Your guide to laboratory and pathology equipment in Europe € 15.– Automation & Sample Processing Chemistry & Immunochemistry Hematology Pathology DNA Microbiology POCT IT Peripheral Devices 2019 Vol. 6 Set up the workflow you need: The UN-Series offers you the freedom to automate your urinalysis workflow from start to finish with maximum flexibility. With fluorescence flow cytometry technology at its core, the Sysmex UN-Series is an innovative solution for any laboratory.

Editorial Dear reader, Welcome to the Labbook 2019. This year, we focus on sourcing and operating analytical instruments, on the selection of suitable peripherals, vials and containers, automation components and sample handlers in order to optimise sampling and sample logistics. In addition, just like last year, we are taking a close look at information technology (IT) since today no medical laboratory can operate efficiently without appropriate software solutions. The core tasks – performing analyses in the required quality and forwarding the results in a timely manner to the physicians – require IT. While in 2018 we focused on sourcing and selecting a laboratory information system (LIS), this year we would like to support your efforts to operate your LIS smoothly and without glitches. The bad news is: error-free software is an illusion. The good news is: nevertheless, you as a user have options, even if you have no idea of the complex and often chaotic software development process. One of the key issues here is to recognize when replacing your legacy software makes sense. As is customary in the Labbook, you will find insights on the successful organisation of automated labs as well as manufacturer-oriented information on current equipment trends. With all this data we didn’t forget our mission: to provide a comprehensive sourcing guide. You will find information on tried and tested instruments, IT systems, accessories and reagents presented in a handy format and categorized by sub-discipline, covering the whole of Europe. A propos Europe: While the political situation remains – let’s say – confusing, our partners, the manufac- turers of the components shown here, are clearly optimistic and keen as ever to showcase their products in this sixth edition of the Labbook to an international audience. Last but not least we would like to point out that beyond the print edition of the Labbook you can find the information online. Go to www.labbook.eu and www.healthcare-in-europe.com to browse the product database and the Labbook as e-paper; you will also find the contact data of all manufacturers and authors. We, the manufacturers, authors and the editorial team, should like to thank you for your interest in the Labbook. We are looking forward to receiving your feedback – suggestions, criticism, kudos are all equally welcome to guide us towards the 2020 edition. Enjoy reading and browsing Daniela Zimmermann Dr Markus Neumann LABBOOK 2019 1

Automation & Sample Processing A u t o m a t e d S a m p l e P r o c e s s i n g Automation Robotics Sample Processing

Sample Processing High-performance tube sorting More than 16 years of experience in the complex matter of workfl ows within clinical labs leads to the latest generation of ASP SortPro tube sorter. T o make the investment in sorting devices effi cient, these must be integrated perfectly into the workfl ow. The ASP team sold hundreds of tube sorters to clinical labs and hospitals worldwide. In all these installations the German engineers have accumulated deep knowledge about the workfl ow in clinical labs. This experience is an integral part of the specifi cation for every new generation of ASP SortPro tube sorter. While ASPs innovation last year focused on software tools to optimize the workfl ow and data integration into the LIS, ASP’s 2019 product release combines these digital benefi ts with a completely new device fulfi lling all the customer demands. This comprehensive update requires a relaunch of the hardware. A high-resolution camera and advanced image processing software are used to identify the processed tubes. It recognizes barcode, cap colour and tube type (manufacturer and size) within milliseconds. This powerful detection unit speeds up the sorting process to more than 3,000 tubes per hour without any change in the proven soft handling of the tubes through the sorting device. The pictures of the tubes can be inspected at the device and are available for export and documentation purposes of processed samples. The new design of the specimen hopper ensures no tubes remain in the hopper by accident. It also detects if the hopper is empty and when tubes are fi lled into the hopper. The priority input allows urgent specimens to bypass the hopper and to be processed immediately without stopping the standard process. SortPro can sort bulk, fi ll analyser racks or hand over tubes to track systems or analysers. Each specimen is identifi ed, registered in the LIS and sorted by internal sorting criteria or input from the LIS. ASP SortPro selects and separates tubes for manual handling while the majority of tubes are sorted for standard processing. Doublets are detected and can be handled individually. With its touch screen and modern user interface, the device is easy to use. Functions to manage and edit sorting rules make sure the device can be adapted to changing requirements at any time. The system works basically without human intervention. If staff is required, the integrated process management sends a text message to the person in charge. Mainte- nance and service tools guarantee maximum availability and minimum operating costs. ASP SortPro does not only register, sort and document your specimens – due to its comprehensive integration into the workfl ow, it constantly improves the effi ciency of your lab. Easy access: The new lightweight target bin with permanent display Priority input: Tubes placed here will be processed within seconds CONTACT ASP Lab Automation AG Rugenranzel 4 · 25373 Ellerhoop, Germany phone: +49 4120 70679-27 info@asplabauto.com · www.asplabauto.com LABBOOK 2019 5

Sarstedt – Sample Distribution System PVS 1625 Sarstedt – Sorter DC/RC 900 Flex Sample Processing Highlights: The PVS 1625 is a tailor made automation system for pre- and post-analytical processing of samples. It is capable to handle any kind of rack and tray type. As an open system, it is complementary to any analytical platform or can be used independently. Loading of unracked or racked sample tubes is via the Bulk Loader or in racks via the loading platform, which is suitable for closed and open tubes. Full function pre- and post-analytical system · Ideal in combination with any analytical platform · Modular configuration according to customer needs with: Loading platform and / or Bulk Loader · ID Module / Decapper / Recapper / Aliquoter / Sorter · For all common tube types: 13 – 16 mm diameter, 65 – 100 mm length · Compatible with most racks or carrier types Sample throughput: Up to 900 tubes / h Highlights: Pre- and post-analytics in one system: · Processes any tube diameter from 11 to 16 mm · Compatible with most racks or carrier types · Online or offline operation · Opens tubes with push caps, stoppers and screw caps · Can be customised to sort by tube type, material (barcode) or test request · Closes tubes with universal archiving caps · Retrofitting of decapping or recapping module is possible · Recapping with screw caps for Sarstedt tubes with 13 or 15 mm diameter T&O LabSystems – ATRAS (RS) Siemens Healthineers – VersaCell X3 Solution Robotics Sample throughput: Dimensions: Over 2,350 samples / h 1,100 × 1,130 × 600 mm (w × h × d) at min. configuration, add 200 mm for every additional module Dimensions: Sample throughput: Power consumption: Assays: 1,520 × 1,780 × 1,040 mm (h × w × d) Up to 200 samples tubes / h 800 W Menu varies based on analyzers connected Highlights: The ATRAS is a bulk-loader and sorter for automated registration and sorting of incoming blood and urine sample tubes. Every ATRAS provides a clear structure, intuitive operation and low maintenance. · Early registration and plausibility check of sample tubes · Priority input for emergency tubes · Bulk to bulk sorting · Bulk to rack sorting · Free combination of bulk and rack targets · Works with or without LIS connection · Processes all standard blood and urine tube types Highlights: Advance workflow capabilities, streamline processes, and meet changing needs with agility – at a cost labs can justify. VersaCell X3 Solutions use robotics with dynamic STAT management to provide the optimal mix of chemistry and/or immunoassay analytics with one-touch sample management. Connect up to three Siemens’ instruments including ADVIA 1800 chemistry System, ADVIA Centaur XPT and/or IMMULITE Immuno- assay systems, and Dimension EXL and RxL Max inte- grated Systems. Product availability varies by country. LABBOOK 2019 7

Touring the laboratory at the Clínic de Barcelona Hospital, Dr José Luis Bedini revealed how the latest Siemens Healthineers technology has trans- formed workfl ow to deliver quicker results, improve effi ciency, conserve energy, and thus make the team of technicians very happy! I n recent months the Core Lab Operative Area at Hospital Clínic de Barcelona has undergone a transformation due to the intro- duction of a new Atellica Solution from Siemens Healthineers. Dr José Luis Bedini, the laboratory head, explained the Atellica Solution from “conception to reality” during a tour of his lab, outlining how the automated environment is slicker, delivers around-the-clock results to clinicians, and provides a more patient-friendly experience. In working with Siemens Healthineers to develop the system the Hospital Clinic has streamlined its operation from ten analysers to just three Atellica Solutions. The Atellica Solution integrates immunoassay and clinical chemistry analysers with new sam- ple-management technology. Scalable, it features bidirectional magnetic sample-transport technology, a broad assay menu and has the fl exibility to create over 300 customisable confi gurations. It can be confi gured as a stand-alone system or connected to Aptio Automation, providing a multidisciplinary total lab solution and improving workfl ow with adaptable, multidisciplinary track confi gurations. A selection of pre- and post-analytical modules can automate sample loading, preparation, and handling to free lab staff from time-consuming, low-value tasks, plus simultaneous STAT and routine testing on a single track. Automation Automation Of the three Atellica Solutions in the Barcelona lab, two are SCI confi gurations (sample handler, chemistry and immunoassay) while the third is SCCI with two chemistry modules. These deliver a wide range of routine and STAT tests. “Our aim with clinicians is to have the results from the STATs in less than 60 minutes and we achieve that,” Bedini explained. “With Atellica, we have improved the turnaround time to 48 minutes – an important benefi t.” The 24/7 laboratory operates and handles 5,000 tubes daily, to produce 21,000-24,000 results per day. Three Atellica Solutions – many results “In the past, to have this portfolio of activity we needed many different analysers; now we do everything on just three Atellica Solutions. There are benefi ts for workfl ow, for technicians and patients, with less turnaround time and quicker results,” he added. The samples arrive from two routes – direct via a tube from the emergency department – or delivered to the lab from older parts of the hospital, such as the cardiology or kidney units. They go to the centrifuge, onto the track and to the Atellica. The machine knows what the sample is – for example a Troponin test – by reading a bar code on the tube, which is automatically de-capped before analysis and then sent to the relevant analyser. In terms of workload, most is generated from in- and out-patient services at the 700-bed hospital, plus 800 – 1,000 samples daily from the phlebotomy area of out-patients. “Our workload is 55 precent out-patients, 45 percent in-patients, but we also receive samples from other hospitals for special tests,” Bedini pointed out. By integrating the most frequent automated tests, resources are released for more specialist tasks, whilst new features of the Siemens Healthineers’ system – notably automatic maintenance, automatic quality control and calibration – offer further advan- tages. Previously, such maintenance required manual input and a 20-minute wait for the outcome before processing patient samples. “With Atellica you can schedule maintenance, quality control >> A Lab environment with the Atellica Solution is slicker, delivers around-the-clock results, and provides a more patient-friendly experience. LABBOOK 2019 9

