h Assays: Weight: Highlights: depending on the assay mix Nominal: 225 tests / h More than 60 programmed assay protocols Analyzer: 150 kg The BN II System is an easy-to-use, reliable nephelometric analyzer that offers a broad range of protein assays. · Connectivity options to Aptio Automation and FlexLab Automation solutions · Fully automated assay processing: from reading of sample tube bar codes to reporting of results · Routine and specialty assay consolidation · Innovative markers including monoclonal kappa and lambda free light chains (FLC), cystatin C, beta-trace pro- tein (BTP), and carbohydrate-deficient transferrin (CDT) Assays: Weight: Highlights: depending on the assay mix Nominal: 100 tests / h More than 60 programmed assay protocols Analyzer: 115 kg The Atellica NEPH 630 System is a mid-volume dedicated nephelometric analyzer that simplifies lab operations in specialty protein testing. · Innovative assays including free light chains (FLC), carbohydrate-deficient transferrin (CDT), and beta-trace protein (BTP) · Sophisticated antigen-excess pre-reaction protocols provide more accurate results and fewer repeats Not available for sale in the US. Product availability may vary from country to country and is subject to varying regulatory requirements Drug Testing Urine Screening Siemens Healthineers – Viva-ProE System Greiner – Vacuette Urine CCM Tube Sample throughput: Weight: Highlights: Up to 133 EMIT tests per hour with two reagents; Up to 65 EMIT tests per hour with three reagents Approx. 93 kg / 205 lbs (excl. monitor arm and panel PC) A flexible approach to dedicated drug-testing analysis, the Viva-ProE System provides greater ease of use, workstation efficiency, and a full drug-testing menu, all in one powerful benchtop system that is supported by unrivaled Syva experts. The system offers peltier cooling for efficient reagent use, can run up to 133 Emit tests per hour and 12 Emit assays simultaneously; 120 tests can be programmed with 10 open test channels. Results available within 10 minutes of processing. Highlights: · For use in microbiology testing · Stabilizes sample for up to 48 hours at room temperature · High solubility of additive in powder form · Immediate stabilization of sample after gentle mixing LABBOOK 2020 27

Chemistry & Immunochemistry Rapid Testing Greiner – Saliva Collection System Sarstedt – Blood gas Monovette and capillaries Highlights: · Simple reproducible saliva collection · Internal standard (tartrazine) enables donor-specific quantification · No absorption of analytes · Sufficient sample volume for A and B sample splitting · Determination of biomarker (α-amylase, cortisol) possible to enable indication of sample adulteration · No detergents which interfere with analysis Highlights: · Blood gas collection systems for arterial, venous and capillary sampling with the smallest sample volumes and Ca2+ balanced heparin. · The Ca2+ balanced heparin in spray-dosed droplet form enables rapid and optimal mixing of blood and anticoagulants. The Blood gas Monovette is available in 1 and 2 ml options and has been designed for venous and arterial blood collection. The blood gas capillaries offer a nominal volume range of 100 – 175 µl. Research Use Only (RUO) Shimadzu – CLAM-2030 Dimensions: 670 × 700 × 1,190 mm (w × d × h) Weight: 185 kg Assays: Immunosuppressants, Vitamin D, Steroids, Antiepileptics, Antiarrhythmics drugs, Amiodarone, Drugs of Abuse, Antidepres- sants, Neuroleptics Highlights: CLAM-2030 provides users seamless integration of automated sample preparation with LC-MS / MS to improve data quality, sample throughput, laboratory efficiency and safety Simple workflows allow users to go from blood collection tubes to results without any additional sample handling. Each sample is processed successively in parallel, to optimize instrument usage. Easy to access software for management of reagents, calibration curves, control samples and maintenance ensure reliability and quality of results. LABBOOK 2020 29

LABBOOK 2020 31

Diatron – Complete Blood Count Versatility with the Aquila Greiner – Vacuette EDTA Tube Hematology Sample throughput: Parameters: Dimensions: Weight: 60 tests / h 22 323 × 272 × 366 mm (h × w × d) ~16 kg inc reagent pack Highlights: · Compact size and unique on-board reagent pack requires little storage and work space · Three part diff hematology results requiring around 20 μl of blood · Closed or open tube mode · Portable with an optional battery pack Highlights: · EDTA tubes are offered as either K2EDTA or K3EDTA tubes · Contain (besides the K2EDTA) an inert barrier gel that is present in the bottom of the tube. · Plasma may be aspirated directly from the collection tube, eliminating the need for transfer to another container · Vacuette EDTA tubes with separator gel improve the plasma yield and enable plasma to be left in the primary tube · This allows stability of certain parameters, when kept under specified conditions. · Also available with pre-attached barcode LABBOOK 2020 33

Hematology Automation improves productivity Automation improves productivity To automate its workfl ow and improve productivity, To automate its workfl ow and improve productivity, Mindray proposed replacing the old stand-alone instru- Mindray proposed replacing the old stand-alone instru- ments with two high performance CAL 8000 Cellular ments with two high performance CAL 8000 Cellular Analysis Lines, each connecting four units of BC-6800Plus Analysis Lines, each connecting four units of BC-6800Plus Auto Hematology Analyzers and one unit of SC-120 Auto Auto Hematology Analyzers and one unit of SC-120 Auto Slide Maker and Stainer. Equipped with the labXpert data Slide Maker and Stainer. Equipped with the labXpert data analysis software, the automation lines can automatically analysis software, the automation lines can automatically validate test results and perform rerun and retest of validate test results and perform rerun and retest of abnormal hematology samples as per pre-defi ned rules. abnormal hematology samples as per pre-defi ned rules. This helps reduce the laboratory‘s manual work substantially This helps reduce the laboratory‘s manual work substantially and improve its Standard Operating Procedures (SOPs). and improve its Standard Operating Procedures (SOPs). The automation lines help the laboratory reduce manual handling and improve work effi ciency. The automation lines help the laboratory reduce manual handling and improve work effi ciency. Customized design optimizes workfl ow Customized design optimizes workfl ow Regular design and sample Regular design and sample Customized design and sample route Customized design and sample route b b a a L L a a c c fi fi í í t t n n e e i i C C © © e e g g a a m m i i But how to arrange the two lines in the extremely compact area in a way that can do more with less? But how to arrange the two lines in the extremely compact area in a way that can do more with less? After tracking the laboratory’s working path of samples, from collection After tracking the laboratory’s working path of samples, from collection to testing to microscopic analysis, Mindray provided a customized to testing to microscopic analysis, Mindray provided a customized solution – placing the two automation lines face-to-face, but re-con- solution – placing the two automation lines face-to-face, but re-con- fi guring one of them to make its sample route in the same direction fi guring one of them to make its sample route in the same direction as the other. This special design will enable just one technician to as the other. This special design will enable just one technician to easily handle large amount of samples on both lines at the same time easily handle large amount of samples on both lines at the same time creating the shortest, most time-saving route from sample loading to creating the shortest, most time-saving route from sample loading to unloading, all the way to microscopic review and result delivery. unloading, all the way to microscopic review and result delivery. By placing one CAL 8000 face-to-face with By placing one CAL 8000 face-to-face with the other, and adjusting the sample routes the other, and adjusting the sample routes in the same direction, we can reduce the in the same direction, we can reduce the number of staff and make the process much number of staff and make the process much simpler. Our processing productivity simpler. Our processing productivity has improved by 50 percent. has improved by 50 percent. Audrei Roberto Bertini Audrei Roberto Bertini Production Manager, Científi caLab Production Manager, Científi caLab During onsite inspection, Mindray team discovered another possibility of During onsite inspection, Mindray team discovered another possibility of helping Científi caLab optimize their workfl ow. Before installing CAL 8000, helping Científi caLab optimize their workfl ow. Before installing CAL 8000, the laboratory technicians had to print out the test result of the abnormal the laboratory technicians had to print out the test result of the abnormal sample, and then bring the result along with the slide to the microscopy sample, and then bring the result along with the slide to the microscopy area for result comparison. These paper documents will be fi led away for area for result comparison. These paper documents will be fi led away for fi ve years, managing which will be a demanding task. Mindray helped digi- fi ve years, managing which will be a demanding task. Mindray helped digi- talize the process by installing the labXpert software at the microscopy area talize the process by installing the labXpert software at the microscopy area which allows data transfer and storage within the laboratory information which allows data transfer and storage within the laboratory information system. Simply by scanning the barcode on the slides, technicians can easily system. Simply by scanning the barcode on the slides, technicians can easily access the information of the test results during microscopic analysis. access the information of the test results during microscopic analysis. LABBOOK 2020 35