Automation Automation Beckman Coulter – DxA 5000 Dynamic inlet: Centrifuges: Decapper: Recapper: Up to 1,200 tubes / h Up to 500 tubes / h (1), Up to 1,000 tubes / h (2) Up to 1,200 tubes / h Up to 1,200 tubes / h Highlights: The DxA 5000 helps laboratories meet the challenges of today’s highly focused healthcare environment through a collection of patented innovations that deliver rapid and consistent turnaround time, provide a new level of comprehensive pre-analytical sample quality detection, and reduce the number of manual processing steps to significantly improve laboratory efficiency. Leveraging first-of-its-kind dynamic system software, the DxA 5000 utilizes Intelligent Routing to bring automated patient-centric workflow to the laboratory. By understanding the tests requested, sample volume available and real-time analyzer capacity and status, the DxA 5000 continuously calculates the most expeditious route for every patient sample — both STAT and routine. The DxA 5000 enhances Beckman Coulter’s comprehensive port- folio of scalable solutions, and is a key component of its vision to bring workflow automation to laboratories of all sizes. Horiba Medical – HELO* Solution Highlights: Horiba Medical has developed a new HELO* configu ration thanks to a new Yumizen T6000 island shape. This compact solution allows to connect analyzers (Yumizen H1500/H2500 and Yumizen SPS options) on both sides of the same track. This innovative track config- uration generates a very high result production capacity per square meter of floorspace. The HELO* Solution is therefore available in four different shapes (Linear, Angular, Workcell, Island) in order to match with many laboratory architectural constraints. *Horiba Evolutive Laboratory Organisation Inpeco SA – Total Laboratory Automation (TLA) Highlights: FlexLab is the most open automation system capable of managing the complete process of a patient sample, from tubes check-in, through pre-analytical and post-analytical modules, that automates all manual routine tasks, such as identification, sorting, centri- fugation, decapping, aliquoting, recapping, storage, disposing and retrieval. FlexLab has over 50 validated connections with the most common analyzers, for many specialties. FlexLab is a completely scalable system, that adapts to the specific laboratory current needs and is open for future integrations, as the lab evolves. It includes an integrated middleware solution, called Data Manage ment Software, that receives patient results from analyzers, and sends the results to the Lab Information Systems. LABBOOK 2019 11

Chemistry & Immunochemistry Clinical Chemistry Immunochemistry Immunoassays Integrated Systems Mass Spectrometry Electrophoresis/ Chromatography Plasma Protein Testing Drug Testing Urine Screening Rapid Testing Research Use Only

Chemistry & Immunochemistry Beckman Coulter – DxC 700 AU Beckman Coulter – HbA1c Advanced Dimensions: Weight: Sample throughput: Power consumption: 1,300 × 1,250 × 890 mm (h × w × d) 460 kg 800 – 1,200 / h 200 – 240 W Highlights: Designed to meet the needs of mid- to high-volume clinical laboratories, the DxC 700 AU reduces the number of test-processing steps by 30 percent due to its intuitive user-interface that allow operators to spend less time on daily tasks and more time producing the quality results that empower better decision-making. · Simple, intuitive design of the DxC analyzer with the robust throughput capabilities of the AU analyzer · Configurable with a total laboratory solution option to connect the DxC 700 AU with pre-analytical automa- tion, immunoassay and clinical IT Highlights: The fully automated HbA1c Advanced assay enables mid- to high-volume laboratories to provide physicians with state-of-the-art precision and accuracy for diagnosing diabetes mellitus, monitoring long-term glucose control in individuals with diabetes mellitus and identifying pa- tients who may be at risk of developing diabetes mellitus. · National Glycohemoglobin Standardization Program (NGSP) certified/DCCT standardized and precise, providing clinically relevant results for diagnosing and monitoring diabetes · Unaffected by common hemoglobin variants, mini- mizing misdiagnosis or missed diagnosis for patients with these blood conditions · Easy to implement and integrate into the laboratory’s existing chemistry testing practices, providing work- flow efficiency · Available in a single all-in-one kit for Beckman Coulter DxC 700 AU analyzers BioSystems – A15 BioSystems – BA200 Sample throughput: Assays: Dimensions: Weight: No. of channels 150 tests / hour Colorimetry, turbidimetry 840 × 615 × 670 mm (w × h × d) 45 kg 48 samples and 30 reagents (20 refrigerated) Highlights: · Random access automatic analyzer · Fully open system with customized filter configuration Sample throughput: No. of parallel samples: Assays: Dimensions: Power Consumption: 200 tests / hour 267 tests / hour with ISE Colorimetry, turbidimetry, ISE 1,077 × 680 × 690 mm (w × h × d) 260 VA Highlights: · STAT and Routine Laboratories Benchtop Random and unlimited external applications · Improved reagent stability due to the new cooling system · Maximum flexibility in samples and reagent loading (primary tubes and sample cups) and reagent configuration · Continuous loading of samples during working session (STAT samples) without stopping the analyzer · Real prozone (antigen excess) and substrate depletion detection · Automatic sample pre- and post-dilution Clinical Chemistry Analyzer · Dynamic baseline with SMART LED Technology · High reagent and sample capacity (88 positions), the highest grade in flexibility · Barcoded dedicated reagents · Highly accurate dispensing · 120-cuvette rotor with washing station · Compact system with low maintenance · Real 200 t / h, even with bi reagent reactions LABBOOK 2019 15

Chemistry & Immunochemistry UF-5000 / UF-4000: technology that makes a difference Fluorescence fl ow cytometry is at the focus of the UF-5000 / UF-4000. The cells are separated and counted by generating different signals depending on cell type. You can process all samples on UF or you can do an automatic selection based on results from the UC-3500. Or, if you don’t need test strip analysis, the UF can be your primary analyser for all urine samples undergoing sediment analysis. U-WAM: workfl ow tailored to you The Urinalysis Work Area Management system, or U-WAM, brings the whole system together and displays all modules’ results on one screen. You get the full diagnostic overview of samples without losing any time or details. To further show that we offer full fl exibility, rule sets can be customised for workfl ow optimisation. Where the UN-Series can really make a difference Bacterial urinary infections are rather common and can lead to serious conditions, however using a UF in your microbiology lab can be extremely benefi cial for both clinicians and patients. The UF allows you to promptly rule out negative samples where a UTI is suspected. This means that you can proceed immediately with those that are UTI-positive. From there, you also get the full bacteria count and based on the cells’ staining behaviour, whether they are Gram-positive or Gram-negative, which allows clinicians to get a good insight on which antibiotic may work best for the patient. More than sediment analysis: infection management By utilising the ‘Bact info’ fl ag**, you can select specifi c culture media for incubating the positive samples and confi rming possible treatment options. You can save a lot of time because initial results are available within minutes instead of days. Treatment can then be started earlier and is more targeted, relieving patients’ pain quicker and helping prevent antibiotic resistances. When it comes to the art of particles, we have superior technology www.art-of-particles.com Lighting the way with diagnostics Sysmex is unique in that we are the world’s only IVD company that stains particles and utilises fl uorescence fl ow cytometry to get the most accurate count and differentiation of cells. We aim to shape the advancement of healthcare by providing healthcare professionals around the world with exceptional medical diagnostics products and solutions. Through our application of knowledge and teamwork with our stakeholders and network, and through the creation of products that truly address issues at hand, we are making a positive impact on the way in which laboratories do business. At the end of the day, our ultimate motivator and shared goal is to improve patient care together. Superior technology – fl uorescence fl ow cytometry for sediment analysis Thanks to our unique signal detection, the UF ensures an accurate cell count through the illumination of each separate cell by a semiconductor laser beam. The UF is also able to sub-classify epithelial cells and casts to immediately get an indication of whether a patient is suffering from renal damage, for example, and to which degree. Every UF has an integrated body fl uid mode available with the click of a button and offers nine diagnostic parameters. In body fl uids, the crucial cell concentrations are usually very low. In its body fl uid mode, the UF covers the minimum detection limit of 15 RBC / µL 2 WBC/µL using its proven fl uorescence fl ow cytometry method. It can count the red and white blood cells and the total of nucleated cells within about a minute. The differentiation of bacterial or viral infections can also be presumed from the combination of WBC differentiation and bacterial count. UD-10: the smart way of digital imaging In some cases, a closer look at your results is required – with the UD-10 we can truly automate your urinalysis workfl ow. The digital imaging device, which captures the particle images in urine samples, provides a detailed view of crucial urine particles without perform- ing any manual steps. By defi ning the trigger criteria for UD analysis, you can modify the workfl ow to meet your lab’s specifi c needs. With our solution, you only look at those samples and particle types that you wish to investigate further. UN-Series – modular, fl exible and scalable according to your needs LABBOOK 2019 17

Chemistry & Immunochemistry Genrui – Auto Electrolyte Analyzer GE500 Greiner – Vacuette CAT Serum Fast Tube Sample throughput: Assays: No. of channels: No. of parallel samples: Dimensions: Up to 100 samples / h Up to 8 items on demand Auto loader with 32 positions Whole blood, serum, plasma, urine 330 × 235 × 439 mm (w × h × d) Highlights: GE500 supports flexible combinations with the parameters including K+, Na+, Cl-, iCa2+, Li+, Mg2+, PH, TCa. All worth and beyond your expectation. · Throughput: 100 samples/hour · Sample Type: Whole blood, Serum, plasma, urine · Auto loader with 32 positions · All-in-one reagent pack with long validity · Easy to use software Highlights: · Tube combines the speed of a plasma tube with the properties of serum · Shorter preanalytical process · Full coagulation in just 5 minutes · Improved turnaround time · Blood collection can be performed shortly before transport of the blood samples · Quicker lab results with on-site analysis Mindray – BS-480 Clinical Chemistry Analyzer Mindray – BS-240Pro Clinical Chemistry Analyzer Sample throughput: No of parallel samples: Dimensions: Weight: Constant 400 t / h, up to 560 t / h with ISE Up to 78 on-board chemistry tests 1,185 × 1150 × 710 mm (w × h × d) 300 kg Highlights: · Discrete, random access, fully automated · Constant throughput with 400 photometric t / h, up to 560 t / h with ISE · 24-hour on board refrigerated reagent compartment at 2~10 C · Reusable cuvettes with auto-washing station · Two independent mixing stirrers · Clot detection, automatic probe cleaning, liquid level detection & collision protection (V&H) · Reversed grating system with 12 wavelengths (340~800nm) · Pre-dilution and post-dilution for sample · Built-in barcode scanner · Bi-directional LIS interface Sample throughput: Dimensions: Weight: Constant 240 t / h, up to 400 t / h with ISE 860 × 550 × 660 mm (w × h × d) 115 kg Highlights: · Constant throughput with 240 photometric t / h, up to 400 t / h with ISE module · Large and flexible capacity: up to 100 sample / reagent positions (50 fixed + 50 interchangeable) · Reduced reagent consumption: 100 μL minimum reaction volume · Intelligent probe with liquid level detection, V&H collision detection, inventory monitoring, reagent pre-heating and optional clog detection · Grating photometer with 12 wavelengths, dual-diaphragm and dual-lens · HbA1c smart-sampling function, automatic hemolysis LABBOOK 2019 19

Chemistry & Immunochemistry Immunochemistry DRG Instruments – DRG:Hybrid-XL Fujirebio – Lumipulse G1200 Sample throughput: Assays: Dimensions: Highlights: 40 tests per run Anti-tTG, Anti-DGP, Calprotectin, 17-OH Prog., Free Testo. , Renin, Aldosterone, 25-OH Vitamin D, Hepcidin-25, Salivary Cortisol, TM-CA72-4, HbA1c, Cystatin C and more 586 × 608 × 635 mm (h × w × d) DRG:Hybrid-XL is a fully-automated bench top analyzer with high flexibility and an intuitive user interface, that simplifies daily work. This unique technology allows the simultaneous determination of immunoassays, immuno- turbidimetry, as well as clinical chemistry tests in the same sample. Calibration is provided via barcoded master curve and a two-point re-calibration set. Calibration as well as reagent cartridges offers a long stability. Sample throughput: Time to first result: Sample capacity: Reagent capacity: Dimensions: 120 tests / h 30 min Up to 100 samples 504 tests on board 1,450 × 1,200 × 800 mm (h × w × d) Highlights: A compact, robust and reliable fully automated chemiluminescent enzyme immunoassay analyzer. The Lumipulse G1200 offers optimized reagent and consumables handling, true random access, and a constant throughput regardless of the assay format or combination. The unique mono test cartridge elimi- nates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers and is fully compatible with laboratory automation systems (LIS). Fujirebio – Lumipulse G600II Sarstedt – ELISA Plates / Micro test plates for immunoanalytics Sample throughput: Time to first result: Sample capacity: Reagent capacity: Dimensions: 60 tests / h 35 min Up to 36 samples (incl. 3 priority specimens) 112 tests on board 642 × 890 × 725 mm (h × w × d) Highlights: A fully automated benchtop chemiluminescent enzyme immunoassay analyzer. The Lumipulse G600II offers optimized reagent and consumables handling, true random access, and a constant throughput regardless of the assay format or combination. The unique mono test cartridge eliminates open reagent bottle stability concerns. It comes with the broad menu of routine and unique Lumipulse G biomarkers. Highlights: One of the analyses most commonly used is the Enzyme-Linked Immunosorbent Assay (ELISA). With this method, even the smallest concentrations of a range of substances (proteins, peptides, antibodies, hormones etc.) can be detected and quantified from complex solutions. LABBOOK 2019 21

Chemistry & Immunochemistry Beckman Coulter – Access High Sensitivity Troponin I (hsTnI) Beckman Coulter – Access Procalcitonin (PCT) Highlights: The Access hsTnI assay provides the advanced diagnostic capabilities necessary to aid physicians in diagnosing at risk patients for acute myocardial infarction earlier and discharging non-acute patients faster. In comparison to standard troponin assays, high-sensi- tivity assays demonstrate significantly improved preci- sion at and below the 99th percentile upper reference limit (URL), allowing better discrimination of small differ- ences in troponin values between serial measurements. · Aids in rapid diagnosis of AMI and confidently excludes AMI in as little as one hour after patient presentation · Provides optimal precision at concentrations about 10x lower than previous generation troponin assays. Improved precision at the clinical cutoff reduces chance of misclassifying patients in the Emergency Department Highlights: Access PCT aids physicians in the risk assessment of critically ill patients for progression to severe sepsis or septic shock. With results you can trust in approximately 20 minutes. Access PCT allows healthcare providers to integrate procalcitonin testing into their routine sepsis workups on core laboratory analyzers as a primary or reflex test programmed though Beckman Coulter’s REMISOL Advance middleware. Such integration simplifies laboratory workflow and optimizes institutional sepsis management protocols while reducing the operation expense of main- taining costly dedicated instrumentation. Access PCT provides confidence in results and improved patient care through: · > 95 percent overall agreement with predicate method for accurate assessment of patients at risk of progres- sion to severe sepsis and septic shock · State-of-the art sensitivity and low-end precision – 20 percent CV LoQ of 0.02 ng / mL – CV ≤ 8 percent at concentrations ≥0.150 ng / mL · Minimal sample draw of 35 µl pick-up volume Beckman Coulter – Access 2 Immunoassay System Beckman Coulter – UniCel DxI 800 Access Immunoassay System Dimensions: Weight: Sample throughput: Assays: 500 × 900 × 610 mm (h × w × d) 91 kg Up to 100 / h > 50 pre-programmed, bar-coded immunoassay methods Dimensions: Weight: Sample throughput: Assays: 1,700 × 1,710 × 970 mm (h × w × d) 630 kg Up to 400 tests / h > 50 preprogrammed, bar-coded immunoassay methods Highlights: Designed to have the robustness of a reference-lab immunoassay analyzer in the convenient size of a benchtop instrument, the Access 2 delivers quality, reliability and speed without sacrificing valuable floor space. The Access 2 features an extensive immunoassay diagnostic-testing menu of more than 50 tests including AMH and TSH (3rd IS). · Standardized reagent and assay testing menus can be used across all immunoassay platforms to drive labo- ratory efficiency and provide consistent results across healthcare networks Highlights: The UniCel DxI 800 includes proven chemiluminescent technology and one of the highest throughput systems available on the market. High volume labs can decrease process steps and improve turnaround time by simplifying and automating immunoassay testing to a single platform. · Beckman Coulter’s immunoassay instruments have common software interfaces and consumables across the whole family, enabling operators to train more quickly, minimize inventory, and ensure consistency in results across platforms LABBOOK 2019 23

Chemistry & Immunochemistry Fast, Accurate True High- Sensitivity Troponin I Results They’re counting on you Visit us at AACC Booth #1039 P r o d u c t a v a i l a b i l i t y m a y v a r y f r o m c o u n t r y t o c o u n t r y a n d i s j s u b e c t t o v a r y i n g r e g u a t o r y r e q u i r e m e n t s . l Powered by Atellica® Solution When every minute counts for cardiac patients, you can be confident in the Siemens Healthineers true High-Sensitivity Troponin I assay to provide results with improved sensitivity and precision at the low end of the assay range. Combined with the revolutionary STAT capabilities of the Atellica Solution, this 10-minute assay enables clinicians to quickly triage chest pain patients. See our website or ask your sales representative for more information. siemens-healthineers.com/TrueTroponin LABBOOK 2019 25 A 9 1 D X - 9 6 3 4 - A 3 - 4 A 0 0 · © S i e m e n s H e a l t h c a r e D a g n o s t i c s I i n c . , 2 0 1 9 A t e l l i c a i s a t r a d e m a r k o f S i e m e n s H e a l t h c a r e D a g n o s t i c s I i n c .

Chemistry & Immunochemistry Snibe – Maglumi 2000 Plus Snibe – Maglumi 4000 Plus Sample throughput : Dimensions: 180 tests / h 1,440 × 760 × 1,520 mm (h × w × d) Sample throughput: Dimensions: 280 tests / h 1,380 × 890 × 1,600 mm (h × w × d) Highlights: · On board capability: up to 144 samples · Reagent position: 25 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Highlights: · On board capability: up to 144 samples · Reagent position: 25 · Refrigerated sample and reagent area · Clot detection · Liquid level detection · Auto dilution for high concentration sample · Color touch screen · Bi-communication with LIS via ASTM protocol Integrated Systems Mindray – SAL 6000 Modular System Mindray – SAL 9000 Modular System Sample throughput: No of channels: Assays: Dimensions: Weight: Chemistry 1,200 tests / h, Immunology up to 240 tests / h 36 63 3,935 × 1,016 × 1,145 mm (w × h × d) 1,078 kg Highlights: The SAL 6000 Modular System is a high-performance integrated system connecting seamlessly the BS-800M Chemistry Analyzer with the CL-2000i Chemiluminescence Immunoassay Analyzer, with a throughput of up to 800 photo metric tests per hour and 240 tests per hour respectively. The system offers a large capacity of 300 sample positions and 36 reagent positions, and supports non-stop continuous sample loading. Highlights: · Consist of clinical chemistry analyzer BS-2000M and chemiluminescence immunoassay analyzer CL-6000i · Large capacity: new rack system with up to 30 racks (300 samples), continuous loading supported · Easy operation: Intuitive interface for ONE integrat- ed system operation software, real-time indication of cuvettes, real-time QC status monitoring, waste and wash buffer status, reflex and re-run function, step-by-step maintenance guide, etc · New SDM achieves effective distribution, quick response, fast STAT LABBOOK 2019 27