Blood Cell Counter Improve Medical – Improvacuter Gel & EDTA.K2 Tube Mindray – BC-6800Plus Auto Hematology Analyzer Hematology Highlights: · Apply for nucleic acid testing which greatly shorten the window period of serological tests, and eliminate the false negative caused by serological tests · Sprayed EDTA K2 additive, avoid plasma dilution, dissolve adequately, prevent haemolysis of specimens · Inert separation gel, separate plasma from blood cells, avoiding specimen variation · Specimen is collected, transported and preserved within 1 tube Sample throughput: CBC+DIFF 200 t / h, RET 120 t / h, BF 40 t / h · Extend the preservative time of the sample for Highlights: more than 72 hours · The tube is sterilized, pyrogen free, DNase and RNase free · Manufactured in 100,000 Grade GMP workshop, with strict process control BC-6800Plus is currently the fastest standalone hematology analyzer in the world, which can process 200 CBC+DIFF samples / h and 120 RET samples / h. Notably, the ERP channel can provide more research parameters such as MCHr and HDW, which can help early diagnosis of various types of anemia Mindray – BC-6200 / 6000 Auto Hematology Analyzer Siemens Healthineers – Advia 360, 560, and 560 AL Hematology Systems Dimensions: Sample throughput: Parameters: 360 × 316 × 492 mm (h × w × d) 520 × 410 × 490 mm (h × w × d) Approx. 60 tests / h 22 – 26 parameters* 3- or 5-part white cell differential Sample throughput: Up to 110 t / h Highlights: Highlights: · Unique SF Cube 3D cellular analysis technology for WBC 6-part diff count including IMG · NRBC in every CBC+DIFF result · Automatic rerun & reflex in case of abnormal results · BC-6200 with RET channel can provide optional Reticulocytes and PLT-O parameters and perform automatic 8-times PLT-O counting for thrombo- cytopenia samples The Advia 360, 560, and 560 AL Hematology Systems provide laboratories with intuitive, easy-to-use, and scalable hematology solutions designed to offer the right fit for every lab. Each system delivers fast, reliable, and accurate CBC and white cell differential testing with the performance and adaptability that low- and mid- volume labs need. The optional autoloader on the Advia 560 AL System streamlines automatic sampling for even greater workflow efficiency. *Not all parameters are available in the U.S. LABBOOK 2020 37

Hematology Beckman Coulter – DxH 900 Hematology Analyzer Dimensions: 755.7 × 1,740 × 828 mm (w × h × d) Weight: 254 kg Sample throughput: Up to 100 samples / h Power consumption: 520 W Highlights: The DxH 900 hematology analyzer is ideal for mid- to high-volume clinical laboratories performing complete blood count and white blood cell differential tests while minimizing repeat testing, allowing you to deliver the right results the first time. · Achieve superb RBC, PLT and WBC differentials through near native-state cellular characterization and precise flagging · Optimized processes help your laboratory maximize staff time through fewer slide reviews, automated QC, and longer walkaway and system uptime · Most reportable results per square meter with industry-leading 93 percent first-pass yield and a > 40 percent smaller footprint than competitive instruments · Exclusive Early Sepsis Indicator: a one-of-a-kind FDA cleared hematologic biomarker designed to help emergency department physicians identify sepsis sooner Sysmex – XN-3100 DI Sysmex – XN-9100 Sorting & Archiving Sample throughput: CBC+DIFF: Dimensions: Weight: Highlights: Up to 200 samples / h, Up to 40 samples / h in BF mode per module SP-50: Up to 30 samples/ h with standard model, Up to 75 samples / h with high throughput model 3,000 × 1,626 × 1,150 mm (w × h × d) 1,020 kg · Fully integrated slide maker & stainer · Choose Advanced Clinical Parameters as needed · Extended IPU for maximum workflow optimisation · Automatic Rerun & Reflex measurement for challenging samples · Integrated backup concept · Digital Imaging (DI) module: – Seamless integrated morphology analysis of slides – Efficient, detailed review and validation for greater accuracy – Faster, improved workflow – Long-term storage and archiving of cell images – Consistency in analysis quality Sample throughput: Dimensions: Weight: CBC+DIFF: From 200 samples / h, From 40 samples / h in BF mode per module Depending on configuration Depending on configuration Highlights: · Scalable and modular haematology automation line · Flexible configuration of XN analysis modules and rack entry and exit positions · Extended IPU for maximum workflow optimisation · Uninhibited workflow from routine to specialised testing · Automatic reflex measurement in case of unreliable results · Choose Advanced Clinical Parameters as needed · Advanced sample management with TS-10: sorting for sub- sequent destinations and automated archiving of samples · Optional integration of ESR and HbA1C analysis LABBOOK 2020 39

Hematology tests. Bringing coagulation factor testing in line with guidelines, MDA helps to distinguish a real factor defi ciency from a defi ciency caused by anti-factor inhibitors or prolonged results due to lupus anticoagulants. CWA helps in identifying atypical in vitro clot reactions that may occur with haemophilia, sepsis or DIC patients, and it also supports the detection of anomalies in the reaction due to interference (e.g. early reaction error). And CN’s cross-mixing function makes inhibitor testing more convenient and closer to the standard (Nijmegen-Bethesda assay), while the automatic dilutions of agonists used for platelet aggregation analysis increase the analytical consistency – and the convenience. Operational power Anything that frees lab staff from analyser hands-on time is welcome. CN-Series was designed with this in mind. Its operation principle is simply based on three buttons, and there are several automated functions such as auto QC, start-up, backup, re-dilution, re-analysis, and refl ex testing that extend walk-away time. You can use CN’s reagent statistics and consumption prediction to make sure your routine runs smoothly without having to attend to the instrument. Finally, you will spend less time on maintenance thanks to a highly durable piercer1, which also reduces the sample dead volume to 65 percent, and long-life LED technology2. Powerful services Peace of mind can be a great asset. CN-Series is there to perform. You can trust in your instrument’s availability with its pro-active maintenance preventing analyser downtime. And should problems occur, you can resolve them quickly thanks to remote support and guided troubleshooting. All this is based on Sysmex’s experience in diagnostics for over 50 years, including best-in-class knowledge provision with Sysmex Academy training courses and webinars. Summary The CN-Series instruments help busy haemostasis labs ease the burden of today’s challenges. CN’s high throughput together with its compact size and wide assay portfolio increase lab productivity and accelerate the time to results, while operation is very convenient with manual tasks reduced to a minimum, freeing up time for the operators. Prospective reagent management and pro-active maintenance help to avoid unnecessary interruptions of the daily routine, and the technological quality and spectrum of the analytical functions ensure a maximum of reliable results, serving as the basis for confi dent decision-making, even in critical clinical situations. 1 Three times the life of the previous type | 2 Thirty-six times the life of a halogen lamp CN-Series: nearing 360° in haemostasis testing Besides the full range of routine testing, CN runs a wide spectrum of specialty tests such as platelet aggregation, DOACs, and chromogenic FVIII and FIX assays: · Haemophilia assays including the ability to monitor latest pharmacological treatment with emicizumab for haemo- philia A patients: FVIII chromogenic assay or diluted FVIII clotting assay (customer application only) · Thrombophilia assays · Antithrombotic assays · Fibrinolytic assays · Antifi brinolytic assays · Inhibitor assays (heparins, VKA, DOACs) including the ability to monitor all DOACs approved for the EU market · Platelet aggregation assays including the unique PAL (platelet aggregation level) score function CN-Series – fl exible and scalable to your needs LABBOOK 2020 41 CONTACT Sysmex Europe GmbH Bornbarch 1 · 22848 Norderstedt, Germany phone: +49 40 527 26-0 segcoagsupports@sysmex-europe.com www.sysmex-europe.com