In this context, beginning in 2018, the French agency regulating medicinal product safety ruled in favor of routine screening for DPD defi ciency before treatment with fl uoropyrimidine. Several technologies are available on the market: · Genotyping of the DPD gene has the advantage of producing a fast, relatively inexpensive and unambiguous response using automated techniques. Specifi city is very good but sensitivity is relatively poor. · Phenotyping is much more time-consuming with more complicated methods, diffi culty of automation and a lower level of evidence. · The indirect phenotypic technique, currently the most used, is the determination of overall DPD activity based on monitoring of the UH2 / U ratio in plasma. This analysis uses sample extraction followed by separation in high performance liquid chromatography coupled with mass spectrometry detection. This technique is faster and cheaper than the direct assay of activity in peripheral blood mononuclear cells. Following an observation period, Haute Autorité de Santé (France) and INCa (Institute National du Cancer) recommend testing for DPD defi ciency by determination of uracil plasma concentration [uracilemia] where fl uoropyrimidine treatment is planned. The INCa statistics database estimated around 100 000 patients receiving fl uoropyrimidine-based chemotherapy each year in France, increasing the need for a quick solution. This monitoring can be done by checking the ratio of dihydrouracil (UH2) to Uracil (U) and/or uracilemia using LC-MS/MS technology as mentioned earlier, and the criteria below are recommended. Ratio U / UH2 Prescription Between 3 and 4 Standard dosage Between 2 and 3 Warning: Dosage reduction not systematic Between 1 and 2 Dosage reduced from 15 to 20 percent 0,5 to 1 < 0,5 Dosage reduced by 30 percent Use not recommended Uracilemia Prescription Below <16 ng/ml Standard dosage ≥ 16 ng/mL Dosage reduced from 15 to 50 percent >100 ng/ml Use not recommended Chemistry & Immunochemistry There have been numerous method developments around the world to analyze the UH2 / U ratio by LC-MS / MS but all of them include complex sample preparation such as LLE (liquid-liquid extraction), centrifugation or SPE (solid phase extraction), making sample preparation both time-consuming and tedious. The recent urge for systematic screening of all patients undergoing 5-FU treatment in France has placed laboratories under much pressure due to the low throughput of existing methods. To cope with the situation, we propose a new solution based on the use of the CLAM-2030, a novel fully automated sample preparation system by Shimadzu, coupling a high-pressure liquid chromatography (NEXERA-X2, Shimadzu) and a triple quadrupole mass spectrometer (LCMS-8060, Shimadzu). Launched in April 2016, the CLAM-2000 has already demonstrated its capabilities for automation prior to LC-MS / MS analysis in various fi elds such as clinical chemistry and toxicology. The new CLAM-2030 version improves reproducibility and accuracy of quantitation by implementation of new closed reagent vials as well as several hardware and software functionalities. The ability of the CLAM-2030 to draw sample from primary or secondary tube, and the capability for sample treatment with overlapping prior to analysis, allow quick sample pretreatment of less than 10 min including protein precipitation and fast LCMS quantitation of U and UH2 in 15 min. In addition, sample volume is low when compared to existing LCMS methods involving several extraction steps, reducing the burden for large blood sampling. The methods developed (details currently under confi dentiality agreement) easily reach an LOQ of 2,5 ng / ml for both U and UH2 compounds in plasma with good linearity for quantitation (r2>0,995). The method was developed with the aim of reaching the requirements of ISO 15189 in the department of Pharmacology and Toxicology of the Limoges University Hospital (France). In particular, the capability to quantify below or above the decision threshold (uracilemia at 16 ng/ml) was evaluated. ISBN number: 978-2-37219-416-7, link to full report in French: https://www.hassante.fr/ portail/jcms/c_2891090/fr/methodes-de-recherche-d-un-defi cit-en-dihydropyrimidine- deshydrogenasevisant-a-prevenir-certaines-toxicites-severes-associees-aux-traitements- incluant-une-fl uoropyrimidine-5-fl uorouracileou-capecitabine Document from GPCO-Unicancer: Dépistage du défi cit en dihydropyrimidinedehy- drogénase (DPD) et sécurisation des chimiothérapies à base de 5FU (fl uorouracile) ou de capécitabine (Xéloda) Loriot M-A, et al. Dépistage du défi cit en dihydropyrimidine deshydrogénase (DPD) et sécurisation des chimiothérapies à base de fl uoropyrimidines : mise au point et recommandations nationales du GPCO-Unicancer et du RNPGx. Bull Cancer (2018), https://doi.org/10.1016/j.bulcan.2018.02.001 CONTACT Shimadzu Europa GmbH Albert-Hahn-Str. 6-10, 47269 Duisburg, Germany phone: +49-203-76 87 0 · Ffx: +49-203-76 66 25 shimadzu@shimadzu.eu · www.shimadzu.eu LABBOOK 2019 29

Chemistry & Immunochemistry Shimadzu – LCMS-8050 CL Shimadzu – LCMS-8045 CL Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg Triple Quadrupole Mass Spectrometry is the method of choice for quantification of trace-level analytes in complex samples for a variety of applications including clinical research, forensic, toxicology, pharmacokinetics. Combined with our world-leading UHPLC systems, and maintaining Shimadzu’s proprietary ultrafast technologies (UFMS), which include high-speed MRM transitions, MS / MS acquisition, and ultra-high speed polarity switching, the LCMS-8050 can dramatically improve analytical throughput. Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg The LCMS-8045 offers the proven high sensitivity, high speed and robustness of Shimadzu’s UFMS series to provide highly reliable data for applications that demand the sensitivity and speed of a mass spectro- meter, such as for simultaneous analysis used in the clinical research field. Due to the heated-ESI probe and UFsweeper II collision cell, it offers the highest sensitivity in the middle-range class (UFsensitivity). Shimadzu – LCMS-8060 CL Shimadzu – nSMOL Antibody BA Kit Assays: 100 Dimensions: Weight: Highlights: 1,180 × 540 × 610 mm (w × d × h) 140 kg Highlights: The LCMS-8060 delivers the highest sensitivity and fastest analysis speed of any LCMS on the market today. A newly developed UF-Qarray boosts ion intensity but suppresses noise. By improving the ion sampling device, the ion guide, and vacuum efficiency, Shimadzu has achieved an unprecedented sensitivity in quantitative analysis by LC / MS / MS while keeping high robustness for daily analysis. nSMOL is a proprietary, innovative technique from Shimadzu, enabling selective proteolysis of the Fab region of monoclonal antibodies. The nSMOL Antibody BA Kit is a ready-to-use reagent kit for collecting monoclonal antibodies from blood or other biological samples using immunoglobulin collection resin, and then performing selective proteolysis of the Fab region of these antibodies via FG beads Trypsin DART. Fab-derived peptide fragments produced by limited digestion can then be quantified via LC-MS / MS. LABBOOK 2019 31

Chemistry & Immunochemistry A quantitative instrument… but so much more The versatile Citrine MS / MS system offers ESI and APCI ioni zation options, an extended mass range up to m / z 2000, and a large linear dynamic range, making this the perfect tool for the measurement of a large variety of polar and non-polar biomarkers and metabolites in biological fl uids, over a large range of concentrations. Also available with SCIEX’s Triple Quadrupole Linear Ion Traps (QTRAP) technology, Citrine becomes a hybrid triple quadrupole / linear ion trap mass spectrometer – a unique, fl exible MS / MS system that can accommo- date a wide variety of both quantitative and qualitative LC-MS/MS workfl ows. It is the ability to use both triple quadrupole and linear ion trap scan functions on a single platform – and even within a single LC-MS/MS run – that makes the QTRAP system adaptable to a wide variety of both screening and quantitative tests. On the quantitation side, in some cases isobaric interferences cannot be differentiated by MRM alone, since the interferences may have the same exact mass as the target com- pound. In these cases, the ability to use second-order Legendary robustness and reliability In the busy diagnostic lab, samples come in all fl avours! Whatever matrix, whatever extraction – Citrine gives you accurate and reliable results, day after day, time after time. Unadjusted Peak Area (no internal standard correction) of 3,500 spiked plasma samples, extracted by protein precipitation/direct injection (without fi ltration) and analysed on the Citrine system for Testosterone (left) and Aldosterone (right), with 6-day 24 / 7 operation with no intervention. fragmentation (MS / MS / MS, or MRM3) provides highly specifi c measure- ments and can remove chromatographic interferences caused by isomers and background ions, without the need for extended chromato- graphy and reduced throughput. The technologies within Citrine puts powerful diagnostic mass spectrometer directly into your hands. Citrine MS/MS truly the one solution for your every challenge ☛ Leverage the ultimate sensitivity of the Citrine MS/MS system to reliably measure at picomole levels for clinically relevant biomarkers and metabolites ☛ Monitor 100’s of MRM transitions per analysis with uncompromised accuracy, precision and sensitivity ☛ Experience faster than ever data acquisition with 5 msec polarity switching ☛ Perform qualitative and quantitative analysis in a single injection with QTRAP technology ☛ Enjoy the confi dence of a medical device that meets the high quality and safety standards required by FDA regulations CONTACT SCIEX Diagnostics 500 Old Connecticut Path · Framingham, MA 01701, USA phone: +1 508 383 7700 clinical@sciex.com · sciex.com/diagnostics AB Sciex is doing business as SCIEX · © 2019 AB Sciex · For in vitro Diagnostic Use, Rx only · Not available in all countries · AB SCIEX is being used under license. LABBOOK 2019 33

Chemistry & Immunochemistry Label Your Life Best choice of • highly pure stable labeled reference standards • isotopically labeled advanced building blocks • TDM Starter Reagent Kits for HPLC-MS-MS www.shimadzu.eu /alsachim LABBOOK 2019 35

Chemistry & Immunochemistry Urine Screening Analyticon Biotechnologies – Urilyzer Flex Sample throughput: Chemistry: Up to 500 samples / h Sediment: Up to 90 samples / h Highlights: · Ideal for labs with max. 150 sediment and max. 250 chemistry samples per day · The automated sediment analysis leads to a standardization and consequently to an improved comparability of the results · Consolidated report and / or connection to LIS · Reduces the number of manual working steps and thus sources of error are minimized · Efficient workflow decreases hands-on BD Vacutainer Urine Collection System Greiner – Vacuette Urine CCM Tube Dimensions: 13 × 75 mm / 4 mL volume 13 × 100 mm / 6 mL volume 16 × 100 mm / 8 – 11 mL volume Highlights: · This closed system offers a range of solutions for collection, transport and preservation of urine samples to meet the needs of each patient according to their age, health and mobility. · A wide range of tube volumes for microbiology and urinalysis determinations, with or without preser- vatives is available. · BD collection devices include specimen cups, 24 hour 3 L containers and transfer straws for all patient collection methods. Highlights: · For use in microbiology testing · Stabilizes sample for up to 48 hours at room temperature · High solubility of additive in powder form · Immediate stabilization of sample after gentle mixing LABBOOK 2019 37

Chemistry & Immunochemistry Rapid Testing Greiner – Saliva Collection System Sarstedt – Blood gas Monovette and capillaries Highlights: · Simple reproducible saliva collection · Internal standard (tartrazine) enables donor-specific quantification · No absorption of analytes · Sufficient sample volume for A and B sample splitting · Determination of biomarker (α-amylase, cortisol) possible to enable indication of sample adulteration · No detergents which interfere with analysis Highlights: · Blood gas collection systems for arterial, venous and capillary sampling with the smallest sample volumes and Ca2+ balanced heparin. · The Ca2+ balanced heparin in spray-dosed droplet form enables rapid and optimal mixing of blood and anticoagulants. The Blood gas Monovette is available in 1 and 2 ml options and has been designed for venous and arterial blood collection. The blood gas capillaries offer a nominal volume range of 100 – 175 µl. Research Use Only (RUO) Shimadzu – CLAM-2030 Dimensions: 670 × 700 × 1,190 mm (w × d × h) Weight: 185 kg Assays: Immunosuppressants, Vitamin D, Steroids, Antiepileptics, Antiarrhythmics drugs, Amiodarone, Drugs of Abuse, Antidepres- sants, Neuroleptics Highlights: CLAM-2030 provides users seamless integration of automated sample preparation with LC-MS / MS to improve data quality, sample throughput, laboratory efficiency and safety Simple workflows allow users to go from blood collection tubes to results without any additional sample handling. Each sample is processed successively in parallel, to optimize instrument usage. Easy to access software for management of reagents, calibration curves, control samples and maintenance ensure reliability and quality of results. LABBOOK 2019 39

Hematology Blood Cell Counter Analyticon Biotechnologogies– Hemolyzer 3 NG / Hemolyzer 5 NG Dimensions: 216 × 280 × 320 mm (w × h × d) Weight: 9 kg Sample throughput: Up to 60 samples / h Power consumption: 0.045 kW Highlights: · Microfludic 3-part and 5-part WBC DIFF hematology analyzers · Gesture-driven interface via touchscreen · Open and closed vial mode · Low sample volume and small footprint offer numerous applications · Autoloader available · Proven reliabilty with ecological and economical performance BC-6000/6200 Auto Hematology Analyzer High Performance for All Unique SF Cube 3D cellular analysis technology for WBC 6-part diff count including IMG NRBC in every CBC+DIFF result Up to 110 t/h throughput, low aspiration volume of 80̀l Smaller footprint with improved performance 4 types of body fluid analysis with up to 7 reportable parameters Simplified workflow with labXpert analysis software Automatic rerun & reflex measurement in case of abnormal results BC-6200 with RET channel can provide optional Reticulocytes and PLT-O parameters and perform automatic 8x PLT-O counting for thrombocytopenia samples BC-6000 BC-6200

Genrui – 5-Part Auto Hematology Analyzer KT-6610 Greiner – Vacuette EDTA Tube Hematology Sample throughput: Dimensions: 60 tests / h 597 × 470 × 590 mm (w × d × h) Highlights: KT-6610 is a compact yet powerful hematology analyzer. It is an all-in-one solution for small and medium labs and clinics with real 5-Part results. · Tri-angle laser scattering, flow cytometry for WBC differentiation and counting · 29 parameters + four scattergrams + two histograms · Three reagents for one test, Two Lyses are placed in the analyzer · 10.4 inch touch screen · Built-in barcode scanner (Optional) · Built-in printer, also support external printer · One click solution for basic trouble shooting · Powerful flag information Highlights: · EDTA tubes are offered as either K2EDTA or K3EDTA tubes · Contain (besides the K2EDTA) an inert barrier gel that is present in the bottom of the tube. · Plasma may be aspirated directly from the collection tube, eliminating the need for transfer to another container · Vacuette EDTA tubes with separator gel improve the plasma yield and enable plasma to be left in the primary tube · This allows stability of certain parameters, when kept under specified conditions. · Also available with pre-attached barcode Horiba Medical – Yumizen H550 Mindray – BC-6800Plus Auto Hematology Analyzer Dimensions: Weight: Highlights: 530 × 620 × 670 mm (w × h × d) 36 kg The Yumizen H550 is a compact 6-Diff hematology analyzer for small-mid size laboratories. It provides safe sample management and combines: · Auto sampling system with full walk away capability · One hour autonomy of 40 samples in rack · Continuous loading · Manual mode for STAT samples · Innovative “three reagents use” technology with low consumption The Yumizen H550 incorporates flexible connectivity with both ASTM and HL7 communication standards and overlapping Quality Controls. Sample throughput: CBC+DIFF 200 t / h, RET 120 t / h, BF 40 t / h Highlights: BC-6800Plus is currently the fastest standalone hematology analyzer in the world, which can process 200 CBC+DIFF samples / h and 120 RET samples / h. Notably, the ERP channel can provide more research parameters such as MCHr and HDW, which can help early diagnosis of various types of anemia LABBOOK 2019 43

Hematology Haematology means Sysmex For labs big and small. Covering cell counting, morphology and functionality. Productivity Clinical insight Intelligence From benchtop to automation models: enhance your workfl ow More information from your routine testing: know more, decide with confi dence, act faster Optimise your EDTA tube management: greater e ffi ciency and time-saving For more information on our solutions, check out the product entries in this magazine andor visit our website www.sysmex-europe.com LABBOOK 2019 45

Hematology THANK YOU FOR YOUR PARTNERSHIP IN PURSUIT OF THE HIGHEST SAMPLE QUALITY AND INTEGRITY. It’s bdcausd of you, thd spdcialists bdhind thd scdnds in hdalthcard who choosd to work with us dvdry day, that BD Vacutaindr ® products and solutions havd bddn abld to so profoundly impact thd diagnostic procdss. With dvdry rdsult that guiddd card, wd hdlpdd changd thd coursd of trdatmdnt for thd pdrson bdhind that sampld, togdthdr. It’s our honor to bd your ongoing partndr as wd ddlivdr tomorrow’s innovations, whild sdtting dvdn highdr standards in diagnostic accuracy and thd patidnt dxpdridncd in thd ydars to comd. fe look forward to an even brighter future advancing the world of health, together. Ldarn mord at bd.com/70YrsHealthy BD, thd BD Logo and Vacutaindr ard traddmarks of Bdcton, Dickinson and Company or its affiliatds. © 2019 BD. All rights rdsdrvdd. 1910002618 (05/19) LABBOOK 2019 47

Olympus – SC180 Olympus – BX53LED Hematology Highlights: · 18-megapixel camera with fast 4K Live image · Dedicated to precise sample documentation even at low magnifications · Assisted sample focusing and image noise cancellation Highlights: · Dedicated LED light source for microscopy The high-resolution, 18-megapixel SC180 color camera reveals your sample’s fine details and structures. The 18 million pixel count exploits the full optical resolution of the objectives, enabling you to make observations exclusively on-screen without using the eyepieces and fostering effective collaboration and audience engagement during full-screen presentations. With a fast 4K Live image, the SC180 camera accel- erates routine work, increases throughput in various applications through fast assisted focusing and noise cancellation, and makes the screen the new standard for documentation, evaluation, and discussion. (Olympus True Color LED) · Ergonomic design for intensive daily usage · Highly expandable frame to follow evolving application needs The BX53 microscope’s ergonomic design helps you stay comfortable during extended periods of use while the intuitive control layout enables fast, efficient obser- vation and imaging. Optimized for laboratory applica- tions, Olympus exclusive True Color LED illumination has a high luminosity and color rendering index so you can see samples in real-to-life colors avoiding color casts of generic LED light sources. Hemostaseology AB Medical – V-Tube Trisodium Citrate 9:1 Greiner – Vacuette Coagulation Tube Dimensions: 13 × 75 mm – 2.7 / 1.8 ml volume Highlights: · The ratio of blood to anticoagulant is 9:1 · Perfectly maintain the ratio (9NC) with double layered tubes – External PET tube: maintain vacuum – Internal PP tube: minimize additive evaporation · Paper or transparent label available · Stable and efficient Push-fit Safety Cap: Six-Crown Rib Grip (Korea Patent) · Made in South Korea Highlights: · With safety twist cap for an easy manual opening as well as automated opening using decapping instruments · Correct mixing ratio of venous blood a sodium citrate is ensured during blood collection, so that the tube contains one part sodium citrate solution to nine parts blood · Double-walled technology: the inner tube is made out of polypropylene (PP) and prevents the citrate solution from evaporating; the outer tube is made of poly ethylene terephthalate (PET) and ensures a long shelf-life for the vacuum LABBOOK 2019 49