Sarstedt – S-Monovette Hirudin – Thrombocyte function Siemens Healthineers – Atellica COAG 360 System Hematology Sample throughput Dimensions: PT and APTT: 350 (simultaneous analysis) 1,858 × 1,042 × 1,415 mm (w × h × d), without LAS connection 2,156 × 1,042 × 1,415 mm (w × h × d), with LAS connection 600 kg (without LAS connection) 617 kg (with LAS connection) Weight: Highlights: Highlights: The S-Monovette Hirudin was developed together with the company Verum Diagnostica, today Roche Diagnostics (bought), for measuring thrombocyte activity using the Multiplate multiple platelet function analyser. Unlike citrate or heparin, hirudin works via direct thrombin inhibition, and thus allows thrombocyte function diagnostics in its native state. It is used for monitoring platelet-inhibiting medications during treatment, as well as for detecting or ruling out throm- bocyte function disorders. The Atellica COAG 360 System* offers high-volume specialty hemostasis labs a transformative array of capa- bilities to streamline and unify hemostasis testing: · Five methodologies–clotting, chromogenic, immu- nologic, platelet aggregation and high-sensitivity immunoassay (LOCI) testing · Primary-tube sample-volume checks, advanced assay-specific sample quality checks for hemolysis, icterus and lipemia (HIL) interference. · Intelligent reagent and consumable management *Not available for sale in the US Siemens Healthineers – Sysmex CA-600 Systems Siemens Healthineers – Sysmex CS-2500 System Dimensions: Sample throughput: Weight: Approx. 490 × 566 × 490 mm (h × w × d) Approx. 60 PT tests / h Approx. 43 kg Highlights: The Sysmex CA-600 Systems – with the smallest foot- print in their class – are built on a history of proven reliability and provide scalable options for routine and specialty* coagulation testing. · Features clotting, chromogenic,* and immunologic* measurements with true random access · Enables critical tests to be processed at any time via STAT sample processing · Offers the most frequently requested routine and specialty tests, including INNOVANCE D-Dimer* *Sysmex CA-660 System only. Dimensions: Sample throughput Weight: Approx. 685 × 1,113 × 895 mm (h × w × d) Approx. 180 simultaneous PT / APTT tests / h Approx. 140 kg Highlights: The Sysmex CS-2500 System offers mid-volume and multisite hemostasis labs smartly designed technolo- gies for improved efficiency, exceptional accuracy, and reliable first-run results. Equipped with next-gen- eration PSI technologies, the system takes hemostasis testing to the next level. The Sysmex CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument. LABBOOK 2020 43

Pathology Scanner Printer Histology Equipment Information Technology LABBOOK 2020 45

DTM Medical – Primera Signature Slide Printer KABE Labortechnik – Consumables for pathology / histology Histology Equipment Pathology Highlights: The Signature Slide Printer can significantly increase the efficiency of labs while helping to reduce the risk of misidentification of specimens. · On-demand, full-colour printing – prints only the number of slides needed · Prints directly onto slides – eliminates handwriting that is hard to read and labels that are hard to apply · Cost reduction by inventorying only white-frosted slides · Xylene-, alcohol-, heat- and chemical-resistant ink – ensures reliable identification of slides · PTSlide Software allows connection to LIS systems · Compact design · Two years warranty (After product registration within six months of purchase) Highlights: Tissue embedding cassettes · Five variants: standard, uni versal, biopsy, bionet and laser · Available in different colours · Without, with separate or with pre-attached hinged lid · Available pre-stacked – ready for use in cassette printers · High quality material is resistant to solvents, guarantees dimen- sional stability and offers good writing and printability · Comprehensive range of accessories Test tubes with formalin solution · Prefilled with four percent formalin solution · Available in different sizes · Individual labelling possible Information Technology Hamamatsu Photonics – NDP.serve3 web slide server VMscope – CMPS: Ki67, ER, PR, CD3 Highlights: NDP.serve3 is the image distribution software that efficiently distributes large-volume whole slide images scanned by NanoZoomer series via the Internet and/or Intranet. Access authorities to the image database can be managed. It enables many people to access the database at the same time and supports a wide range of applications, such as image obser vation from a remote location and student education. Options: · Utilizing information from LDAP server · Supporting non-Hamamatsu slide format images · Synchronized viewing slides among visitors Highlights: · Fully automatic quantification of Ki67, ER, PR, CD3 and further stains · Analysis in less than one second, no user interaction necessary · Analysis of WSIs, still images or live images from the microscope camera · Ki67 quantification clinically validated · Multiple regions per case to take into account the tumor heterogeneity · Export of the results into images, MS Excel or other systems · Integration into any LIMS system via open interfaces LABBOOK 2020 47

Amplification Orion Diagnostica Oy – Orion GenRead Sarstedt – White Multiply PCR Plates DNA Assays: C difficile, campylobacter Highlights: Orion GenRead system is a small benchtop system for molecular pathogen detection, based on proprietary technology SIBA (Strand Invasion Based Amplification). · Flexibility with 1 – 12 samples in one run · Fast test results are available in less than one hour · Ready to use kits contain all needed reagents · Bi-directional HIS / LIS connectivity · Portable and robust instrument suitable for various laboratory settings · CE marked test kits for C difficile and campylobacter. Next: RSV and Influenza A&B Highlights: · White wells for improved fluorescence reflection · Thin-walled reaction tubes for quick temperature transfer · Free from DNA, DNase, RNase and PCR inhibitors · Barcode labeling on plates with half or full skirt is available on request Amplification / Detection Quidel – Solana - molecular testing platform Extraction Genrui – NE48 Dimensions: Weight: Power consumption: 150 × 240 × 240 mm (h × w × d) 4 kg Bordetella pertussis, C. difficile, Group A Strep, Group B Strep, HSV 1+2 / VZV, Influenza A+B, RSV + hMPV, Strep A+C / G, Trichomonas, SARS-CoV-2* *New test in development Highlights: A simplified molecular testing platform with a small footprint, is making molecular diagnostics faster and easier, without sacrificing performance. Solana combines Quidel’s proprietary helicase-dependent amplification with fluorescence detection to deliver results you can trust, in an actionable timeframe. · Ensures molecular sensitivity with moderate complexity · Testing of 1– 12 samples – single test or batch mode · Time to result: 25 – 50 min · Reduced Hands-On-time: 2 – 3 min · LIS and Middleware capable Dimensions: Weight: Highlights: 398 × 428 × 465 mm (w × h × d) 29.7 kg NE48 is a fully-auto nucleic acid extraction Instrument. It is equipped with 9.2-inch touch screen and auto- ultraviolet disinfection module. With the rapid heating / cooling and excellent extraction performance, it brings the user-friendly operation and much convenience for the customer. · Principle: Auto magnetic bead extraction · Number of magnetic rod: 48 · Dispensing volume: 20 ~ 1,000 ul · Extraction time: 10 ~ 30 min LABBOOK 2020 49