Siemens Healthineers – Sysmex CA-600 Systems Siemens Healthineers – Sysmex CS-2500 System Hematology Dimensions: Sample throughput: Weight: Approx. 490 × 566 × 490 mm (h × w × d) Approx. 60 PT tests / h Approx. 43 kg Highlights: The Sysmex CA-600 Systems – with the smallest foot- print in their class – are built on a history of proven reliability and provide scalable options for routine and specialty* coagulation testing. · Features clotting, chromogenic,* and immunologic* measurements with true random access · Enables critical tests to be processed at any time via STAT sample processing · Offers the most frequently requested routine and specialty tests, including INNOVANCE D-Dimer* *Sysmex CA-660 System only. Dimensions: Sample throughput Weight: Approx. 685 × 1,113 × 895 mm (h × w × d) Approx. 180 simultaneous PT / APTT tests / h Approx. 140 kg Highlights: The Sysmex CS-2500 System offers mid-volume and multisite hemostasis labs smartly designed technolo- gies for improved efficiency, exceptional accuracy, and reliable first-run results. Equipped with next-gen- eration PSI technologies, the system takes hemostasis testing to the next level. The Sysmex CS-2500 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays), all on a single instrument. Siemens Healthineers – Sysmex CS-5100 System Sysmex – CS-1600 Dimensions: Sample throughput Weight: Approx. 1,280 × 1,576 × 1,150 mm (h × w × d) Approx. 400 simultaneous PT/APTT tests / h Approx. 362 kg Highlights: The Sysmex CS-5100 System offers high-volume and multisite labs smartly designed PSI technology and automation connectivity for streamlined workflow and high-quality test results on the first run. Simultaneous, multiwavelength PSI technology helps labs to identify and manage unsuitable test specimens prior to analysis. The Sysmex CS-5100 System offers an expansive test menu of routine and specialty hemostasis assays (including several INNOVANCE assays). Sample throughput: Dimensions: Weight: Assays: Up to 120 tests / h (PT) 540 × 760 × 690 mm (h × w × d) Approx. 85 kg 18 simultaneously Highlights: · Optimised solution for medium-size labs with needs for specialty testing · Proven, reliable technical performance with advanced CS-technology · High-quality results based on advanced multi-wave- length technology · Traceability for operation history and results · System shares the same reagents, controls, calibrators, and sample reference ranges with Sysmex CS and CA systems · Minimal needs for hands-on maintenance LABBOOK 2019 51

Scanner Hamamatsu Photonics – NanoZoomer S60 Hamamatsu Photonics – NanoZoomer S360 Pathology Highlights: NanoZoomer S60: The most flexible slide scanner for any histology lab – The best of Hamamatsu’s know-how, combining flexibility and outstanding image quality. Features: · High-speed and sensitivity in fluorescence · Best image quality both in brightfield and fluorescence · Double-size slides scan · Ideal for all research and pathology laboratories Highlights: · Real high throughput: Greatly improved throughput (more than 80 slides / h at 40 × mode for 15 × 15 mm sample sizes) and slide capacity of 360 for high work- load laboratories. · Hassle free: Simple operation and hassle free scanning. New, powerful scan software for fast and easy operation · Error free: Robust and stable scanning. Automatic system calibration. · Blur free: Sharp focus on entire specimen. Dynamic Pre-Focusing (DPF) method and advanced focus scoring with automated rescan option for higher success rate. Hamamatsu Photonics – NanoZoomer S210 DTM Medical – Primera Signature Cassette Printer Printer Highlights: With over a decade of experience in digital pathology, Hamamatsu presents the NanoZoomer S210. Features: · 210 slide scanning capability · Batch scanning or continuous loading of slides · High performance · Cost-effective · Simple operation · New sleek design and small footprint Highlights: The Signature Cassette Printer is designed for printing text, graphics or bar codes directly onto cassettes, helping to reduce the risk of misidentification of speci- mens. It is available as a stand-alone, manual printer or as a completely automated system consisting of a printer and a robotic picking system called Autoloader. · On-demand or batch mode printing · Black or colour printing · Cost reduction by inventorying only white cassettes · Chemical-resistant ink – ensures reliable identification of cassettes · USB interface – ability to integrate with LIS · Two years warranty (After product registration within six months of purchase) LABBOOK 2019 53

Information Technology Hamamatsu Photonics – NDP.serve3 Image Server Software VMscope – CMPS: Ki67, ER, PR, CD3 Pathology Highlights: NDP.serve3 is the next generation of our established image server software. It is a power solution to share and manage whole slide images (WSI) across a network, either as a stand-alone solution or integrated with your LIS/LIMS software. Key Benefits / Features: · Secure database with enhanced security functionality · Intuitive, simple to use graphical user interface · Easy to share whole slide images · Seamless integration with NDP.view2 – the fastest Mac and Windows WSI viewer on the market Highlights: · Fully automatic quantification of Ki67, ER, PR, CD3 and further stains · Analysis in less than one second, no user interaction necessary · Analysis of WSIs, still images or live images from the microscope camera · Ki67 quantification clinically validated · Multiple regions per case to take into account the tumor heterogeneity · Export of the results into images, MS Excel or other systems · Integration into any LIMS system via open interfaces Your Partner in Medicine and Science Worldwide Blood Collection & Diagnostic Products Medical Products & Transfusion Laboratory Automation & Devices Laboratory Products & Life Science www.sarstedt.com · info@sarstedt.com SARSTEDT AG & Co. KG · P.O. Box 12 20 · D-51582 Nümbrecht · Phone +49 2293 305 - 0 · Fax +49 2293 305 - 3992

DNA Amplification Extraction Infectious Disease Infectious Disease/ Hepatitis Liquid Biopsy Research Use Only

Promega – Maxwell RSC 48 Instrument Siemens Healthineers – Fast Track Diagnostics Real-time PCR assays Infectious Disease DNA Dimensions: Weight: Sample throughput: Assays: 530 × 510 × 220 mm (w × h × d) 31 kg Up to 48 samples / 22 minutes Blood, Whole Blood, RNA Blood, RNA Cells, RNA Tissue, DNA FFPE, RNA FFPE , ccfDNA, miRNA, Viral total NA Highlights: · High-quality nucleic acid purification with minimal steps and less hands-on time · Purifies 1 – 48 samples in a single run · Process a variety of sample types for downstream applications in molecular diagnostic and for other clinical applications · UV decontamination and barcode scanner · CE IVD registered · Pre filled cartridges, no cross contamination · For tissue, stool, blood, buffy coat, swabs, plasma, serum and other human sample types · Intuitive software and integrated vision system for detecting and preventing errors Highlights: Siemens Healthineers offers one of the largest ranges of syndromically grouped real-time PCR multiplex assays* covering the major disease groups such as respiratory infections, gastroenteritis, sexually transmitted infec- tions, childhood infections, meningitis, eye infections, immunosuppression, hepatitis, and tropical fever. * Fast Track Diagnostics assays are CE-marked for IVD use in the EU. Product availability will vary by country. Infectious Disease / Hepatitis Liquid Biopsy Siemens Healthineers – Versant HCV Genotype 2.0 Assay (LiPA) BD / Qiagen PAXgene Blood ccfDNA Tube Highlights: Optimize your laboratory’s testing with the widely used Versant HCV Genotype 2.0 Assay (LiPA)*. · LiPA utilizes reverse-hybridization technology to detect HCV genotypes 1–6 and subtypes 1a and 1b. · LiPA provides highly accurate identification of HCV genotypes and subtypes for optimal and personalized patient therapy. Dimensions: 16 × 100 mm / 10 mL volume Highlights: A complete, integrated preanalytical workflow solution for circulating cell-free DNA · Non-crosslinking preservation of ccfDNA levels · Seamless integration with proven ccfDNA isolation kits · Streamlined with primary tube sampling during auto- mated processing · Designed for sensitive research assays, including analysis of circulating tumor DNA and non-invasive prenatal testing · Sample transport and storage at room temperature for * LiPA assay is FDA-approved in the U.S. and CE-marked in the EU for IVD use. up to seven days LABBOOK 2019 59

Microbiology Mass Spectrometry Identification / Susceptibility Microscopy Other

Identification / Susceptibility Sysmex – UF-5000 Microscopy Hund – medicus plus Myko Microbiology Sample throughput: Dimensions: Weight: Up to 105 (urine), 20 (body fluids) samples / h 855 × 760 × 754 mm (h × w × d) 90 kg Highlights: · Fully automated urine particle analysis · Exclude negative UTI samples in less than a minute · Bacteria quantification and indication of gram typing · 28 clinically relevant parameters for urinalysis · Subclassification of EC and CAST · Body fluid mode integrated as standard · Nine parameters incl. bacteria count and WBC differentiation · Daily external quality control via SNCS Highlights: With the medicus plus Myko, an easy and reliable detec- tion of mycoses in native preparations becomes possible. The dedicated fluorochrome, Mykoval, is easy to use and very cost efficient. · High contrast and resolution · No cultivation necessary · Easy operation of the microscope · Long lifetime of LED fluorescence illuminator · Retrofit of existing medicus plus microscopes possible Olympus – CX33 BD Vacutainer Urine Tubes for Microbiology Other Highlights: · Maintenance free Koehler illumination with LED · Fully ergonomic design The CX33 microscopes enable users to remain comfor table during long periods of routine microscopy observations. The microscope frame conforms to the user’s hands and the location of the control knobs maximize ergonomics to improve work efficiency. Users can quickly set a specimen with one hand, while adjusting the focus and operating the stage with the other hand with minimal movement. A fixed Koehler illumination system provides detailed images while minimizing the need for maintenance and the possibility of operator errors. The microscope also features an optional camera port for digital imaging. Dimensions: 13 × 75 mm / 4 mL volume 16 × 100 mm / 10 mL volume Highlights: · BD offers a range of tube types with boric acid based preservatives all clinically validated to provide 48 hour specimen stability at room temperature. · BD Urine System has been proven to have a three times greater chance of achieving accurate urinary tract infection results over an open system. · Introduction of closed system has been shown to decrease contamination rates by 19 percent. · Research has shown a ten percent lower incidence of bacterial overgrowth and thus reduces the possibility of false positive results. LABBOOK 2019 63

Blood Glucose Lifotronic – H8 Hemoglobin Analyzer Lifotronic – H9 Hemoglobin Analyzer POCT Highlights: Reliable partner for diabetes test · Ion-Exchange HPLC · Gold standard methodology for HbA1C · 130 seconds / test (Variant mode) · High precision, CV ≤ 1.5 % · 10 sample positions · Variant hemoglobin detection · HbA1a/b, LA1c, HbF, A1c, A0 · No sample preparation required · NGSP and IFCC certified Highlights: Reliable partner for diabetes test · Ion-Exchange HPLC · Gold standard methodology for HbA1C · 72 seconds / test (Fast mode) · High precision, CV ≤ 1.5 % · 110 sample positions · Variant hemoglobin detection · HbA1a/b, LA1c, HbF, A1c, A0 · No sample preparation required · NGSP and IFCC certified Siemens Healthineers – DCA Vantage Analyzer Genrui – Automatic Specific Protein Analyzer FA50 Immunoassays Dimensions: Weight: Highlights: 287 × 254 × 277 mm (w × h × d) 3.88 kg Sample throughput: Assays: Weight: 4 to 20 samples / h Up to 20 parameters Less than 5 kg The DCA Vantage Analyzer makes in-office diabetes testing easy, with accurate, clinically trusted results shown to improve decision making, patient compliance, and outcomes. Get precise HbA1c, albumin, creatinine, and A:C ratio results in minutes with good correlation to laboratory methods and simplify management for POC coordinators with advanced operator, data-manage- ment, and security capabilities. Product availability varies by country. Highlights: FA50 is a powerful POCT immunofluorescence analyzer, which is proved with FDA certificate. it is designed to be very easy to use with smart card calibration and 5.6 inch touch screen. · Support whole blood, serum and plasma · Room temperature for test kits storage · Easy to use: three steps to report · Up to 20 parameters, including HbA1c, cTnI, PCT, T3, T4, TSH, etc LABBOOK 2019 65

KABE Labortechnik – Consumables for blood gas analysis KABE Labortechnik – Pipette-Adapter for Capillaries (PAC) POCT Highlights: The best sampling system in every situation Plastic blood gas capillary: · Unbreakable plastic · Fast drawing · Crystal clear · Numerous drawing volumes and diameters available · Minimum gas permeability for oxygen and carbon dioxide · Comprehensive range of accessories Blood gas tube: · Rapid anticoagulation thanks to liquid preparation · Optimal filling with special piston geometry · In individual sterile packing Both sampling systems are prepared with Ca-balanced heparin and are ideal for blood gas and electrolyte analyses on all common blood gas systems. Highlights: Assists in the handling of capillaries and their targeted and dropwise draining on POCT-test strips or into vessels · Suitable for different capillaries · The transparent tip provides the entire visibility of the capillary: easy and complete filling Handling: · Fix capillary in the PAC while using oneway gloves · The capillary is filled as usual – afterwards the thump is put gently on the upper mouth of the PAC · The (dropwise) draining is carried out by generating a slight gauge pressure with the thumb Siemens Healthineers – epoc Blood Analysis System Siemens Healthineers – RapidLab 1200 Blood Gas System Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, TCO2, Na+, K+, Ca++, Cl-, Hct, Glu, Lacm Crea, BUN 77 × 27 × 147 mm (w × h × d) Host: Reader: 85 × 50 × 215 mm (w × h × d) Host: 0.359 kg / Reader: < 0.5 kg The epoc Blood Analysis System is a handheld, wireless solution that provides blood gas, electrolyte and meta- bolite results at the patient’s side in less than one minute. Deliver pH, pCO2, pO2, TCO2, Na+, K+, Ca++, Cl-, Hct, Glu, Lacm Crea, BUN while empowering clinicians to make faster decisions with lab-quality results to improve patient outcomes. Product availability varies by country. Assays: Dimensions: Weight: Highlights: pH, pCO2, pO2, Na+, K+, Ca++, Cl-, Glu, Lac, Neonatal Total Bilirubin, CO-oximetry 230 × 240 × 610 mm (w × h × d) 2.5 kg Siemens RapidLab 1200 Blood Gas System is uniquely designed to meet high-volume critical-care testing needs. The system has an ultra-fast sample processing and microsample capability, with results in 60 seconds. Cartridge-based reagent system simplifies operation, and Ready Sensor technology offers reliability with minimal maintenance. Product availability varies by country. LABBOOK 2019 67

Sysmex – UC-1000 Siemens Healthineers – POCcelerator Data Management System Information Technology POCT Sample throughput: Dimensions: Weight: Up to 480 samples / h 315 × 135 × 215 mm (h × w × d) 2.6 kg Highlights: · Semi-automated urine chemistry analysis · Up to 16 parameters · Complete online training available · mALB + CRE on a routine test strip · Can be connected to POCT middleware Highlights: Connect securely with an open, reliable POC informatics platform. Gain vendor independence and free choice in selecting the appropriate POCT device to meet your clinical requirements. Create a long-term solution that saves time and money by simplifying the complexity and cost of maintaining multiple IT systems. Product availability varies by country. Other Jadak– HS-1R Handheld HF RFID Reader Sarstedt – Minivette POCT / Capillary Blood Collection Dimensions: Weight: Handheld/Stationary: 33.4 × 51.3 × 108.2 mm (h × w × d) 98 grams Handheld 1D & 2D barcode scanner with HF RFID reading & writing functionality Highlights: The flexpoint HS-1R from JADAK integrates 1D & 2D barcode scanning with HF RFID reading & writing functionality. Sure to be an integral part of many medical and clinical applications, the HS-1R enables patient ID via wristband scanning, clinician security login via badge scanning, pharmaceutical applications incl. drug inventory tracking & digital signature capture using built in camera modes, and much more. JADAK products can be tailored to meet specific customer requirements. Highlights: · Collection devices for Point-of-Care tests · Easy sample recovery · Precise and dispensing of small whole blood volumes · Prevents spillage during transfer · Volume range: 10µl – 200µl · Preparations: Neutral, Heparin and EDTA LABBOOK 2019 69

LIS, Middleware, POCT Beckman Coulter – DxONE Command Central Workstation Beckman Coulter – Remisol Advance Information Technology Highlights: Beckman Coulter’s DxONE Command Central remote monitoring system helps manage lab workflow and improve decision-making steps. The system can connect up to 18 instruments or automation systems, and up to five networked DxONE Command Central workstations within a single laboratory, allowing the operator to place DxONE Command Central workstations in prime laboratory locations for increased flexibility. DxONE Command Central maximizes workflow efficien- cies by providing lab technicians with a real-time view of laboratory systems from a single point of control. DxONE Command Central works with data managers such as REMISOL Advance to achieve workflow efficiencies, or can serve as a stand-alone product for users to monitor automation and/or multiple analyzers and quickly respond to any instrument issues. Highlights: Remisol Advance is an enterprise data management solution that can help improve sample workflow through consolidated management, drive consistency through network standardization across multiple sites, create efficiency through autoverification, and improve reli- ability by integrating quality control management. It is a unique software product that consolidates patient test information from multiple instruments in the lab or from multiple labs in the hospital network. REMISOL Advance features virtualization capability to help reduce failure points and increase uptime. i-Solutions Health – LabCentre Medat – Laboratory Information System Highlights: LabCentre is a market-leading laboratory and pathology information management system. It helps doctors, scientists, technologists and management staff to track samples and testing processes, communicate results to other health professionals, and monitor costs and reporting. Highlights: LabCentre supports the following disciplines: · Blood Sciences · Microbiology · Hygiene · Transfusion Medicine · Pathology · Billing · Flexible, private company with 50 employees. · Complete solution from order entry to billing. · Highly customisable modules for microbiology, virology, environmental hygiene, cytopathology, histo- pathology, clinical chemistry, serology / toxicology, blood bank and human genetics. · Single, integrated system for all divisions and sites. · Reliable operation in some of Europe’s biggest laboratories. LABBOOK 2019 71

◼ Typical activities in software development ◼ Typical activities in software development referring to the domains of the Cynefin-Framework2 referring to the domains of the Cynefin-Framework2 3% Unknown 3% Chaotic 16% Simple 18% Complicated 25% Complex 38% “chaotic” context is not to be understood as static—rather it opens the possibility for predicting reactions in the entire system by application of strict and formal rules to thus attain the “obvious” context. Assistance for the user The following procedures can be considered: · Supplier audit: before entering a longer-term contractual relation- ship with a software supplier3, there should at least be a check to see if this supplier really fi ts. It can be determined then whether the manufacturer is aware of the complexity of his assignment and how he has mastered this. · Verifi cation: In the context ranges complex and chaotic, emergent and novel practices ought to be applied. In other words, things ought to be “tested” or “just done”. The aim is to create conditions by means of program entries that will force a system failure and thus expose a defect in the program code. It has been shown that software products tend to reproduce certain error types due to the programming language, tools used, persons involved and last but not least intended functions. A detailed record and categorisation of errors found in the past is an aid not to be underestimated for the verifi cation. · Statistics: Another indicator of software stability is the quantitative analysis of the number of errors found during verifi cation. As is the case with every engineering product there is also a similar course (bathtub curve) followed through the product lifetime and this enables the user to estimate the “software age” and thus predict whether the software used will soon reach a condition in which the number of errors renders further use ineffi cient. Outlook for new software ... and new errors New demands on software in laboratories are increasingly met by new technologies in operations and the development of this software. The therapy decision is oriented more and more toward the individual patient with his complex biological profi le. Identifi cation and assessment of the profi le requires a steady growth in the processing capacity of IT systems. They also require application of new paradigms and Information Technology algorithms for pattern recognition and machine learning—often known collectively by the term “artifi cial intelligence”. The new software and hardware paradigms lead to a new type of complexity and thus to new errors. “People” create in machine learning only the foundation for learning. Learning itself is determined by the machine’s “learning environment” and its training data sets, the quality of which again infl uence the system’s capability of distinguishing between the healthy and ill. An error in this categorisation can originate at any level of the overall system — in extreme cases; the system has learned the wrong selector. Hence the task of validation, as before, is to measure the impact of this “defect” to derive the necessary actions (to eliminate the error). Also, the defi nition of errors in the fi eld of AI algorithms leads to sharp- ening of the concept of human responsibility: as stated by the norm, errors are always due to human acts, since AI cannot make any mistakes on its own. If it acts unpredictably for human reasoning, this creates an incomparably greater ethical responsibility for the construction of IT systems, training and particularly the training data. If health profession- als are to authorize the use of AI on a patient, every referring activity must be recorded in detail to show at any time to patients, inspection authorities and the public that due diligence has been exercised. ◼ ” Bathtub-Curve” as an estimate for the failure rate of software during its life Decreasing failure rate Constant failure rate Increasing failure rate e t a r e r u l i a F Early “infant mortality” failure Observed failure rate Constant (random) failures Wear out failures Time 1 D. Snowden. (2000) “Cynefi n, A Sense of Time and Place: An Ecological Approach to Sense Making and Learning in Formal and Informal Communities” conference proceedings of KMAC at the University of Aston, July 2000 and D. Snowden. (2000) “Cynefi n: a sense of time and space, the social ecology of knowledge management”. In Knowledge Horizons: The Present and the Promise of Knowledge Management ed. C Despres & D Chauvel Butterworth Heinemann Oktober 2000 2 https://www.butterfl ying.de/cynefi n-lego-game/ 3 Marry in haste, repent at lesiure (2018); by Markus Neumann Harald Maier & Gabriele Egert; Labbook 2018; published by European Hospital Verlags GmbH, page 76 ff. CONTACT Dr. Neumann & Kindler GmbH & Co. KG Herner Straße 324 · 44807 Bochum, Germany phone: +49 234 957 1969 – 0 info@labcore.de · www.labcore.de LABBOOK 2019 73