Improve Medical – SARS-CoV-2 Test Kit (Real-time PCR) Siemens Healthineers – Versant HCV Genotype 2.0 Assay (LiPA) Infectious Disease / Hepatitis DNA Method: Target: Internal Control: Test Channel: Limit of Detection: Test Time: Packing: Quantitative real-time PCR ORF1ab / N gene RNase P FAM / HEX / ROX 200 copies / ml (95 %) 80 min 48 T / Kit Highlights: The kit can be operated with the following real-time PCR thermal cycler with FAM, HEX and ROX detection channels: Bio-Rad CFX96, ABI 7500 etc. Highlights: Optimize your laboratory’s testing with the widely used Versant HCV Genotype 2.0 Assay (LiPA)*. · LiPA utilizes reverse-hybridization technology to detect HCV genotypes 1–6 and subtypes 1a and 1b. · LiPA provides highly accurate identification of HCV genotypes and subtypes for optimal and personalized patient therapy. * LiPA assay is FDA-approved in the U.S. and CE-marked in the EU for IVD use. Sample Collection Research Use Only (RUO) Improve Medical – Improviral Liquid Transport Medium Sarstedt – Low DNA Binding Micro Tubes Highlights: Improviral Viral Preservative Medium(VPM) for collection and preservation of viruses and pathogens. Improviral NAT(Nucleic Acid Test) Medium inactivates microbes and protect nucleic acids. · Safe specimen collection with microbiological Highlights: transport swab · Safe processing · Safe transportation · Safe preservation · Offer premium samples for molecular detection assay, maximize sensitivity As the trend towards decreasing sample volumes continues, it is increasingly important to minimize potential interaction between the analyte and tube. Our low protein and new low DNA binding micro tubes are specifically designed to meet the requirements in protein and DNA analytics while maximizing recovery rates. LABBOOK 2020 51

Mass Spectrometry Shimadzu – Axima iDplus Assurance Shimadzu – Axima iDplus Confidence Microbiology Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 330 kg, excluding data system Axima Assurance – Flexibility and Quality: The Axima Assurance is designed with the general analytical and life science laboratory in mind. Incorporating a variable repetition rate 50 Hz N2 laser, the system provides high quality and high sensitivity rapid MALDI mass spectra and is particularly suited to identification in the microbiology field. Positive and negative ion modes are included as standard, allowing greater flexibility and extending the compound categories that may be analysed. Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 330 kg, excluding data system iDplus Confidence – Sensitivity and Flexibility: · Rapid microbial identification for research use · Identifies and classifies strains based on phenotype characteristics · SuperSpectra reduce the incidence of false positives and ensure robustness and reproducibility · Open system allows addition of new species / entries to the database or the creation of new databases · Clustering allows molecular profiling and tracking of change or evolution · High performance MS for large molecule analysis · MS / M Shimadzu – Axima iDplus Performance Shimadzu – Maldi-8020 Dimensions: Weight: Highlights: 700 × 1,920 × 850 mm (w × h × d) 375 kg, excluding data system iDplus Performance – application-centric solutions: · Rapid microbial identification for research use · Identifies and classifies strains based on phenotype characteristics · SuperSpectra reduce the incidence of false positives and ensure robustness and reproducibility Dimensions: Weight: 450 × 1,055 × 745 mm (w × h × d) 86 kg · Open system allows addition of new species / entries Highlights: to the database or the creation of new databases · Clustering allows molecular profiling and tracking of change or evolution · High performance MS for large molecule analysis · MS / MS The Maldi-8020 is a benchtop, linear-only MALDI-TOF mass spectrometer designed to meet the needs of laboratories requiring a cost-effective MALDI-TOF platform. This newly designed MALDI-TOF mass spectrometer is functionally simple but provides out- standing MS performance in a compact footprint. LABBOOK 2020 53

MAP Sciences had initially developed the technology with a view to screening populations for haemoglobinopathies and the most common genetic diseases, such as sickle cell disease or alpha or beta thalassemia from a pin-prick blood test. The biotech fi rm developed these tests and proved their validity with colleagues at Addenbrooke’s Hospital in Cambridge and Cam- bridge University, while also working with partners in the United Arab Emirates and the United States to confi rm the technique works on their mass spectrometers. Then the coronavirus pandemic struck. However, this unexpectedly presented a new opportunity. “I always felt that the next step would be to use mass spectrometry and take samples and look for viruses, because viruses are packages of proteins,” Iles explained. From early March, MAP Sciences teamed up with Professor Jonathan Heeney at Cambridge University to understand the biology of the virus, and developed the biochemical approach for a new MS Covid-19 test. The team specifi cally used the compact Shimadzu MALDI-ToF 8020 mass spectrometer to detect proteins associated with Covid-19 and created the new gargle test, which also overcomes the relatively unpleasant approach of PCR testing with swabs of the throat and up the nose. How does the gargle test work? “What we’ve developed,” Iles explained, “is ways of enriching the virus in the sample, breaking the viral envelope, releasing these large glycoproteins and then identifying these glycoproteins on the mass spectrometer.” “Someone with suspected Covid-19 gargles with 10 mls of water for 30 seconds and spits into a pot, which is then delivered to the lab where ice cold acetone is added to the solution to kill the virus and cause precipitation of large molecules. The sample is spun in the centrifuge with a chemical solution added to break up the virus and release the viral proteins, and then transformed into a small pellet and placed on a matrix plate. It’s these viral proteins we look for to tell whether someone has Covid-19 or not, but it also means we can identify any other virus there as well – for example H1N1 fl u.” Lab technician Vicky Lewis prepares the matrix plate for the mass spectrometer Mass Spectrometry The Shimadzu MALDI-ToF 8020 mass spectrometer used for the MAP Sciences COVID-19 gargle test samples. The matrix pellet is placed in the MALDI-ToF mass spectrometer. A readout on the computer screen produces peaks highlighting the presence – or absence - of the coronavirus, or any other virus. The mass spectrometer is looking for the SARS-CoV-2 Spike Glyco- protein-S1 Protein. “We’ll only get the S1 spike with virus being present,” explained Iles, who adds that the gargle test is a fraction of the cost of the PCR swab test for coronavirus and sampling can be performed at home and sent through the post to laboratories. Mass spec – compact size and fl exible software With data still being collated, Iles maintains that the gargle MS test is as accurate, if not more so, as the PCR test, believed to be about 80% accurate and with an unclear false positive rate. “We are cheaper, we are faster and we are an alternative technique that can confi rm or refute a PCR test. We also have quality controls in place and we are ready to go,” the professor confi rmed. Iles favours the Shimadzu MALDI-ToF 8020 because of its software fl exibility and compact size. It can conduct about 500 tests a day, meaning signifi cant investment in MS hardware will be required if the gargle test is to contribute to the UK government’s testing aspirations, though Iles’ team is working closely with Shimadzu over potential modifi cations. Yet, he believes their sophisticated and affordable testing technol- ogy, with fewer consumables than other Covid-19 tests, will complement the simple binary Covid-19 tests currently in use and produce accurate results with fewer false positives as the global fi ght against coronavirus continues. CONTACT Shimadzu Europa GmbH Albert-Hahn-Str. 6-10, 47269 Duisburg, Germany phone: +49-203-76 87 0 · fax: +49-203-76 66 25 shimadzu@shimadzu.eu · www.shimadzu.eu LABBOOK 2020 55