Peripheral Devices Blood Collection Pipette Tips Centrifuges Incubators Compressors Specialties

Sarstedt – Microvette – Capillary Blood Collection Sarstedt – Multi-Safe Disposal boxes Peripheral Devices Highlights: · Flexible capillary blood collection systems such as the Microvette – tailor-made to the individual needs of each patient group. · Different patient groups and collection techniques Highlights: · Our wide, tailor-made range of Multi-Safe disposal require different collection systems. · With a nominal volume range from 100 – 500 µl, the capillary blood collection systems product range is one of the most extensive in the entire market. · Depending on the requirements, our portfolio in- cludes Microvettes with conical or round bottom inner tubes and the option for various different collection techniques, end-to-end or with a collection rim. boxes corresponds to the current European directive on the prevention of needle stick injuries. · With our extensive product range of Multi-Safe boxes we are able to meet any disposal need in the field of medicine and laboratory. · With the various options, from the convenient 200 ml format to the autoclavable 60 l disposal box for clinical waste, we offer an optimal solution for every need. Sarstedt – S-Monovette – Venous Blood Collection Sarstedt – Low Retention Pipette Tips Pipette Tips Highlights: · S-Monovette – The Revolution in Blood Collection. A blood collection system that combines two blood collection techniques – the aspiration technique and the vacuum technique. · The S-Monovette is suitable for all vein conditions and achieves an optimal sample quality, thereby producing the best results. · The aspiration technique is a gentle technique for routine blood collection. Using the vacuum technique, a “fresh” vacuum is always available. · Suitable for all ages, from young to old, the S-Monovette is as individual as your patients. Highlights: · Minimising sample loss · Optimised surface for enhanced dispensing behavior · Improved sample recovery · Minimal sample loss of highly viscous liquids or samples containing detergents · Cost savings in valuable reagents LABBOOK 2019 77

Specialities ibidi – Solutions for microcopy and cell-based assays Sarstedt – Cell Culture Products Peripheral Devices Highlights: · Investigate angiogenesis, chemotaxis, wound healing, and cells under flow · Cultivate your cells and perform high-resolution microscopy · Benefit from excellent cell culture conditions on the unique ibidi Polymer Coverslip · Available in various open formats or channel slides · Test with a free sample Highlights: For over 25 years Sarstedt has produced a wide range of high quality cell culture products which are distributed worldwide. These many years of experience and know- ledge of the needs of users have allowed us to optimise and continually expand the product range. Sarstedt – Sediplus Sedimentation System Highlights: · Venous and capillary blood collection systems for blood sedimentation with matching accessories and devices for automatic detection are available. · The automatic blood sedimentation system Sediplus S 200 with 10 measurement positions, and the Sediplus S 2000 with 40 positions (can optionally be extended to 160 positions) for a high sample throughput, optimise ESR measurement. · The S-Sedivette venous blood collection system enables hygienic, easy handling in an enclosed system. The Microvette CB 200 ESR blood collection system is designed for 200 µl of blood only and ensures minimal patient discomfort when collecting blood. Both systems are proven to perform well in comparison with the Westergren method. Integrated solution management for your laboratory dr. neumann kindler & www.labcore.de LABBOOK 2019 79

Companies & Suppliers y r t s i m e h c o n u m m I & y r t s i m e h C ■ g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ l i y g o o b o r c i M ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ 53 54 A N D ■ 60 21 18 19 19 37 39 43 43 49 43 50 53 55 11 l y g o o n h c e T n o i t a m r o f n ■ I T C O P ■ 66 65 66 s e c i v e D l a r e h p i r e P ■ 78 76 78 LABBOOK 2019 81 Page Index DTM Medical Mainzer Straße 131 65187 Wiesbaden, Germany phone: +49 611 92777-0 info@dtm-medical.eu www.dtm-medical.eu Dürr Technik GmbH & Co. KG Pleidelsheimer Straße 30 74321 Bietigheim-Bissingen, Germany phone: +49 7142 9022-0 fax: +49 7142 9022-99 office@duerr-technik.de www.duerr-technik.com Eppendorf AG Barkhausenweg 1 22339 Hamburg, Germany phone: +49 40 53801-0 fax: +49 40 53801-556 eppendorf@eppendorf.de www.eppendorf.de EXIAS Medical GmbH Kratkystraße 2 8020 Graz, Austria phone: +43 316 922953 office@exias-medical.com www.exias-medical.com Fujirebio Europe NV Technologiepark 6 9052 Gent, Belgium phone: +32 9 329 1329 www.fujirebio-europe.com Genrui Biotech Inc. 4-10F, Building 3, Geya Technology Park Guangming District 518106 Shenzhen, China phone: +86 755 26 83 55 60-1 (-2) international@genrui-bio.com www.genrui-bio.com Greiner Bio-One GmbH Bad Haller Straße 32 4550 Kremsmünster, Austria phone: +43 7583 6791-0 office@at.gbo.com www.gbo.com Hamamatsu Photonics Deutschland GmbH Arzbergerstraße 10 82211 Herrsching, Germany phone: +49 8152 375-203 marketing@hamamatsu.de www.nanozoomer.com Andreas Hettich GmbH & Co. KG Föhrenstraße 12 78532 Tuttlingen, Germany phone: +49 7461 705-0 info@hettichlab.com www.hettichlab.com HORIBA Medical Parc Euromédecine · Rue du Caducée – BP7290 34184 Montpellier, France phone: +33 467 141516 webmaster.med@horiba.com www.horiba.com

y r t s i m e h c o n u m m I & y r t s i m e h C ■ Companies & Suppliers l y g o o n h c e T n o i t a m r o f n ■ I s e c i v e D l a r e h p i r e P ■ T C O P ■ l i y g o o b o r c i M ■ y r t e m o r t c e p S s s a M ■ l y g o o t a m e H ■ l y g o o h t a P ■ A N D ■ 58 49 54 63 58 58 59 50 58 60 69 77 79 g n i s s e c o r P e l p m a S ■ n o i t a m o t u A ■ 12 4 6 7 20 21 38 39 20 30 34 39 31 62 12 7 30 36 44 50 51 59 65 66 67 68 69 74 LABBOOK 2019 83 Page Index Molzym GmbH & Co. KG Mary-Astell-Straße 10 28359 Bremen, Germany phone: +49 421 696 162-17 info@molzym.com www.molzym.com Olympus Europa SE & Co. KG Amsinckstraße 63 20097 Hamburg, Germany phone: +49 40 23773-0 ScientificSolutions@olympus-europa.com www.olympus-lifescience.com Orion Diagnostica Oy Koivu-Mankkaantie 6 B 02200 Espoo, Finland phone: +358 10 4261 orion.diagnostica@oriondiagnostica.fi www.oriondiagnostica.com Promega GmbH Schildkrötstraße 15 68199 Mannheim, Germany phone: +49 621 8501-0 de_custserv@promega.com www.promega.com Samplision Limesstraße 17 61273 Wehrheim, Germany phone: +49 6081 982550 info@samplision.de www.samplision.de SARSTEDT AG & Co. Sarstedtstraße 1 51588 Nümbrecht, Germany phone: +49 2293 305-0 fax: +49 2293 305-122 info@sarstedt.com www.sarstedt.com Sentinel CH. SpA Via Robert Koch, 2 20152 Milano, Italy phone +39 02 3455141 sentinel@sentinel.it www. sentineldiagnostics.com SCIEX Diagnostics 500 Old Connecticut Path Framingham, MA 01701, USA phone: +1 508 383 7700 sciex.com/about-us/contact-us sciex.com/diagnostics SHIMADZU Europa GmbH Albert-Hahn-Straße 6-10 47269 Duisburg, Germany phone: +49 203 7687-0 shimadzu@shimadzu.eu www.shimadzu.eu Siemens Healthineers Laboaratory Diagnostics 511 Benedict Avenue 10591 Tarrytown, NY, USA phone: +1 914 631 8000 www.healthcare.siemens.com

The accuracy of LC-MS/MS technology with the convenience of automation Launch your lab into the future with the IVD/CE-marked Thermo Scientific™ Cascadion™ SM Clinical Analyzer A fully automated clinical analyzer using liquid chromatography- tandem mass spectrometry (LC-MS/MS) technology: • Designed for the clinical lab as a random access system • Easy to use without specialized knowledge or experience • Dedicated Cascadion assays for a complete system solution Find out more at thermofisher.com/cascadion *Product not 510(k) cleared and not yet available for sale in the U.S. © 2018 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. 0718 Cascadion SM 25-Hydroxy Vitamin D Assay Quantitative measurement of 25-Hydroxy Vitamin D3 and 25-Hydroxy Vitamin D2 while excluding C3 epimers