Microbiology LABBOOK 2020 57

Mass Spectrometry that several interactions not only enhanced chemical diversity, but also inhibited the growth of several clinically relevant pathogens, she explained. “Furthermore, we could gain a better understanding of the chemical ecology during bacterial compe- tition, where changing conditions aggravate the complexity of these interactions. Therefore, we demonstrated that MS-based metabolomics is an exciting strategy to study microbial ecology and to prioritise novel chemistry.” Metabolomics approaches – referring to the study of the complete set of metabolites found in a cell, tissue, organ or organism - in general are applied to compare the chemical profi les of different experimental groups to fi nd out the chemical response to external stimuli such as environmental stresses, she explained. “MS-based metabolomics approaches in microbial ecology enable the under standing of microbial interactions in complex communities. Meta bolomics allows the analysis of those metabolites that are produced during microbial interactions, therefore, providing a snapshot of the ecological role of these metabolites in the producers. This allows the understanding of biological questions such as ’Why are certain metabolites produced under specifi c conditions?’”, she pointed out. By studying the secondary metabolism of organisms in complex communities and understanding the role of interesting metabolites, Castaño-Espriu continued, it is possible to gain greater insights in the correlation between phenotypic traits and microbial interactions. PROFILE Laia Castaño-Espriu is a fi nal year PhD student at the University of Strathclyde in Glasgow under the supervision of Dr Katherine R. Duncan, with a particular research interest in metabolomics, actinobacteria and drug discovery. Identifi cation of potentially signifi cant metabolites Her work utilises Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Liquid Chromatography Mass Spectrometry (LC-MS). The MS-based metabolomics studies follow the steps of sample collection and preparation, generation and acquisition of MS data (metabolic profi les), data processing using a deconvolution software such as MZmine, and statistical analyses. “This approach,” she said, “enables the identifi cation of potentially signifi cant metabolites belonging to the groups of interest, therefore, prioritising these for chemical identifi cation and further experiments to understand the underlying mechanisms of the metabolic pathways.” MS-based metabolomics techniques offer advantages in fi elds including the effect of drugs at a metabolite level; drug devel- opment; the study of diseases such as cancer, nutrition science, toxicology analyses to natural products; and chemical ecology research. “Therefore,” Castaño-Espriu added, “MS-metabolomics represents a multi- and interdisciplinary approach that can be used in different fi elds to understand metabolic pathways.” Metabolomics, she added, aims to deliver more rapid and reliable analyses combined with more economical methods, data standard- isation and the sharing of more MS data through online databases. Recent applications of metabolomics include disease biomarkers and drug development, with a signifi cant increase in the use of MS-based metabolomics observed in the area of microbial ecology in the last decade. Compared to other techniques, Castaño-Espriu believes that metabolomics is the best approach to accelerate drug development as it is low-costs and also rapid and effective. “This effectiveness makes a metabolomics approach ideal for other life and medical sciences.” She feels it will become necessary to develop new technologies that offer greater sensitivity and spatial resolution to improve data quality, and to create databases with more MS data coverage to facilitate metabolite identifi cation. Another challenge lies in data variability based on sample prepa- ration and the sample matrix among other factors. However, she believes the development of new instruments and new methods will aim to overcome this limitation. CONTACT University of Strathclyde Institute of Pharmacy and Biomedical Science 161 Cathedral St, Glasgow G4 0RE, UK www.strath.ac.uk LABBOOK 2020 59

Blood Glucose Siemens Healthineers – DCA Vantage Analyzer Immunoassays Genrui – FA50 POCT Dimensions: Weight: Highlights: 287 × 254 × 277 mm (w × h × d) 3.88 kg Highlights: The DCA Vantage Analyzer makes in-office diabetes testing easy, with accurate, clinically trusted results shown to improve decision making, patient compliance, and outcomes. Get precise HbA1c, albumin, creatinine, and A:C ratio results in minutes with good correlation to laboratory methods and simplify management for POC coordinators with advanced operator, data-manage- ment, and security capabilities. Product availability varies by country. FA50 is a simple, innovate and accurate POCT analyzer that certified by FDA. It is integrated with magcard calibration and capable to perform tests over different sample types including whole blood, serum and plasma. It is perfectly designed for use in clinics and doctors’ offices, as well as different hospital departments including ICU, CCU, etc. Currently following tests are available: HbA1c, PCT, hs-CRP, cTnI, Myo, CK-MB, NT-proBNP, D-Dimer, TSH, T3, T4 More tests are in development Quidel – Sofia 2 - Fluorescent Immunoassay Analyzer Quidel – Triage MeterPro Cardiology Dimensions: Weight: Handheld/Stationary: 120 × 120 × 220 mm (h × w × d) 1 kg SARS-CoV-2 Antigen, Influenza A+B, Influenza A+B + SARS Antigen, SARS-CoV-2 Antibody IgG*, RSV, C. difficile GDH + Toxin*, Legionella, S. pneumoniae, Lyme, Strep A *New tests in development Highlights: Proven lateral-flow technology, proprietary advanced fluorescence chemistry and assay development tech- niques, all in a small bench-top analyzer that can be used near patient and in laboratory settings. · Intuitive, fast and easy-to-use interface allows operator to quickly run patient samples or navigate stored data · Test results in as few as 3 – 15 min (depends on assay) · Hands-on-Time: < 1 min · Walk Away- and Read Now-mode can be used depending on workflow requirements · Room temperature storage Assays: Highlights: High Sensitivity Troponin I, BNP, NT-proBNP, Troponin I, D-dimer, CK-MB, Myoglobin, PLGF, qualitative Drug Screen (urine) Quidel Triage MeterPro is designed to provide diagnostic results quickly and easily. With a variety of immunoas- says and the ability to use whole blood, plasma, or urine, the Quidel Triage MeterPro gives you a flexible solution at the point-of-care. · Quantitative test results in about 15-20 minutes · Single- and multimarker panels available · Built in quality controls into the meter, software, and test device · Interface with any LIS solution · Can improve clinical, economic and operational outcomes LABBOOK 2020 61

POCT Authentifi cation in a clinical environment Case in time-consuming point: the blood gas analyser. As a POCT device, it is used in the OR to control ventilation in certain regular intervals. If such a device fails, the consequences for the patient can be fatal. Under BSI law, these devices require a time-con- suming and overly complicated authentifi cation procedure. The user name and a 16-digit password have to be entered on a tiny screen – unthinkable in an emergency: much too long-winded and much too error-prone. While technically speaking, the biometric fi ngerprint might be an option, it requires personal data to be stored on the central servers, which is something that has to be avoided in view of the EU GDPR. “Currently, we scan the employee ID card with a barcode,” Professor Streichert explains and adds that theoretically, a second type of authenti- fi cation, such as a password, is required. This combination, however, is problematic as IDs get lost or end up in coat pockets in the hospital laundry and passwords are forgotten or no lon- ger valid. In the ER or in an understaffed ward, this procedure is unrealistic. Another idea that is being bandied about is a personnel number and a PIN, but this option is currently not technically feasible. There are further potential security gaps such as remote maintenance accesses that are used by external providers, ports, hard disks with unencrypted data or SSDs with data that is unencrypted and/or cannot be deleted. PROFILE Professor Dr Thomas Streichert is managing director of the Center for Laboratory Diagnostics (Clinical Chemistry, Microbiology, Virology, Pharmacology, Endocrinology) and acting director of the Institute of Pharmacology, Therapeutic Drug Monitoring at the University Hospital Cologne, Germany. Born in South Africa, Professor Streichert studied medicine in Hamburg, Germany, where he also worked as junior and senior physician. In 2013, the specialist physician for laboratory medicine joined the University Hospital Cologne. He is chairman of the advisory committee “E-learning” at the University Hospital Cologne and member of the German Society for Clinical Chemistry and Laboratory Medicine. with quality standards enjoys top priority throughout the facility. All POCT devices are centrally managed by the hospital’s clinical laboratory. This is a sensible approach since the lab medicine specialists have the relevant knowledge and can ensure facility- wide highly competent and target-oriented quality assurance. “The colleagues like to use our service offering. While dealing with the ins and outs of the POCT systems is daily fare for us, the care staff in the wards or the physicians in the ICU are grateful that they don’t have to bother. They have important other tasks to tend to.” Professor Streichert underlines that this level of service requires a constructive partnership with the IT department: “In the lab, we need quite a bit of IT support, thus, over the years we have developed a very good working relationship with the IT team.” Not always on the same page: data security standards and clinical work Nevertheless, Professor Streichert identifi ed defi nite room for improvement: “Despite all the activities, we are not perfect when it comes to IT security.” This is partially due to the so-called KRITIS bylaw in Germany which requires the operators of critical infrastructure to establish state-of-the-art protection of their IT systems, components and processes against disruptions in availability, integrity, authenticity and confi dentiality in line with Federal Offi ce for Information Security (BSI) specifi cations. “In order to be able to comply with these requirements, each industry has to develop specifi c security standards that are reviewed by the BSI for adequacy and suitability.” The major hurdle: security standards and everyday operation of a hospital, particularly with regard to POCT, are very diffi cult to align. Round table on IT security “In view of the complexity of the problem and the fact that we need to establish standards accepted by all stakeholders, we launched a round table with the POCT providers to discuss possible options as well as options that might already be in the pipeline and common denominators.” This debate was very constructive – quite surprisingly since today, IT security is a major issue in procurement and there were understandable fears that competing providers were loath to engage in an open discussion. The round table did show that the companies are well aware of all issues and that they are working hard on solutions – and in fact some at least partial solutions seem to be in the wings. One of the major issues that remain to be solved is the user procedure in an emergency context. The good news is that there was a consensus around the round table: technical requirements alone won’t do. Any solution has to refl ect the everyday situation in a hospital and it has to fi t in the overall IT approach. Professor Streichert summarizes the credo: “The leaner the organisation, the simpler the process, the better the solution.” A follow-up round table with the same cast of characters is planned for next year. CONTACT Uniklinik Köln Institut für Klinische Chemie, Kerpener Straße 62, 50937 Köln, Germany www.uk-koeln.de LABBOOK 2020 63

Siemens Healthineers – RapidLab 1200 Blood Gas System Siemens Healthineers – RapidLab 348EX Blood Gas System POCT Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, Neonatal Total Bilirubin, CO-oximetry 230 × 240 × 610 mm (w × h × d) 2.5 kg Siemens RapidLab 1200 Blood Gas System is uniquely designed to meet high-volume critical-care testing needs. The system has an ultra-fast sample processing and microsample capability, with results in 60 seconds. Cartridge-based reagent system simplifies operation, and Ready Sensor technology offers reliability with minimal maintenance. Product availability varies by country. Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Hct 385 × 382 × 353 mm (w × h × d) 9.4 kg The RapidLab 348EX Blood Gas System is a cost-effective solution for low-volume laboratory settings. Report accurate patient results from a whole-blood sample in 60 seconds, with minimal operator interaction. Increase operator efficiency with bar-code data entry of patient and operator IDs, automatic sample aspiration and calibrations. Not available for sale in the U.S. Product availability varies by country. Siemens Healthineers – RapidPoint 500e Blood Gas System Analyticon Biotechnologies – Urilyzer 100 Pro Urinalysis Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, CO-oximetry, Lac 300 × 550 × 420 mm (w × h × d) 16.55 kg The RapidPoint 500e Blood Gas System features a redesigned user interface and upgraded hardware and software to deliver an intuitive, heightened user experience. It incorporates Siemens Healthineers proprietary Integri-sense technology to deliver confi- dence with every result and elevates blood gas solution to a new level, allowing more time for patient care. Product availability varies by country to country. Sample throughput: Dimensions: Weight: Up to 120 tests / h (fast mode) 208 × 290 × 80 mm (w × d × h) 1.2 kg Highlights: Urine test strip analyzer connectable to POC middleware Optimized for POCT application with · Positive patient identification · Remote software update · Test strip management · QC solution management · Proficiency test feature · Messaging function · Operator management LABBOOK 2020 65

Other Jadak– HS-1R Handheld HF RFID Reader Sarstedt – Minivette POCT / Capillary Blood Collection POCT Dimensions: Weight: Handheld/Stationary: 33.4 × 51.3 × 108.2 mm (h × w × d) 98 grams Handheld 1D & 2D barcode scanner with HF RFID reading & writing functionality Highlights: The flexpoint HS-1R from JADAK integrates 1D & 2D barcode scanning with HF RFID reading & writing functionality. Sure to be an integral part of many medical and clinical applications, the HS-1R enables patient ID via wristband scanning, clinician security login via badge scanning, pharmaceutical applications incl. drug inventory tracking & digital signature capture using built in camera modes, and much more. JADAK products can be tailored to meet specific customer requirements. Highlights: · Collection devices for Point-of-Care tests · Easy sample recovery · Precise and dispensing of small whole blood volumes · Prevents spillage during transfer · Volume range: 10µl – 200µl · Preparations: Neutral, Heparin and EDTA

LIS / Middleware / POCT Beckman Coulter – DxONE Command Central Workstation Beckman Coulter – Remisol Advance Information Technology Highlights: Beckman Coulter’s DxONE Command Central remote monitoring system helps manage lab workflow and improve decision-making steps. The system can connect up to 18 instruments or automation systems, and up to five networked DxONE Command Central workstations within a single laboratory, allowing the operator to place DxONE Command Central workstations in prime laboratory locations for increased flexibility. DxONE Command Central maximizes workflow efficien- cies by providing lab technicians with a real-time view of laboratory systems from a single point of control. DxONE Command Central works with data managers such as REMISOL Advance to achieve workflow efficiencies, or can serve as a stand-alone product for users to monitor automation and/or multiple analyzers and quickly respond to any instrument issues. Highlights: Remisol Advance is an enterprise data management solution that can help improve sample workflow through consolidated management, drive consistency through network standardization across multiple sites, create efficiency through autoverification, and improve reli- ability by integrating quality control management. It is a unique software product that consolidates patient test information from multiple instruments in the lab or from multiple labs in the hospital network. REMISOL Advance features virtualization capability to help reduce failure points and increase uptime. CompuGroup Medical – CGM VT CompuGroup Medical – MOLIS Highlights: · CGM VT is future-oriented due to modern technology and an integrated communication platform. Highlights: · The cost saving installation concept rapid deployment enables your lab to change to the new LIS in a short time. · Easy click rules allow lab doctors to independently feed their knowledge into CGM VT and use it in future. · The intuitive info-card principle allows easy application without long training. · The LIS can be used across multiple locations and includes the mapping of in- and outpatient senders. MOLIS is the premium LIS solution from CompuGroup Medical, europe’s biggest provider of healthcare-IT. With MOLIS you put safety first. The unmatched stability, reliability and performance of MOLIS has been proven in more than 160 installations in hospitals and private laboratories of all sizes, every discipline, as stand-alone or multi-site configurations. With the flexibility of MOLIS you continuously optimize every process in your organization to offer the best possible service to your requesters. LABBOOK 2020 69

Siemens Healthineers – Atellica Data Manager Siemens Healthineers – Atellica Inventory Manager Inventory Management Information Technology Highlights: Open, scalable, easy-to-use solution with powerful rules to standardize testing, enhance QC and streamline result management. Enhance visibility, automate process- es, autoverify results and centralize management of analyzers, automation, sites and networks to increase productivity. Reduce errors and process variation with consistent review/reporting. Sharpen clinical focus with details needed to make informed, accurate decisions. Product availability varies by country. Highlights: Get the right materials at the right time — Atellica Inventory Manager* provides automated, real-time control of reagents and consumables across multiple locations to reduce costs, save time, and improve lab quality. *Product availability varies by country. Specialties Zenon – Doc-db Forms & Records Highlights: The new Doc-db module forms and records does all the work. It makes forms that were not previously in the document management system to records that, using the software, can be created, checked, shared, and after manual editing digital archived. · Automated creation of recurring forms and records · Automatic reminder and check for completeness · Direct distribution as a print job to the employees responsible · General and individual design of the workflows for each form / record Integrated solution management for your laboratory dr. neumann kindler & www.labcore.de LABBOOK 2020 71

Blood Collection Greiner – Vacuette Safety Blood Collection Sets Improve Medical – Improsafe Blood Collection Needles Other Applications Highlights: · Specially developed for blood collection from patients with difficult vein conditions · Protection from the risk of needlestick injuries · Simple activation of safety mechanism · Transparent view window provides clear vein entry indication · Particularly safe due to activation of the safety mechanism while the needle is still in the vein Highlights: · Eliminate needle exposure · Eliminate needle stick injuries · Needle is completely and securely locked after use, preventing reuse · More flexibility due to assorted tube lengths for blood · Pre-attached holder reduces the risk of accidental collection · Optional use as an infusion set needle-stick injuries · Full line FDA 510k clearance KABE Labortechnik – Capillary Blood Collection GK KABE Labortechnik – Primavette S and V Highlights: Capillary Blood Collection GK – for small amounts of blood The system offers special advantages for the collection of blood samples from new-borns, children, elderly people and emergency patients, thus everywhere, where only small amounts of blood are available · The test vessel is prepared on the entire inner surface. Besides it can be used as centrifugal vessel · The capillary is coated on the entire inner surface and guarantees an exact filling volume · The attached stopper, which is optionally available with an integrated elastically re-deforming rubber membran, offers perfect tightness · Different measurements and preparations are available Highlights: The safe and variable blood collection system · Gentle – Aspiration technique suitable for all vein conditions · Safe – Unbreakable, high quality plastic ensures maximum user and patient safety · Clean – The high grade rubber membrane closure guarantees absolute tightness · Flexible – Vacuum technique possible · Versatile – Available in different tube sizes and preparations · Comprehensive – Offered with a broad range of accessories LABBOOK 2020 73

Disinfection UVentions – UVbase Compressors Dürr Technik – Sicolab – compressor stations Other Applications Dimension: Weight: Highlights: Outside: 600 × 340 × 540 mm (w × h × d) Inside: 480 × 130 × 220 mm (w × h × d) 29 kg Disinfection with UV light of objects as for example protective masks (PPE), mobile phones, keyboards, computer mice, glasses / goggles, tools and much more. · Removes 99.999 % (5-log10) of all viruses and bacteria · Safe and user-friendly use · Disinfection within a few minutes (average three minutes) · Suitable for a wide variety of objects due to individual brackets · Environmentally sustainable and chemical-free · Easy cleaning from inside and outside · Long-life UV lamps · Made in Germany Air flow: Compressed air quality: Up to 145 l / min at 5 bar Up to 1:3:1 (according to ISO 8573-1) Highlights: · Oilfree compressed air for many applications · Silent – thanks to excellent soundproofing (48 – 54 db [A]) · Compact – fits under the laboratory bench · Mobile – with wheels or handling grips · Wide variety of versions · Membrane dryer and filters as options Specialties Sarstedt – Cell Culture Products Sarstedt – Sediplus Sedimentation System Highlights: For over 25 years Sarstedt has produced a wide range of high quality cell culture products which are distributed worldwide. These many years of experience and know- ledge of the needs of users have allowed us to optimise and continually expand the product range. Highlights: · Venous and capillary blood collection systems for blood sedimentation with matching accessories and devices for automatic detection are available. · The automatic blood sedimentation system Sediplus S 200 with 10 measurement positions, and the Sediplus S 2000 with 40 positions (can optionally be extended to 160 positions) for a high sample throughput, optimise ESR measurement. · The S-Sedivette venous blood collection system enables hygienic, easy handling in an enclosed system. The Microvette CB 200 ESR blood collection system is designed for 200 µl of blood only and ensures minimal patient discomfort when collecting blood. Both systems are proven to perform well in comparison with the Westergren method. LABBOOK 2020 75

In FOCUS ON CHINA we are showcasing regional medium-size enterprises which are producing interesting small devices and test kits for the European market. All companies are CE-certified and their products are trans por ted to Europe. LABBOOK 2020 77

Heal Force – Biosafety Cabinet Highlights: Heal Force HFsafe LC biosafety cabinets set the standard in quality, design,and innovation that comes from a heritage of over 25 years experience. Health Gene – SARS-CoV-2 Virus Detection Diagnostic Kit Highlights: · SARS-CoV-2 Virus Detection Diagnostic Kit (RT-qPCR Method) · WHO EUL; CE and Canadian FDA certified. Lifotronic– H9 Hemoglobin Analyzer Dimensions: 580 × 600 × 520 mm (h × w × d) Weight: 50 kg Sample loading capacity: 110 samples HbA1c test time: 1.2 min / T Highlights: · HPLC methodology · Dual mode: Hemoglobin analysis · Automatic cap pierce · Fully automated start – & thalassemia identification up, maintenance and shutdown · HbA1c test: 1.2 min / T; Thalassemia test: 1.6 min / T · NGSP and IFCC certified · Designed for medium to big · High capacity: 110 sample position · CV ≤ 1.5 % labs with daily test more than 20 test s / day Focus on China ZHEJIANG GENE SCIENCE CO.,LTD. Tel：+86-575-82963126 E-Mail：sales@gene-science.com Web：www.gene-science.com Zhejiang Gene Science Co., Ltd. is a practical, innovative and pioneering Biotech company with the tenet: "high efficiency, precision and safety". Our business involves molecular pathology, immunohistochemistry, routine pathology, medical testing, and genetic testing. We have R&D center, production base, a n d m a r k e t i n g c e n t e r . Y e a r s o f exploration and innovation allow us to build a multi-level marketing network, offering high-quality self-owned branded reagents and instruments with perfect after-sales service system for our global customers. With professional backgrounds and years of experience in the medical device industry, our team members have the latest tec h n o l o g i e s a n d c o n c e p t s , providing you with the best products and the best quality service experience. Welcome to contact us. LABBOOK 2019 79

Livzon Diagnostic – Rapid Test for SARS-CoV-2 Antigen (Lateral Flow) Snibe – Maglumi SARS-CoV-2 S-RBD IgG (CLIA) Focus on China Highlights: This test kit is used for in vitro qualitative detection of SARS-CoV-2 antigen. Earlier than antibody detection, and it can be detected in the early period of infection. · Easy to use · No equipment required · No PCR Lab required · Instant result in 15 minutes Highlights: A better choice in post-pandemic era! · The fully automated quantitative serology test · Strong correlation to neutralizing antibodies level · Assessing immunity in individuals and communities · Accurate test result within 30 mins with ONLY 10μL sample volume (High throughput of 14,400 tests / day) LABBOOK 2019 81

Wuhan HealthCare – Corona Virus Disease 2019 Nucleic Acid YHLO – iFlash 1800 Chemiluminescence Immunoassay Analyzer Focus on China Highlights: · Accurate results: Contains internal standard to avoid false negative results Highlights: · High sensitivity: Minimum detection baseline is 500 copies / mL, which ensures the detection of low virus content sample results · Anti-pollution: “One-step” PCR reduces reaction time and avoids aerosol pollution · High-throughput: Triple PCR reaction system, high detection flux, timely and rapid completion of multiple sample detection · Bench-top Acridinium Easter labeled direct chemiluminescence · Throughput up to 180 tests / hour · More than 112 reagents available · 50 sample position with STAT function · 20 refrigerated reagent positions (2 - 8°C) · 1,000 reaction vessel capacity for continuous loading C V I D - 1 9 D e t e c t i o n S o l u t i o n 2019-nCoV Ag 2019-nCoV Ab Sampling Swab IL-6 PCT/CRP Latex / fluorescence chromatography platform Two major platforms, high accuracy Qualitative/quantitative testing Simple operation Fast Results in 10-15min T C T C C T P O C T c Henan wayray Biotech co.,Ltd Web:www.wayraybio.cn Tel:0371-22738550 Add: NO.12，Song cheng street no.6，Henan pilot Free Trade Zone Kaifeng district，China. E-mail:market@wayraybio.com LABBOOK 2019 83

Companies & Suppliers y r t s i m e h c o n u m m I & y r t s i m e h C ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ l i y g o o b o r c i M ■ l y g o o n h c e T n o i t a m r o f n ■ I T C O P ■ 56 49 61 16 22 23 17 23 17 27 29 33 42 46 47 s n o i t a c i l p p A r e h t O ■ 73 i a n h C n o s u c o F ■ 78 78 79 79 7 42 56 HUMAN HEALTH WE CARE 7 4 37 51 73 LABBOOK 2020 85 Page Index FUJIFILM Wako Chemicals Europe GmbH Fuggerstraße 12 41468 Neuss, Germany phone: +49 2131 311-272 diagnostics_wkeu@fujifilm.com www.wako-chemicals.de Zhejiang Gene Science Co., Ltd. 2rd Building, Pharmaceutical industry park, HSEDA, Shaoxing City, Zhejiang Province, China. phone: +575 82963126 sales@gene-science.com www.gene-science.com Genrui Biotech Inc. 4-10F, Building 3, Geya Technology Park Guangming District 518106 Shenzhen, China phone: +86 755 26 83 55 60-1 (-2) international@genrui-bio.com www.genrui-bio.com Shenzhen Lvshiyuan Biotechnology Co., Ltd. D Building, National Biological Industrial Park of Marinelife, No.2 Binhai Road, Dapeng, 518120 Shenzhen, China phone: +86 755 28438788 info@lsybt.com www.lsybt.com Greiner Bio-One GmbH Bad Haller Straße 32 4550 Kremsmünster, Austria phone: +43 7583 6791-0 office@at.gbo.com www.gbo.com Hamamatsu Photonics Deutschland GmbH Arzbergerstraße 10 82211 Herrsching, Germany phone: +49 8152 375-203 info@hamamatsu.de www.nanozoomer.com Heal Force Bio-meditech Holdings Ltd. 6788 Songze Avenue, Qingpu District, Shanghai 201706, China phone: +86 21 62728646 export@healforce.com www. healforce.com HEALTH Gene Technologies Co., Ltd. 396 Mingzhu Road, Hi-Tech Park, Ningbo 315040, China phone: +86 574 2797 8799 mingye.mao@healthgenetech.com www.healthgenetech.com HORIBA Medical Parc Euromédecine · Rue du Caducée – BP7290 34184 Montpellier, France phone: +33 467 141516 webmaster.med@horiba.com www.horiba.com Helmut HUND GmbH Artur-Herzog-Straße 2 35580 Wetzlar, Germany phone: +49 6441 2004-0 info@hund.de www.hund.de Improve Medical No. 102, Kaiyuan Avenue, Science City, Guangzhou Economic & Technological Development District, Guangzhou, China phone: +86 20 32312610 info@improve-medical.com www.improve-med.com

g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ 8 9 5 5 6 8 6 Page Index Orion Diagnostica Oy Koivu-Mankkaantie 6 B 02200 Espoo, Finland phone: +358 10 4261 orion.diagnostica@oriondiagnostica.fi www.oriondiagnostica.com Promega GmbH Gutenbergring 10 69190 Walldorf, Germany phone: +49 6227 6906-257 wiktoria.banczyk@promega.com www. promega.com Quidel Germany GmbH Leibnizstraße 11 70806 Kornwestheim, Germany MarketingEurope@quidel.com www.quidel.com Samplision Limesstraße 17 61273 Wehrheim, Germany phone: +49 6081 982550 info@samplision.de www.samplision.de SARSTEDT AG & Co. Sarstedtstraße 1 51588 Nümbrecht, Germany phone: +49 2293 305-0 export@sarstedt.com www.tempus600.com www.sarstedt.com Sentinel CH. SpA Via Robert Koch, 2 20152 Milano, Italy phone: +39 02 3455141 sentinel@sentinel.it www. sentineldiagnostics.com SHIMADZU Europa GmbH Albert-Hahn-Straße 6-10 47269 Duisburg, Germany phone: +49 203 7687-0 shimadzu@shimadzu.eu www.shimadzu.eu Siemens Healthineers Laboaratory Diagnostics 511 Benedict Avenue 10591 Tarrytown, NY, USA phone: +1 914 631 8000 www.healthcare.siemens.com Shenzhen New Industries Biomedical Engineering Co., Ltd. 21st Floor, Block A, Building 1, Shenzhen Software Industry Base, No. 1008, Keyuan Road, Nanshan District 518000 Shenzhen, China phone: +86 755 26501514 sales@snibe.com www.snibe.com Sysmex Europe GmbH Bornbarch 1 22848 Norderstedt, Germany phone: +49 40 527 26-0 info@sysmex-europe.com www.sysmex-europe.com Guangzhou Tianbao Songyuan Biotechnology Development Co., Ltd. 233 Tianhe north road, Tianhe district, Guangzhou Room 2415, 24 / F, Citic Square, China phone: +86 20 87520147 Zijun.Lun@tebsun.com www.tebsun.com y r t s i m e h c o n u m m I & y r t s i m e h C ■ Companies & Suppliers l y g o o n h c e T n o i t a m r o f n ■ I s n o i t a c i l p p A r e h t O ■ i a n h C n o s u c o F ■ T C O P ■ l i y g o o b o r c i M ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ 49 50 18 19 28 29 19 26 29 25 27 28 49 61 42 43 49 51 67 74 75 25 26 53 37 38 43 44 38 39 44 50 51 61 64 65 66 70 71 56 66 81 82 82 LABBOOK 2020 87

Today, there is so much less to do when operating an analyser, and so much more to see, know and decide when looking at the results. At Sysmex, we believe that technological excellence must go hand in hand with a deeper understanding of diagnostics as a whole – and, in particular, the people who work in it. We believe that our technology can make people’s jobs easier, more rewarding, and more fulfilling. And we believe that there is a deep emotional value to every diagnostic value. Because ultimately, this always relates to a patient and his or her individual fate. ‘Lighting the way with diagnostics’ is our bold vision of a community of innovators and caregivers who passionately seek synergies, drive change and together unleash the full potential of diagnostics. Therefore, we will stay curious, challenge current standards and truly embrace a spirit of collaboration. Care. Connect. Inspire. www.sysmex-europe.com